MCA_01193_1

Protein

Length

1,322 amino acids

Gene name: SMC1

Description: Structural maintenance of chromosomes protein 1

Browser: contigA:3778811-3782842+

RNA-seq: read pairs 1152, FPKM 10.8, percentile rank 27.1% (100% = highest expression)

Protein function

Annotation:		SMC1	Structural maintenance of chromosomes protein 1
KEGG:	K06636	SMC1	structural maintenance of chromosome 1
EGGNOG:	0PH43	SMC1	structural maintenance of chromosomes protein
SGD closest match:	S000001886	SMC1	Structural maintenance of chromosomes protein 1
CGD closest match:	CAL0000179192	SMC1	Structural maintenance of chromosomes protein

Protein alignments

	%id	Aln length	E-value
A0A0J9YHK5_GEOCN	49.18%	1279	0.0	Structural maintenance of chromosomes protein OS=Geotrichum candidum GN=BN980_GECA01s05840g PE=3 SV=1
UniRef50_A0A0J9YHK5	49.18%	1279	0.0	Structural maintenance of chromosomes protein n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9YHK5_GEOCN
MIA_06287_1	47.21%	1290	0.0	MIA_06287_1
A0A060TI49_BLAAD	39.77%	1285	0.0	Structural maintenance of chromosomes protein OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D43648g PE=3 SV=1
A0A167CA43_9ASCO	36.27%	1180	0.0	Structural maintenance of chromosomes protein OS=Sugiyamaella lignohabitans GN=SMC1 PE=3 SV=1
Q6C5S3_YARLI	36.27%	1293	0.0	Structural maintenance of chromosomes protein OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E15620g PE=3 SV=1
A0A1D8PSI8_CANAL	36.90%	1298	0.0	Structural maintenance of chromosomes protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SMC1 PE=3 SV=1
SMC1_YEAST	34.77%	1300	0.0	Structural maintenance of chromosomes protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SMC1 PE=1 SV=1
A0A1E4TCC0_9ASCO	32.24%	1343	0.0	Structural maintenance of chromosomes protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_3915 PE=3 SV=1
A0A1E3PJ65_9ASCO	38.94%	226	7e-38	Structural maintenance of chromosomes protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_25651 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0475
Predicted cleavage: 71

Protein family membership

Structural maintenance of chromosomes protein (IPR024704)

Domains and repeats

Domain
5 - 1,257
RecF/RecN/SMC, N-terminal (IPR003395)
Domain
8 - 77
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
110 - 197
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
499 - 698
SMCs flexible hinge (IPR010935)
1,164 - 1,252
P-loop containing nucleoside triphosphate hydrolase (IPR027417)

1 200 400 600 800 1000 1200 1322

Detailed signature matches

IPR024704

Structural maintenance of chromosomes protein
1. PIRSF005719 (SMC)
  
  3 - 1,275
  
  PIRSF
  PIRSF005719 (SMC)
IPR003395

RecF/RecN/SMC, N-terminal
1. PF02463 (SMC_N)
  
  5 - 1,257
  
  Pfam
  PF02463 (SMC_N)
IPR027417

P-loop containing nucleoside triphosphate hydrolase
1. SSF52540 (P-loop co...)
  
  8 - 77
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
  
  110 - 197
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
  
  1,164 - 1,252
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
IPR010935

SMCs flexible hinge
1. PF06470 (SMC_hinge)
  
  536 - 650
  
  Pfam
  PF06470 (SMC_hinge)
2. SM00968 (SMC_hinge_2)
  
  536 - 652
  
  SMART
  SM00968 (SMC_hinge_2)
3. SSF75553 (Smc hinge...)
  
  499 - 698
  
  SUPERFAMILY
  SSF75553 (Smc hinge domain)

no IPR

Unintegrated signatures

Coil

1,019 - 1,039

COILS
Coil (Coil)

268 - 323

COILS
Coil (Coil)

396 - 444

COILS
Coil (Coil)

452 - 490

COILS
Coil (Coil)

338 - 379

COILS
Coil (Coil)

693 - 713

COILS
Coil (Coil)

855 - 910

COILS
Coil (Coil)

1,049 - 1,110

COILS
Coil (Coil)

733 - 788

COILS
Coil (Coil)
G3DSA:1.10.28...

808 - 942

GENE3D
G3DSA:1.10.287.620 (G3DSA:1.10.287.620)

683 - 796

GENE3D
G3DSA:1.10.287.620 (G3DSA:1.10.287.620)
G3DSA:1.20.12...

253 - 401

GENE3D
G3DSA:1.20.120.330 (G3DSA:1.20.120.330)
G3DSA:1.20.5.730

404 - 487

GENE3D
G3DSA:1.20.5.730 (G3DSA:1.20.5.730)
G3DSA:3.40.50...

978 - 1,273

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)

4 - 200

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
cd03275 (ABC_SMC1_euk)

5 - 174

CDD
cd03275 (ABC_SMC1_euk)

1,165 - 1,268

CDD
cd03275 (ABC_SMC1_euk)
mobidb-lite (disord...)

77 - 100

MobiDB Lite
mobidb-lite (disorder_prediction)

996 - 1,018

MobiDB Lite
mobidb-lite (disorder_prediction)

1,273 - 1,322

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

Walker A/P-loop cd...

34G

Walker A/P-loop
34G, 35P, 36N, 37G, 38S, 39G, 40K, 41S
CDD
cd03275 (ABC_SMC1_euk)

35P

Walker A/P-loop
34G, 35P, 36N, 37G, 38S, 39G, 40K, 41S
CDD
cd03275 (ABC_SMC1_euk)

36N

Walker A/P-loop
34G, 35P, 36N, 37G, 38S, 39G, 40K, 41S
CDD
cd03275 (ABC_SMC1_euk)

37G

Walker A/P-loop
34G, 35P, 36N, 37G, 38S, 39G, 40K, 41S
CDD
cd03275 (ABC_SMC1_euk)

38S

Walker A/P-loop
34G, 35P, 36N, 37G, 38S, 39G, 40K, 41S
CDD
cd03275 (ABC_SMC1_euk)

39G

Walker A/P-loop
34G, 35P, 36N, 37G, 38S, 39G, 40K, 41S
CDD
cd03275 (ABC_SMC1_euk)

40K

Walker A/P-loop
34G, 35P, 36N, 37G, 38S, 39G, 40K, 41S
CDD
cd03275 (ABC_SMC1_euk)

41S

Walker A/P-loop
34G, 35P, 36N, 37G, 38S, 39G, 40K, 41S
CDD
cd03275 (ABC_SMC1_euk)
ATP binding site c...

37G

ATP binding site
37G, 38S, 40K, 41S, 42N, 163Q
CDD
cd03275 (ABC_SMC1_euk)

38S

ATP binding site
37G, 38S, 40K, 41S, 42N, 163Q
CDD
cd03275 (ABC_SMC1_euk)

40K

ATP binding site
37G, 38S, 40K, 41S, 42N, 163Q
CDD
cd03275 (ABC_SMC1_euk)

41S

ATP binding site
37G, 38S, 40K, 41S, 42N, 163Q
CDD
cd03275 (ABC_SMC1_euk)

42N

ATP binding site
37G, 38S, 40K, 41S, 42N, 163Q
CDD
cd03275 (ABC_SMC1_euk)

163Q

ATP binding site
37G, 38S, 40K, 41S, 42N, 163Q
CDD
cd03275 (ABC_SMC1_euk)
Q-loop/lid cd03275

160L

Q-loop/lid
160L, 161V, 162F, 163Q
CDD
cd03275 (ABC_SMC1_euk)

161V

Q-loop/lid
160L, 161V, 162F, 163Q
CDD
cd03275 (ABC_SMC1_euk)

162F

Q-loop/lid
160L, 161V, 162F, 163Q
CDD
cd03275 (ABC_SMC1_euk)

163Q

Q-loop/lid
160L, 161V, 162F, 163Q
CDD
cd03275 (ABC_SMC1_euk)
ABC transporter si...

1,177L

ABC transporter signature motif
1,177L, 1,178S, 1,179G, 1,180G, 1,181E, 1,182K, 1,183T, 1,184M, 1,185A, 1,186A
CDD
cd03275 (ABC_SMC1_euk)

1,178S

ABC transporter signature motif
1,177L, 1,178S, 1,179G, 1,180G, 1,181E, 1,182K, 1,183T, 1,184M, 1,185A, 1,186A
CDD
cd03275 (ABC_SMC1_euk)

1,179G

ABC transporter signature motif
1,177L, 1,178S, 1,179G, 1,180G, 1,181E, 1,182K, 1,183T, 1,184M, 1,185A, 1,186A
CDD
cd03275 (ABC_SMC1_euk)

1,180G

ABC transporter signature motif
1,177L, 1,178S, 1,179G, 1,180G, 1,181E, 1,182K, 1,183T, 1,184M, 1,185A, 1,186A
CDD
cd03275 (ABC_SMC1_euk)

1,181E

ABC transporter signature motif
1,177L, 1,178S, 1,179G, 1,180G, 1,181E, 1,182K, 1,183T, 1,184M, 1,185A, 1,186A
CDD
cd03275 (ABC_SMC1_euk)

1,182K

ABC transporter signature motif
1,177L, 1,178S, 1,179G, 1,180G, 1,181E, 1,182K, 1,183T, 1,184M, 1,185A, 1,186A
CDD
cd03275 (ABC_SMC1_euk)

1,183T

ABC transporter signature motif
1,177L, 1,178S, 1,179G, 1,180G, 1,181E, 1,182K, 1,183T, 1,184M, 1,185A, 1,186A
CDD
cd03275 (ABC_SMC1_euk)

1,184M

ABC transporter signature motif
1,177L, 1,178S, 1,179G, 1,180G, 1,181E, 1,182K, 1,183T, 1,184M, 1,185A, 1,186A
CDD
cd03275 (ABC_SMC1_euk)

1,185A

ABC transporter signature motif
1,177L, 1,178S, 1,179G, 1,180G, 1,181E, 1,182K, 1,183T, 1,184M, 1,185A, 1,186A
CDD
cd03275 (ABC_SMC1_euk)

1,186A

ABC transporter signature motif
1,177L, 1,178S, 1,179G, 1,180G, 1,181E, 1,182K, 1,183T, 1,184M, 1,185A, 1,186A
CDD
cd03275 (ABC_SMC1_euk)
Walker B cd03275

1,201F

Walker B
1,201F, 1,202F, 1,203V, 1,204L, 1,205D, 1,206E
CDD
cd03275 (ABC_SMC1_euk)

1,202F

Walker B
1,201F, 1,202F, 1,203V, 1,204L, 1,205D, 1,206E
CDD
cd03275 (ABC_SMC1_euk)

1,203V

Walker B
1,201F, 1,202F, 1,203V, 1,204L, 1,205D, 1,206E
CDD
cd03275 (ABC_SMC1_euk)

1,204L

Walker B
1,201F, 1,202F, 1,203V, 1,204L, 1,205D, 1,206E
CDD
cd03275 (ABC_SMC1_euk)

1,205D

Walker B
1,201F, 1,202F, 1,203V, 1,204L, 1,205D, 1,206E
CDD
cd03275 (ABC_SMC1_euk)

1,206E

Walker B
1,201F, 1,202F, 1,203V, 1,204L, 1,205D, 1,206E
CDD
cd03275 (ABC_SMC1_euk)
ATP binding site c...

1,205D

ATP binding site
1,205D, 1,206E, 1,238L
CDD
cd03275 (ABC_SMC1_euk)

1,206E

ATP binding site
1,205D, 1,206E, 1,238L
CDD
cd03275 (ABC_SMC1_euk)

1,238L

ATP binding site
1,205D, 1,206E, 1,238L
CDD
cd03275 (ABC_SMC1_euk)
D-loop cd03275

1,209A

D-loop
1,209A, 1,210A, 1,211L, 1,212D
CDD
cd03275 (ABC_SMC1_euk)

1,210A

D-loop
1,209A, 1,210A, 1,211L, 1,212D
CDD
cd03275 (ABC_SMC1_euk)

1,211L

D-loop
1,209A, 1,210A, 1,211L, 1,212D
CDD
cd03275 (ABC_SMC1_euk)

1,212D

D-loop
1,209A, 1,210A, 1,211L, 1,212D
CDD
cd03275 (ABC_SMC1_euk)
H-loop/switch regi...

1,234I

H-loop/switch region
1,234I, 1,235V, 1,236I, 1,237S, 1,238L, 1,239K, 1,240N
CDD
cd03275 (ABC_SMC1_euk)

1,235V

H-loop/switch region
1,234I, 1,235V, 1,236I, 1,237S, 1,238L, 1,239K, 1,240N
CDD
cd03275 (ABC_SMC1_euk)

1,236I

H-loop/switch region
1,234I, 1,235V, 1,236I, 1,237S, 1,238L, 1,239K, 1,240N
CDD
cd03275 (ABC_SMC1_euk)

1,237S

H-loop/switch region
1,234I, 1,235V, 1,236I, 1,237S, 1,238L, 1,239K, 1,240N
CDD
cd03275 (ABC_SMC1_euk)

1,238L

H-loop/switch region
1,234I, 1,235V, 1,236I, 1,237S, 1,238L, 1,239K, 1,240N
CDD
cd03275 (ABC_SMC1_euk)

1,239K

H-loop/switch region
1,234I, 1,235V, 1,236I, 1,237S, 1,238L, 1,239K, 1,240N
CDD
cd03275 (ABC_SMC1_euk)

1,240N

H-loop/switch region
1,234I, 1,235V, 1,236I, 1,237S, 1,238L, 1,239K, 1,240N
CDD
cd03275 (ABC_SMC1_euk)

Protein sequence

>MCA_01193_1
MVGKLQIIELYNFKSYCGKVRVEFGSAHFTSIIGPNGSGKSNMMDAISFVLGIRSNVLRSGQLADLVYRGRVMNHKNSED
AESNEQVASTQEQRSDPKSAYVSAEYVKENGEVLELKRSITITNSNTISQYLINGEIVSSKEYEKVLAKENILIKARNFL
VFQGDVESIANRKAEDLTNLIEQISGSLQYKAEYDRRKEITDLKAEESSAALSKKRYFKGEMRQYTEQQRDVEQYNEMTR
QRDAAILRLTLWKLYHLEKTGRGVDSQLARLMEDLATESDKLDELRRVVSESKAQYARINEQMLVLKKQVQQKQRAYDNK
KNDITPIDQKISIFKDKIASISKTIELQTAELENQEKATAKYQQELQVAISQKDQFEKNNEAQSRAAGLDLSDEDLQEYE
RLKALYTRQTSQQEAEINTAKRQLDTEEKKLATLEAREKQLKYRESSLSGDIVNLKRQIEVLTNEVNEIKDNYKSKKEKL
NEKIRIREARTARETELHARLQEATEYLLKYNAYVHENERDAKLREDTETMKRLIPGVRGFVHNLCTPKQRKFQTAVSTV
LGKNYNSIIVDTFAVGQQCINYMKEQRSGMATFIPLDSVSVHPISSNLRGISDSVRLAIDSIDFDPELLPAMNYVCGNTI
ICDDLNVAKYVRWTKKYDVKAVTLDGSVIHKAGLMTGGAVENNRGIVWNDTEINNKKKIKEDCTAELNKLSMEKSSFAED
ELQREINHLTISMNSKRDSIAEAQHTLENRESELRVITQQHSSLYEKLEEIRERVSRFRDQYNTAMESVRGIQESIFGDF
VARIGVTSIEDYESAHSGYITEVAAQRLSFTKKISQAEKVLQFEIRKKSGIEARLQKLRSDLTTEQTKLNEFLQEKEILV
RQLSQIEEEIETLNVELNRKKTEADDFKALHASRQSEYAESQKTYDEIRRNIVYQQELLDKVLMGRIKTLRNCKIESLQL
PLSQGSLDLLPLDDAFIGVSVNGTQNVASYNEDVEFTDDNNNESAQENTQERRSGKTAKERAREILDQIVIDYDGLEQRF
KDDDDEATEELLSLEIKQLNSNLDQMTINTRAQERLEYSKEKLDEVAREFDIARQEAKIAREEYDKVKTKRKELFLKAFQ
HISGVIDSIYKELTKTKTFPLGGTAYLSLTDETEPYLGGLNYVVMPPMKRFTAMAALSGGEKTMAALALLFAIHSYHPSP
FFVLDEVDAALDNANVSNIAKYIKHHAGPGFQFIVISLKNGLFEHSQSLVGIYRDQDVNSSRALMMDLQVYDERPANSRS
SKEQNGNGTVGESQQQKEPTEEDINQDLAGEADDEDTEMADV

GO term prediction

Biological Process

GO:0051276 chromosome organization

Molecular Function

GO:0005515 protein binding
GO:0005524 ATP binding

Cellular Component

GO:0005694 chromosome

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Entry type

Status

Per-residue features