Protein
MCA_02694_1
Length
186 amino acids
Gene name: UBC2
Description: Ubiquitin-conjugating enzyme E2 2
Browser: contigB:2074613-2075264-
RNA-seq: read pairs 2114, FPKM 139.7, percentile rank 84.0% (100% = highest expression)
Protein function
| Annotation: | UBC2 | Ubiquitin-conjugating enzyme E2 2 | |
|---|---|---|---|
| KEGG: | K10573 | UBE2A | ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23] |
| EGGNOG: | 0PHPZ | UBC2 | Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation (By similarity) |
| SGD closest match: | S000003026 | RAD6 | Ubiquitin-conjugating enzyme E2 2 |
| CGD closest match: | CAL0000194082 | UBC2 | Ubiquitin-conjugating enzyme E2 2 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| A0A060SVX7_BLAAD | 84.00% | 150 | 2e-97 | ARAD1A00968p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A00968g PE=3 SV=1 |
| MIA_06143_1 | 86.58% | 149 | 1e-96 | MIA_06143_1 |
| A0A0J9XEC1_GEOCN | 82.55% | 149 | 3e-93 | Similar to Saccharomyces cerevisiae YGL058W RAD6 Ubiquitin-conjugating enzyme (E2) OS=Geotrichum candidum GN=BN980_GECA10s01759g PE=3 SV=1 |
| UBC2_YARLI | 82.55% | 149 | 8e-94 | Ubiquitin-conjugating enzyme E2 2 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=UBC2 PE=3 SV=1 |
| UniRef50_Q6BU36 | 82.67% | 150 | 5e-89 | Ubiquitin-conjugating enzyme E2 2 n=54 Tax=Fungi TaxID=4751 RepID=UBC2_DEBHA |
| UBC2_CANAL | 81.33% | 150 | 5e-91 | Ubiquitin-conjugating enzyme E2 2 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=UBC2 PE=2 SV=1 |
| A0A1E3PHJ7_9ASCO | 77.85% | 149 | 1e-87 | Ubiquitin-conjugating enzyme E2 2 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83700 PE=3 SV=1 |
| UBC2_YEAST | 77.18% | 149 | 2e-87 | Ubiquitin-conjugating enzyme E2 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RAD6 PE=1 SV=1 |
| A0A1E4TJB5_9ASCO | 82.09% | 134 | 1e-83 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_78119 PE=3 SV=1 |
| A0A167DXB5_9ASCO | 47.24% | 127 | 1e-35 | Putative E2 ubiquitin-protein ligase UBC11 OS=Sugiyamaella lignohabitans GN=UBC11 PE=3 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.9900
Protein family membership
None predicted.
Domains and repeats
-
Domain
1
20
40
60
80
100
120
140
160
186
Detailed signature matches
no IPR
Unintegrated signatures
-
SM00212 (ubc_7)
-
mobidb-lite (disord...)
Residue annotation
-
E3 interaction res...
-
Ub thioester inter...
-
active site cystei...
Protein sequence
>MCA_02694_1 MSTTARRRLMRDFKRMQQDPPSGVSASPVEDNVMIWNAVIIGPADTPFEDGMFRLAIQFDEQYPTKPPTVKFISEMFHPN IYPTGDLCLDILQNKWSPTYDVAAILTSIQSLLNDPNTASPANVEASELFKDHRSQYNKRVRQTVEKSWNDIDDEDDDDD DDDEDDDEDDDDDDDEDNDEESDKKQ
GO term prediction
Biological Process
None predicted.
Molecular Function
None predicted.
Cellular Component
None predicted.