MIA_06287_1

Protein

Length

1,257 amino acids

Protein function

EGGNOG:	0PH43	SMC1	structural maintenance of chromosomes protein
SGD closest match:	S000001886	SMC1	Structural maintenance of chromosomes protein 1
CGD closest match:	CAL0000179192	SMC1	Structural maintenance of chromosomes protein

Protein alignments

	%id	Aln length	E-value
A0A0J9YHK5_GEOCN	52.729%	1246	0.0	Structural maintenance of chromosomes protein OS=Geotrichum candidum GN=BN980_GECA01s05840g PE=3 SV=1
UniRef50_A0A0J9YHK5	52.729%	1246	0.0	Structural maintenance of chromosomes protein n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9YHK5_GEOCN
MCA_01193_1	47.209%	1290	0.0	MCA_01193_1
A0A060TI49_BLAAD	41.401%	1256	0.0	Structural maintenance of chromosomes protein OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D43648g PE=3 SV=1
Q6C5S3_YARLI	37.311%	1257	0.0	Structural maintenance of chromosomes protein OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E15620g PE=3 SV=1
A0A1D8PSI8_CANAL	38.231%	1266	0.0	Structural maintenance of chromosomes protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SMC1 PE=3 SV=1
A0A167CA43_9ASCO	35.620%	1137	0.0	Structural maintenance of chromosomes protein OS=Sugiyamaella lignohabitans GN=SMC1 PE=3 SV=1
SMC1_YEAST	36.599%	1276	0.0	Structural maintenance of chromosomes protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SMC1 PE=1 SV=1
A0A1E4TCC0_9ASCO	31.591%	1301	0.0	Structural maintenance of chromosomes protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_3915 PE=3 SV=1
A0A1E3PJ65_9ASCO	42.593%	162	4.57e-34	Structural maintenance of chromosomes protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_25651 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0820

Protein family membership

Structural maintenance of chromosomes protein (IPR024704)

Domains and repeats

Domain
4 - 1,221
RecF/RecN/SMC, N-terminal (IPR003395)
Domain
4 - 238
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
490 - 692
SMCs flexible hinge (IPR010935)
1,071 - 1,215
P-loop containing nucleoside triphosphate hydrolase (IPR027417)

1 200 400 600 800 1000 1257

Detailed signature matches

IPR024704

Structural maintenance of chromosomes protein
1. PIRSF005719 (SMC)
  
  1 - 1,237
  
  PIRSF
  PIRSF005719 (SMC)
IPR027417

P-loop containing nucleoside triphosphate hydrolase
1. SSF52540 (P-loop co...)
  
  1,071 - 1,215
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
  
  4 - 238
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
IPR003395

RecF/RecN/SMC, N-terminal
1. PF02463 (SMC_N)
  
  4 - 1,221
  
  Pfam
  PF02463 (SMC_N)
IPR010935

SMCs flexible hinge
1. PF06470 (SMC_hinge)
  
  528 - 643
  
  Pfam
  PF06470 (SMC_hinge)
2. SM00968 (SMC_hinge_2)
  
  528 - 644
  
  SMART
  SM00968 (SMC_hinge_2)
3. SSF75553 (Smc hinge...)
  
  490 - 692
  
  SUPERFAMILY
  SSF75553 (Smc hinge domain)

no IPR

Unintegrated signatures

Coil

685 - 705

COILS
Coil (Coil)

409 - 436

COILS
Coil (Coil)

826 - 916

COILS
Coil (Coil)

1,031 - 1,072

COILS
Coil (Coil)

760 - 787

COILS
Coil (Coil)

344 - 371

COILS
Coil (Coil)

260 - 280

COILS
Coil (Coil)

451 - 471

COILS
Coil (Coil)
G3DSA:1.10.28...

798 - 944

GENE3D
G3DSA:1.10.287.620 (G3DSA:1.10.287.620)
G3DSA:1.20.11...

381 - 791

GENE3D
G3DSA:1.20.1170.10 (G3DSA:1.20.1170.10)
G3DSA:1.20.12...

251 - 380

GENE3D
G3DSA:1.20.120.330 (G3DSA:1.20.120.330)
G3DSA:3.40.50...

3 - 192

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)

952 - 1,235

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
SSF57997 (Tropomyosin)

245 - 374

SUPERFAMILY
SSF57997 (Tropomyosin)
cd03275 (ABC_SMC1_euk)

4 - 178

CDD
cd03275 (ABC_SMC1_euk)

1,127 - 1,230

CDD
cd03275 (ABC_SMC1_euk)
mobidb-lite (disord...)

1,238 - 1,257

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

Walker A/P-loop cd...

33G

Walker A/P-loop
33G, 34P, 35N, 36G, 37S, 38G, 39K, 40S
CDD
cd03275 (ABC_SMC1_euk)

34P

Walker A/P-loop
33G, 34P, 35N, 36G, 37S, 38G, 39K, 40S
CDD
cd03275 (ABC_SMC1_euk)

35N

Walker A/P-loop
33G, 34P, 35N, 36G, 37S, 38G, 39K, 40S
CDD
cd03275 (ABC_SMC1_euk)

36G

Walker A/P-loop
33G, 34P, 35N, 36G, 37S, 38G, 39K, 40S
CDD
cd03275 (ABC_SMC1_euk)

37S

Walker A/P-loop
33G, 34P, 35N, 36G, 37S, 38G, 39K, 40S
CDD
cd03275 (ABC_SMC1_euk)

38G

Walker A/P-loop
33G, 34P, 35N, 36G, 37S, 38G, 39K, 40S
CDD
cd03275 (ABC_SMC1_euk)

39K

Walker A/P-loop
33G, 34P, 35N, 36G, 37S, 38G, 39K, 40S
CDD
cd03275 (ABC_SMC1_euk)

40S

Walker A/P-loop
33G, 34P, 35N, 36G, 37S, 38G, 39K, 40S
CDD
cd03275 (ABC_SMC1_euk)
ATP binding site c...

36G

ATP binding site
36G, 37S, 39K, 40S, 41N, 155Q
CDD
cd03275 (ABC_SMC1_euk)

37S

ATP binding site
36G, 37S, 39K, 40S, 41N, 155Q
CDD
cd03275 (ABC_SMC1_euk)

39K

ATP binding site
36G, 37S, 39K, 40S, 41N, 155Q
CDD
cd03275 (ABC_SMC1_euk)

40S

ATP binding site
36G, 37S, 39K, 40S, 41N, 155Q
CDD
cd03275 (ABC_SMC1_euk)

41N

ATP binding site
36G, 37S, 39K, 40S, 41N, 155Q
CDD
cd03275 (ABC_SMC1_euk)

155Q

ATP binding site
36G, 37S, 39K, 40S, 41N, 155Q
CDD
cd03275 (ABC_SMC1_euk)
Q-loop/lid cd03275

152L

Q-loop/lid
152L, 153V, 154F, 155Q
CDD
cd03275 (ABC_SMC1_euk)

153V

Q-loop/lid
152L, 153V, 154F, 155Q
CDD
cd03275 (ABC_SMC1_euk)

154F

Q-loop/lid
152L, 153V, 154F, 155Q
CDD
cd03275 (ABC_SMC1_euk)

155Q

Q-loop/lid
152L, 153V, 154F, 155Q
CDD
cd03275 (ABC_SMC1_euk)
ABC transporter si...

176I

ABC transporter signature motif
176I, 177S, 178G
CDD
cd03275 (ABC_SMC1_euk)

177S

ABC transporter signature motif
176I, 177S, 178G
CDD
cd03275 (ABC_SMC1_euk)

178G

ABC transporter signature motif
176I, 177S, 178G
CDD
cd03275 (ABC_SMC1_euk)
ABC transporter si...

1,139L

ABC transporter signature motif
1,139L, 1,140S, 1,141G, 1,142G, 1,143E, 1,144K, 1,145T, 1,146M, 1,147A, 1,148A
CDD
cd03275 (ABC_SMC1_euk)

1,140S

ABC transporter signature motif
1,139L, 1,140S, 1,141G, 1,142G, 1,143E, 1,144K, 1,145T, 1,146M, 1,147A, 1,148A
CDD
cd03275 (ABC_SMC1_euk)

1,141G

ABC transporter signature motif
1,139L, 1,140S, 1,141G, 1,142G, 1,143E, 1,144K, 1,145T, 1,146M, 1,147A, 1,148A
CDD
cd03275 (ABC_SMC1_euk)

1,142G

ABC transporter signature motif
1,139L, 1,140S, 1,141G, 1,142G, 1,143E, 1,144K, 1,145T, 1,146M, 1,147A, 1,148A
CDD
cd03275 (ABC_SMC1_euk)

1,143E

ABC transporter signature motif
1,139L, 1,140S, 1,141G, 1,142G, 1,143E, 1,144K, 1,145T, 1,146M, 1,147A, 1,148A
CDD
cd03275 (ABC_SMC1_euk)

1,144K

ABC transporter signature motif
1,139L, 1,140S, 1,141G, 1,142G, 1,143E, 1,144K, 1,145T, 1,146M, 1,147A, 1,148A
CDD
cd03275 (ABC_SMC1_euk)

1,145T

ABC transporter signature motif
1,139L, 1,140S, 1,141G, 1,142G, 1,143E, 1,144K, 1,145T, 1,146M, 1,147A, 1,148A
CDD
cd03275 (ABC_SMC1_euk)

1,146M

ABC transporter signature motif
1,139L, 1,140S, 1,141G, 1,142G, 1,143E, 1,144K, 1,145T, 1,146M, 1,147A, 1,148A
CDD
cd03275 (ABC_SMC1_euk)

1,147A

ABC transporter signature motif
1,139L, 1,140S, 1,141G, 1,142G, 1,143E, 1,144K, 1,145T, 1,146M, 1,147A, 1,148A
CDD
cd03275 (ABC_SMC1_euk)

1,148A

ABC transporter signature motif
1,139L, 1,140S, 1,141G, 1,142G, 1,143E, 1,144K, 1,145T, 1,146M, 1,147A, 1,148A
CDD
cd03275 (ABC_SMC1_euk)
Walker B cd03275

1,163F

Walker B
1,163F, 1,164F, 1,165V, 1,166L, 1,167D, 1,168E
CDD
cd03275 (ABC_SMC1_euk)

1,164F

Walker B
1,163F, 1,164F, 1,165V, 1,166L, 1,167D, 1,168E
CDD
cd03275 (ABC_SMC1_euk)

1,165V

Walker B
1,163F, 1,164F, 1,165V, 1,166L, 1,167D, 1,168E
CDD
cd03275 (ABC_SMC1_euk)

1,166L

Walker B
1,163F, 1,164F, 1,165V, 1,166L, 1,167D, 1,168E
CDD
cd03275 (ABC_SMC1_euk)

1,167D

Walker B
1,163F, 1,164F, 1,165V, 1,166L, 1,167D, 1,168E
CDD
cd03275 (ABC_SMC1_euk)

1,168E

Walker B
1,163F, 1,164F, 1,165V, 1,166L, 1,167D, 1,168E
CDD
cd03275 (ABC_SMC1_euk)
ATP binding site c...

1,167D

ATP binding site
1,167D, 1,168E, 1,200L
CDD
cd03275 (ABC_SMC1_euk)

1,168E

ATP binding site
1,167D, 1,168E, 1,200L
CDD
cd03275 (ABC_SMC1_euk)

1,200L

ATP binding site
1,167D, 1,168E, 1,200L
CDD
cd03275 (ABC_SMC1_euk)
D-loop cd03275

1,171A

D-loop
1,171A, 1,172A, 1,173L, 1,174D
CDD
cd03275 (ABC_SMC1_euk)

1,172A

D-loop
1,171A, 1,172A, 1,173L, 1,174D
CDD
cd03275 (ABC_SMC1_euk)

1,173L

D-loop
1,171A, 1,172A, 1,173L, 1,174D
CDD
cd03275 (ABC_SMC1_euk)

1,174D

D-loop
1,171A, 1,172A, 1,173L, 1,174D
CDD
cd03275 (ABC_SMC1_euk)
H-loop/switch regi...

1,196I

H-loop/switch region
1,196I, 1,197V, 1,198I, 1,199S, 1,200L, 1,201K, 1,202N
CDD
cd03275 (ABC_SMC1_euk)

1,197V

H-loop/switch region
1,196I, 1,197V, 1,198I, 1,199S, 1,200L, 1,201K, 1,202N
CDD
cd03275 (ABC_SMC1_euk)

1,198I

H-loop/switch region
1,196I, 1,197V, 1,198I, 1,199S, 1,200L, 1,201K, 1,202N
CDD
cd03275 (ABC_SMC1_euk)

1,199S

H-loop/switch region
1,196I, 1,197V, 1,198I, 1,199S, 1,200L, 1,201K, 1,202N
CDD
cd03275 (ABC_SMC1_euk)

1,200L

H-loop/switch region
1,196I, 1,197V, 1,198I, 1,199S, 1,200L, 1,201K, 1,202N
CDD
cd03275 (ABC_SMC1_euk)

1,201K

H-loop/switch region
1,196I, 1,197V, 1,198I, 1,199S, 1,200L, 1,201K, 1,202N
CDD
cd03275 (ABC_SMC1_euk)

1,202N

H-loop/switch region
1,196I, 1,197V, 1,198I, 1,199S, 1,200L, 1,201K, 1,202N
CDD
cd03275 (ABC_SMC1_euk)

Protein sequence

>MIA_06287_1
MGRLKSIELHNFKSYSDTVRVEFGDAYFTSIIGPNGSGKSNMMDAISFVLGMRSNILRSGQLTDLIYRGRVMKESKDSSS
TTFQDTKNTDPRSAYVMAIYEKDDKSILELKRSIGYSSGGSQYRINNEVVSIQEYESILAKENILIKAKNFLVFQGDVEA
IASQSPKDLSRMIEQISGSLKYKAEYEKKKEIKDSTSNINSLSHRKKRLFIAEIKQYRVQADEARIFDKMVRDRDAVVLK
HALWRLYHLEKSGETSETELNSLLLQLNDKSRKISDLQQLFNTINRTFTISKSEINGLDRDTKTQEKVIEDKKNSLLPVD
EKINMTQQNIKKIKGTISSLEPNLERQSETIKNLSRDMSIVEQEKETFESQSSQIIKTAGLDLSDRDIEEYDNLKSRFAQ
ATSDRQSEIDGFKRSLKTEEEKVKTLESRFNQLKVQEGNLSKEVTDMKIRLQNYNSQSEDYSAELDSKNKKLNDFVTERR
NRLAKEHELQAKLQEVTEFLVRYSVNHRESERDARMKDEVATMKRCIPGVKGFVFDLCQPKQRKYDTAISTVLGKNFNSI
IVDSFQTAQQCLSYIKERRVGIATFIPLDSVSVQPINNKLRGISNKVRLAVDTVDYDPELEAAINYVCGSAVVCDDLNTA
KYVRWTKNIDVKAVTLDGAVIHKAGLMTGGRVEKKNSQQWNDKEISRAKKKKEEYQTQIHELSKSKFDTQEEQLRSDIAG
LRLKLGVISDEVSNLKETLKGREIELQHVIKNLKDIEFPLRDARNLLSDTKSRYKNLQILVEKTEDNIFAQFAAKIGVKN
IREYRQAQSGFVTEISQKRLDFVNQISRLNNQIQFEMARRDDMQSRINNMHKKLERENDRLKELKKEKDVLSNQIKSEQS
LLDDTKEEVNTKKEALEKLSHEISDCRGKLNAVQDEQDTIQKRITLRQEEIFKIAMGRIKTLKDCKIEGIDLPLSSGSLN
MIKMEGIHNDDEIEEESTNAKNDHHEILQNIVVDYSELNEDLKLNDDDSVGEQLERDVQLLTINLEKMVVNSRARDRLDE
AERKLKEVDDDAEKTRSEHKKAKDDFESVKRRRYELFNRAYKHISSQIDRIYKELTKTPTFPLGGTATLSLEDEDEPYLD
GVNYHAMPPMKRFCDMELLSGGEKTMAALALLFAIHSYHPSPFFVLDEVDAALDNANVGNIARYIQRHAGPGFQFIVISL
KNGLFENSQSLVGIYRDQDENSSRALTINLQMYSSSNTDLKNRGNNSSGGEASLIME

GO term prediction

Biological Process

GO:0051276 chromosome organization

Molecular Function

GO:0005515 protein binding
GO:0005524 ATP binding

Cellular Component

GO:0005694 chromosome

Filter view on

Entry type

Status

Per-residue features