Protein

MIA_06269_1

Length
509 amino acids

Browser: contig10:754183-755713-

Protein function

EGGNOG:0PIDUMRH4ATP-binding RNA helicase involved in mitochondrial RNA metabolism. Required for maintenance of mitochondrial DNA (By similarity)
SGD closest match:S000003032MRH4ATP-dependent RNA helicase MRH4, mitochondrial
CGD closest match:CAL0000186407MRH4ATP-dependent RNA helicase MRH4, mitochondrial

Protein alignments

%idAln lengthE-value
MCA_05609_162.708%4800.0MCA_05609_1
A0A0J9XG59_GEOCN62.389%4520.0Similar to Saccharomyces cerevisiae YGL064C MRH4 Mitochondrial ATP-dependent RNA helicase of the DEAD-box family OS=Geotrichum candidum GN=BN980_GECA14s01836g PE=4 SV=1
UniRef50_A0A0J9XG5962.389%4520.0Similar to Saccharomyces cerevisiae YGL064C MRH4 Mitochondrial ATP-dependent RNA helicase of the DEAD-box family n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XG59_GEOCN
A0A167DBE8_9ASCO52.477%4445.39e-159Mrh4p OS=Sugiyamaella lignohabitans GN=MRH4 PE=4 SV=1
A0A060TBN7_BLAAD48.359%4571.13e-147ARAD1D33440p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D33440g PE=4 SV=1
A0A1E3PP63_9ASCO47.849%3724.67e-125p-loop containing nucleoside triphosphate hydrolase protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_9058 PE=4 SV=1
MRH4_YEAST37.045%4941.47e-92ATP-dependent RNA helicase MRH4, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MRH4 PE=1 SV=1
MRH4_CANAL36.994%5194.32e-92ATP-dependent RNA helicase MRH4, mitochondrial OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MRH4 PE=3 SV=2
MRH4_YARLI37.528%4539.95e-83ATP-dependent RNA helicase MRH4, mitochondrial OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=MRH4 PE=3 SV=1
A0A1E4TKA8_9ASCO34.685%4445.27e-74Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_147496 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9787
Predicted cleavage: 40

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 450 509

Detailed signature matches

  1. Domain IPR014014
    RNA helicase, DEAD-box type, Q motif
    1. PS51195 (Q_MOTIF)
  2. Domain IPR014001
    Helicase superfamily 1/2, ATP-binding domain
    1. PS51192 (HELICASE_A...)
    2. SM00487 (ultradead3)
  3. Domain IPR011545
    DEAD/DEAH box helicase domain
    1. PF00270 (DEAD)
  4. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  5. Domain IPR001650
    Helicase, C-terminal
    1. PS51194 (HELICASE_CTER)
    2. SM00490 (helicmild6)
    3. PF00271 (Helicase_C)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. cd00079 (HELICc)
  3. mobidb-lite (disord...)

Residue annotation

  1. nucleotide binding...
  2. ATP-binding site c...

Protein sequence

>MIA_06269_1
MFIKNPIKVNRFSAKFLVRTIATKAIKNDRRLSLNVSKSSKGSSKGSSKGSSKKAVRDPKFLVGPPNSGKFAGLHMIDPK
DRLQGKATVSKINTFEALKIDSGVRNAIENDILSHLNYKQPSEIQVLATKAIQARRKNSDEFRSFLIAAETGSGKTLAYL
APLMSKLKEQETSDPNWEHLKELPIIRSIILVPTLELTAQVISTVKRICHVAKLSSFALTPEISLKSISSKLEQRIDVLV
ANPEKLLAAFKNQNALKGHLKYCKWVVVDEADTLMDESFVESTQKVLEATSSSATDVVFCSATIPRRFDKVMTKLYPETN
RIVTHSLHKIPRHIDFRVVEVFNPPYLNSKPRALQQALYAIHNDNTEAGHLKRVVVFLNHKDEIPALATFLKEKGYNSVS
ISSKMTIQERKDLIADFVNPAPPLNLDDTTPKVKVLLTTDLLSRGVDMNNIRNVILYDLPYSSVDLIHRAGRTGRMGKRG
RVFLFVEKKESRGWVKGLEKVVKKGMVLA

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003676 nucleic acid binding
GO:0005524 ATP binding

Cellular Component

None predicted.