Protein

MIA_06226_1

Length
199 amino acids

Browser: contig10:632754-633472-

Protein function

EGGNOG:0PFAPRHO1GTP-binding Protein
SGD closest match:S000006369RHO1GTP-binding protein RHO1
CGD closest match:CAL0000192659RHO1GTP-binding protein RHO1

Protein alignments

%idAln lengthE-value
A0A0J9X4P3_GEOCN93.467%1991.11e-136Similar to Saccharomyces cerevisiae YPR165W RHO1 GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity OS=Geotrichum candidum GN=BN980_GECA03s01451g PE=3 SV=1
MCA_00499_293.467%1997.21e-136MCA_00499_2
A0A060T930_BLAAD88.442%1993.04e-133ARAD1C34738p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C34738g PE=3 SV=1
A0A167FEB8_9ASCO84.925%1991.22e-127Rho family GTPase RHO1 OS=Sugiyamaella lignohabitans GN=RHO1 PE=3 SV=1
A0A1E4TFZ1_9ASCO83.920%1994.66e-126Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_25035 PE=3 SV=1
Q6C4X3_YARLI82.843%2045.98e-125YALI0E23001p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E23001g PE=3 SV=1
UniRef50_A0A061H5N182.990%1942.51e-117Uncharacterized protein n=102 Tax=Opisthokonta TaxID=33154 RepID=A0A061H5N1_9BASI
A0A1E3PPT3_9ASCO75.610%2053.26e-116Beta-1,3-glucan synthase regulatory subunit OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81918 PE=3 SV=1
RHO1_CANAL82.703%1851.36e-113GTP-binding protein RHO1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=RHO1 PE=3 SV=1
RHO1_YEAST80.110%1813.40e-109GTP-binding protein RHO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RHO1 PE=1 SV=3

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0110

Protein family membership

Domains and repeats

  1. Domain
1 20 40 60 80 100 120 140 160 180 199

Detailed signature matches

  1. Family IPR001806
    Small GTPase superfamily
    1. PF00071 (Ras)
  2. Family IPR003578
    Small GTPase superfamily, Rho type
    1. PS51420 (RHO)
  3. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  4. Domain IPR005225
    Small GTP-binding protein domain
    1. TIGR00231
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.30.70...
  2. G3DSA:3.40.50...
  3. PR00449 (RASTRNSFRMNG)
  4. SM00173 (ras_sub_4)
  5. SM00174 (rho_sub_3)
  6. SM00175 (rab_sub_5)
  7. cd01870 (RhoA_like)

Residue annotation

  1. GEF (guanine nucle...
  2. G1 box cd01870
  3. GTP/Mg2+ binding s...
  4. PKN/PRK1 effector ...
  5. Switch I region cd...
  6. GAP (GTPase-activa...
  7. G2 box cd01870
  8. GDI (guanine nucle...
  9. Rho kinase (ROCK) ...
  10. Mdia effector inte...
  11. G3 box cd01870
  12. Switch II region c...
  13. G4 box cd01870
  14. G5 box cd01870

Protein sequence

>MIA_06226_1
MVGQPAELRRKLVIVGDGACGKTCLLIVFSKGTFPQVYLPTVFENYVSDVEVDGRHVELALWDTAGQEDYDRLRPLSYPD
SNVILICFAIDSPDSLDNVQEKWISEVLHFCQGVPILLVGCKADLRFDPKTIEELKRTSQRPVTPEEGQAVAQKIGALKY
LECSAKTQEGVKEVFEHATRAALMVKDKERKPTRRCLIL

GO term prediction

Biological Process

GO:0007264 small GTPase mediated signal transduction

Molecular Function

GO:0003924 GTPase activity
GO:0005525 GTP binding

Cellular Component

GO:0005622 intracellular