Protein

MIA_06129_1

Length
399 amino acids

Browser: contig10:332029-333647-

Protein function

EGGNOG:0PFYVPDA1pyruvate dehydrogenase e1 component
SGD closest match:S000000980PDA1Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial
CGD closest match:CAL0000181135PDA1Pyruvate dehydrogenase E1 component subunit alpha

Protein alignments

%idAln lengthE-value
MCA_03948_287.744%3590.0MCA_03948_2
A0A0J9X7H5_GEOCN81.492%3620.0Pyruvate dehydrogenase E1 component subunit alpha OS=Geotrichum candidum GN=BN980_GECA03s07127g PE=4 SV=1
A0A1E3PL97_9ASCO75.066%3770.0Pyruvate dehydrogenase E1 component subunit alpha OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82632 PE=4 SV=1
A0A167F5S1_9ASCO76.111%3600.0Pyruvate dehydrogenase E1 component subunit alpha OS=Sugiyamaella lignohabitans GN=PDA1 PE=4 SV=1
A0A060TD31_BLAAD74.255%3690.0Pyruvate dehydrogenase E1 component subunit alpha OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D03960g PE=4 SV=1
ODPA_YEAST68.930%3830.0Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PDA1 PE=1 SV=2
UniRef50_P1638768.930%3830.0Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial n=122 Tax=Opisthokonta TaxID=33154 RepID=ODPA_YEAST
Q5A0Z9_CANAL67.647%3740.0Pyruvate dehydrogenase E1 component subunit alpha OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PDA1 PE=4 SV=1
Q6C0Y7_YARLI71.745%3610.0Pyruvate dehydrogenase E1 component subunit alpha OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F20702g PE=4 SV=1
A0A1E4TKT7_9ASCO67.021%3760.0Pyruvate dehydrogenase E1 component subunit alpha OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_951 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9858
Predicted cleavage: 28

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 399

Detailed signature matches

  1. Family IPR017597
    Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y
    1. TIGR03182
  2. Domain IPR029061
    Thiamin diphosphate-binding fold
    1. SSF52518 (Thiamin d...)
  3. Domain IPR001017
    Dehydrogenase, E1 component
    1. PF00676 (E1_dh)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. cd02000 (TPP_E1_PDC...)

Residue annotation

  1. tetramer interface...
  2. TPP-binding site c...
  3. heterodimer interf...
  4. phosphorylation lo...

Protein sequence

>MIA_06129_1
MLRSSSSHLLRAVRLAPPAAGLPKFRTMATVPENAPTAVHTIELPEKTFATYNLDAPALSVPLTTEELIKMYKDMVTVRR
LEMASDALYKAKKIRGFHLSIGQEAVAVGIEHAITKQDSVITSYRCHGFTYLRGATVKAVLAELLGRREGVSFGKGGSMH
MYAHHFYGGNGIVGAQVPLGTGLAFAHKYLGQDAATVTLYGDGASNQGQIFESFNMAKLWNIPCIYACENNKYGMGTAAS
RASALTKFYERGQYIPGLKVNGMDVIAVYQATKYAKAWTSAGKGPIVLEFETYRYGGHSMSDPGTTYRTREEIQHMRSES
DPIAGLKHRLVNEGIITEDELKKVDKETRAFVEKEAAAAEASPPPAAEPKILFEDVYVPGTEVPVLRGRIPQENWSFKK

GO term prediction

Biological Process

GO:0006086 acetyl-CoA biosynthetic process from pyruvate
GO:0008152 metabolic process

Molecular Function

GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity
GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

Cellular Component

GO:0043231 intracellular membrane-bounded organelle