Protein

MCA_05609_1

Length
574 amino acids

Gene name: MRH4

Description: ATP-dependent RNA helicase MRH4, mitochondrial

Browser: contigD:1791848-1793573+

RNA-seq: read pairs 661, FPKM 14.2, percentile rank 32.8% (100% = highest expression)

Protein function

Annotation:MRH4ATP-dependent RNA helicase MRH4, mitochondrial
KEGG:K17678MRH4 ATP-dependent RNA helicase MRH4, mitochondrial [EC:3.6.4.13]
EGGNOG:0PIDUMRH4ATP-binding RNA helicase involved in mitochondrial RNA metabolism. Required for maintenance of mitochondrial DNA (By similarity)
SGD closest match:S000003032MRH4ATP-dependent RNA helicase MRH4, mitochondrial
CGD closest match:CAL0000186407MRH4ATP-dependent RNA helicase MRH4, mitochondrial

Protein alignments

%idAln lengthE-value
MIA_06269_162.71%4800.0MIA_06269_1
A0A0J9XG59_GEOCN61.25%4800.0Similar to Saccharomyces cerevisiae YGL064C MRH4 Mitochondrial ATP-dependent RNA helicase of the DEAD-box family OS=Geotrichum candidum GN=BN980_GECA14s01836g PE=4 SV=1
UniRef50_A0A0J9XG5961.25%4800.0Similar to Saccharomyces cerevisiae YGL064C MRH4 Mitochondrial ATP-dependent RNA helicase of the DEAD-box family n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XG59_GEOCN
A0A167DBE8_9ASCO48.73%4721e-152Mrh4p OS=Sugiyamaella lignohabitans GN=MRH4 PE=4 SV=1
A0A060TBN7_BLAAD45.79%4873e-140ARAD1D33440p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D33440g PE=4 SV=1
A0A1E3PP63_9ASCO47.59%3953e-123p-loop containing nucleoside triphosphate hydrolase protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_9058 PE=4 SV=1
MRH4_YEAST35.34%5153e-86ATP-dependent RNA helicase MRH4, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MRH4 PE=1 SV=1
MRH4_CANAL35.85%5444e-82ATP-dependent RNA helicase MRH4, mitochondrial OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MRH4 PE=3 SV=2
MRH4_YARLI35.64%4773e-78ATP-dependent RNA helicase MRH4, mitochondrial OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=MRH4 PE=3 SV=1
A0A1E4TKA8_9ASCO33.92%4574e-65Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_147496 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9877
Predicted cleavage: 40

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 574

Detailed signature matches

  1. Domain IPR014014
    RNA helicase, DEAD-box type, Q motif
    1. PS51195 (Q_MOTIF)
  2. Domain IPR014001
    Helicase superfamily 1/2, ATP-binding domain
    1. PS51192 (HELICASE_A...)
    2. SM00487 (ultradead3)
  3. Domain IPR011545
    DEAD/DEAH box helicase domain
    1. PF00270 (DEAD)
  4. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  5. Domain IPR001650
    Helicase, C-terminal
    1. PS51194 (HELICASE_CTER)
    2. SM00490 (helicmild6)
    3. PF00271 (Helicase_C)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. cd00079 (HELICc)
  3. mobidb-lite (disord...)

Residue annotation

  1. nucleotide binding...
  2. ATP-binding site c...

Protein sequence

>MCA_05609_1
MIRHANSSLFKKLTVVQCVRAHSTRSNPTRTIKNSQRLSKKVAQTNIDITNDNKPRRSNRQREKSTVELNTFSRDLGKDI
KKMSPKHLSTELKMNPAFLTGPPNSGEFARLRAVPPEERIKTANVISKIDTFEALKINNEVRESILNNVLGHLEYKKPSA
IQTLGIRAIQAKRRHPDEFRSFLLAAETGSGKTLAYLAPLLSKLKDQEDAMRKIHAQVNDDKPSDTARTSKTMPWDYFSN
LPVVRSLILVPTLELVSQVTATVKKISYSAKVSSFAITNDISLKAVKENLESRRIDVLITTPDKFLHSFKNEASLKGHLK
FCQTVVVDEADTLMDKSFLESTQHVLSLTQHSELRDLVFCSATIPRNFDKTMRKFYPDIKRIVTPSLHKIPRHIDFRVIE
VFNPPYLNSKTLALQQALYAIHNDNTEQGIKKRVVVFLNHKKDIKPLADLLNSKGYDARYVSGDMDSNERKALVQEFVGP
AEKLPTEGEEASKQPNKVQVLLTSDLLARGIDMDNVRNVILYDLPYSSVDLLHRSGRTGRMGKRGRVFLFVEKKESRGWV
KGLEKVVKRGMSLA

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003676 nucleic acid binding
GO:0005524 ATP binding

Cellular Component

None predicted.