Protein

MCA_00698_1

Length
516 amino acids

Gene name: OSC1

Description: succinyl-CoA:3-oxoadipate CoA-transferase

Browser: contigA:2188791-2190342+

RNA-seq: read pairs 887, FPKM 21.2, percentile rank 42.8% (100% = highest expression)

Protein function

Annotation:OSC1succinyl-CoA:3-oxoadipate CoA-transferase
KEGG:K01027OXCT 3-oxoacid CoA-transferase [EC:2.8.3.5]
EGGNOG:0PMDRKey enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity)
CGD closest match:CAL0000177837orf19.2281Succinyl-CoA:3-ketoacid-coenzyme A transferase

Protein alignments

%idAln lengthE-value
MIA_06252_180.59%5100.0MIA_06252_1
A0A0J9X450_GEOCN72.02%5110.0Succinyl-CoA:3-ketoacid-coenzyme A transferase OS=Geotrichum candidum GN=BN980_GECA02s06841g PE=3 SV=1
Q59Z19_CANAL69.11%4920.0Succinyl-CoA:3-ketoacid-coenzyme A transferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.2281 PE=3 SV=1
UniRef50_G8BJM668.21%4970.0Succinyl-CoA:3-ketoacid-coenzyme A transferase n=583 Tax=Eukaryota TaxID=2759 RepID=G8BJM6_CANPC
A0A167DFS0_9ASCO66.21%5090.0Succinyl-CoA:3-ketoacid-coenzyme A transferase OS=Sugiyamaella lignohabitans GN=AWJ20_1147 PE=3 SV=1
A0A060T9I3_BLAAD62.50%4960.0Succinyl-CoA:3-ketoacid-coenzyme A transferase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D18348g PE=3 SV=1
Q6C098_YARLI60.08%5110.0Succinyl-CoA:3-ketoacid-coenzyme A transferase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F26587g PE=3 SV=1
A0A1E4TET3_9ASCO55.01%4492e-177Succinyl-CoA:3-ketoacid-coenzyme A transferase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_104292 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9967
Predicted cleavage: 33

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 450 516

Detailed signature matches

  1. Family IPR004165
    Coenzyme A transferase family I
    1. PF01144 (CoA_trans)
    2. SM00882 (CoA_trans_3)
  2. Family IPR014388
    3-oxoacid CoA-transferase
    1. PIRSF000858 (SCOT-t)
  3. Domain IPR012791
    3-oxoacid CoA-transferase, subunit B
    1. TIGR02428
  4. SITE IPR004164
    Coenzyme A transferase active site
    1. PS01274 (COA_TRANSF_2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.10...
  2. SSF100950 (NagB/Rpi...)

Protein sequence

>MCA_00698_1
MLTLSSTAARVPRYLTNSLSHVRFFSKGNTYYYQSKVVSVEDAVKKIQPNSILLSGGFGLSGVADTIINELKNHPEINNL
TAVSNNAGVDGRGLSLLLETGQITKMISSYIGGNKYFEAKYLKGEIDLELTPQGTLAEKVRAGGAGVPAFFTPAGYGTWI
EQGKLPVRYAPGGGEVVKYSKPKEVREYNGRKYILEDAIFGDVAIVKAYKADKIGNLWFRGAANNFNSAMARSGKYTIVE
AEHIVEPGEIPAEDVHVPSIYVDAIIQSTTPKEIEIYKFAVEESSDASSENKPKKESEIRRERIVKRAAKEFKNGDFVNL
GIGIPTLIPNYLPEGVEVTLQSENGILGLGPYPKPGEEDPDFINAGKETVTLAPGASLFGSDESFGMIRAGKVDVTVLGA
MQVSQYGDLANWALPTMVKGMGGAMDLVSNPSNTKVVVVMEHTDKKGRAKILEECAFPLTGPKCVSKIVTDLAVFDVSPT
EGLTLIEVIEGKTPEDIAQITAAKFKVSPNLKPYDA

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0046952 ketone body catabolic process

Molecular Function

GO:0008410 CoA-transferase activity

Cellular Component

None predicted.