Protein

MCA_05012_1

Length
464 amino acids

Gene name: CWC27

Description: Peptidyl-prolyl isomerase CWC27

Browser: contigD:100906-102301-

RNA-seq: read pairs 751, FPKM 20.0, percentile rank 41.4% (100% = highest expression)

Protein function

Annotation:CWC27Peptidyl-prolyl isomerase CWC27
KEGG:K12737SDCCAG10 peptidyl-prolyl cis-trans isomerase SDCCAG10 [EC:5.2.1.8]
EGGNOG:0PHGDCWC27PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing (By similarity)
SGD closest match:S000005985CWC27Peptidyl-prolyl isomerase CWC27
CGD closest match:CAL0000190365orf19.6990Peptidyl-prolyl cis-trans isomerase

Protein alignments

%idAln lengthE-value
MIA_06197_141.16%4641e-78MIA_06197_1
A0A060T5H0_BLAAD49.15%1773e-48ARAD1C12144p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C12144g PE=4 SV=1
A0A167DZ98_9ASCO49.22%1938e-49Putative peptidylprolyl isomerase CWC27 OS=Sugiyamaella lignohabitans GN=CWC27 PE=4 SV=1
UniRef50_A0A167DZ9849.22%1932e-45Putative peptidylprolyl isomerase CWC27 n=1 Tax=Sugiyamaella lignohabitans TaxID=796027 RepID=A0A167DZ98_9ASCO
A0A1E3PNL4_9ASCO40.40%1988e-40Cyclophilin-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82527 PE=4 SV=1
A0A1E4TG24_9ASCO41.46%1231e-21Peptidyl-prolyl cis-trans isomerase (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_26423 PE=3 SV=1
A0A0J9XDF7_GEOCN37.90%1243e-18Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA09s00956g PE=4 SV=1
CWC27_YARLI34.27%1439e-17Peptidyl-prolyl isomerase CWC27 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=CWC27 PE=3 SV=1
CWC27_YEAST27.49%2117e-17Peptidyl-prolyl isomerase CWC27 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CWC27 PE=1 SV=1
A0A1D8PKA6_CANAL35.97%1395e-14Peptidyl-prolyl cis-trans isomerase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.6990 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1730

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 464

Detailed signature matches

  1. Domain IPR029000
    Cyclophilin-like domain
    1. SSF50891 (Cyclophil...)
    2. G3DSA:2.40.10...
  2. Domain IPR002130
    Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
    1. PF00160 (Pro_isomerase)
    2. PS50072 (CSA_PPIASE_2)
    3. PR00153 (CSAPPISMRASE)
  3. SITE IPR020892
    Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
    1. PS00170 (CSA_PPIASE_1)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. mobidb-lite (disord...)

Protein sequence

>MCA_05012_1
MSDSFSIEPPTTATVVFLTSKGSLRFNLWAKETPIACRNFIERSLEGYYNDSKFHRIIKDFIIQGGIGWRDNKDPDSNEK
KGFPDEFNSRLKFNRIGIVGTANIEGVKNSNGSQFIITIGSQGAPQLNNKNTVFGKIDQESIYNLLAIGTEGEIIEGTDG
EPLYPVKILKAEVPEPYFQDIKDKIARGDYNTQQNPGKEDAESMRIRKIKSLSGRKVKEKLKLSYENEEEEDVGPVLNKK
EGFRMKLPSKAEKSKKKKKEEAKQKDLDIQEELSKSGNDAIKKSTTDENTKKSNTIEESEIGNYSIDIKSTTEGVSKFDN
KIRENMEIKKDVKELSDEYELLKQQFKKRKRGDEKESYSTKEHKLTKTPDPSKTADDIYSVEKFKSKSKIPKSGDQREAE
TLAMLQKFKSKLSTNTLFTPDKNQNKASSNEGDKDLLEQAGSDLSEEEDEDPTSLYNHKFVANM

GO term prediction

Biological Process

GO:0000413 protein peptidyl-prolyl isomerization
GO:0006457 protein folding

Molecular Function

GO:0003755 peptidyl-prolyl cis-trans isomerase activity

Cellular Component

None predicted.