Protein

MIA_06183_1

Length
698 amino acids

Browser: contig10:484167-486318-

Protein function

EGGNOG:0PHSNFG01789.1Ferric-chelate reductase
SGD closest match:S000001703FRE2Ferric/cupric reductase transmembrane component 2
CGD closest match:CAL0000177334FRE10Fre10p

Protein alignments

%idAln lengthE-value
MCA_05580_139.202%7271.87e-177MCA_05580_1
A0A0J9XI25_GEOCN34.703%7063.79e-150Similar to Saccharomyces cerevisiae YOR384W FRE5 Putative ferric reductase with similarity to Fre2p OS=Geotrichum candidum GN=BN980_GECA16s00164g PE=4 SV=1
UniRef50_A0A0J9XI2534.703%7067.75e-147Similar to Saccharomyces cerevisiae YOR384W FRE5 Putative ferric reductase with similarity to Fre2p n=2 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XI25_GEOCN
Q6CET5_YARLI33.232%6566.60e-119YALI0B13112p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B13112g PE=4 SV=1
A0A060SVU5_BLAAD33.871%5584.59e-108ARAD1A00286p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A00286g PE=4 SV=1
A0A1E3PIN1_9ASCO30.349%6591.50e-107Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83263 PE=4 SV=1
A0A167FY66_9ASCO29.750%6794.12e-106Fre2p OS=Sugiyamaella lignohabitans GN=FRE2 PE=4 SV=1
A0A1E4TLJ7_9ASCO31.447%4771.84e-87Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_14985 PE=4 SV=1
Q59PA1_CANAL31.083%5631.14e-83Fre10p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=FRE10 PE=4 SV=1
FRE2_YEAST27.778%6664.01e-83Ferric/cupric reductase transmembrane component 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FRE2 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.3402

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 698

Detailed signature matches

  1. Domain IPR013130
    Ferric reductase transmembrane component-like domain
    1. PF01794 (Ferric_reduct)
  2. Domain IPR017938
    Riboflavin synthase-like beta-barrel
    1. SSF63380 (Riboflavi...)
  3. Domain IPR017927
    Ferredoxin reductase-type FAD-binding domain
    1. PS51384 (FAD_FR)
  4. Domain IPR013112
    FAD-binding 8
    1. PF08022 (FAD_binding_8)
  5. Domain IPR013121
    Ferric reductase, NAD binding domain
    1. PF08030 (NAD_binding_6)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. G3DSA:2.40.30.10
  3. G3DSA:3.40.50.80
  4. NON_CYTOPLASM... (N...)
  5. SFLDG01168 (Ferric_...)
  6. SFLDS00052 (Ferric_...)
  7. SIGNAL_PEPTIDE (Sig...)
  8. SIGNAL_PEPTID... (S...)
  9. SIGNAL_PEPTID... (S...)
  10. SIGNAL_PEPTID... (S...)
  11. SSF52343 (Ferredoxi...)
  12. SignalP-noTM
  13. TMhelix
  14. TRANSMEMBRANE (Tran...)
  15. cd06186 (NOX_Duox_l...)

Residue annotation

  1. FAD binding pocket...
  2. FAD binding motif ...
  3. beta-alpha-beta st...
  4. NAD pyrophosphate ...
  5. NAD binding pocket...
  6. NADP ribose bindin...

Protein sequence

>MIA_06183_1
MKITFLTFIFCLSTALANNVEADALFLACLKLVGPYKYACDGRTLVLPGYVASPCNCYSSAFQAGYVDCINRAKNGNRKR
ALNSLVTSCAESSSRQDLTSDYLNQIYSNQTDNFIDSTSYSNQTEISSPLRFSQEKIDLYFRSYRSKTYSTYSSQLYGGL
MNAYFAALFAITTISNFLRRCTPGFVQSMSRYRLVLWVRQHIANPALISYKHNVPLKWGPINMSLPTRAQGWVLTGYLIM
FIIFMFIKYDVFEGNVTYSTKRIQLLRVVSERSGIIAVSQFPLLFTFAGRNNVLLWVTGLSYDTMNLYHRWVARLMTTSA
FIHVICFTLYFQSKHYYPAIFHVRYIRFGAAAITAACLLMFFSLRHFREHLYEVFLAFHWALVIAFTATIWHHLTKAGHI
EWLYAAVAVWAFDRAVRIAKVVLNGLVTHCNAELHTQNLIKVKVKYTNYWRPMPGSYVFVHFLRMWGFWESHPFSIYPSY
VEGEEDVLVLCMRVRGGKTQKIKQYFEQQPNGMTRIPLLVDGPYGHAFPIQNSESMVFISGGIGFTAMYSYACNLKHHGE
KKQITFIWAIRNYENTETFREELAYLTDNGQINVILYLTNETDSSQSSLNIHEKKNTDISDDEINEKIWEINHQNFQIKY
GRPDIEAIISTSIDQAPGSIGIAVCGPERMNDDVRFYGNKYMGKGSGRVDIYTEAFNW

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

None predicted.