MIA_06314_1

Protein

Length

2,403 amino acids

Protein function

EGGNOG:	0PGA0	TOR1	Phosphatidylinositol 3-kinase
SGD closest match:	S000001686	TOR2	Serine/threonine-protein kinase TOR2
CGD closest match:	CAL0000187577	TOR1	Phosphatidylinositol kinase-related protein kinase

Protein alignments

	%id	Aln length
MCA_01949_1	78.645%	2435	MCA_01949_1
A0A0J9XDV1_GEOCN	75.602%	2410	Similar to Saccharomyces cerevisiae YKL203C TOR2 PIK-related protein kinase and rapamycin target OS=Geotrichum candidum GN=BN980_GECA12s01055g PE=3 SV=1
A0A060T7U1_BLAAD	69.012%	2217	ARAD1C30470p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C30470g PE=3 SV=1
UniRef50_A0A061AS31	59.692%	2404	CYFA0S04e00980g1_1 n=5 Tax=Fungi TaxID=4751 RepID=A0A061AS31_CYBFA
A0A161HMR9_9ASCO	67.251%	2052	Phosphatidylinositol kinase-related protein kinase TOR1 OS=Sugiyamaella lignohabitans GN=TOR1 PE=3 SV=1
Q6C2K6_YARLI	62.506%	2267	YALI0F07084p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F07084g PE=3 SV=1
A0A1E3PD23_9ASCO	58.186%	2425	FAT-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_53585 PE=3 SV=1
A0A1E4TIV8_9ASCO	59.533%	2271	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_46867 PE=3 SV=1
A0A1D8PHX3_CANAL	56.313%	2376	Phosphatidylinositol kinase-related protein kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TOR1 PE=3 SV=1
TOR2_YEAST	55.091%	2298	Serine/threonine-protein kinase TOR2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TOR2 PE=1 SV=3

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0746

Protein family membership

None predicted.

Domains and repeats

Domain
15 - 468
Armadillo-type fold (IPR016024)
Armadillo-like helical (IPR011989)
474 - 1,602
Armadillo-type fold (IPR016024)
Armadillo-like helical (IPR011989)
1,667 - 1,826
Armadillo-type fold (IPR016024)
1,839 - 1,936
FKBP12-rapamycin binding domain (IPR009076)
1,993 - 2,079
Armadillo-type fold (IPR016024)
2,371 - 2,403
FATC domain (IPR003152)
Domain
750 - 909
Domain of unknown function DUF3385, target of rapamycin protein (IPR024585)
1,521 - 1,645
Tetratricopeptide-like helical domain (IPR011990)
1,916 - 2,403
Protein kinase-like domain (IPR011009)
Phosphatidylinositol 3-/4-kinase, catalytic domain (IPR000403)
Domain
1,252 - 1,806
PIK-related kinase (IPR014009)
PIK-related kinase, FAT (IPR003151)

1 500 1000 1500 2000 2403

Detailed signature matches

IPR016024

Armadillo-type fold
1. SSF48371 (ARM repeat)
  
  1,993 - 2,079
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  1,197 - 1,335
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  1,667 - 1,826
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  1,386 - 1,602
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  15 - 445
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  485 - 536
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  1,152 - 1,381
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  411 - 442
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  484 - 1,117
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
IPR011989

Armadillo-like helical
1. G3DSA:1.25.10.10
  
  474 - 743
  
  GENE3D
  G3DSA:1.25.10.10 (G3DSA:1.25.10.10)
  
  744 - 1,520
  
  GENE3D
  G3DSA:1.25.10.10 (G3DSA:1.25.10.10)
  
  30 - 468
  
  GENE3D
  G3DSA:1.25.10.10 (G3DSA:1.25.10.10)
IPR024585

Domain of unknown function DUF3385, target of rapamycin protein
1. PF11865 (DUF3385)
  
  750 - 909
  
  Pfam
  PF11865 (DUF3385)
2. SM01346 (DUF3385_3)
  
  750 - 909
  
  SMART
  SM01346 (DUF3385_3)
IPR014009

PIK-related kinase
1. PS51189 (FAT)
  
  1,252 - 1,806
  
  PROSITE profiles
  PS51189 (FAT)
IPR003151

PIK-related kinase, FAT
1. PF02259 (FAT)
  
  1,382 - 1,732
  
  Pfam
  PF02259 (FAT)
IPR011990

Tetratricopeptide-like helical domain
1. G3DSA:1.25.40.10
  
  1,521 - 1,645
  
  GENE3D
  G3DSA:1.25.40.10 (G3DSA:1.25.40.10)
IPR009076

FKBP12-rapamycin binding domain
1. PF08771 (FRB_dom)
  
  1,839 - 1,936
  
  Pfam
  PF08771 (FRB_dom)
2. SSF47212 (FKBP12-ra...)
  
  1,843 - 1,935
  
  SUPERFAMILY
  SSF47212 (FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP))
3. G3DSA:1.20.12...
  
  1,843 - 1,925
  
  GENE3D
  G3DSA:1.20.120.150 (G3DSA:1.20.120.150)
IPR011009

Protein kinase-like domain
1. SSF56112 (Protein k...)
  
  2,117 - 2,253
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
  
  1,916 - 2,082
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR000403

Phosphatidylinositol 3-/4-kinase, catalytic domain
1. PS50290 (PI3_4_KINA...)
  
  2,006 - 2,403
  
  PROSITE profiles
  PS50290 (PI3_4_KINASE_3)
2. SM00146 (pi3k_hr1_6)
  
  2,007 - 2,304
  
  SMART
  SM00146 (pi3k_hr1_6)
3. PF00454 (PI3_PI4_ki...)
  
  2,006 - 2,252
  
  Pfam
  PF00454 (PI3_PI4_kinase)
4. G3DSA:1.10.10...
  
  2,108 - 2,363
  
  GENE3D
  G3DSA:1.10.1070.11 (G3DSA:1.10.1070.11)
IPR003152

FATC domain
1. SM01343 (FATC_2)
  
  2,371 - 2,403
  
  SMART
  SM01343 (FATC_2)
2. PF02260 (FATC)
  
  2,374 - 2,403
  
  Pfam
  PF02260 (FATC)
3. PS51190 (FATC)
  
  2,371 - 2,403
  
  PROSITE profiles
  PS51190 (FATC)
IPR018936

Phosphatidylinositol 3/4-kinase, conserved site
1. PS00916 (PI3_4_KINA...)
  
  2,146 - 2,166
  
  PROSITE patterns
  PS00916 (PI3_4_KINASE_2)
2. PS00915 (PI3_4_KINA...)
  
  2,010 - 2,024
  
  PROSITE patterns
  PS00915 (PI3_4_KINASE_1)

no IPR

Unintegrated signatures

G3DSA:3.30.10...

1,926 - 2,065

GENE3D
G3DSA:3.30.1010.10 (G3DSA:3.30.1010.10)
SM01345 (Rapamycin_...)

1,839 - 1,938

SMART
SM01345 (Rapamycin_bind_3)
cd05169 (PIKKc_TOR)

1,977 - 2,252

CDD
cd05169 (PIKKc_TOR)
mobidb-lite (disord...)

2,295 - 2,345

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

ATP binding site c...

1,987I

ATP binding site
1,987I, 1,989S, 1,990K, 1,991Q, 1,993P, 2,009V, 2,011K, 2,014E, 2,049Y, 2,061L, 2,062G, 2,063W, 2,064V, 2,069T, 2,166N, 2,168M, 2,179V, 2,180D
CDD
cd05169 (PIKKc_TOR)

1,989S

ATP binding site
1,987I, 1,989S, 1,990K, 1,991Q, 1,993P, 2,009V, 2,011K, 2,014E, 2,049Y, 2,061L, 2,062G, 2,063W, 2,064V, 2,069T, 2,166N, 2,168M, 2,179V, 2,180D
CDD
cd05169 (PIKKc_TOR)

1,990K

ATP binding site
1,987I, 1,989S, 1,990K, 1,991Q, 1,993P, 2,009V, 2,011K, 2,014E, 2,049Y, 2,061L, 2,062G, 2,063W, 2,064V, 2,069T, 2,166N, 2,168M, 2,179V, 2,180D
CDD
cd05169 (PIKKc_TOR)

1,991Q

ATP binding site
1,987I, 1,989S, 1,990K, 1,991Q, 1,993P, 2,009V, 2,011K, 2,014E, 2,049Y, 2,061L, 2,062G, 2,063W, 2,064V, 2,069T, 2,166N, 2,168M, 2,179V, 2,180D
CDD
cd05169 (PIKKc_TOR)

1,993P

ATP binding site
1,987I, 1,989S, 1,990K, 1,991Q, 1,993P, 2,009V, 2,011K, 2,014E, 2,049Y, 2,061L, 2,062G, 2,063W, 2,064V, 2,069T, 2,166N, 2,168M, 2,179V, 2,180D
CDD
cd05169 (PIKKc_TOR)

2,009V

ATP binding site
1,987I, 1,989S, 1,990K, 1,991Q, 1,993P, 2,009V, 2,011K, 2,014E, 2,049Y, 2,061L, 2,062G, 2,063W, 2,064V, 2,069T, 2,166N, 2,168M, 2,179V, 2,180D
CDD
cd05169 (PIKKc_TOR)

2,011K

ATP binding site
1,987I, 1,989S, 1,990K, 1,991Q, 1,993P, 2,009V, 2,011K, 2,014E, 2,049Y, 2,061L, 2,062G, 2,063W, 2,064V, 2,069T, 2,166N, 2,168M, 2,179V, 2,180D
CDD
cd05169 (PIKKc_TOR)

2,014E

ATP binding site
1,987I, 1,989S, 1,990K, 1,991Q, 1,993P, 2,009V, 2,011K, 2,014E, 2,049Y, 2,061L, 2,062G, 2,063W, 2,064V, 2,069T, 2,166N, 2,168M, 2,179V, 2,180D
CDD
cd05169 (PIKKc_TOR)

2,049Y

ATP binding site
1,987I, 1,989S, 1,990K, 1,991Q, 1,993P, 2,009V, 2,011K, 2,014E, 2,049Y, 2,061L, 2,062G, 2,063W, 2,064V, 2,069T, 2,166N, 2,168M, 2,179V, 2,180D
CDD
cd05169 (PIKKc_TOR)

2,061L

ATP binding site
1,987I, 1,989S, 1,990K, 1,991Q, 1,993P, 2,009V, 2,011K, 2,014E, 2,049Y, 2,061L, 2,062G, 2,063W, 2,064V, 2,069T, 2,166N, 2,168M, 2,179V, 2,180D
CDD
cd05169 (PIKKc_TOR)

2,062G

ATP binding site
1,987I, 1,989S, 1,990K, 1,991Q, 1,993P, 2,009V, 2,011K, 2,014E, 2,049Y, 2,061L, 2,062G, 2,063W, 2,064V, 2,069T, 2,166N, 2,168M, 2,179V, 2,180D
CDD
cd05169 (PIKKc_TOR)

2,063W

ATP binding site
1,987I, 1,989S, 1,990K, 1,991Q, 1,993P, 2,009V, 2,011K, 2,014E, 2,049Y, 2,061L, 2,062G, 2,063W, 2,064V, 2,069T, 2,166N, 2,168M, 2,179V, 2,180D
CDD
cd05169 (PIKKc_TOR)

2,064V

ATP binding site
1,987I, 1,989S, 1,990K, 1,991Q, 1,993P, 2,009V, 2,011K, 2,014E, 2,049Y, 2,061L, 2,062G, 2,063W, 2,064V, 2,069T, 2,166N, 2,168M, 2,179V, 2,180D
CDD
cd05169 (PIKKc_TOR)

2,069T

ATP binding site
1,987I, 1,989S, 1,990K, 1,991Q, 1,993P, 2,009V, 2,011K, 2,014E, 2,049Y, 2,061L, 2,062G, 2,063W, 2,064V, 2,069T, 2,166N, 2,168M, 2,179V, 2,180D
CDD
cd05169 (PIKKc_TOR)

2,166N

ATP binding site
1,987I, 1,989S, 1,990K, 1,991Q, 1,993P, 2,009V, 2,011K, 2,014E, 2,049Y, 2,061L, 2,062G, 2,063W, 2,064V, 2,069T, 2,166N, 2,168M, 2,179V, 2,180D
CDD
cd05169 (PIKKc_TOR)

2,168M

ATP binding site
1,987I, 1,989S, 1,990K, 1,991Q, 1,993P, 2,009V, 2,011K, 2,014E, 2,049Y, 2,061L, 2,062G, 2,063W, 2,064V, 2,069T, 2,166N, 2,168M, 2,179V, 2,180D
CDD
cd05169 (PIKKc_TOR)

2,179V

ATP binding site
1,987I, 1,989S, 1,990K, 1,991Q, 1,993P, 2,009V, 2,011K, 2,014E, 2,049Y, 2,061L, 2,062G, 2,063W, 2,064V, 2,069T, 2,166N, 2,168M, 2,179V, 2,180D
CDD
cd05169 (PIKKc_TOR)

2,180D

ATP binding site
1,987I, 1,989S, 1,990K, 1,991Q, 1,993P, 2,009V, 2,011K, 2,014E, 2,049Y, 2,061L, 2,062G, 2,063W, 2,064V, 2,069T, 2,166N, 2,168M, 2,179V, 2,180D
CDD
cd05169 (PIKKc_TOR)
mLST8 interface cd...

2,095A

mLST8 interface
2,095A, 2,096P, 2,097D, 2,100S, 2,101L, 2,102A, 2,103H, 2,105Q, 2,107I, 2,108E, 2,111T
CDD
cd05169 (PIKKc_TOR)

2,096P

mLST8 interface
2,095A, 2,096P, 2,097D, 2,100S, 2,101L, 2,102A, 2,103H, 2,105Q, 2,107I, 2,108E, 2,111T
CDD
cd05169 (PIKKc_TOR)

2,097D

mLST8 interface
2,095A, 2,096P, 2,097D, 2,100S, 2,101L, 2,102A, 2,103H, 2,105Q, 2,107I, 2,108E, 2,111T
CDD
cd05169 (PIKKc_TOR)

2,100S

mLST8 interface
2,095A, 2,096P, 2,097D, 2,100S, 2,101L, 2,102A, 2,103H, 2,105Q, 2,107I, 2,108E, 2,111T
CDD
cd05169 (PIKKc_TOR)

2,101L

mLST8 interface
2,095A, 2,096P, 2,097D, 2,100S, 2,101L, 2,102A, 2,103H, 2,105Q, 2,107I, 2,108E, 2,111T
CDD
cd05169 (PIKKc_TOR)

2,102A

mLST8 interface
2,095A, 2,096P, 2,097D, 2,100S, 2,101L, 2,102A, 2,103H, 2,105Q, 2,107I, 2,108E, 2,111T
CDD
cd05169 (PIKKc_TOR)

2,103H

mLST8 interface
2,095A, 2,096P, 2,097D, 2,100S, 2,101L, 2,102A, 2,103H, 2,105Q, 2,107I, 2,108E, 2,111T
CDD
cd05169 (PIKKc_TOR)

2,105Q

mLST8 interface
2,095A, 2,096P, 2,097D, 2,100S, 2,101L, 2,102A, 2,103H, 2,105Q, 2,107I, 2,108E, 2,111T
CDD
cd05169 (PIKKc_TOR)

2,107I

mLST8 interface
2,095A, 2,096P, 2,097D, 2,100S, 2,101L, 2,102A, 2,103H, 2,105Q, 2,107I, 2,108E, 2,111T
CDD
cd05169 (PIKKc_TOR)

2,108E

mLST8 interface
2,095A, 2,096P, 2,097D, 2,100S, 2,101L, 2,102A, 2,103H, 2,105Q, 2,107I, 2,108E, 2,111T
CDD
cd05169 (PIKKc_TOR)

2,111T

mLST8 interface
2,095A, 2,096P, 2,097D, 2,100S, 2,101L, 2,102A, 2,103H, 2,105Q, 2,107I, 2,108E, 2,111T
CDD
cd05169 (PIKKc_TOR)
catalytic loop cd0...

2,158G

catalytic loop
2,158G, 2,159L, 2,160G, 2,161D, 2,162R, 2,163H, 2,164P, 2,165S, 2,166N
CDD
cd05169 (PIKKc_TOR)

2,159L

catalytic loop
2,158G, 2,159L, 2,160G, 2,161D, 2,162R, 2,163H, 2,164P, 2,165S, 2,166N
CDD
cd05169 (PIKKc_TOR)

2,160G

catalytic loop
2,158G, 2,159L, 2,160G, 2,161D, 2,162R, 2,163H, 2,164P, 2,165S, 2,166N
CDD
cd05169 (PIKKc_TOR)

2,161D

catalytic loop
2,158G, 2,159L, 2,160G, 2,161D, 2,162R, 2,163H, 2,164P, 2,165S, 2,166N
CDD
cd05169 (PIKKc_TOR)

2,162R

catalytic loop
2,158G, 2,159L, 2,160G, 2,161D, 2,162R, 2,163H, 2,164P, 2,165S, 2,166N
CDD
cd05169 (PIKKc_TOR)

2,163H

catalytic loop
2,158G, 2,159L, 2,160G, 2,161D, 2,162R, 2,163H, 2,164P, 2,165S, 2,166N
CDD
cd05169 (PIKKc_TOR)

2,164P

catalytic loop
2,158G, 2,159L, 2,160G, 2,161D, 2,162R, 2,163H, 2,164P, 2,165S, 2,166N
CDD
cd05169 (PIKKc_TOR)

2,165S

catalytic loop
2,158G, 2,159L, 2,160G, 2,161D, 2,162R, 2,163H, 2,164P, 2,165S, 2,166N
CDD
cd05169 (PIKKc_TOR)

2,166N

catalytic loop
2,158G, 2,159L, 2,160G, 2,161D, 2,162R, 2,163H, 2,164P, 2,165S, 2,166N
CDD
cd05169 (PIKKc_TOR)
activation loop (A...

2,180D

activation loop (A-loop)
2,180D, 2,181F, 2,182G, 2,183D, 2,184C, 2,185F, 2,186E, 2,187A, 2,188A, 2,189I, 2,190L, 2,191R, 2,192E, 2,193K, 2,194Y, 2,195P, 2,196E, 2,197K, 2,198V, 2,199P, 2,200F, 2,201R, 2,202L, 2,203T
CDD
cd05169 (PIKKc_TOR)

2,181F

activation loop (A-loop)
2,180D, 2,181F, 2,182G, 2,183D, 2,184C, 2,185F, 2,186E, 2,187A, 2,188A, 2,189I, 2,190L, 2,191R, 2,192E, 2,193K, 2,194Y, 2,195P, 2,196E, 2,197K, 2,198V, 2,199P, 2,200F, 2,201R, 2,202L, 2,203T
CDD
cd05169 (PIKKc_TOR)

2,182G

activation loop (A-loop)
2,180D, 2,181F, 2,182G, 2,183D, 2,184C, 2,185F, 2,186E, 2,187A, 2,188A, 2,189I, 2,190L, 2,191R, 2,192E, 2,193K, 2,194Y, 2,195P, 2,196E, 2,197K, 2,198V, 2,199P, 2,200F, 2,201R, 2,202L, 2,203T
CDD
cd05169 (PIKKc_TOR)

2,183D

activation loop (A-loop)
2,180D, 2,181F, 2,182G, 2,183D, 2,184C, 2,185F, 2,186E, 2,187A, 2,188A, 2,189I, 2,190L, 2,191R, 2,192E, 2,193K, 2,194Y, 2,195P, 2,196E, 2,197K, 2,198V, 2,199P, 2,200F, 2,201R, 2,202L, 2,203T
CDD
cd05169 (PIKKc_TOR)

2,184C

activation loop (A-loop)
2,180D, 2,181F, 2,182G, 2,183D, 2,184C, 2,185F, 2,186E, 2,187A, 2,188A, 2,189I, 2,190L, 2,191R, 2,192E, 2,193K, 2,194Y, 2,195P, 2,196E, 2,197K, 2,198V, 2,199P, 2,200F, 2,201R, 2,202L, 2,203T
CDD
cd05169 (PIKKc_TOR)

2,185F

activation loop (A-loop)
2,180D, 2,181F, 2,182G, 2,183D, 2,184C, 2,185F, 2,186E, 2,187A, 2,188A, 2,189I, 2,190L, 2,191R, 2,192E, 2,193K, 2,194Y, 2,195P, 2,196E, 2,197K, 2,198V, 2,199P, 2,200F, 2,201R, 2,202L, 2,203T
CDD
cd05169 (PIKKc_TOR)

2,186E

activation loop (A-loop)
2,180D, 2,181F, 2,182G, 2,183D, 2,184C, 2,185F, 2,186E, 2,187A, 2,188A, 2,189I, 2,190L, 2,191R, 2,192E, 2,193K, 2,194Y, 2,195P, 2,196E, 2,197K, 2,198V, 2,199P, 2,200F, 2,201R, 2,202L, 2,203T
CDD
cd05169 (PIKKc_TOR)

2,187A

activation loop (A-loop)
2,180D, 2,181F, 2,182G, 2,183D, 2,184C, 2,185F, 2,186E, 2,187A, 2,188A, 2,189I, 2,190L, 2,191R, 2,192E, 2,193K, 2,194Y, 2,195P, 2,196E, 2,197K, 2,198V, 2,199P, 2,200F, 2,201R, 2,202L, 2,203T
CDD
cd05169 (PIKKc_TOR)

2,188A

activation loop (A-loop)
2,180D, 2,181F, 2,182G, 2,183D, 2,184C, 2,185F, 2,186E, 2,187A, 2,188A, 2,189I, 2,190L, 2,191R, 2,192E, 2,193K, 2,194Y, 2,195P, 2,196E, 2,197K, 2,198V, 2,199P, 2,200F, 2,201R, 2,202L, 2,203T
CDD
cd05169 (PIKKc_TOR)

2,189I

activation loop (A-loop)
2,180D, 2,181F, 2,182G, 2,183D, 2,184C, 2,185F, 2,186E, 2,187A, 2,188A, 2,189I, 2,190L, 2,191R, 2,192E, 2,193K, 2,194Y, 2,195P, 2,196E, 2,197K, 2,198V, 2,199P, 2,200F, 2,201R, 2,202L, 2,203T
CDD
cd05169 (PIKKc_TOR)

2,190L

activation loop (A-loop)
2,180D, 2,181F, 2,182G, 2,183D, 2,184C, 2,185F, 2,186E, 2,187A, 2,188A, 2,189I, 2,190L, 2,191R, 2,192E, 2,193K, 2,194Y, 2,195P, 2,196E, 2,197K, 2,198V, 2,199P, 2,200F, 2,201R, 2,202L, 2,203T
CDD
cd05169 (PIKKc_TOR)

2,191R

activation loop (A-loop)
2,180D, 2,181F, 2,182G, 2,183D, 2,184C, 2,185F, 2,186E, 2,187A, 2,188A, 2,189I, 2,190L, 2,191R, 2,192E, 2,193K, 2,194Y, 2,195P, 2,196E, 2,197K, 2,198V, 2,199P, 2,200F, 2,201R, 2,202L, 2,203T
CDD
cd05169 (PIKKc_TOR)

2,192E

activation loop (A-loop)
2,180D, 2,181F, 2,182G, 2,183D, 2,184C, 2,185F, 2,186E, 2,187A, 2,188A, 2,189I, 2,190L, 2,191R, 2,192E, 2,193K, 2,194Y, 2,195P, 2,196E, 2,197K, 2,198V, 2,199P, 2,200F, 2,201R, 2,202L, 2,203T
CDD
cd05169 (PIKKc_TOR)

2,193K

activation loop (A-loop)
2,180D, 2,181F, 2,182G, 2,183D, 2,184C, 2,185F, 2,186E, 2,187A, 2,188A, 2,189I, 2,190L, 2,191R, 2,192E, 2,193K, 2,194Y, 2,195P, 2,196E, 2,197K, 2,198V, 2,199P, 2,200F, 2,201R, 2,202L, 2,203T
CDD
cd05169 (PIKKc_TOR)

2,194Y

activation loop (A-loop)
2,180D, 2,181F, 2,182G, 2,183D, 2,184C, 2,185F, 2,186E, 2,187A, 2,188A, 2,189I, 2,190L, 2,191R, 2,192E, 2,193K, 2,194Y, 2,195P, 2,196E, 2,197K, 2,198V, 2,199P, 2,200F, 2,201R, 2,202L, 2,203T
CDD
cd05169 (PIKKc_TOR)

2,195P

activation loop (A-loop)
2,180D, 2,181F, 2,182G, 2,183D, 2,184C, 2,185F, 2,186E, 2,187A, 2,188A, 2,189I, 2,190L, 2,191R, 2,192E, 2,193K, 2,194Y, 2,195P, 2,196E, 2,197K, 2,198V, 2,199P, 2,200F, 2,201R, 2,202L, 2,203T
CDD
cd05169 (PIKKc_TOR)

2,196E

activation loop (A-loop)
2,180D, 2,181F, 2,182G, 2,183D, 2,184C, 2,185F, 2,186E, 2,187A, 2,188A, 2,189I, 2,190L, 2,191R, 2,192E, 2,193K, 2,194Y, 2,195P, 2,196E, 2,197K, 2,198V, 2,199P, 2,200F, 2,201R, 2,202L, 2,203T
CDD
cd05169 (PIKKc_TOR)

2,197K

activation loop (A-loop)
2,180D, 2,181F, 2,182G, 2,183D, 2,184C, 2,185F, 2,186E, 2,187A, 2,188A, 2,189I, 2,190L, 2,191R, 2,192E, 2,193K, 2,194Y, 2,195P, 2,196E, 2,197K, 2,198V, 2,199P, 2,200F, 2,201R, 2,202L, 2,203T
CDD
cd05169 (PIKKc_TOR)

2,198V

activation loop (A-loop)
2,180D, 2,181F, 2,182G, 2,183D, 2,184C, 2,185F, 2,186E, 2,187A, 2,188A, 2,189I, 2,190L, 2,191R, 2,192E, 2,193K, 2,194Y, 2,195P, 2,196E, 2,197K, 2,198V, 2,199P, 2,200F, 2,201R, 2,202L, 2,203T
CDD
cd05169 (PIKKc_TOR)

2,199P

activation loop (A-loop)
2,180D, 2,181F, 2,182G, 2,183D, 2,184C, 2,185F, 2,186E, 2,187A, 2,188A, 2,189I, 2,190L, 2,191R, 2,192E, 2,193K, 2,194Y, 2,195P, 2,196E, 2,197K, 2,198V, 2,199P, 2,200F, 2,201R, 2,202L, 2,203T
CDD
cd05169 (PIKKc_TOR)

2,200F

activation loop (A-loop)
2,180D, 2,181F, 2,182G, 2,183D, 2,184C, 2,185F, 2,186E, 2,187A, 2,188A, 2,189I, 2,190L, 2,191R, 2,192E, 2,193K, 2,194Y, 2,195P, 2,196E, 2,197K, 2,198V, 2,199P, 2,200F, 2,201R, 2,202L, 2,203T
CDD
cd05169 (PIKKc_TOR)

2,201R

activation loop (A-loop)
2,180D, 2,181F, 2,182G, 2,183D, 2,184C, 2,185F, 2,186E, 2,187A, 2,188A, 2,189I, 2,190L, 2,191R, 2,192E, 2,193K, 2,194Y, 2,195P, 2,196E, 2,197K, 2,198V, 2,199P, 2,200F, 2,201R, 2,202L, 2,203T
CDD
cd05169 (PIKKc_TOR)

2,202L

activation loop (A-loop)
2,180D, 2,181F, 2,182G, 2,183D, 2,184C, 2,185F, 2,186E, 2,187A, 2,188A, 2,189I, 2,190L, 2,191R, 2,192E, 2,193K, 2,194Y, 2,195P, 2,196E, 2,197K, 2,198V, 2,199P, 2,200F, 2,201R, 2,202L, 2,203T
CDD
cd05169 (PIKKc_TOR)

2,203T

activation loop (A-loop)
2,180D, 2,181F, 2,182G, 2,183D, 2,184C, 2,185F, 2,186E, 2,187A, 2,188A, 2,189I, 2,190L, 2,191R, 2,192E, 2,193K, 2,194Y, 2,195P, 2,196E, 2,197K, 2,198V, 2,199P, 2,200F, 2,201R, 2,202L, 2,203T
CDD
cd05169 (PIKKc_TOR)

Protein sequence

>MIA_06314_1
MPSIPNSLQQEGFVLNGIFAGLRSKNPEERDKAGTELQQYFLTVGVENSENGSPRPNNEINKRIFEFLRSTDVSSRLGGI
TAIDKLLDVYQSDEMSTKVTRFANYLRSTIPTNDIEVLRAAVNTMGKLTAYEGLAAEIVEFEITRALEWLQSDRQEARRH
SAVLMIAALAKSSKTLLYSYVNQIIDVIWVGLRDSKVSIRLDAAEALHSCLEILVGRDTDAQQKCYRKIYDGALVGLKIG
TTDDIHGTLLAFRELLRTAGMFMQPYYSDVCETVLKYKDHKDLLVRRTVIQILPILAQYSPIEFTKKYLSDSMNHLILQF
KKERERPIVFVSIGKIALSVRSNIAFYLDPILEGIKEVLTSKRSRREQESAVFECLGMLSGAVGQALSKHLSKDVLDLLF
SCGLSEDLDKCLTKIVINIPPLHIPIRDRLLDMISLTLSGSHFQPPGSPNSLQKINVVAAMEYRETMINRDNNNSNTSQD
YTDDRVIVLALKILGTFDFKGQSLSEFVKNCALYYIDHENPQVRKAAALTSINLFTADPICYQSSSYSLKSVNQVLEKLL
TVALSDPVPEIRREILNSLQSKLDYHLAQAENVRMLFMAMNDEDFHVREAAITIIGRLSRINPAYVVPSLRKTLLQLLTE
LEFATVSRSKEESSKLLGLLISSTNNLVRPYIKPILATLIPCARDSSPLVASSVIAAIGELSKVTGEDLSPYFSELMQLI
LDTLQDQSSTIKRDAALRTLGQLSSSSGYVIDPLIDYPQLLGILVSILKASDQNLTLKRETVRVMGILGALDPYKHREVE
RKTEDDSTEYDSAPIDVLLLMQGMSPSAEEYYPTVVITTLMGLLKDPSLVTHHNAIAQAVLHIFKSLGLKCVPFLNQIIP
GLISVIRSSSHVMAEFIFRQLSNLIQVVKQHARPFLPSIFEVAQEYFSIPILQTVILSLIDSIAQALDGEFKAYMPRLLP
LLINLIQNDKSHIRDTSVKVLNSFIIFGSTIEEYVNLIVPCIVSMIEYTPINLRIAAIETVGELCRTVNLNDMAPRIIHP
LLRTLNLEIDELKTPIVNTLCALAFSMNSEYTIFISVVNKSLLKHKIHAPNYEQLVTKILNSEPLPQNLNPYRKRIKIGD
ESSPADVATRKLRVNQMHLQLAWNTSQRTTRDDWLEWLRRFSLELLKESPSQALRASASIAGVYAPLAKDLFNPSFYSCW
GALYDQSKEDLVRSLEIALTSPNIPPEVLQTLLNLAEYMEHDEKSLPIDIRTLANYAQKCHAYAKALHYKELEYMQDPQT
NTIEALITINNHLQQSDSAIGILTRAQQHHSLQLKETWYEKLQRWDDALEAYNRREKEDPDSMEVTMGKMRCLHALGEWE
QLSKLAQERWANSTYDIKRAVAPLAAAAAWGLGEWERMDTYISVMKTESPDRSFFNAILSIHRGNYNDASKQIIIARDLL
ATELTALVSESYNRAYGVVVRVQMLAELEEIITYKNLPDDSETRQTMKKTWMKRLKGCQRNVDIWQRMLKVRALVIKPKE
DMDMWIKFANLCRKSGRLGLAEKSLSRILEPDENDRTSGTVEFLPKVVYAQLKYEWARGNHEEALDKLMEFTNRMSHLLN
LQDDDLIAQPLPSTRTDASPTVKENTRLLARCFLKQGEWKVALRESWMTEEPDTILGSYLLASHFDESWYKAWHNWALAN
FEFITLFDTCRIQGVGTDRLIQHHVVPAIKGFFKSIALSEQKSLQDTLRLLTLWFKYGGLDEPAKAMAEGFQLIHLEVWL
GVLPQLISSIHQPDPVVSKALQSLLTELGRNHPQALIYPLTVAIKSDSASRQMAASSIIDKMRQHSATLVEQAELVSYEL
IRVAVLWHEQWHEGLEDASRYYFGEHNIEKMFSTLEGLHAMLDRGPETLREVAFQTAFARDLHEAHNWLISYRRTNDPAN
LNQAWDIYYNVFRRITRQLPQAQTLDLQYVSPKLQAARNLQLAVPGTYVPGKPIISIAKFDPMFSVISSKQRPRRLTIKA
SDGKDYQYVLKGHEDIRQDNLVMQLFGLVNTLLSDDPECFKRHLNIQQYPAIPLSPKSGLLGWVPHADTFHVLIREYREG
KILLNIEYRVMLQMAPDYDSLAHLQKIEIFTYALDNTRGQDLYRVLWLKSRSSEAWLDRRTQYTRSLAVMSMVGYILGLG
DRHPSNLMLDRYTGKVIHVDFGDCFEAAILREKYPEKVPFRLTRMLVYAMEVSGIEGSFRITCEHVMSLLRDNKESLMAI
LEAFAHDPLINWGFDIPMKTDGPTVATQTGPGGLVGGMGGLMDYGNNNNGFLNGDKTGNGIKEDSRTGRSSNGTSTLSLS
AIKGNLTTQTDKTSESQAAINRNQRSRDNRADIVLKRITDKLTGNDFRNVKDIDVPTQVDKLILQATNVENLCLHYIGWC
SFW

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0005488 binding
GO:0005515 protein binding
GO:0016301 kinase activity
GO:0044877 macromolecular complex binding

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

MIA_06314_1

Protein function

Protein alignments

Mitochondrial localization by mitoprotII

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

Protein sequence

GO term prediction

Biological Process

Molecular Function

Cellular Component