MIA_06324_1

Protein

Length

1,218 amino acids

Protein function

EGGNOG:	0PFI2	FG02460.1	Cation-transporting atpase
SGD closest match:	S000000757	SPF1	Manganese-transporting ATPase 1
CGD closest match:	CAL0000181174	SPF1	Cation-transporting ATPase

Protein alignments

	%id	Aln length
MCA_01991_1	79.441%	1216	MCA_01991_1
A0A0J9X7U6_GEOCN	77.025%	1210	Cation-transporting ATPase OS=Geotrichum candidum GN=BN980_GECA04s00857g PE=3 SV=1
A0A060T7I5_BLAAD	71.663%	1221	Cation-transporting ATPase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B19404g PE=3 SV=1
A0A167EGB3_9ASCO	73.050%	1154	Cation-transporting ATPase OS=Sugiyamaella lignohabitans GN=SPF1 PE=3 SV=1
A0A1E3PKR6_9ASCO	68.387%	1221	Cation-transporting ATPase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_70338 PE=3 SV=1
Q59Q34_CANAL	63.830%	1222	Cation-transporting ATPase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SPF1 PE=3 SV=1
A0A1E4TCD0_9ASCO	63.076%	1216	Cation-transporting ATPase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_148529 PE=3 SV=1
UniRef50_C1H4Y7	59.637%	1266	Cation-transporting ATPase n=40 Tax=leotiomyceta TaxID=716546 RepID=C1H4Y7_PARBA
ATC6_YEAST	60.826%	1210	Manganese-transporting ATPase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SPF1 PE=1 SV=1
Q6C0T2_YARLI	61.116%	1219	Cation-transporting ATPase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F21967g PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.5052

Protein family membership

P-type ATPase (IPR001757)
- P-type ATPase, subfamily V (IPR006544)

Domains and repeats

Domain
175 - 258
P-type ATPase, transmembrane domain (IPR023298)
391 - 484
P-type ATPase, transmembrane domain (IPR023298)
977 - 1,192
P-type ATPase, transmembrane domain (IPR023298)
Domain
259 - 389
P-type ATPase, A domain (IPR008250)
452 - 718
HAD-like domain (IPR023214)
P-type ATPase, cytoplasmic domain N (IPR023299)
775 - 850
HAD-like domain (IPR023214)

1 200 400 600 800 1000 1218

Detailed signature matches

IPR001757

P-type ATPase
1. TIGR01494
  
  788 - 837
  
  TIGRFAMs
  TIGR01494 (TIGR01494)
  
  404 - 508
  
  TIGRFAMs
  TIGR01494 (TIGR01494)
IPR006544

P-type ATPase, subfamily V
1. TIGR01657
  
  51 - 1,172
  
  TIGRFAMs
  TIGR01657 (TIGR01657)
IPR023298

P-type ATPase, transmembrane domain
1. SSF81665 (Calcium A...)
  
  977 - 1,192
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
  
  391 - 484
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
  
  175 - 258
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
IPR008250

P-type ATPase, A domain
1. SSF81653 (Calcium A...)
  
  259 - 389
  
  SUPERFAMILY
  SSF81653 (Calcium ATPase, transduction domain A)
IPR023214

HAD-like domain
1. SSF56784 (HAD-like)
  
  486 - 501
  
  SUPERFAMILY
  SSF56784 (HAD-like)
  
  775 - 850
  
  SUPERFAMILY
  SSF56784 (HAD-like)
  
  628 - 718
  
  SUPERFAMILY
  SSF56784 (HAD-like)
IPR023299

P-type ATPase, cytoplasmic domain N
1. SSF81660 (Metal cat...)
  
  496 - 683
  
  SUPERFAMILY
  SSF81660 (Metal cation-transporting ATPase, ATP-binding domain N)
2. G3DSA:3.40.11...
  
  669 - 705
  
  GENE3D
  G3DSA:3.40.1110.10 (G3DSA:3.40.1110.10)
  
  452 - 668
  
  GENE3D
  G3DSA:3.40.1110.10 (G3DSA:3.40.1110.10)
IPR018303

P-type ATPase, phosphorylation site
1. PS00154 (ATPASE_E1_E2)
  
  492 - 498
  
  PROSITE patterns
  PS00154 (ATPASE_E1_E2)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

86 - 202

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 33

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

244 - 403

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1,009 - 1,014

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1,190 - 1,218

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1,073 - 1,130

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.11...

706 - 1,193

GENE3D
G3DSA:1.20.1110.10 (G3DSA:1.20.1110.10)
G3DSA:2.70.15...

221 - 391

GENE3D
G3DSA:2.70.150.10 (G3DSA:2.70.150.10)
NON_CYTOPLASM... (N...)

424 - 986

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

221 - 225

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1,148 - 1,166

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1,033 - 1,051

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

51 - 61

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
PF00122 (E1-E2_ATPase)

258 - 469

Pfam
PF00122 (E1-E2_ATPase)
PF00702 (Hydrolase)

486 - 717

Pfam
PF00702 (Hydrolase)
PR00119 (CATATPASE)

490 - 504

PRINTS
PR00119 (CATATPASE)

818 - 837

PRINTS
PR00119 (CATATPASE)

694 - 704

PRINTS
PR00119 (CATATPASE)

309 - 323

PRINTS
PR00119 (CATATPASE)
PS01229 (COF_2)

818 - 840

PROSITE patterns
PS01229 (COF_2)
TMhelix

404 - 423

TMHMM
TMhelix (TMhelix)

63 - 85

TMHMM
TMhelix (TMhelix)

1,133 - 1,152

TMHMM
TMhelix (TMhelix)

1,050 - 1,072

TMHMM
TMhelix (TMhelix)

1,167 - 1,189

TMHMM
TMhelix (TMhelix)

224 - 243

TMHMM
TMhelix (TMhelix)

34 - 53

TMHMM
TMhelix (TMhelix)

203 - 220

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

987 - 1,008

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

34 - 50

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,131 - 1,147

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,015 - 1,032

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,167 - 1,189

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

203 - 220

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

404 - 423

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,052 - 1,072

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

226 - 243

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

62 - 85

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
cd07543 (P-type_ATP...)

175 - 1,132

CDD
cd07543 (P-type_ATPase_cation)

Residue annotation

phosphorylation si...

492D

phosphorylation site
492D
CDD
cd07543 (P-type_ATPase_cation)
P-type ATPase sign...

492D

P-type ATPase signature motif
492D, 493K, 494T, 495G, 496T, 497L, 498T
CDD
cd07543 (P-type_ATPase_cation)

493K

P-type ATPase signature motif
492D, 493K, 494T, 495G, 496T, 497L, 498T
CDD
cd07543 (P-type_ATPase_cation)

494T

P-type ATPase signature motif
492D, 493K, 494T, 495G, 496T, 497L, 498T
CDD
cd07543 (P-type_ATPase_cation)

495G

P-type ATPase signature motif
492D, 493K, 494T, 495G, 496T, 497L, 498T
CDD
cd07543 (P-type_ATPase_cation)

496T

P-type ATPase signature motif
492D, 493K, 494T, 495G, 496T, 497L, 498T
CDD
cd07543 (P-type_ATPase_cation)

497L

P-type ATPase signature motif
492D, 493K, 494T, 495G, 496T, 497L, 498T
CDD
cd07543 (P-type_ATPase_cation)

498T

P-type ATPase signature motif
492D, 493K, 494T, 495G, 496T, 497L, 498T
CDD
cd07543 (P-type_ATPase_cation)
putative ATP bindi...

492D

putative ATP binding site
492D, 493K, 494T, 586F, 608K, 609G, 610A, 640L, 702T, 703G, 704D, 795R, 798P, 801K, 820D, 823N
CDD
cd07543 (P-type_ATPase_cation)

493K

putative ATP binding site
492D, 493K, 494T, 586F, 608K, 609G, 610A, 640L, 702T, 703G, 704D, 795R, 798P, 801K, 820D, 823N
CDD
cd07543 (P-type_ATPase_cation)

494T

putative ATP binding site
492D, 493K, 494T, 586F, 608K, 609G, 610A, 640L, 702T, 703G, 704D, 795R, 798P, 801K, 820D, 823N
CDD
cd07543 (P-type_ATPase_cation)

586F

putative ATP binding site
492D, 493K, 494T, 586F, 608K, 609G, 610A, 640L, 702T, 703G, 704D, 795R, 798P, 801K, 820D, 823N
CDD
cd07543 (P-type_ATPase_cation)

608K

putative ATP binding site
492D, 493K, 494T, 586F, 608K, 609G, 610A, 640L, 702T, 703G, 704D, 795R, 798P, 801K, 820D, 823N
CDD
cd07543 (P-type_ATPase_cation)

609G

putative ATP binding site
492D, 493K, 494T, 586F, 608K, 609G, 610A, 640L, 702T, 703G, 704D, 795R, 798P, 801K, 820D, 823N
CDD
cd07543 (P-type_ATPase_cation)

610A

putative ATP binding site
492D, 493K, 494T, 586F, 608K, 609G, 610A, 640L, 702T, 703G, 704D, 795R, 798P, 801K, 820D, 823N
CDD
cd07543 (P-type_ATPase_cation)

640L

putative ATP binding site
492D, 493K, 494T, 586F, 608K, 609G, 610A, 640L, 702T, 703G, 704D, 795R, 798P, 801K, 820D, 823N
CDD
cd07543 (P-type_ATPase_cation)

702T

putative ATP binding site
492D, 493K, 494T, 586F, 608K, 609G, 610A, 640L, 702T, 703G, 704D, 795R, 798P, 801K, 820D, 823N
CDD
cd07543 (P-type_ATPase_cation)

703G

putative ATP binding site
492D, 493K, 494T, 586F, 608K, 609G, 610A, 640L, 702T, 703G, 704D, 795R, 798P, 801K, 820D, 823N
CDD
cd07543 (P-type_ATPase_cation)

704D

putative ATP binding site
492D, 493K, 494T, 586F, 608K, 609G, 610A, 640L, 702T, 703G, 704D, 795R, 798P, 801K, 820D, 823N
CDD
cd07543 (P-type_ATPase_cation)

795R

putative ATP binding site
492D, 493K, 494T, 586F, 608K, 609G, 610A, 640L, 702T, 703G, 704D, 795R, 798P, 801K, 820D, 823N
CDD
cd07543 (P-type_ATPase_cation)

798P

putative ATP binding site
492D, 493K, 494T, 586F, 608K, 609G, 610A, 640L, 702T, 703G, 704D, 795R, 798P, 801K, 820D, 823N
CDD
cd07543 (P-type_ATPase_cation)

801K

putative ATP binding site
492D, 493K, 494T, 586F, 608K, 609G, 610A, 640L, 702T, 703G, 704D, 795R, 798P, 801K, 820D, 823N
CDD
cd07543 (P-type_ATPase_cation)

820D

putative ATP binding site
492D, 493K, 494T, 586F, 608K, 609G, 610A, 640L, 702T, 703G, 704D, 795R, 798P, 801K, 820D, 823N
CDD
cd07543 (P-type_ATPase_cation)

823N

putative ATP binding site
492D, 493K, 494T, 586F, 608K, 609G, 610A, 640L, 702T, 703G, 704D, 795R, 798P, 801K, 820D, 823N
CDD
cd07543 (P-type_ATPase_cation)
putative cation bi...

989K

putative cation binding site
989K, 993L, 994N, 996L, 997I, 1,024L, 1,027C, 1,028F
CDD
cd07543 (P-type_ATPase_cation)

993L

putative cation binding site
989K, 993L, 994N, 996L, 997I, 1,024L, 1,027C, 1,028F
CDD
cd07543 (P-type_ATPase_cation)

994N

putative cation binding site
989K, 993L, 994N, 996L, 997I, 1,024L, 1,027C, 1,028F
CDD
cd07543 (P-type_ATPase_cation)

996L

putative cation binding site
989K, 993L, 994N, 996L, 997I, 1,024L, 1,027C, 1,028F
CDD
cd07543 (P-type_ATPase_cation)

997I

putative cation binding site
989K, 993L, 994N, 996L, 997I, 1,024L, 1,027C, 1,028F
CDD
cd07543 (P-type_ATPase_cation)

1,024L

putative cation binding site
989K, 993L, 994N, 996L, 997I, 1,024L, 1,027C, 1,028F
CDD
cd07543 (P-type_ATPase_cation)

1,027C

putative cation binding site
989K, 993L, 994N, 996L, 997I, 1,024L, 1,027C, 1,028F
CDD
cd07543 (P-type_ATPase_cation)

1,028F

putative cation binding site
989K, 993L, 994N, 996L, 997I, 1,024L, 1,027C, 1,028F
CDD
cd07543 (P-type_ATPase_cation)

Protein sequence

>MIA_06324_1
MLTLSFSRASKLVPNPSIAEATLHNPLPLIYRPYIWPFLFLYPLFGYFYFFRYDEYIGGSEWTFVFLGTICSFNLLFWLM
PFWNVELDRIFNTKLAKSVEEASLIRLIPVANGGASEICTIQRAFYDGEEEIFFLFQRRRFIYNSESKTFNPPTFTIDSP
QKISFYQKSVGLTGDLENLERQYGENKFDIPVPTFLELWKEHAVAPFFVFQMFCVALWLMDEMWYYPLFTLFMLLAFEST
VVWQRQGTLREFRGMSITPYKIWAYRDKEWIEIDSDELLPGDLISVTRSKEESGLPCDLILVNGTVIVNEAMLSGESTPL
LKESISLRPGDEFIDVEGLDKNSVLHGGTKALQVTSPINPHVPLPPDNGALAIVTKIGFETSQGSLVRVMIFSTERVGAG
NKEAYFFILFLLNFAIAASWYVWKEGVKTNRKRSKLILDCILIITSVVPPELPMELTLAVNSSLASLSKFYIYCTEPFRI
PFAGRVDVCCFDKTGTLTGEDLVVEGIAGIAANPTVLSSVADISRETELVLAAAHALVLLDDGETVGDPMEKNTLKAIKW
TVAKNDVVQNKEIPSEKLTILRRFQFSSALKRSSSIANVDGKTFVAVKGAPETLREMIDVLPKEYETTFKSFTRSGSRVL
ALGYKYLENNISSNKLNKITREEVESHLVFGGFLVFHTPLKEDAVETVKMLNESSHRVVMITGDNPLTAVHVAKEVGIVE
RETLILDLPEIDHGDHELVWRSVDESTIIPVKPSDPLNLSIFEDFDLCITGYALAKLSDHEHIVDLVKHTWIYARVSPMQ
KEFILKVLKEAGYMTLMCGDGTNDVGALKQAHVGVALLNGTTGGMKKMADDRKIEATKQVYEKQVALMKRWGSAKVPPVP
PAIAHLYPPGPNNPHYRKAVEEKGGVLDEKTIQEIEKYSKTTEAPQQAAAFADKLTSIIEENEDEAPKLKLGDASVAAPF
TSKLADVSAITNIIRQGRCTLVATIQMYKILALNCLISAYSLSVLYLAGIKIGDAQATASGLLLSVCFMSISRSRAIEKL
SKQRPQPGIFNIYIMGSILGQFAVHIVTLVFITNRVYEIEPRESDIDLEAEFKPSLLNTAIYLLQLGQQVSTFAVNYQGR
PFRESLRENKGMYYGLLGVGALALSGSTEFIPELNEALKLVPMTDKFRFQLTGCILLDLSVCWLIELTLKYFFMDYKPAD
IALRLEERKGHLLQKKEK

GO term prediction

Biological Process

GO:0006812 cation transport

Molecular Function

GO:0000166 nucleotide binding
GO:0016887 ATPase activity

Cellular Component

GO:0016021 integral component of membrane

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Status

Per-residue features