Protein

MIA_06143_1

Length
174 amino acids


Browser: contig10:365169-365742+

Protein function

EGGNOG:0PHPZUBC2Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation (By similarity)
SGD closest match:S000003026RAD6Ubiquitin-conjugating enzyme E2 2
CGD closest match:CAL0000194082UBC2Ubiquitin-conjugating enzyme E2 2

Protein alignments

%idAln lengthE-value
MCA_02694_186.577%1493.20e-98MCA_02694_1
A0A0J9XEC1_GEOCN83.893%1491.60e-95Similar to Saccharomyces cerevisiae YGL058W RAD6 Ubiquitin-conjugating enzyme (E2) OS=Geotrichum candidum GN=BN980_GECA10s01759g PE=3 SV=1
A0A060SVX7_BLAAD81.879%1498.53e-95ARAD1A00968p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A00968g PE=3 SV=1
UBC2_YARLI82.550%1492.30e-93Ubiquitin-conjugating enzyme E2 2 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=UBC2 PE=3 SV=1
UniRef50_Q96UP581.879%1497.67e-90Ubiquitin-conjugating enzyme E2 2 n=302 Tax=Eukaryota TaxID=2759 RepID=UBC2_EMENI
UBC2_CANAL80.537%1493.92e-92Ubiquitin-conjugating enzyme E2 2 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=UBC2 PE=2 SV=1
A0A1E3PHJ7_9ASCO78.000%1507.26e-90Ubiquitin-conjugating enzyme E2 2 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83700 PE=3 SV=1
UBC2_YEAST75.168%1496.51e-88Ubiquitin-conjugating enzyme E2 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RAD6 PE=1 SV=1
A0A1E4TJB5_9ASCO80.597%1341.31e-81Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_78119 PE=3 SV=1
A0A167DXB5_9ASCO44.882%1273.63e-36Putative E2 ubiquitin-protein ligase UBC11 OS=Sugiyamaella lignohabitans GN=UBC11 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9902

Protein family membership

None predicted.

Domains and repeats

1 20 40 60 80 100 120 140 160 174

Detailed signature matches

    1. SSF54495 (UBC-like)
    1. PS50127 (UBIQUITIN_...)
    2. cd00195 (UBCc)
    3. PF00179 (UQ_con)
    1. PS00183 (UBIQUITIN_...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. SM00212 (ubc_7)
  2. mobidb-lite (disord...)

Residue annotation

  1. E3 interaction res...
  2. Ub thioester inter...
  3. active site cystei...

Protein sequence

>MIA_06143_1
MSTNARRRLMRDFMRMQQDPPTGVSASPVENNVMIWNAVIIGPEGTPFQDGTFRLALQFDEQYPNKPPQVKFVSEMFHPN
VYPTGELCLDILQNKWSPTYDVAAILTSIQSLLNDPNTGSPANVEASNMFKDHRTQYIKRVRSTVEKSWVDDDDEDDDDD
DDDEDDDEMSEIEK

GO term prediction

Biological Process

None predicted.

Molecular Function

None predicted.

Cellular Component

None predicted.