MCA_01991_1

Protein

Length

1,232 amino acids

Gene name: SPF1

Description: Manganese-transporting ATPase 1; P-type ATPase

Browser: contigA:6048886-6052759+

RNA-seq: read pairs 8241, FPKM 82.6, percentile rank 75.8% (100% = highest expression)

Protein function

Annotation:		SPF1	Manganese-transporting ATPase 1; P-type ATPase
KEGG:	K14950	ATP13A1	manganese-transporting P-type ATPase [EC:3.6.3.-]
EGGNOG:	0PFI2	FG02460.1	Cation-transporting atpase
SGD closest match:	S000000757	SPF1	Manganese-transporting ATPase 1
CGD closest match:	CAL0000181174	SPF1	Cation-transporting ATPase

Protein alignments

	%id	Aln length
MIA_06324_1	79.28%	1216	MIA_06324_1
A0A0J9X7U6_GEOCN	74.03%	1213	Cation-transporting ATPase OS=Geotrichum candidum GN=BN980_GECA04s00857g PE=3 SV=1
A0A060T7I5_BLAAD	70.75%	1224	Cation-transporting ATPase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B19404g PE=3 SV=1
A0A167EGB3_9ASCO	70.50%	1156	Cation-transporting ATPase OS=Sugiyamaella lignohabitans GN=SPF1 PE=3 SV=1
A0A1E3PKR6_9ASCO	66.69%	1222	Cation-transporting ATPase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_70338 PE=3 SV=1
A0A1E4TCD0_9ASCO	62.02%	1219	Cation-transporting ATPase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_148529 PE=3 SV=1
Q59Q34_CANAL	62.09%	1224	Cation-transporting ATPase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SPF1 PE=3 SV=1
UniRef50_C1H4Y7	58.45%	1266	Cation-transporting ATPase n=40 Tax=leotiomyceta TaxID=716546 RepID=C1H4Y7_PARBA
ATC6_YEAST	60.53%	1211	Manganese-transporting ATPase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SPF1 PE=1 SV=1
Q6C0T2_YARLI	60.47%	1222	Cation-transporting ATPase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F21967g PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0365

Protein family membership

P-type ATPase (IPR001757)
- P-type ATPase, subfamily V (IPR006544)

Domains and repeats

Domain
188 - 271
P-type ATPase, transmembrane domain (IPR023298)
405 - 498
P-type ATPase, transmembrane domain (IPR023298)
991 - 1,206
P-type ATPase, transmembrane domain (IPR023298)
Domain
272 - 403
P-type ATPase, A domain (IPR008250)
465 - 732
HAD-like domain (IPR023214)
P-type ATPase, cytoplasmic domain N (IPR023299)
789 - 859
HAD-like domain (IPR023214)

1 200 400 600 800 1000 1232

Detailed signature matches

IPR001757

P-type ATPase
1. TIGR01494
  
  418 - 526
  
  TIGRFAMs
  TIGR01494 (TIGR01494)
IPR006544

P-type ATPase, subfamily V
1. TIGR01657
  
  65 - 1,186
  
  TIGRFAMs
  TIGR01657 (TIGR01657)
IPR023298

P-type ATPase, transmembrane domain
1. SSF81665 (Calcium A...)
  
  991 - 1,206
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
  
  188 - 271
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
  
  405 - 498
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
IPR008250

P-type ATPase, A domain
1. SSF81653 (Calcium A...)
  
  272 - 403
  
  SUPERFAMILY
  SSF81653 (Calcium ATPase, transduction domain A)
IPR023214

HAD-like domain
1. SSF56784 (HAD-like)
  
  500 - 515
  
  SUPERFAMILY
  SSF56784 (HAD-like)
  
  789 - 859
  
  SUPERFAMILY
  SSF56784 (HAD-like)
  
  642 - 732
  
  SUPERFAMILY
  SSF56784 (HAD-like)
IPR023299

P-type ATPase, cytoplasmic domain N
1. SSF81660 (Metal cat...)
  
  510 - 697
  
  SUPERFAMILY
  SSF81660 (Metal cation-transporting ATPase, ATP-binding domain N)
2. G3DSA:3.40.11...
  
  465 - 693
  
  GENE3D
  G3DSA:3.40.1110.10 (G3DSA:3.40.1110.10)
IPR018303

P-type ATPase, phosphorylation site
1. PS00154 (ATPASE_E1_E2)
  
  506 - 512
  
  PROSITE patterns
  PS00154 (ATPASE_E1_E2)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

1,208 - 1,232

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 46

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

99 - 215

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

257 - 417

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1,087 - 1,145

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1,023 - 1,028

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
Coil

1,216 - 1,232

COILS
Coil (Coil)
G3DSA:1.20.11...

721 - 1,216

GENE3D
G3DSA:1.20.1110.10 (G3DSA:1.20.1110.10)
G3DSA:2.70.15...

234 - 405

GENE3D
G3DSA:2.70.150.10 (G3DSA:2.70.150.10)
NON_CYTOPLASM... (N...)

438 - 1,000

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1,166 - 1,184

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

234 - 238

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1,047 - 1,065

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

66 - 76

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
PF00122 (E1-E2_ATPase)

271 - 483

Pfam
PF00122 (E1-E2_ATPase)
PF00702 (Hydrolase)

500 - 731

Pfam
PF00702 (Hydrolase)
PR00119 (CATATPASE)

832 - 851

PRINTS
PR00119 (CATATPASE)

708 - 718

PRINTS
PR00119 (CATATPASE)

504 - 518

PRINTS
PR00119 (CATATPASE)

322 - 336

PRINTS
PR00119 (CATATPASE)
PS01229 (COF_2)

832 - 854

PROSITE patterns
PS01229 (COF_2)
TMhelix

47 - 66

TMHMM
TMhelix (TMhelix)

1,185 - 1,207

TMHMM
TMhelix (TMhelix)

1,064 - 1,086

TMHMM
TMhelix (TMhelix)

1,146 - 1,165

TMHMM
TMhelix (TMhelix)

76 - 98

TMHMM
TMhelix (TMhelix)

237 - 256

TMHMM
TMhelix (TMhelix)

216 - 233

TMHMM
TMhelix (TMhelix)

418 - 437

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

239 - 256

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,029 - 1,046

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

77 - 98

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

47 - 65

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

216 - 233

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

418 - 437

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,185 - 1,207

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,066 - 1,086

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,001 - 1,022

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,146 - 1,165

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
cd07543 (P-type_ATP...)

188 - 1,146

CDD
cd07543 (P-type_ATPase_cation)

Residue annotation

phosphorylation si...

506D

phosphorylation site
506D
CDD
cd07543 (P-type_ATPase_cation)
P-type ATPase sign...

506D

P-type ATPase signature motif
506D, 507K, 508T, 509G, 510T, 511L, 512T
CDD
cd07543 (P-type_ATPase_cation)

507K

P-type ATPase signature motif
506D, 507K, 508T, 509G, 510T, 511L, 512T
CDD
cd07543 (P-type_ATPase_cation)

508T

P-type ATPase signature motif
506D, 507K, 508T, 509G, 510T, 511L, 512T
CDD
cd07543 (P-type_ATPase_cation)

509G

P-type ATPase signature motif
506D, 507K, 508T, 509G, 510T, 511L, 512T
CDD
cd07543 (P-type_ATPase_cation)

510T

P-type ATPase signature motif
506D, 507K, 508T, 509G, 510T, 511L, 512T
CDD
cd07543 (P-type_ATPase_cation)

511L

P-type ATPase signature motif
506D, 507K, 508T, 509G, 510T, 511L, 512T
CDD
cd07543 (P-type_ATPase_cation)

512T

P-type ATPase signature motif
506D, 507K, 508T, 509G, 510T, 511L, 512T
CDD
cd07543 (P-type_ATPase_cation)
putative ATP bindi...

506D

putative ATP binding site
506D, 507K, 508T, 600F, 622K, 623G, 624A, 654L, 716T, 717G, 718D, 809R, 812P, 815K, 834D, 837N
CDD
cd07543 (P-type_ATPase_cation)

507K

putative ATP binding site
506D, 507K, 508T, 600F, 622K, 623G, 624A, 654L, 716T, 717G, 718D, 809R, 812P, 815K, 834D, 837N
CDD
cd07543 (P-type_ATPase_cation)

508T

putative ATP binding site
506D, 507K, 508T, 600F, 622K, 623G, 624A, 654L, 716T, 717G, 718D, 809R, 812P, 815K, 834D, 837N
CDD
cd07543 (P-type_ATPase_cation)

600F

putative ATP binding site
506D, 507K, 508T, 600F, 622K, 623G, 624A, 654L, 716T, 717G, 718D, 809R, 812P, 815K, 834D, 837N
CDD
cd07543 (P-type_ATPase_cation)

622K

putative ATP binding site
506D, 507K, 508T, 600F, 622K, 623G, 624A, 654L, 716T, 717G, 718D, 809R, 812P, 815K, 834D, 837N
CDD
cd07543 (P-type_ATPase_cation)

623G

putative ATP binding site
506D, 507K, 508T, 600F, 622K, 623G, 624A, 654L, 716T, 717G, 718D, 809R, 812P, 815K, 834D, 837N
CDD
cd07543 (P-type_ATPase_cation)

624A

putative ATP binding site
506D, 507K, 508T, 600F, 622K, 623G, 624A, 654L, 716T, 717G, 718D, 809R, 812P, 815K, 834D, 837N
CDD
cd07543 (P-type_ATPase_cation)

654L

putative ATP binding site
506D, 507K, 508T, 600F, 622K, 623G, 624A, 654L, 716T, 717G, 718D, 809R, 812P, 815K, 834D, 837N
CDD
cd07543 (P-type_ATPase_cation)

716T

putative ATP binding site
506D, 507K, 508T, 600F, 622K, 623G, 624A, 654L, 716T, 717G, 718D, 809R, 812P, 815K, 834D, 837N
CDD
cd07543 (P-type_ATPase_cation)

717G

putative ATP binding site
506D, 507K, 508T, 600F, 622K, 623G, 624A, 654L, 716T, 717G, 718D, 809R, 812P, 815K, 834D, 837N
CDD
cd07543 (P-type_ATPase_cation)

718D

putative ATP binding site
506D, 507K, 508T, 600F, 622K, 623G, 624A, 654L, 716T, 717G, 718D, 809R, 812P, 815K, 834D, 837N
CDD
cd07543 (P-type_ATPase_cation)

809R

putative ATP binding site
506D, 507K, 508T, 600F, 622K, 623G, 624A, 654L, 716T, 717G, 718D, 809R, 812P, 815K, 834D, 837N
CDD
cd07543 (P-type_ATPase_cation)

812P

putative ATP binding site
506D, 507K, 508T, 600F, 622K, 623G, 624A, 654L, 716T, 717G, 718D, 809R, 812P, 815K, 834D, 837N
CDD
cd07543 (P-type_ATPase_cation)

815K

putative ATP binding site
506D, 507K, 508T, 600F, 622K, 623G, 624A, 654L, 716T, 717G, 718D, 809R, 812P, 815K, 834D, 837N
CDD
cd07543 (P-type_ATPase_cation)

834D

putative ATP binding site
506D, 507K, 508T, 600F, 622K, 623G, 624A, 654L, 716T, 717G, 718D, 809R, 812P, 815K, 834D, 837N
CDD
cd07543 (P-type_ATPase_cation)

837N

putative ATP binding site
506D, 507K, 508T, 600F, 622K, 623G, 624A, 654L, 716T, 717G, 718D, 809R, 812P, 815K, 834D, 837N
CDD
cd07543 (P-type_ATPase_cation)
putative cation bi...

1,003K

putative cation binding site
1,003K, 1,007L, 1,008N, 1,010L, 1,011I, 1,038L, 1,041C, 1,042F
CDD
cd07543 (P-type_ATPase_cation)

1,007L

putative cation binding site
1,003K, 1,007L, 1,008N, 1,010L, 1,011I, 1,038L, 1,041C, 1,042F
CDD
cd07543 (P-type_ATPase_cation)

1,008N

putative cation binding site
1,003K, 1,007L, 1,008N, 1,010L, 1,011I, 1,038L, 1,041C, 1,042F
CDD
cd07543 (P-type_ATPase_cation)

1,010L

putative cation binding site
1,003K, 1,007L, 1,008N, 1,010L, 1,011I, 1,038L, 1,041C, 1,042F
CDD
cd07543 (P-type_ATPase_cation)

1,011I

putative cation binding site
1,003K, 1,007L, 1,008N, 1,010L, 1,011I, 1,038L, 1,041C, 1,042F
CDD
cd07543 (P-type_ATPase_cation)

1,038L

putative cation binding site
1,003K, 1,007L, 1,008N, 1,010L, 1,011I, 1,038L, 1,041C, 1,042F
CDD
cd07543 (P-type_ATPase_cation)

1,041C

putative cation binding site
1,003K, 1,007L, 1,008N, 1,010L, 1,011I, 1,038L, 1,041C, 1,042F
CDD
cd07543 (P-type_ATPase_cation)

1,042F

putative cation binding site
1,003K, 1,007L, 1,008N, 1,010L, 1,011I, 1,038L, 1,041C, 1,042F
CDD
cd07543 (P-type_ATPase_cation)

Protein sequence

>MCA_01991_1
MHEHFIIDLICFIQQKLKLIMASKLVPTPSIKEATLHNRKPILARPYVWPFIFLYPAFAYFYFFHYDEYIGGREWTFVYF
GSIISFNLLFWLMPFWNVEVDTLFNTTKASSVADASLIRLIPVSNSGSSEICELKRAVFDDEEEISFYFQRRRFIYDPDT
NTFNPPTFFIDSPRTIATIKSSKGLSGDLEHLEIMYGENRFDIPIPTFIELWKEHAVAPFFVFQMFCVALWFMDEMWYYP
LFTLFMLLTFESTVVWQRQRTLQEFRGMSIAPYKIWVYRDSNWIEVDTDELLPNDVVSVTRSKEESGLPCDMILLQGTVI
VNEAMLSGESTPLLKESIELRPASATLDLDGDDKNSVLHGGTKVLQVTPPTAISTIPAAPDNGALALVTKIGFETSQGSL
VRVMIFSTERVGAGNKEAYFFILFLLIFAIAASWYVWKEGVKTDRDRYKLIIDCILIITSVVPPELPMELTLAVNSSLAA
LAKYYIYCTEPFRIPYAGRIDVCCFDKTGTLTGEDLVVEGITGITDDPHQLCSIDSISSETRHVLAAAHALVLLDDGEIV
GDPMEQNTLKAINWTVDKNDVIKSKTSPSEKLQVLRRFQFSSALKRSSSIAAVNDKLLVAVKGAPETIRQMIDIVPPKYE
ETYKTFTRNGSRVLALAYKYLDSKTSLTRVNSLNREEIESNLIFAGFLVFHTPLKKDAAETVKMLNESSHRVVMITGDNP
LTAVHVAKQVSIVERDTLILDLPEPGHGSHDLVWRSTDETTIIPVDPRKSLDISLFDDYDLCITGYALEKLNDHDQIVDL
VRHTWVYARVSPNQKEFILTVLKDAGYMTLMCGDGTNDVGALKQAHIGVALLNGTDEGMKKMAENAKLNAVRNVYEKQVA
LMKRWGSKQVPPVPPAIAHLYPPGPNNPHYRKAIEARGGKLDEKSLQDIEKYSKEEQAPVQAAAFADKLTAMMEENDDEA
PQIKLGDASVAAPFTSKLGDVSSITKIIRQGRCTLVATIQMYKILALNCLISAYSLSVLYLAGIKIGDAQATASGLLLSV
CFMSISRSKAIEKLSKQRPQPGIFNIYIMGSILGQFAIHIITLVYISQRVYENEPKSASVDLEAEFKPSLLNTAIYLLQL
GQQVSTFAVNYQGRPFRESLRENKGMYYGLLGVSLLALAGSTEFIPEMNEALKLVPMTDKFKFQLTGSIILDFSFCWIIE
LTLKYFFMDYKPADIALRLEERNGQLIQKKNK

GO term prediction

Biological Process

GO:0006812 cation transport

Molecular Function

GO:0000166 nucleotide binding
GO:0016887 ATPase activity

Cellular Component

GO:0016021 integral component of membrane

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Status

Per-residue features