MCA_06132_1

Protein

Length

486 amino acids

RNA-seq: read pairs 1625, FPKM 41.2, percentile rank 60.9% (100% = highest expression)

Protein function

KEGG:	K11826	AP2M1	AP-2 complex subunit mu-1
EGGNOG:	0PHH4	FG02105.1	AP-2 complex subunit
SGD closest match:	S000005423	APM4	AP-2 complex subunit mu
CGD closest match:	CAL0000182232	APM4	Apm4p

Protein alignments

	%id	Aln length	E-value
MIA_06118_1	71.28%	491	0.0	MIA_06118_1
A0A060TD50_BLAAD	68.31%	486	0.0	ARAD1B21670p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B21670g PE=3 SV=1
Q6CC50_YARLI	55.69%	492	0.0	YALI0C12474p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C12474g PE=3 SV=2
UniRef50_Q6CC50	55.69%	492	0.0	YALI0C12474p n=3 Tax=Saccharomycetales TaxID=4892 RepID=Q6CC50_YARLI
A0A0J9XA36_GEOCN	79.37%	286	4e-154	Similar to Saccharomyces cerevisiae YOL062C APM4 Mu2-like subunit of the clathrin associated protein complex (AP-2), involved in vesicle transport OS=Geotrichum candidum GN=BN980_GECA05s05015g PE=3 SV=1
A0A1E4TK72_9ASCO	43.53%	510	3e-145	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_63534 PE=3 SV=1
A0A1E3PL48_9ASCO	57.93%	290	2e-121	AP-2 complex subunit MU OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_58932 PE=3 SV=1
AP2M_YEAST	38.19%	508	3e-109	AP-2 complex subunit mu OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=APM4 PE=1 SV=1
A0A167BXE1_9ASCO	33.74%	495	2e-88	Apm1p OS=Sugiyamaella lignohabitans GN=APM1 PE=3 SV=1
Q5A2L1_CANAL	46.29%	283	3e-80	Apm4p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=APM4 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0897

Protein family membership

Clathrin adaptor, mu subunit (IPR001392)

Domains and repeats

Domain
1 - 138
Longin-like domain (IPR011012)
AP complex, mu/sigma subunit (IPR022775)
210 - 485
Mu homology domain (IPR028565)

1 50 100 150 200 250 300 350 400 450 486

Detailed signature matches

IPR001392

Clathrin adaptor, mu subunit
1. PIRSF005992 (AP_com...)
  
  1 - 486
  
  PIRSF
  PIRSF005992 (AP_complex_mu)
2. PR00314 (CLATHRINADPT)
  
  12 - 32
  
  PRINTS
  PR00314 (CLATHRINADPT)
  
  97 - 124
  
  PRINTS
  PR00314 (CLATHRINADPT)
IPR011012

Longin-like domain
1. SSF64356 (SNARE-like)
  
  1 - 138
  
  SUPERFAMILY
  SSF64356 (SNARE-like)
IPR022775

AP complex, mu/sigma subunit
1. PF01217 (Clat_adapt...)
  
  1 - 128
  
  Pfam
  PF01217 (Clat_adaptor_s)
IPR028565

Mu homology domain
1. SSF49447 (Second do...)
  
  210 - 485
  
  SUPERFAMILY
  SSF49447 (Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor)
2. PF00928 (Adap_comp_sub)
  
  210 - 485
  
  Pfam
  PF00928 (Adap_comp_sub)
3. PS51072 (MHD)
  
  221 - 485
  
  PROSITE profiles
  PS51072 (MHD)
IPR018240

Clathrin adaptor, mu subunit, conserved site
1. PS00990 (CLAT_ADAPT...)
  
  210 - 230
  
  PROSITE patterns
  PS00990 (CLAT_ADAPTOR_M_1)

no IPR

Unintegrated signatures

G3DSA:2.60.40...

210 - 370

GENE3D
G3DSA:2.60.40.1170 (G3DSA:2.60.40.1170)

376 - 481

GENE3D
G3DSA:2.60.40.1170 (G3DSA:2.60.40.1170)
G3DSA:3.30.45...

1 - 140

GENE3D
G3DSA:3.30.450.60 (G3DSA:3.30.450.60)
cd09251 (AP-2_Mu2_C...)

219 - 485

CDD
cd09251 (AP-2_Mu2_Cterm)
mobidb-lite (disord...)

163 - 183

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

signal peptide bin...

225F

signal peptide binding site
225F, 226V, 227D, 254K, 372S, 445S, 447S, 456V, 457R, 471K, 472W, 473V, 474R, 476L
CDD
cd09251 (AP-2_Mu2_Cterm)

226V

signal peptide binding site
225F, 226V, 227D, 254K, 372S, 445S, 447S, 456V, 457R, 471K, 472W, 473V, 474R, 476L
CDD
cd09251 (AP-2_Mu2_Cterm)

227D

signal peptide binding site
225F, 226V, 227D, 254K, 372S, 445S, 447S, 456V, 457R, 471K, 472W, 473V, 474R, 476L
CDD
cd09251 (AP-2_Mu2_Cterm)

254K

signal peptide binding site
225F, 226V, 227D, 254K, 372S, 445S, 447S, 456V, 457R, 471K, 472W, 473V, 474R, 476L
CDD
cd09251 (AP-2_Mu2_Cterm)

372S

signal peptide binding site
225F, 226V, 227D, 254K, 372S, 445S, 447S, 456V, 457R, 471K, 472W, 473V, 474R, 476L
CDD
cd09251 (AP-2_Mu2_Cterm)

445S

signal peptide binding site
225F, 226V, 227D, 254K, 372S, 445S, 447S, 456V, 457R, 471K, 472W, 473V, 474R, 476L
CDD
cd09251 (AP-2_Mu2_Cterm)

447S

signal peptide binding site
225F, 226V, 227D, 254K, 372S, 445S, 447S, 456V, 457R, 471K, 472W, 473V, 474R, 476L
CDD
cd09251 (AP-2_Mu2_Cterm)

456V

signal peptide binding site
225F, 226V, 227D, 254K, 372S, 445S, 447S, 456V, 457R, 471K, 472W, 473V, 474R, 476L
CDD
cd09251 (AP-2_Mu2_Cterm)

457R

signal peptide binding site
225F, 226V, 227D, 254K, 372S, 445S, 447S, 456V, 457R, 471K, 472W, 473V, 474R, 476L
CDD
cd09251 (AP-2_Mu2_Cterm)

471K

signal peptide binding site
225F, 226V, 227D, 254K, 372S, 445S, 447S, 456V, 457R, 471K, 472W, 473V, 474R, 476L
CDD
cd09251 (AP-2_Mu2_Cterm)

472W

signal peptide binding site
225F, 226V, 227D, 254K, 372S, 445S, 447S, 456V, 457R, 471K, 472W, 473V, 474R, 476L
CDD
cd09251 (AP-2_Mu2_Cterm)

473V

signal peptide binding site
225F, 226V, 227D, 254K, 372S, 445S, 447S, 456V, 457R, 471K, 472W, 473V, 474R, 476L
CDD
cd09251 (AP-2_Mu2_Cterm)

474R

signal peptide binding site
225F, 226V, 227D, 254K, 372S, 445S, 447S, 456V, 457R, 471K, 472W, 473V, 474R, 476L
CDD
cd09251 (AP-2_Mu2_Cterm)

476L

signal peptide binding site
225F, 226V, 227D, 254K, 372S, 445S, 447S, 456V, 457R, 471K, 472W, 473V, 474R, 476L
CDD
cd09251 (AP-2_Mu2_Cterm)
AP-2 beta subunit ...

243I

AP-2 beta subunit interface
243I, 244K, 299D, 300C, 301Q, 302F, 303H, 304Q, 308L, 309D, 330R, 332R, 436S, 438P, 481S, 483E
CDD
cd09251 (AP-2_Mu2_Cterm)

244K

AP-2 beta subunit interface
243I, 244K, 299D, 300C, 301Q, 302F, 303H, 304Q, 308L, 309D, 330R, 332R, 436S, 438P, 481S, 483E
CDD
cd09251 (AP-2_Mu2_Cterm)

299D

AP-2 beta subunit interface
243I, 244K, 299D, 300C, 301Q, 302F, 303H, 304Q, 308L, 309D, 330R, 332R, 436S, 438P, 481S, 483E
CDD
cd09251 (AP-2_Mu2_Cterm)

300C

AP-2 beta subunit interface
243I, 244K, 299D, 300C, 301Q, 302F, 303H, 304Q, 308L, 309D, 330R, 332R, 436S, 438P, 481S, 483E
CDD
cd09251 (AP-2_Mu2_Cterm)

301Q

AP-2 beta subunit interface
243I, 244K, 299D, 300C, 301Q, 302F, 303H, 304Q, 308L, 309D, 330R, 332R, 436S, 438P, 481S, 483E
CDD
cd09251 (AP-2_Mu2_Cterm)

302F

AP-2 beta subunit interface
243I, 244K, 299D, 300C, 301Q, 302F, 303H, 304Q, 308L, 309D, 330R, 332R, 436S, 438P, 481S, 483E
CDD
cd09251 (AP-2_Mu2_Cterm)

303H

AP-2 beta subunit interface
243I, 244K, 299D, 300C, 301Q, 302F, 303H, 304Q, 308L, 309D, 330R, 332R, 436S, 438P, 481S, 483E
CDD
cd09251 (AP-2_Mu2_Cterm)

304Q

AP-2 beta subunit interface
243I, 244K, 299D, 300C, 301Q, 302F, 303H, 304Q, 308L, 309D, 330R, 332R, 436S, 438P, 481S, 483E
CDD
cd09251 (AP-2_Mu2_Cterm)

308L

AP-2 beta subunit interface
243I, 244K, 299D, 300C, 301Q, 302F, 303H, 304Q, 308L, 309D, 330R, 332R, 436S, 438P, 481S, 483E
CDD
cd09251 (AP-2_Mu2_Cterm)

309D

AP-2 beta subunit interface
243I, 244K, 299D, 300C, 301Q, 302F, 303H, 304Q, 308L, 309D, 330R, 332R, 436S, 438P, 481S, 483E
CDD
cd09251 (AP-2_Mu2_Cterm)

330R

AP-2 beta subunit interface
243I, 244K, 299D, 300C, 301Q, 302F, 303H, 304Q, 308L, 309D, 330R, 332R, 436S, 438P, 481S, 483E
CDD
cd09251 (AP-2_Mu2_Cterm)

332R

AP-2 beta subunit interface
243I, 244K, 299D, 300C, 301Q, 302F, 303H, 304Q, 308L, 309D, 330R, 332R, 436S, 438P, 481S, 483E
CDD
cd09251 (AP-2_Mu2_Cterm)

436S

AP-2 beta subunit interface
243I, 244K, 299D, 300C, 301Q, 302F, 303H, 304Q, 308L, 309D, 330R, 332R, 436S, 438P, 481S, 483E
CDD
cd09251 (AP-2_Mu2_Cterm)

438P

AP-2 beta subunit interface
243I, 244K, 299D, 300C, 301Q, 302F, 303H, 304Q, 308L, 309D, 330R, 332R, 436S, 438P, 481S, 483E
CDD
cd09251 (AP-2_Mu2_Cterm)

481S

AP-2 beta subunit interface
243I, 244K, 299D, 300C, 301Q, 302F, 303H, 304Q, 308L, 309D, 330R, 332R, 436S, 438P, 481S, 483E
CDD
cd09251 (AP-2_Mu2_Cterm)

483E

AP-2 beta subunit interface
243I, 244K, 299D, 300C, 301Q, 302F, 303H, 304Q, 308L, 309D, 330R, 332R, 436S, 438P, 481S, 483E
CDD
cd09251 (AP-2_Mu2_Cterm)

Protein sequence

>MCA_06132_1
MISAIIFYNLKGEVLISRLYRDGLRRSIADVFRIQVISNPDNRSPVLTLGSTSFLHIRHENLYIVGITRSNVDAALVFEF
LYRLVALGKSYFNKLDEQAVKSNFALIYELLDEVVDFGFPQNTDTDTLKRYITTEGVKSSNNSSSSLLPSQIARIGKIGI
GGGSNNNSSGNNGDHAYSSHSDSGHGFSLGLHNGKNSSSQKITMQATGAISWRRPGIKYRKNEVFVDVMEDMNLLMSATG
AVIKADVSGHINLKAQLSGIPECKFGLNDSLMLDTDHYDEDDPSHRRNMANAGAVKLEDCQFHQCVKLDDFDNDRIISFV
PPDGEFELMRYRAVDNINLPFRVVAQVTEMGKLKVDYEITVQGNFGNKLFASDVVIRIPTPLNTSETTSSTTSGKAKYDP
SVNQIIWKINRFSGGAEQSIHATATLVSTTVVKPWSRPPISMDFSLSMFTSSGIVVRYLKIFEKSNYSTVKWVRYLVRAG
SYEIRY

GO term prediction

Biological Process

GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0016192 vesicle-mediated transport

Molecular Function

None predicted.

Cellular Component

GO:0030131 clathrin adaptor complex

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Entry type

Status

Per-residue features