MIA_06118_1

Protein

Length

460 amino acids

Protein function

EGGNOG:	0PHH4	FG02105.1	AP-2 complex subunit
SGD closest match:	S000005423	APM4	AP-2 complex subunit mu
CGD closest match:	CAL0000182232	APM4	Apm4p

Protein alignments

	%id	Aln length	E-value
MCA_06132_1	70.876%	491	0.0	MCA_06132_1
A0A060TD50_BLAAD	68.478%	460	0.0	ARAD1B21670p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B21670g PE=3 SV=1
A0A0J9XA36_GEOCN	68.696%	460	0.0	Similar to Saccharomyces cerevisiae YOL062C APM4 Mu2-like subunit of the clathrin associated protein complex (AP-2), involved in vesicle transport OS=Geotrichum candidum GN=BN980_GECA05s05015g PE=3 SV=1
UniRef50_R1G5G1	59.259%	459	0.0	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial n=5 Tax=leotiomyceta TaxID=716546 RepID=R1G5G1_BOTPV
A0A1E3PL48_9ASCO	57.261%	482	0.0	AP-2 complex subunit MU OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_58932 PE=3 SV=1
Q6CC50_YARLI	57.174%	460	0.0	YALI0C12474p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C12474g PE=3 SV=2
A0A1E4TK72_9ASCO	46.186%	472	2.08e-145	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_63534 PE=3 SV=1
Q5A2L1_CANAL	42.387%	486	1.64e-123	Apm4p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=APM4 PE=3 SV=1
AP2M_YEAST	39.554%	493	1.57e-107	AP-2 complex subunit mu OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=APM4 PE=1 SV=1
A0A167BXE1_9ASCO	35.760%	467	4.49e-95	Apm1p OS=Sugiyamaella lignohabitans GN=APM1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1280

Protein family membership

Clathrin adaptor, mu subunit (IPR001392)

Domains and repeats

Domain
1 - 137
Longin-like domain (IPR011012)
179 - 459
Mu homology domain (IPR028565)

1 50 100 150 200 250 300 350 400 460

Detailed signature matches

IPR001392

Clathrin adaptor, mu subunit
1. PIRSF005992 (AP_com...)
  
  1 - 460
  
  PIRSF
  PIRSF005992 (AP_complex_mu)
2. PR00314 (CLATHRINADPT)
  
  181 - 209
  
  PRINTS
  PR00314 (CLATHRINADPT)
  
  271 - 298
  
  PRINTS
  PR00314 (CLATHRINADPT)
  
  12 - 32
  
  PRINTS
  PR00314 (CLATHRINADPT)
  
  380 - 391
  
  PRINTS
  PR00314 (CLATHRINADPT)
  
  340 - 355
  
  PRINTS
  PR00314 (CLATHRINADPT)
IPR011012

Longin-like domain
1. SSF64356 (SNARE-like)
  
  1 - 137
  
  SUPERFAMILY
  SSF64356 (SNARE-like)
IPR028565

Mu homology domain
1. SSF49447 (Second do...)
  
  179 - 459
  
  SUPERFAMILY
  SSF49447 (Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor)
2. PF00928 (Adap_comp_sub)
  
  180 - 459
  
  Pfam
  PF00928 (Adap_comp_sub)
3. PS51072 (MHD)
  
  190 - 459
  
  PROSITE profiles
  PS51072 (MHD)
IPR018240

Clathrin adaptor, mu subunit, conserved site
1. PS00991 (CLAT_ADAPT...)
  
  291 - 305
  
  PROSITE patterns
  PS00991 (CLAT_ADAPTOR_M_2)

no IPR

Unintegrated signatures

G3DSA:2.60.40...

179 - 336

GENE3D
G3DSA:2.60.40.1170 (G3DSA:2.60.40.1170)
G3DSA:2.60.40...

337 - 410

GENE3D
G3DSA:2.60.40.1220 (G3DSA:2.60.40.1220)
G3DSA:3.30.45...

1 - 140

GENE3D
G3DSA:3.30.450.60 (G3DSA:3.30.450.60)
cd09251 (AP-2_Mu2_C...)

188 - 459

CDD
cd09251 (AP-2_Mu2_Cterm)
mobidb-lite (disord...)

155 - 178

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

signal peptide bin...

194F

signal peptide binding site
194F, 195V, 196D, 223K, 346T, 419S, 421S, 430V, 431R, 445K, 446W, 447V, 448R, 450L
CDD
cd09251 (AP-2_Mu2_Cterm)

195V

signal peptide binding site
194F, 195V, 196D, 223K, 346T, 419S, 421S, 430V, 431R, 445K, 446W, 447V, 448R, 450L
CDD
cd09251 (AP-2_Mu2_Cterm)

196D

signal peptide binding site
194F, 195V, 196D, 223K, 346T, 419S, 421S, 430V, 431R, 445K, 446W, 447V, 448R, 450L
CDD
cd09251 (AP-2_Mu2_Cterm)

223K

signal peptide binding site
194F, 195V, 196D, 223K, 346T, 419S, 421S, 430V, 431R, 445K, 446W, 447V, 448R, 450L
CDD
cd09251 (AP-2_Mu2_Cterm)

346T

signal peptide binding site
194F, 195V, 196D, 223K, 346T, 419S, 421S, 430V, 431R, 445K, 446W, 447V, 448R, 450L
CDD
cd09251 (AP-2_Mu2_Cterm)

419S

signal peptide binding site
194F, 195V, 196D, 223K, 346T, 419S, 421S, 430V, 431R, 445K, 446W, 447V, 448R, 450L
CDD
cd09251 (AP-2_Mu2_Cterm)

421S

signal peptide binding site
194F, 195V, 196D, 223K, 346T, 419S, 421S, 430V, 431R, 445K, 446W, 447V, 448R, 450L
CDD
cd09251 (AP-2_Mu2_Cterm)

430V

signal peptide binding site
194F, 195V, 196D, 223K, 346T, 419S, 421S, 430V, 431R, 445K, 446W, 447V, 448R, 450L
CDD
cd09251 (AP-2_Mu2_Cterm)

431R

signal peptide binding site
194F, 195V, 196D, 223K, 346T, 419S, 421S, 430V, 431R, 445K, 446W, 447V, 448R, 450L
CDD
cd09251 (AP-2_Mu2_Cterm)

445K

signal peptide binding site
194F, 195V, 196D, 223K, 346T, 419S, 421S, 430V, 431R, 445K, 446W, 447V, 448R, 450L
CDD
cd09251 (AP-2_Mu2_Cterm)

446W

signal peptide binding site
194F, 195V, 196D, 223K, 346T, 419S, 421S, 430V, 431R, 445K, 446W, 447V, 448R, 450L
CDD
cd09251 (AP-2_Mu2_Cterm)

447V

signal peptide binding site
194F, 195V, 196D, 223K, 346T, 419S, 421S, 430V, 431R, 445K, 446W, 447V, 448R, 450L
CDD
cd09251 (AP-2_Mu2_Cterm)

448R

signal peptide binding site
194F, 195V, 196D, 223K, 346T, 419S, 421S, 430V, 431R, 445K, 446W, 447V, 448R, 450L
CDD
cd09251 (AP-2_Mu2_Cterm)

450L

signal peptide binding site
194F, 195V, 196D, 223K, 346T, 419S, 421S, 430V, 431R, 445K, 446W, 447V, 448R, 450L
CDD
cd09251 (AP-2_Mu2_Cterm)
AP-2 beta subunit ...

212I

AP-2 beta subunit interface
212I, 213K, 273D, 274C, 275Q, 276F, 277H, 278Q, 282L, 283D, 304R, 306R, 410T, 412P, 455S, 457E
CDD
cd09251 (AP-2_Mu2_Cterm)

213K

AP-2 beta subunit interface
212I, 213K, 273D, 274C, 275Q, 276F, 277H, 278Q, 282L, 283D, 304R, 306R, 410T, 412P, 455S, 457E
CDD
cd09251 (AP-2_Mu2_Cterm)

273D

AP-2 beta subunit interface
212I, 213K, 273D, 274C, 275Q, 276F, 277H, 278Q, 282L, 283D, 304R, 306R, 410T, 412P, 455S, 457E
CDD
cd09251 (AP-2_Mu2_Cterm)

274C

AP-2 beta subunit interface
212I, 213K, 273D, 274C, 275Q, 276F, 277H, 278Q, 282L, 283D, 304R, 306R, 410T, 412P, 455S, 457E
CDD
cd09251 (AP-2_Mu2_Cterm)

275Q

AP-2 beta subunit interface
212I, 213K, 273D, 274C, 275Q, 276F, 277H, 278Q, 282L, 283D, 304R, 306R, 410T, 412P, 455S, 457E
CDD
cd09251 (AP-2_Mu2_Cterm)

276F

AP-2 beta subunit interface
212I, 213K, 273D, 274C, 275Q, 276F, 277H, 278Q, 282L, 283D, 304R, 306R, 410T, 412P, 455S, 457E
CDD
cd09251 (AP-2_Mu2_Cterm)

277H

AP-2 beta subunit interface
212I, 213K, 273D, 274C, 275Q, 276F, 277H, 278Q, 282L, 283D, 304R, 306R, 410T, 412P, 455S, 457E
CDD
cd09251 (AP-2_Mu2_Cterm)

278Q

AP-2 beta subunit interface
212I, 213K, 273D, 274C, 275Q, 276F, 277H, 278Q, 282L, 283D, 304R, 306R, 410T, 412P, 455S, 457E
CDD
cd09251 (AP-2_Mu2_Cterm)

282L

AP-2 beta subunit interface
212I, 213K, 273D, 274C, 275Q, 276F, 277H, 278Q, 282L, 283D, 304R, 306R, 410T, 412P, 455S, 457E
CDD
cd09251 (AP-2_Mu2_Cterm)

283D

AP-2 beta subunit interface
212I, 213K, 273D, 274C, 275Q, 276F, 277H, 278Q, 282L, 283D, 304R, 306R, 410T, 412P, 455S, 457E
CDD
cd09251 (AP-2_Mu2_Cterm)

304R

AP-2 beta subunit interface
212I, 213K, 273D, 274C, 275Q, 276F, 277H, 278Q, 282L, 283D, 304R, 306R, 410T, 412P, 455S, 457E
CDD
cd09251 (AP-2_Mu2_Cterm)

306R

AP-2 beta subunit interface
212I, 213K, 273D, 274C, 275Q, 276F, 277H, 278Q, 282L, 283D, 304R, 306R, 410T, 412P, 455S, 457E
CDD
cd09251 (AP-2_Mu2_Cterm)

410T

AP-2 beta subunit interface
212I, 213K, 273D, 274C, 275Q, 276F, 277H, 278Q, 282L, 283D, 304R, 306R, 410T, 412P, 455S, 457E
CDD
cd09251 (AP-2_Mu2_Cterm)

412P

AP-2 beta subunit interface
212I, 213K, 273D, 274C, 275Q, 276F, 277H, 278Q, 282L, 283D, 304R, 306R, 410T, 412P, 455S, 457E
CDD
cd09251 (AP-2_Mu2_Cterm)

455S

AP-2 beta subunit interface
212I, 213K, 273D, 274C, 275Q, 276F, 277H, 278Q, 282L, 283D, 304R, 306R, 410T, 412P, 455S, 457E
CDD
cd09251 (AP-2_Mu2_Cterm)

457E

AP-2 beta subunit interface
212I, 213K, 273D, 274C, 275Q, 276F, 277H, 278Q, 282L, 283D, 304R, 306R, 410T, 412P, 455S, 457E
CDD
cd09251 (AP-2_Mu2_Cterm)

Protein sequence

>MIA_06118_1
MISAIIIYNLKGEVLISRLYRDGLRRSIADVFRIQVISNPDSRSPVLTLGSTSFLHIRHENLYIVGITRSNVDAGLVFEF
LYKLVDLGRSYFGTFDETVVKNGFALIYELLDEVLDFGFPQNTEIETLKRYITTEGLKTSTNTAASVVSLARIGKKDDSS
SNGNKKSKGAITTQATSATPWRRPGIKYRKNEVFVDIFEDLNLLMSATGSVIKADVAGRVMLKTHLSGQPECKFGLNDSL
TLNTRDVFDDENDNDDDPNFGHMANAGAVKLEDCQFHQCVRLDDFDSDRIISFIPPDGEFELMRYRAVENINLPFRVIAQ
VTEVGRLKVDYEITVRANFGPKLYATDVVVHVPTPLNTTDTTCSTSGGKAKYDPAVNQIVWRIGRCAGGAEYSLRASAQL
TSTTVLKPWTRPPISMDFSLSMFTSSGIMVRYLKIFEKTNYATVKWVRYLVRAGSYEIRY

GO term prediction

Biological Process

GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0016192 vesicle-mediated transport

Molecular Function

None predicted.

Cellular Component

GO:0030131 clathrin adaptor complex

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Entry type

Status

Per-residue features