Protein

MIA_06205_1

Length
90 amino acids


Browser: contig10:561729-562002-

Protein function

EGGNOG:0PRY8DPH3Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L- methionine to a histidine residue. Diphthamide is a post- translational modification of histidine which occurs in elongation factor 2
SGD closest match:S000007587KTI11Diphthamide biosynthesis protein 3
CGD closest match:CAL0000195342KTI11Kti11p

Protein alignments

%idAln lengthE-value
A0A0J9X4Z0_GEOCN80.597%673.87e-37Similar to Saccharomyces cerevisiae YBL071W-A KTI11 Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 OS=Geotrichum candidum GN=BN980_GECA02s07292g PE=4 SV=1
MCA_03466_174.286%701.35e-33MCA_03466_1
A0A060TE89_BLAAD72.857%709.47e-33ARAD1D49918p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D49918g PE=4 SV=1
UniRef50_Q6CMG473.134%671.25e-27Diphthamide biosynthesis protein 3 n=75 Tax=Eukaryota TaxID=2759 RepID=DPH3_KLULA
DPH3_YEAST62.857%701.43e-29Diphthamide biosynthesis protein 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KTI11 PE=1 SV=1
A0A1E3PP01_9ASCO67.143%706.34e-29Zf-CSL-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_57530 PE=4 SV=1
DPH3_YARLI67.164%672.20e-27Diphthamide biosynthesis protein 3 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=DPH3 PE=3 SV=1
A0A1E4TA65_9ASCO73.333%603.93e-27Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_29424 PE=4 SV=1
A0A1D8PHF7_CANAL63.235%681.60e-25Kti11p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=KTI11 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0018

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 10 20 30 40 50 60 70 80 90 90

Detailed signature matches

    1. PS51074 (ZF_DPH)
    2. SSF144217 (CSL zinc...)
    3. PF05207 (zf-CSL)

Protein sequence

>MIA_06205_1
MSIYDEIEIEDMTFDEDTQLFTYPCPCGDRFQIFIDDLVDGSNNIAVCPSCSLQIEVIFEASDLEKYIKKEDSDAEEADG
ITSAPDLICA

GO term prediction

Biological Process

None predicted.

Molecular Function

None predicted.

Cellular Component

None predicted.