Protein
MCA_03466_1
Length
80 amino acids
Gene name: DPH3
Description: Diphthamide biosynthesis protein 3
Browser: contigC:53803-54136+
RNA-seq: read pairs 955, FPKM 145.7, percentile rank 84.5% (100% = highest expression)
Protein function
| Annotation: | DPH3 | Diphthamide biosynthesis protein 3 | |
|---|---|---|---|
| KEGG: | K15455 | DPH3 | diphthamide biosynthesis protein 3 |
| EGGNOG: | 0PRY8 | DPH3 | Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L- methionine to a histidine residue. Diphthamide is a post- translational modification of histidine which occurs in elongation factor 2 |
| SGD closest match: | S000007587 | KTI11 | Diphthamide biosynthesis protein 3 |
| CGD closest match: | CAL0000195342 | KTI11 | Kti11p |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_06205_1 | 74.29% | 70 | 2e-32 | MIA_06205_1 |
| A0A0J9X4Z0_GEOCN | 70.15% | 67 | 2e-29 | Similar to Saccharomyces cerevisiae YBL071W-A KTI11 Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 OS=Geotrichum candidum GN=BN980_GECA02s07292g PE=4 SV=1 |
| UniRef50_C9SLN9 | 63.64% | 77 | 4e-25 | Diphthamide biosynthesis protein n=5 Tax=Fungi TaxID=4751 RepID=C9SLN9_VERA1 |
| A0A060TE89_BLAAD | 65.15% | 66 | 2e-26 | ARAD1D49918p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D49918g PE=4 SV=1 |
| A0A1E4TA65_9ASCO | 73.68% | 57 | 1e-23 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_29424 PE=4 SV=1 |
| DPH3_YARLI | 62.69% | 67 | 2e-23 | Diphthamide biosynthesis protein 3 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=DPH3 PE=3 SV=1 |
| A0A1E3PP01_9ASCO | 58.21% | 67 | 4e-22 | Zf-CSL-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_57530 PE=4 SV=1 |
| DPH3_YEAST | 54.05% | 74 | 8e-22 | Diphthamide biosynthesis protein 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KTI11 PE=1 SV=1 |
| A0A1D8PHF7_CANAL | 60.00% | 65 | 5e-21 | Kti11p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=KTI11 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0011
Protein family membership
None predicted.
Domains and repeats
-
Domain
1
10
20
30
40
50
60
70
80
80
Detailed signature matches
Protein sequence
>MCA_03466_1 MIYDEIEIEDMNYDEDMQIFTYPCPCGDQFQVAIDDLLDESTDIAVCPSCSLEIRVIFEMSDLSKFKKPEDEQQPPMICT
GO term prediction
Biological Process
None predicted.
Molecular Function
None predicted.
Cellular Component
None predicted.