Protein

MIA_06252_1

Length
515 amino acids

Browser: contig10:723061-724609-

Protein function

EGGNOG:0PMDRKey enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity)
CGD closest match:CAL0000177837orf19.2281Succinyl-CoA:3-ketoacid-coenzyme A transferase

Protein alignments

%idAln lengthE-value
MCA_00698_180.588%5100.0MCA_00698_1
A0A0J9X450_GEOCN73.320%5060.0Succinyl-CoA:3-ketoacid-coenzyme A transferase OS=Geotrichum candidum GN=BN980_GECA02s06841g PE=3 SV=1
Q59Z19_CANAL68.685%4790.0Succinyl-CoA:3-ketoacid-coenzyme A transferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.2281 PE=3 SV=1
UniRef50_G8BJM667.828%4880.0Succinyl-CoA:3-ketoacid-coenzyme A transferase n=583 Tax=Eukaryota TaxID=2759 RepID=G8BJM6_CANPC
A0A167DFS0_9ASCO68.191%4810.0Succinyl-CoA:3-ketoacid-coenzyme A transferase OS=Sugiyamaella lignohabitans GN=AWJ20_1147 PE=3 SV=1
A0A060T9I3_BLAAD64.898%4900.0Succinyl-CoA:3-ketoacid-coenzyme A transferase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D18348g PE=3 SV=1
Q6C098_YARLI63.241%5060.0Succinyl-CoA:3-ketoacid-coenzyme A transferase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F26587g PE=3 SV=1
A0A1E4TET3_9ASCO54.705%4577.03e-180Succinyl-CoA:3-ketoacid-coenzyme A transferase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_104292 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.8730
Predicted cleavage: 33

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 450 515

Detailed signature matches

  1. Family IPR004165
    Coenzyme A transferase family I
    1. PF01144 (CoA_trans)
    2. SM00882 (CoA_trans_3)
  2. Family IPR014388
    3-oxoacid CoA-transferase
    1. PIRSF000858 (SCOT-t)
  3. Domain IPR012792
    3-oxoacid CoA-transferase, subunit A
    1. TIGR02429
  4. Domain IPR012791
    3-oxoacid CoA-transferase, subunit B
    1. TIGR02428
  5. SITE IPR004164
    Coenzyme A transferase active site
    1. PS01274 (COA_TRANSF_2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.10...
  2. SSF100950 (NagB/Rpi...)

Protein sequence

>MIA_06252_1
MIRIATPTKSATASFGKYLMSARLFSSASAFYYHSKVTSVKEAVAGIKPGSTILSGGFGLSGVSDTVINELKNHPEINNL
TAVSNNAGVDGCGLSQLLETGQIVKMISSYIGGNKYFEAKYLKGEIDLELTPQGTIAERVRAGGAGIPAFYTSAGVGTWI
EQGELPVRYAPGGGEVVKKSAPREVREFNGRKYVMEEAIVGDVALVKAFKADKVGNVWFRGASRNFNSAMARAGKYTIVE
AEHIVEPGEIPAEDVHVPGIYVDKVVQSTTPKNIEIYKFAVTEGEKGAEDKPRKDSEIRRERIVKRAAKEFKDGYFVNLG
IGIPTLIPNYLAEGVHVTLQSENGILGLGPYPQPGQEDPDYINAGKETVTLAPGASLFGSEESFGMIRAGKIDVTVLGAM
QVSQYGDLANWALPNMVKGMGGAMDLVSNPAATEVIVVTDHTDKKGRAKILEECVFPLTGAKCVSKIITELAVFDVSPTE
GLTLIEALEGWTPEKLQEITGAKFKVSPNLKPYDV

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0046952 ketone body catabolic process

Molecular Function

GO:0008410 CoA-transferase activity

Cellular Component

None predicted.