MCA_01949_1

Protein

Length

2,413 amino acids

Gene name: TOR1

Description: Phosphatidylinositol kinase-related protein kinase Tor1; in S. cerevisiae subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy

Browser: contigA:5952677-5960059+

RNA-seq: read pairs 3837, FPKM 19.6, percentile rank 41.0% (100% = highest expression)

Protein function

Annotation:		TOR1	Phosphatidylinositol kinase-related protein kinase Tor1; in S. cerevisiae subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy
KEGG:	K07203	MTOR	serine/threonine-protein kinase mTOR [EC:2.7.11.1]
EGGNOG:	0PGA0	TOR1	Phosphatidylinositol 3-kinase
SGD closest match:	S000001686	TOR2	Serine/threonine-protein kinase TOR2
CGD closest match:	CAL0000187577	TOR1	Phosphatidylinositol kinase-related protein kinase

Protein alignments

	%id	Aln length
MIA_06314_1	78.74%	2432	MIA_06314_1
A0A0J9XDV1_GEOCN	74.99%	2415	Similar to Saccharomyces cerevisiae YKL203C TOR2 PIK-related protein kinase and rapamycin target OS=Geotrichum candidum GN=BN980_GECA12s01055g PE=3 SV=1
A0A060T7U1_BLAAD	66.20%	2361	ARAD1C30470p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C30470g PE=3 SV=1
Q6C2K6_YARLI	59.93%	2421	YALI0F07084p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F07084g PE=3 SV=1
UniRef50_Q6C2K6	59.93%	2421	YALI0F07084p n=15 Tax=Saccharomycetales TaxID=4892 RepID=Q6C2K6_YARLI
A0A161HMR9_9ASCO	67.83%	2055	Phosphatidylinositol kinase-related protein kinase TOR1 OS=Sugiyamaella lignohabitans GN=TOR1 PE=3 SV=1
A0A1E3PD23_9ASCO	57.46%	2414	FAT-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_53585 PE=3 SV=1
A0A1E4TIV8_9ASCO	57.74%	2430	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_46867 PE=3 SV=1
A0A1D8PHX3_CANAL	54.78%	2523	Phosphatidylinositol kinase-related protein kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TOR1 PE=3 SV=1
TOR2_YEAST	53.94%	2451	Serine/threonine-protein kinase TOR2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TOR2 PE=1 SV=3

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1078

Protein family membership

None predicted.

Domains and repeats

Domain
5 - 447
Armadillo-type fold (IPR016024)
Armadillo-like helical (IPR011989)
472 - 1,860
Armadillo-type fold (IPR016024)
Armadillo-like helical (IPR011989)
1,931 - 2,413
Protein kinase-like domain (IPR011009)
Phosphatidylinositol 3-/4-kinase, catalytic domain (IPR000403)
Domain
747 - 906
Domain of unknown function DUF3385, target of rapamycin protein (IPR024585)
1,249 - 1,821
PIK-related kinase (IPR014009)
PIK-related kinase, FAT (IPR003151)
1,854 - 1,951
FKBP12-rapamycin binding domain (IPR009076)
2,381 - 2,413
FATC domain (IPR003152)

1 500 1000 1500 2000 2413

Detailed signature matches

IPR016024

Armadillo-type fold
1. SSF48371 (ARM repeat)
  
  1,149 - 1,378
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  506 - 1,114
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  15 - 436
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  472 - 579
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
IPR011989

Armadillo-like helical
1. G3DSA:1.25.10.10
  
  472 - 1,860
  
  GENE3D
  G3DSA:1.25.10.10 (G3DSA:1.25.10.10)
  
  5 - 447
  
  GENE3D
  G3DSA:1.25.10.10 (G3DSA:1.25.10.10)
IPR024585

Domain of unknown function DUF3385, target of rapamycin protein
1. PF11865 (DUF3385)
  
  747 - 906
  
  Pfam
  PF11865 (DUF3385)
2. SM01346 (DUF3385_3)
  
  747 - 906
  
  SMART
  SM01346 (DUF3385_3)
IPR014009

PIK-related kinase
1. PS51189 (FAT)
  
  1,249 - 1,821
  
  PROSITE profiles
  PS51189 (FAT)
IPR003151

PIK-related kinase, FAT
1. PF02259 (FAT)
  
  1,379 - 1,747
  
  Pfam
  PF02259 (FAT)
IPR009076

FKBP12-rapamycin binding domain
1. PF08771 (FRB_dom)
  
  1,854 - 1,951
  
  Pfam
  PF08771 (FRB_dom)
2. SSF47212 (FKBP12-ra...)
  
  1,858 - 1,950
  
  SUPERFAMILY
  SSF47212 (FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP))
3. G3DSA:1.20.12...
  
  1,861 - 1,940
  
  GENE3D
  G3DSA:1.20.120.150 (G3DSA:1.20.120.150)
IPR011009

Protein kinase-like domain
1. SSF56112 (Protein k...)
  
  1,931 - 2,097
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
  
  2,132 - 2,268
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR000403

Phosphatidylinositol 3-/4-kinase, catalytic domain
1. PS50290 (PI3_4_KINA...)
  
  2,021 - 2,413
  
  PROSITE profiles
  PS50290 (PI3_4_KINASE_3)
2. SM00146 (pi3k_hr1_6)
  
  2,022 - 2,317
  
  SMART
  SM00146 (pi3k_hr1_6)
3. PF00454 (PI3_PI4_ki...)
  
  2,021 - 2,267
  
  Pfam
  PF00454 (PI3_PI4_kinase)
4. G3DSA:1.10.10...
  
  2,122 - 2,277
  
  GENE3D
  G3DSA:1.10.1070.11 (G3DSA:1.10.1070.11)
IPR003152

FATC domain
1. SM01343 (FATC_2)
  
  2,381 - 2,413
  
  SMART
  SM01343 (FATC_2)
2. PF02260 (FATC)
  
  2,383 - 2,413
  
  Pfam
  PF02260 (FATC)
3. PS51190 (FATC)
  
  2,381 - 2,413
  
  PROSITE profiles
  PS51190 (FATC)
IPR018936

Phosphatidylinositol 3/4-kinase, conserved site
1. PS00916 (PI3_4_KINA...)
  
  2,161 - 2,181
  
  PROSITE patterns
  PS00916 (PI3_4_KINASE_2)
2. PS00915 (PI3_4_KINA...)
  
  2,025 - 2,039
  
  PROSITE patterns
  PS00915 (PI3_4_KINASE_1)

no IPR

Unintegrated signatures

G3DSA:3.30.10...

1,941 - 2,080

GENE3D
G3DSA:3.30.1010.10 (G3DSA:3.30.1010.10)
SM01345 (Rapamycin_...)

1,854 - 1,953

SMART
SM01345 (Rapamycin_bind_3)
cd05169 (PIKKc_TOR)

1,992 - 2,267

CDD
cd05169 (PIKKc_TOR)

Residue annotation

ATP binding site c...

2,002I

ATP binding site
2,002I, 2,004S, 2,005K, 2,006Q, 2,008P, 2,024A, 2,026K, 2,029E, 2,064Y, 2,076L, 2,077G, 2,078W, 2,079V, 2,084T, 2,181N, 2,183M, 2,194V, 2,195D
CDD
cd05169 (PIKKc_TOR)

2,004S

ATP binding site
2,002I, 2,004S, 2,005K, 2,006Q, 2,008P, 2,024A, 2,026K, 2,029E, 2,064Y, 2,076L, 2,077G, 2,078W, 2,079V, 2,084T, 2,181N, 2,183M, 2,194V, 2,195D
CDD
cd05169 (PIKKc_TOR)

2,005K

ATP binding site
2,002I, 2,004S, 2,005K, 2,006Q, 2,008P, 2,024A, 2,026K, 2,029E, 2,064Y, 2,076L, 2,077G, 2,078W, 2,079V, 2,084T, 2,181N, 2,183M, 2,194V, 2,195D
CDD
cd05169 (PIKKc_TOR)

2,006Q

ATP binding site
2,002I, 2,004S, 2,005K, 2,006Q, 2,008P, 2,024A, 2,026K, 2,029E, 2,064Y, 2,076L, 2,077G, 2,078W, 2,079V, 2,084T, 2,181N, 2,183M, 2,194V, 2,195D
CDD
cd05169 (PIKKc_TOR)

2,008P

ATP binding site
2,002I, 2,004S, 2,005K, 2,006Q, 2,008P, 2,024A, 2,026K, 2,029E, 2,064Y, 2,076L, 2,077G, 2,078W, 2,079V, 2,084T, 2,181N, 2,183M, 2,194V, 2,195D
CDD
cd05169 (PIKKc_TOR)

2,024A

ATP binding site
2,002I, 2,004S, 2,005K, 2,006Q, 2,008P, 2,024A, 2,026K, 2,029E, 2,064Y, 2,076L, 2,077G, 2,078W, 2,079V, 2,084T, 2,181N, 2,183M, 2,194V, 2,195D
CDD
cd05169 (PIKKc_TOR)

2,026K

ATP binding site
2,002I, 2,004S, 2,005K, 2,006Q, 2,008P, 2,024A, 2,026K, 2,029E, 2,064Y, 2,076L, 2,077G, 2,078W, 2,079V, 2,084T, 2,181N, 2,183M, 2,194V, 2,195D
CDD
cd05169 (PIKKc_TOR)

2,029E

ATP binding site
2,002I, 2,004S, 2,005K, 2,006Q, 2,008P, 2,024A, 2,026K, 2,029E, 2,064Y, 2,076L, 2,077G, 2,078W, 2,079V, 2,084T, 2,181N, 2,183M, 2,194V, 2,195D
CDD
cd05169 (PIKKc_TOR)

2,064Y

ATP binding site
2,002I, 2,004S, 2,005K, 2,006Q, 2,008P, 2,024A, 2,026K, 2,029E, 2,064Y, 2,076L, 2,077G, 2,078W, 2,079V, 2,084T, 2,181N, 2,183M, 2,194V, 2,195D
CDD
cd05169 (PIKKc_TOR)

2,076L

ATP binding site
2,002I, 2,004S, 2,005K, 2,006Q, 2,008P, 2,024A, 2,026K, 2,029E, 2,064Y, 2,076L, 2,077G, 2,078W, 2,079V, 2,084T, 2,181N, 2,183M, 2,194V, 2,195D
CDD
cd05169 (PIKKc_TOR)

2,077G

ATP binding site
2,002I, 2,004S, 2,005K, 2,006Q, 2,008P, 2,024A, 2,026K, 2,029E, 2,064Y, 2,076L, 2,077G, 2,078W, 2,079V, 2,084T, 2,181N, 2,183M, 2,194V, 2,195D
CDD
cd05169 (PIKKc_TOR)

2,078W

ATP binding site
2,002I, 2,004S, 2,005K, 2,006Q, 2,008P, 2,024A, 2,026K, 2,029E, 2,064Y, 2,076L, 2,077G, 2,078W, 2,079V, 2,084T, 2,181N, 2,183M, 2,194V, 2,195D
CDD
cd05169 (PIKKc_TOR)

2,079V

ATP binding site
2,002I, 2,004S, 2,005K, 2,006Q, 2,008P, 2,024A, 2,026K, 2,029E, 2,064Y, 2,076L, 2,077G, 2,078W, 2,079V, 2,084T, 2,181N, 2,183M, 2,194V, 2,195D
CDD
cd05169 (PIKKc_TOR)

2,084T

ATP binding site
2,002I, 2,004S, 2,005K, 2,006Q, 2,008P, 2,024A, 2,026K, 2,029E, 2,064Y, 2,076L, 2,077G, 2,078W, 2,079V, 2,084T, 2,181N, 2,183M, 2,194V, 2,195D
CDD
cd05169 (PIKKc_TOR)

2,181N

ATP binding site
2,002I, 2,004S, 2,005K, 2,006Q, 2,008P, 2,024A, 2,026K, 2,029E, 2,064Y, 2,076L, 2,077G, 2,078W, 2,079V, 2,084T, 2,181N, 2,183M, 2,194V, 2,195D
CDD
cd05169 (PIKKc_TOR)

2,183M

ATP binding site
2,002I, 2,004S, 2,005K, 2,006Q, 2,008P, 2,024A, 2,026K, 2,029E, 2,064Y, 2,076L, 2,077G, 2,078W, 2,079V, 2,084T, 2,181N, 2,183M, 2,194V, 2,195D
CDD
cd05169 (PIKKc_TOR)

2,194V

ATP binding site
2,002I, 2,004S, 2,005K, 2,006Q, 2,008P, 2,024A, 2,026K, 2,029E, 2,064Y, 2,076L, 2,077G, 2,078W, 2,079V, 2,084T, 2,181N, 2,183M, 2,194V, 2,195D
CDD
cd05169 (PIKKc_TOR)

2,195D

ATP binding site
2,002I, 2,004S, 2,005K, 2,006Q, 2,008P, 2,024A, 2,026K, 2,029E, 2,064Y, 2,076L, 2,077G, 2,078W, 2,079V, 2,084T, 2,181N, 2,183M, 2,194V, 2,195D
CDD
cd05169 (PIKKc_TOR)
mLST8 interface cd...

2,110A

mLST8 interface
2,110A, 2,111P, 2,112D, 2,115S, 2,116L, 2,117A, 2,118H, 2,120Q, 2,122I, 2,123E, 2,126T
CDD
cd05169 (PIKKc_TOR)

2,111P

mLST8 interface
2,110A, 2,111P, 2,112D, 2,115S, 2,116L, 2,117A, 2,118H, 2,120Q, 2,122I, 2,123E, 2,126T
CDD
cd05169 (PIKKc_TOR)

2,112D

mLST8 interface
2,110A, 2,111P, 2,112D, 2,115S, 2,116L, 2,117A, 2,118H, 2,120Q, 2,122I, 2,123E, 2,126T
CDD
cd05169 (PIKKc_TOR)

2,115S

mLST8 interface
2,110A, 2,111P, 2,112D, 2,115S, 2,116L, 2,117A, 2,118H, 2,120Q, 2,122I, 2,123E, 2,126T
CDD
cd05169 (PIKKc_TOR)

2,116L

mLST8 interface
2,110A, 2,111P, 2,112D, 2,115S, 2,116L, 2,117A, 2,118H, 2,120Q, 2,122I, 2,123E, 2,126T
CDD
cd05169 (PIKKc_TOR)

2,117A

mLST8 interface
2,110A, 2,111P, 2,112D, 2,115S, 2,116L, 2,117A, 2,118H, 2,120Q, 2,122I, 2,123E, 2,126T
CDD
cd05169 (PIKKc_TOR)

2,118H

mLST8 interface
2,110A, 2,111P, 2,112D, 2,115S, 2,116L, 2,117A, 2,118H, 2,120Q, 2,122I, 2,123E, 2,126T
CDD
cd05169 (PIKKc_TOR)

2,120Q

mLST8 interface
2,110A, 2,111P, 2,112D, 2,115S, 2,116L, 2,117A, 2,118H, 2,120Q, 2,122I, 2,123E, 2,126T
CDD
cd05169 (PIKKc_TOR)

2,122I

mLST8 interface
2,110A, 2,111P, 2,112D, 2,115S, 2,116L, 2,117A, 2,118H, 2,120Q, 2,122I, 2,123E, 2,126T
CDD
cd05169 (PIKKc_TOR)

2,123E

mLST8 interface
2,110A, 2,111P, 2,112D, 2,115S, 2,116L, 2,117A, 2,118H, 2,120Q, 2,122I, 2,123E, 2,126T
CDD
cd05169 (PIKKc_TOR)

2,126T

mLST8 interface
2,110A, 2,111P, 2,112D, 2,115S, 2,116L, 2,117A, 2,118H, 2,120Q, 2,122I, 2,123E, 2,126T
CDD
cd05169 (PIKKc_TOR)
catalytic loop cd0...

2,173G

catalytic loop
2,173G, 2,174L, 2,175G, 2,176D, 2,177R, 2,178H, 2,179P, 2,180S, 2,181N
CDD
cd05169 (PIKKc_TOR)

2,174L

catalytic loop
2,173G, 2,174L, 2,175G, 2,176D, 2,177R, 2,178H, 2,179P, 2,180S, 2,181N
CDD
cd05169 (PIKKc_TOR)

2,175G

catalytic loop
2,173G, 2,174L, 2,175G, 2,176D, 2,177R, 2,178H, 2,179P, 2,180S, 2,181N
CDD
cd05169 (PIKKc_TOR)

2,176D

catalytic loop
2,173G, 2,174L, 2,175G, 2,176D, 2,177R, 2,178H, 2,179P, 2,180S, 2,181N
CDD
cd05169 (PIKKc_TOR)

2,177R

catalytic loop
2,173G, 2,174L, 2,175G, 2,176D, 2,177R, 2,178H, 2,179P, 2,180S, 2,181N
CDD
cd05169 (PIKKc_TOR)

2,178H

catalytic loop
2,173G, 2,174L, 2,175G, 2,176D, 2,177R, 2,178H, 2,179P, 2,180S, 2,181N
CDD
cd05169 (PIKKc_TOR)

2,179P

catalytic loop
2,173G, 2,174L, 2,175G, 2,176D, 2,177R, 2,178H, 2,179P, 2,180S, 2,181N
CDD
cd05169 (PIKKc_TOR)

2,180S

catalytic loop
2,173G, 2,174L, 2,175G, 2,176D, 2,177R, 2,178H, 2,179P, 2,180S, 2,181N
CDD
cd05169 (PIKKc_TOR)

2,181N

catalytic loop
2,173G, 2,174L, 2,175G, 2,176D, 2,177R, 2,178H, 2,179P, 2,180S, 2,181N
CDD
cd05169 (PIKKc_TOR)
activation loop (A...

2,195D

activation loop (A-loop)
2,195D, 2,196F, 2,197G, 2,198D, 2,199C, 2,200F, 2,201E, 2,202A, 2,203A, 2,204I, 2,205L, 2,206R, 2,207E, 2,208K, 2,209Y, 2,210P, 2,211E, 2,212K, 2,213V, 2,214P, 2,215F, 2,216R, 2,217L, 2,218T
CDD
cd05169 (PIKKc_TOR)

2,196F

activation loop (A-loop)
2,195D, 2,196F, 2,197G, 2,198D, 2,199C, 2,200F, 2,201E, 2,202A, 2,203A, 2,204I, 2,205L, 2,206R, 2,207E, 2,208K, 2,209Y, 2,210P, 2,211E, 2,212K, 2,213V, 2,214P, 2,215F, 2,216R, 2,217L, 2,218T
CDD
cd05169 (PIKKc_TOR)

2,197G

activation loop (A-loop)
2,195D, 2,196F, 2,197G, 2,198D, 2,199C, 2,200F, 2,201E, 2,202A, 2,203A, 2,204I, 2,205L, 2,206R, 2,207E, 2,208K, 2,209Y, 2,210P, 2,211E, 2,212K, 2,213V, 2,214P, 2,215F, 2,216R, 2,217L, 2,218T
CDD
cd05169 (PIKKc_TOR)

2,198D

activation loop (A-loop)
2,195D, 2,196F, 2,197G, 2,198D, 2,199C, 2,200F, 2,201E, 2,202A, 2,203A, 2,204I, 2,205L, 2,206R, 2,207E, 2,208K, 2,209Y, 2,210P, 2,211E, 2,212K, 2,213V, 2,214P, 2,215F, 2,216R, 2,217L, 2,218T
CDD
cd05169 (PIKKc_TOR)

2,199C

activation loop (A-loop)
2,195D, 2,196F, 2,197G, 2,198D, 2,199C, 2,200F, 2,201E, 2,202A, 2,203A, 2,204I, 2,205L, 2,206R, 2,207E, 2,208K, 2,209Y, 2,210P, 2,211E, 2,212K, 2,213V, 2,214P, 2,215F, 2,216R, 2,217L, 2,218T
CDD
cd05169 (PIKKc_TOR)

2,200F

activation loop (A-loop)
2,195D, 2,196F, 2,197G, 2,198D, 2,199C, 2,200F, 2,201E, 2,202A, 2,203A, 2,204I, 2,205L, 2,206R, 2,207E, 2,208K, 2,209Y, 2,210P, 2,211E, 2,212K, 2,213V, 2,214P, 2,215F, 2,216R, 2,217L, 2,218T
CDD
cd05169 (PIKKc_TOR)

2,201E

activation loop (A-loop)
2,195D, 2,196F, 2,197G, 2,198D, 2,199C, 2,200F, 2,201E, 2,202A, 2,203A, 2,204I, 2,205L, 2,206R, 2,207E, 2,208K, 2,209Y, 2,210P, 2,211E, 2,212K, 2,213V, 2,214P, 2,215F, 2,216R, 2,217L, 2,218T
CDD
cd05169 (PIKKc_TOR)

2,202A

activation loop (A-loop)
2,195D, 2,196F, 2,197G, 2,198D, 2,199C, 2,200F, 2,201E, 2,202A, 2,203A, 2,204I, 2,205L, 2,206R, 2,207E, 2,208K, 2,209Y, 2,210P, 2,211E, 2,212K, 2,213V, 2,214P, 2,215F, 2,216R, 2,217L, 2,218T
CDD
cd05169 (PIKKc_TOR)

2,203A

activation loop (A-loop)
2,195D, 2,196F, 2,197G, 2,198D, 2,199C, 2,200F, 2,201E, 2,202A, 2,203A, 2,204I, 2,205L, 2,206R, 2,207E, 2,208K, 2,209Y, 2,210P, 2,211E, 2,212K, 2,213V, 2,214P, 2,215F, 2,216R, 2,217L, 2,218T
CDD
cd05169 (PIKKc_TOR)

2,204I

activation loop (A-loop)
2,195D, 2,196F, 2,197G, 2,198D, 2,199C, 2,200F, 2,201E, 2,202A, 2,203A, 2,204I, 2,205L, 2,206R, 2,207E, 2,208K, 2,209Y, 2,210P, 2,211E, 2,212K, 2,213V, 2,214P, 2,215F, 2,216R, 2,217L, 2,218T
CDD
cd05169 (PIKKc_TOR)

2,205L

activation loop (A-loop)
2,195D, 2,196F, 2,197G, 2,198D, 2,199C, 2,200F, 2,201E, 2,202A, 2,203A, 2,204I, 2,205L, 2,206R, 2,207E, 2,208K, 2,209Y, 2,210P, 2,211E, 2,212K, 2,213V, 2,214P, 2,215F, 2,216R, 2,217L, 2,218T
CDD
cd05169 (PIKKc_TOR)

2,206R

activation loop (A-loop)
2,195D, 2,196F, 2,197G, 2,198D, 2,199C, 2,200F, 2,201E, 2,202A, 2,203A, 2,204I, 2,205L, 2,206R, 2,207E, 2,208K, 2,209Y, 2,210P, 2,211E, 2,212K, 2,213V, 2,214P, 2,215F, 2,216R, 2,217L, 2,218T
CDD
cd05169 (PIKKc_TOR)

2,207E

activation loop (A-loop)
2,195D, 2,196F, 2,197G, 2,198D, 2,199C, 2,200F, 2,201E, 2,202A, 2,203A, 2,204I, 2,205L, 2,206R, 2,207E, 2,208K, 2,209Y, 2,210P, 2,211E, 2,212K, 2,213V, 2,214P, 2,215F, 2,216R, 2,217L, 2,218T
CDD
cd05169 (PIKKc_TOR)

2,208K

activation loop (A-loop)
2,195D, 2,196F, 2,197G, 2,198D, 2,199C, 2,200F, 2,201E, 2,202A, 2,203A, 2,204I, 2,205L, 2,206R, 2,207E, 2,208K, 2,209Y, 2,210P, 2,211E, 2,212K, 2,213V, 2,214P, 2,215F, 2,216R, 2,217L, 2,218T
CDD
cd05169 (PIKKc_TOR)

2,209Y

activation loop (A-loop)
2,195D, 2,196F, 2,197G, 2,198D, 2,199C, 2,200F, 2,201E, 2,202A, 2,203A, 2,204I, 2,205L, 2,206R, 2,207E, 2,208K, 2,209Y, 2,210P, 2,211E, 2,212K, 2,213V, 2,214P, 2,215F, 2,216R, 2,217L, 2,218T
CDD
cd05169 (PIKKc_TOR)

2,210P

activation loop (A-loop)
2,195D, 2,196F, 2,197G, 2,198D, 2,199C, 2,200F, 2,201E, 2,202A, 2,203A, 2,204I, 2,205L, 2,206R, 2,207E, 2,208K, 2,209Y, 2,210P, 2,211E, 2,212K, 2,213V, 2,214P, 2,215F, 2,216R, 2,217L, 2,218T
CDD
cd05169 (PIKKc_TOR)

2,211E

activation loop (A-loop)
2,195D, 2,196F, 2,197G, 2,198D, 2,199C, 2,200F, 2,201E, 2,202A, 2,203A, 2,204I, 2,205L, 2,206R, 2,207E, 2,208K, 2,209Y, 2,210P, 2,211E, 2,212K, 2,213V, 2,214P, 2,215F, 2,216R, 2,217L, 2,218T
CDD
cd05169 (PIKKc_TOR)

2,212K

activation loop (A-loop)
2,195D, 2,196F, 2,197G, 2,198D, 2,199C, 2,200F, 2,201E, 2,202A, 2,203A, 2,204I, 2,205L, 2,206R, 2,207E, 2,208K, 2,209Y, 2,210P, 2,211E, 2,212K, 2,213V, 2,214P, 2,215F, 2,216R, 2,217L, 2,218T
CDD
cd05169 (PIKKc_TOR)

2,213V

activation loop (A-loop)
2,195D, 2,196F, 2,197G, 2,198D, 2,199C, 2,200F, 2,201E, 2,202A, 2,203A, 2,204I, 2,205L, 2,206R, 2,207E, 2,208K, 2,209Y, 2,210P, 2,211E, 2,212K, 2,213V, 2,214P, 2,215F, 2,216R, 2,217L, 2,218T
CDD
cd05169 (PIKKc_TOR)

2,214P

activation loop (A-loop)
2,195D, 2,196F, 2,197G, 2,198D, 2,199C, 2,200F, 2,201E, 2,202A, 2,203A, 2,204I, 2,205L, 2,206R, 2,207E, 2,208K, 2,209Y, 2,210P, 2,211E, 2,212K, 2,213V, 2,214P, 2,215F, 2,216R, 2,217L, 2,218T
CDD
cd05169 (PIKKc_TOR)

2,215F

activation loop (A-loop)
2,195D, 2,196F, 2,197G, 2,198D, 2,199C, 2,200F, 2,201E, 2,202A, 2,203A, 2,204I, 2,205L, 2,206R, 2,207E, 2,208K, 2,209Y, 2,210P, 2,211E, 2,212K, 2,213V, 2,214P, 2,215F, 2,216R, 2,217L, 2,218T
CDD
cd05169 (PIKKc_TOR)

2,216R

activation loop (A-loop)
2,195D, 2,196F, 2,197G, 2,198D, 2,199C, 2,200F, 2,201E, 2,202A, 2,203A, 2,204I, 2,205L, 2,206R, 2,207E, 2,208K, 2,209Y, 2,210P, 2,211E, 2,212K, 2,213V, 2,214P, 2,215F, 2,216R, 2,217L, 2,218T
CDD
cd05169 (PIKKc_TOR)

2,217L

activation loop (A-loop)
2,195D, 2,196F, 2,197G, 2,198D, 2,199C, 2,200F, 2,201E, 2,202A, 2,203A, 2,204I, 2,205L, 2,206R, 2,207E, 2,208K, 2,209Y, 2,210P, 2,211E, 2,212K, 2,213V, 2,214P, 2,215F, 2,216R, 2,217L, 2,218T
CDD
cd05169 (PIKKc_TOR)

2,218T

activation loop (A-loop)
2,195D, 2,196F, 2,197G, 2,198D, 2,199C, 2,200F, 2,201E, 2,202A, 2,203A, 2,204I, 2,205L, 2,206R, 2,207E, 2,208K, 2,209Y, 2,210P, 2,211E, 2,212K, 2,213V, 2,214P, 2,215F, 2,216R, 2,217L, 2,218T
CDD
cd05169 (PIKKc_TOR)

Protein sequence

>MCA_01949_1
MAPILPALQQESVVLNRIFSDLRSKSSEEREKAGNELQQHFLALGAEDIKDGVHPPNDEINKRIFEYLRSTDIYSRLGGI
TAIDKLLDVYQADEMSTKVTRFANYLRQVIPTNDIEVLRAAVNTMGKLTAYEGLAAEIVEFEITRALEWLQSDRQESRRH
SAVLMIGALAKSSKTLLYSYVNKILEVIWVGLRDPKVAIRMDAAETLHSCLEIMAGRDNQTQTTCYNKIYEEAKSGLKIG
TTDDVHGSLLAIRELLRTAGMFMQKYYGEVCTTILSYKDHKDLLVRRTIISLLPDLAQYSPIEFTKKYLSDSMIHLIAQF
KKERERALIFLSIGHIALSVRSNITFYLDAILKNVKDGLTSKGRYRKEQEAAIFECIGMLSIAVGQSLTKHLSKEVLDLL
FSCGLSKELNECLTKIIVNIPPLHIPIRDRLLDIISLTLSGSHFQPPGSPSGVQTINVAAARSYREVMLSKEGLTSNMTD
DELIVLTLEILGSFDFKGQSLAEFVKNCALYYIDHDNPRVRKAAALTSSHLYIDDPICFQVSAHSLQLVSQVLERLLTVA
LSDQVAEIRLDVLNSLESTLDCHLAQVENVRMLFMTLNDENFHVREAAICIIGRLSKINPAYVVPSLRKTLLQFLTDIEY
ATTPRGKEESAKLLGLLINSTGNLVKPYIKPILATLVPKARDSNPLVASSVIASIGELSKVCGEDMSPYFDELMQLILEN
LQDQSSGSKRDAALRTLGQLSSSSGYVIDPLLDYPQLLGILVSILKSADQNVNLKREVVRVMGILGALDPYKHREVERKT
EDDSAEYDSAPIDILLLMQGMSPSSDEYYPTVVITTLMGLLKDPSLVTHHNAIAQAVLHIFKSLGLKCVPFLNQIIPGLI
SVIRSSGHVMAEFIFRQLSNLVQVVKQHVRPFLPSILEVCQEYFQVVFLQPVILSLIDSIAQALDGEFKAFMPQLLPLLL
GVLQNDRSTNRDSTIKVLNSFIVFGSTIEEYVHLIVPNIVGLLEYNPLNLIIAAVETLGELCRTVNLNDMAPRIIHPLLR
ILSSGPEELRNPIMNTLSALAFSMNSEYTIFIPVVNSVLTKQKIHASKYEQLVTKILNSEHLPQNLNPYRKRIKMGDETS
QADVTVRKLRVNQPQLQMAWDTSQRTTRDDWLEWLRRLSLELLKESPSHALRASASIAGVYAPLARDLFNPSFYSCWGAL
YDKYKEDLASSLQKALVSPNIPPEVLQTILNLAEYMEHDEKSLPIDIRMLSTYAQKCHAYAKALHYKELEFMQESKTSII
ESLITINNQLQQSDSAIGILTRAQQLETLELKETWYEKLQRWDDALVAYNAREKNEPDSMEVTMGKMRCLHALGEWEQLS
KLAQERWTNSSYEIKRAVAPLAAAAAWGLGQWERMDTYISVMKPESPDRSFFNAILSIHRDNFDEASKQIIIARDLLATE
LTALISESYNRAYGVVVRVQMLAELEEIIQYKKLYQSSPSDSYEIRKTMRKTWMKRLKGCQRNVDIWQRMLKVRALVIKP
KEDMDMWIKFANLCRKSGRLGLAEKSLNRINNDSNDVDRPMGGGQVDFYPKVIYAQLKYMWAIGDHNDALEHLIEFTSRM
SHILKLNNDDLITQTLPSERPDATETTIENTKLLARCFLKQGEWRVALKGSSWKRDDPDTILGSFLLATHFDKTWYKAWH
NWALANFECIKAYNDGLSSKSYDDEVSTQFDHTLIVQHHVVPAIEGFFRSVSLSEQKSLQDTLRLLTLWFNYGGLPDTAK
AMADGLQMIRIEVWLGVLPQLISQIHQPDPVVNKALHGLLSELGRTHPQALIYPLTVAIKSDSASRQKAASSIIDKMRQH
SAVLVEQAELVSNELIRVAVLWHEIWHEGLEDASRYYFGEHNIEKMFATLEGLHAILERGPETMREVSFQTVYGKDLNEA
YGWLLSYKRTKDSTNLNQAWDIYYNVFRRIARQLPQTQTFDLQHVSPKLQAARNLQLAVPGTYVPGKPVISIVKFDPIFN
IISSKQRPRRLTVKGSDGKDYQYALKGHEDIRQDNLVMQLFGLVNTLLTDDPECFKRHLNIQQYPAIPLSPKSGLLGWVP
HADTFHVLIREYREGKILLNIEYRVMLQMAPDYDSLAHLQKIEVFTYALDNTRGQDLYRVLWLKSRSSEAWLDRRTQYTR
SLAVMSMVGYILGLGDRHPSNLMLDRYTGKVIHVDFGDCFEAAILREKYPEKVPFRLTRMLVYAMEVSGIEGSFRITCEH
VMSLLRENKESLMAILEAFAYDPLINWGFEIPTKTDGAYIHGGGPGGVTGGIGETSKGIASDGPKRPVHTDAKPVNFGAP
IPVNREQDGLSNGDLNGRMFNATEEAEYQQLQQLKVRNIRAGIVLKRITDKLTGNDFRNVSDLDVPSQVDKLILQATNVE
NLCLHYIGWCSFW

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0005488 binding
GO:0005515 protein binding
GO:0016301 kinase activity
GO:0044877 macromolecular complex binding

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

MCA_01949_1

Protein function

Protein alignments

Mitochondrial localization by mitoprotII

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

Protein sequence

GO term prediction

Biological Process

Molecular Function

Cellular Component