Protein

MIA_06197_1

Length
543 amino acids

Browser: contig10:535323-536955+

Protein function

EGGNOG:0PHGDCWC27PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing (By similarity)
SGD closest match:S000005985CWC27Peptidyl-prolyl isomerase CWC27
CGD closest match:CAL0000190365orf19.6990Peptidyl-prolyl cis-trans isomerase

Protein alignments

%idAln lengthE-value
MCA_05012_158.470%1837.67e-70MCA_05012_1
A0A167DZ98_9ASCO50.000%1943.68e-58Putative peptidylprolyl isomerase CWC27 OS=Sugiyamaella lignohabitans GN=CWC27 PE=4 SV=1
UniRef50_A0A167DZ9850.000%1941.01e-54Putative peptidylprolyl isomerase CWC27 n=1 Tax=Sugiyamaella lignohabitans TaxID=796027 RepID=A0A167DZ98_9ASCO
A0A060T5H0_BLAAD47.541%1838.20e-55ARAD1C12144p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C12144g PE=4 SV=1
A0A1E3PNL4_9ASCO40.097%2078.20e-44Cyclophilin-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82527 PE=4 SV=1
A0A0J9XKZ0_GEOCN36.181%1995.05e-22Similar to Saccharomyces cerevisiae YPL064C CWC27 Component of a complex containing Cef1p OS=Geotrichum candidum GN=BN980_GECA26s00703g PE=4 SV=1
CWC27_YARLI32.768%1772.97e-21Peptidyl-prolyl isomerase CWC27 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=CWC27 PE=3 SV=1
CWC27_YEAST31.401%2071.67e-21Peptidyl-prolyl isomerase CWC27 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CWC27 PE=1 SV=1
A0A1E4TG24_9ASCO36.885%1222.21e-16Peptidyl-prolyl cis-trans isomerase (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_26423 PE=3 SV=1
A0A1D8PKA6_CANAL30.556%1802.12e-11Peptidyl-prolyl cis-trans isomerase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.6990 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0998

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 450 500 543

Detailed signature matches

  1. Domain IPR029000
    Cyclophilin-like domain
    1. SSF50891 (Cyclophil...)
    2. G3DSA:2.40.10...
  2. Domain IPR002130
    Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
    1. PF00160 (Pro_isomerase)
    2. PS50072 (CSA_PPIASE_2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. mobidb-lite (disord...)

Protein sequence

>MIA_06197_1
MNEQTGGFHGIEPPTTARAILYTSRGQLEIEIWAKETPIASRNFLQRCGEGYYDGTTFGRLIRGFIIQGGAGWRDNNSDE
SGSGGFPDEFHSRLKFNRRGIVGTANVEGVRNSNGSQFIMTLAPGGAPQLDGKNTVFGKLTPQSLYTLAEMVSDDVAMEA
PEGEDGDDRPLYPVVIERAEVVEPYFKDLEIKSMEERARAKKAVSEAKQQKKKDIPRGKKVKQRVKVVYDGEDEDGDGEV
DKKRKFVMKTPSINTKKKMKLAVNPPEPEKPEAQKSPEKPADKKIEVPHVSSDKSSQYKESTQVESSSLYATSNEGPSKA
AIAPQKTAAELNAEFETLKSALKLKSKLMLPQKATAKATPADDEMERYAKASRARAKKGSEKREAETLAMLRGFRARLVG
AAESSPSSAAPKESSKTAGEGASDASEDEAGGDLSDEENDDPYSLYAHQFGSIGGRTKGKEDGGDDDSLQKLRPRRFGGA
VVSARDVQLIAQDDEKNRRADKYLREDPDGTLMRRRKQQDAREGGSRARERDAYRARKAGSGV

GO term prediction

Biological Process

GO:0000413 protein peptidyl-prolyl isomerization
GO:0006457 protein folding

Molecular Function

GO:0003755 peptidyl-prolyl cis-trans isomerase activity

Cellular Component

None predicted.