Protein

MCA_03948_2

Length
404 amino acids

Gene name: PDA1

Description: Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

Browser: contigC:1596551-1598129+

RNA-seq: read pairs 35172, FPKM 1073.1, percentile rank 96.7% (100% = highest expression)

Protein function

Annotation:PDA1Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial
KEGG:K00161PDHA pyruvate dehydrogenase E1 component alpha subunit [EC:1.2.4.1]
EGGNOG:0PFYVPDA1pyruvate dehydrogenase e1 component
SGD closest match:S000000980PDA1Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial
CGD closest match:CAL0000181135PDA1Pyruvate dehydrogenase E1 component subunit alpha

Protein alignments

%idAln lengthE-value
MIA_06129_180.79%4060.0MIA_06129_1
A0A0J9XE67_GEOCN75.73%4120.0Pyruvate dehydrogenase E1 component subunit alpha OS=Geotrichum candidum GN=BN980_GECA11s03222g PE=4 SV=1
A0A1E3PL97_9ASCO74.94%3910.0Pyruvate dehydrogenase E1 component subunit alpha OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82632 PE=4 SV=1
A0A167F5S1_9ASCO76.88%3590.0Pyruvate dehydrogenase E1 component subunit alpha OS=Sugiyamaella lignohabitans GN=PDA1 PE=4 SV=1
ODPA_YEAST72.70%3590.0Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PDA1 PE=1 SV=2
UniRef50_P1638772.70%3590.0Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial n=122 Tax=Opisthokonta TaxID=33154 RepID=ODPA_YEAST
A0A060TD31_BLAAD75.77%3590.0Pyruvate dehydrogenase E1 component subunit alpha OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D03960g PE=4 SV=1
Q5A0Z9_CANAL70.87%3570.0Pyruvate dehydrogenase E1 component subunit alpha OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PDA1 PE=4 SV=1
Q6C0Y7_YARLI73.20%3620.0Pyruvate dehydrogenase E1 component subunit alpha OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F20702g PE=4 SV=1
A0A1E4TKT7_9ASCO65.19%4050.0Pyruvate dehydrogenase E1 component subunit alpha OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_951 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9930
Predicted cleavage: 31

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 404

Detailed signature matches

  1. Family IPR017597
    Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y
    1. TIGR03182
  2. Domain IPR029061
    Thiamin diphosphate-binding fold
    1. SSF52518 (Thiamin d...)
  3. Domain IPR001017
    Dehydrogenase, E1 component
    1. PF00676 (E1_dh)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. cd02000 (TPP_E1_PDC...)

Residue annotation

  1. tetramer interface...
  2. TPP-binding site c...
  3. heterodimer interf...
  4. phosphorylation lo...

Protein sequence

>MCA_03948_2
MLRTSVARLSLRSHLTAAASRAAVSIPKRTMASEASEASEAGKFAIELPETTFETYKLDAPELKVELTGDALIQMYKDML
TVRRLEMASDALYKAKKIRGLCHLSIGQEAVAVGIEHAISKLDSVITSYRCHGFTYMRGATVKAVLAELLGRREGVSYGK
GGSMHMYAPRFYGGNGIVGAQVPLGLGLAFAHKYTGENAATVTLYGDGASNQGQIFESYNMAKLWNIPCIFACENNKYGM
GTSAARSSALTKFYQRGQYIPGLKVNGMDVVAVYQATKFAKEWTGSGKGPIVLEFETYRYGGHSMSDPGTTYRTREEIQH
MRSESDPIAGLKLRLLNNKIISEDELKKVDKETRAFVDKEAAAAEASPPPAAEAKILFEDVYVPGTEIPVLRGRIPEENW
SFNK

GO term prediction

Biological Process

GO:0006086 acetyl-CoA biosynthetic process from pyruvate
GO:0008152 metabolic process

Molecular Function

GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity
GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

Cellular Component

GO:0043231 intracellular membrane-bounded organelle