MIA_06100_1

Protein

Length

2,880 amino acids

Browser: contig10:223158-232012+

Protein function

EGGNOG:	0PFW9	TEL1	Serine threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence ST -Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity)
SGD closest match:	S000000184	TEL1	Serine/threonine-protein kinase TEL1
CGD closest match:	CAL0000195481	TEL1	Serine/threonine-protein kinase TEL1

Protein alignments

	%id	Aln length	E-value
MCA_06151_1	28.651%	2890	0.0	MCA_06151_1
A0A0J9XD48_GEOCN	29.713%	1602	0.0	Similar to Saccharomyces cerevisiae YBL088C TEL1 Protein kinase primarily involved in telomere length regulation OS=Geotrichum candidum GN=BN980_GECA10s02419g PE=3 SV=1
UniRef50_A0A0J9XD48	29.713%	1602	0.0	Similar to Saccharomyces cerevisiae YBL088C TEL1 Protein kinase primarily involved in telomere length regulation n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XD48_GEOCN
A0A060TA48_BLAAD	32.727%	1155	1.33e-161	ARAD1D16368p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D16368g PE=3 SV=1
A0A167E140_9ASCO	28.267%	1316	1.80e-144	DNA-binding protein kinase TEL1 OS=Sugiyamaella lignohabitans GN=TEL1 PE=3 SV=1
ATM_CANAL	28.791%	1365	1.27e-131	Serine/threonine-protein kinase TEL1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TEL1 PE=3 SV=2
ATM_YARLI	28.410%	1063	1.91e-109	Serine/threonine-protein kinase TEL1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=TEL1 PE=3 SV=1
ATM_YEAST	27.358%	1283	2.24e-107	Serine/threonine-protein kinase TEL1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TEL1 PE=1 SV=3
A0A1E4TMF2_9ASCO	39.869%	306	5.33e-66	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_23198 PE=3 SV=1
A0A1E3PPX1_9ASCO	48.768%	203	2.68e-57	Uncharacterized protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_9314 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0442

Protein family membership

None predicted.

Domains and repeats

Domain
1 - 148
Telomere-length maintenance and DNA damage repair (IPR021668)
1,829 - 2,420
PIK-related kinase (IPR014009)
2,487 - 2,863
Protein kinase-like domain (IPR011009)
Phosphatidylinositol 3-/4-kinase, catalytic domain (IPR000403)
Domain
432 - 2,324
Armadillo-like helical (IPR011989)
2,844 - 2,880
FATC domain (IPR003152)

1 500 1000 1500 2000 2500 2880

Detailed signature matches

IPR021668

Telomere-length maintenance and DNA damage repair
1. SM01342 (TAN_2)
  
  1 - 148
  
  SMART
  SM01342 (TAN_2)
2. PF11640 (TAN)
  
  7 - 144
  
  Pfam
  PF11640 (TAN)
IPR011989

Armadillo-like helical
1. G3DSA:1.25.10.10
  
  432 - 2,324
  
  GENE3D
  G3DSA:1.25.10.10 (G3DSA:1.25.10.10)
IPR014009

PIK-related kinase
1. PS51189 (FAT)
  
  1,829 - 2,420
  
  PROSITE profiles
  PS51189 (FAT)
IPR011009

Protein kinase-like domain
1. SSF56112 (Protein k...)
  
  2,667 - 2,806
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
  
  2,487 - 2,634
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR000403

Phosphatidylinositol 3-/4-kinase, catalytic domain
1. PS50290 (PI3_4_KINA...)
  
  2,556 - 2,796
  
  PROSITE profiles
  PS50290 (PI3_4_KINASE_3)
2. SM00146 (pi3k_hr1_6)
  
  2,557 - 2,863
  
  SMART
  SM00146 (pi3k_hr1_6)
3. PF00454 (PI3_PI4_ki...)
  
  2,563 - 2,802
  
  Pfam
  PF00454 (PI3_PI4_kinase)
4. G3DSA:1.10.10...
  
  2,649 - 2,852
  
  GENE3D
  G3DSA:1.10.1070.11 (G3DSA:1.10.1070.11)
IPR003152

FATC domain
1. PS51190 (FATC)
  
  2,844 - 2,880
  
  PROSITE profiles
  PS51190 (FATC)
IPR018936

Phosphatidylinositol 3/4-kinase, conserved site
1. PS00916 (PI3_4_KINA...)
  
  2,696 - 2,716
  
  PROSITE patterns
  PS00916 (PI3_4_KINASE_2)
2. PS00915 (PI3_4_KINA...)
  
  2,560 - 2,575
  
  PROSITE patterns
  PS00915 (PI3_4_KINASE_1)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

384 - 1,406

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

266 - 276

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
Coil

2,573 - 2,593

COILS
Coil (Coil)

2,879 - 2,880

COILS
Coil (Coil)

2,264 - 2,284

COILS
Coil (Coil)
G3DSA:3.30.10...

2,360 - 2,616

GENE3D
G3DSA:3.30.1010.10 (G3DSA:3.30.1010.10)
NON_CYTOPLASM... (N...)

296 - 363

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1 - 244

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1,439 - 2,880

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TRANSMEMBRANE (Tran...)

1,407 - 1,438

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

245 - 265

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

277 - 295

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

364 - 383

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
cd05171 (PIKKc_ATM)

2,527 - 2,802

CDD
cd05171 (PIKKc_ATM)

Residue annotation

ATP binding site c...

2,537A

ATP binding site
2,537A, 2,539G, 2,540L, 2,541S, 2,543P, 2,559L, 2,561K, 2,565D, 2,600Y, 2,612I, 2,613E, 2,614F, 2,615V, 2,620A, 2,716N, 2,718L, 2,729I, 2,730D
CDD
cd05171 (PIKKc_ATM)

2,539G

ATP binding site
2,537A, 2,539G, 2,540L, 2,541S, 2,543P, 2,559L, 2,561K, 2,565D, 2,600Y, 2,612I, 2,613E, 2,614F, 2,615V, 2,620A, 2,716N, 2,718L, 2,729I, 2,730D
CDD
cd05171 (PIKKc_ATM)

2,540L

ATP binding site
2,537A, 2,539G, 2,540L, 2,541S, 2,543P, 2,559L, 2,561K, 2,565D, 2,600Y, 2,612I, 2,613E, 2,614F, 2,615V, 2,620A, 2,716N, 2,718L, 2,729I, 2,730D
CDD
cd05171 (PIKKc_ATM)

2,541S

ATP binding site
2,537A, 2,539G, 2,540L, 2,541S, 2,543P, 2,559L, 2,561K, 2,565D, 2,600Y, 2,612I, 2,613E, 2,614F, 2,615V, 2,620A, 2,716N, 2,718L, 2,729I, 2,730D
CDD
cd05171 (PIKKc_ATM)

2,543P

ATP binding site
2,537A, 2,539G, 2,540L, 2,541S, 2,543P, 2,559L, 2,561K, 2,565D, 2,600Y, 2,612I, 2,613E, 2,614F, 2,615V, 2,620A, 2,716N, 2,718L, 2,729I, 2,730D
CDD
cd05171 (PIKKc_ATM)

2,559L

ATP binding site
2,537A, 2,539G, 2,540L, 2,541S, 2,543P, 2,559L, 2,561K, 2,565D, 2,600Y, 2,612I, 2,613E, 2,614F, 2,615V, 2,620A, 2,716N, 2,718L, 2,729I, 2,730D
CDD
cd05171 (PIKKc_ATM)

2,561K

ATP binding site
2,537A, 2,539G, 2,540L, 2,541S, 2,543P, 2,559L, 2,561K, 2,565D, 2,600Y, 2,612I, 2,613E, 2,614F, 2,615V, 2,620A, 2,716N, 2,718L, 2,729I, 2,730D
CDD
cd05171 (PIKKc_ATM)

2,565D

ATP binding site
2,537A, 2,539G, 2,540L, 2,541S, 2,543P, 2,559L, 2,561K, 2,565D, 2,600Y, 2,612I, 2,613E, 2,614F, 2,615V, 2,620A, 2,716N, 2,718L, 2,729I, 2,730D
CDD
cd05171 (PIKKc_ATM)

2,600Y

ATP binding site
2,537A, 2,539G, 2,540L, 2,541S, 2,543P, 2,559L, 2,561K, 2,565D, 2,600Y, 2,612I, 2,613E, 2,614F, 2,615V, 2,620A, 2,716N, 2,718L, 2,729I, 2,730D
CDD
cd05171 (PIKKc_ATM)

2,612I

ATP binding site
2,537A, 2,539G, 2,540L, 2,541S, 2,543P, 2,559L, 2,561K, 2,565D, 2,600Y, 2,612I, 2,613E, 2,614F, 2,615V, 2,620A, 2,716N, 2,718L, 2,729I, 2,730D
CDD
cd05171 (PIKKc_ATM)

2,613E

ATP binding site
2,537A, 2,539G, 2,540L, 2,541S, 2,543P, 2,559L, 2,561K, 2,565D, 2,600Y, 2,612I, 2,613E, 2,614F, 2,615V, 2,620A, 2,716N, 2,718L, 2,729I, 2,730D
CDD
cd05171 (PIKKc_ATM)

2,614F

ATP binding site
2,537A, 2,539G, 2,540L, 2,541S, 2,543P, 2,559L, 2,561K, 2,565D, 2,600Y, 2,612I, 2,613E, 2,614F, 2,615V, 2,620A, 2,716N, 2,718L, 2,729I, 2,730D
CDD
cd05171 (PIKKc_ATM)

2,615V

ATP binding site
2,537A, 2,539G, 2,540L, 2,541S, 2,543P, 2,559L, 2,561K, 2,565D, 2,600Y, 2,612I, 2,613E, 2,614F, 2,615V, 2,620A, 2,716N, 2,718L, 2,729I, 2,730D
CDD
cd05171 (PIKKc_ATM)

2,620A

ATP binding site
2,537A, 2,539G, 2,540L, 2,541S, 2,543P, 2,559L, 2,561K, 2,565D, 2,600Y, 2,612I, 2,613E, 2,614F, 2,615V, 2,620A, 2,716N, 2,718L, 2,729I, 2,730D
CDD
cd05171 (PIKKc_ATM)

2,716N

ATP binding site
2,537A, 2,539G, 2,540L, 2,541S, 2,543P, 2,559L, 2,561K, 2,565D, 2,600Y, 2,612I, 2,613E, 2,614F, 2,615V, 2,620A, 2,716N, 2,718L, 2,729I, 2,730D
CDD
cd05171 (PIKKc_ATM)

2,718L

ATP binding site
2,537A, 2,539G, 2,540L, 2,541S, 2,543P, 2,559L, 2,561K, 2,565D, 2,600Y, 2,612I, 2,613E, 2,614F, 2,615V, 2,620A, 2,716N, 2,718L, 2,729I, 2,730D
CDD
cd05171 (PIKKc_ATM)

2,729I

ATP binding site
2,537A, 2,539G, 2,540L, 2,541S, 2,543P, 2,559L, 2,561K, 2,565D, 2,600Y, 2,612I, 2,613E, 2,614F, 2,615V, 2,620A, 2,716N, 2,718L, 2,729I, 2,730D
CDD
cd05171 (PIKKc_ATM)

2,730D

ATP binding site
2,537A, 2,539G, 2,540L, 2,541S, 2,543P, 2,559L, 2,561K, 2,565D, 2,600Y, 2,612I, 2,613E, 2,614F, 2,615V, 2,620A, 2,716N, 2,718L, 2,729I, 2,730D
CDD
cd05171 (PIKKc_ATM)
catalytic loop cd0...

2,708G

catalytic loop
2,708G, 2,709I, 2,710G, 2,711D, 2,712R, 2,713H, 2,714M, 2,715G, 2,716N
CDD
cd05171 (PIKKc_ATM)

2,709I

catalytic loop
2,708G, 2,709I, 2,710G, 2,711D, 2,712R, 2,713H, 2,714M, 2,715G, 2,716N
CDD
cd05171 (PIKKc_ATM)

2,710G

catalytic loop
2,708G, 2,709I, 2,710G, 2,711D, 2,712R, 2,713H, 2,714M, 2,715G, 2,716N
CDD
cd05171 (PIKKc_ATM)

2,711D

catalytic loop
2,708G, 2,709I, 2,710G, 2,711D, 2,712R, 2,713H, 2,714M, 2,715G, 2,716N
CDD
cd05171 (PIKKc_ATM)

2,712R

catalytic loop
2,708G, 2,709I, 2,710G, 2,711D, 2,712R, 2,713H, 2,714M, 2,715G, 2,716N
CDD
cd05171 (PIKKc_ATM)

2,713H

catalytic loop
2,708G, 2,709I, 2,710G, 2,711D, 2,712R, 2,713H, 2,714M, 2,715G, 2,716N
CDD
cd05171 (PIKKc_ATM)

2,714M

catalytic loop
2,708G, 2,709I, 2,710G, 2,711D, 2,712R, 2,713H, 2,714M, 2,715G, 2,716N
CDD
cd05171 (PIKKc_ATM)

2,715G

catalytic loop
2,708G, 2,709I, 2,710G, 2,711D, 2,712R, 2,713H, 2,714M, 2,715G, 2,716N
CDD
cd05171 (PIKKc_ATM)

2,716N

catalytic loop
2,708G, 2,709I, 2,710G, 2,711D, 2,712R, 2,713H, 2,714M, 2,715G, 2,716N
CDD
cd05171 (PIKKc_ATM)
activation loop (A...

2,730D

activation loop (A-loop)
2,730D, 2,731L, 2,732G, 2,733I, 2,734A, 2,735F, 2,736D, 2,737A, 2,738G, 2,739K, 2,740L, 2,741L, 2,742A, 2,743I, 2,744P, 2,745E, 2,746I, 2,747V, 2,748P, 2,749F, 2,750R, 2,751L, 2,752T
CDD
cd05171 (PIKKc_ATM)

2,731L

activation loop (A-loop)
2,730D, 2,731L, 2,732G, 2,733I, 2,734A, 2,735F, 2,736D, 2,737A, 2,738G, 2,739K, 2,740L, 2,741L, 2,742A, 2,743I, 2,744P, 2,745E, 2,746I, 2,747V, 2,748P, 2,749F, 2,750R, 2,751L, 2,752T
CDD
cd05171 (PIKKc_ATM)

2,732G

activation loop (A-loop)
2,730D, 2,731L, 2,732G, 2,733I, 2,734A, 2,735F, 2,736D, 2,737A, 2,738G, 2,739K, 2,740L, 2,741L, 2,742A, 2,743I, 2,744P, 2,745E, 2,746I, 2,747V, 2,748P, 2,749F, 2,750R, 2,751L, 2,752T
CDD
cd05171 (PIKKc_ATM)

2,733I

activation loop (A-loop)
2,730D, 2,731L, 2,732G, 2,733I, 2,734A, 2,735F, 2,736D, 2,737A, 2,738G, 2,739K, 2,740L, 2,741L, 2,742A, 2,743I, 2,744P, 2,745E, 2,746I, 2,747V, 2,748P, 2,749F, 2,750R, 2,751L, 2,752T
CDD
cd05171 (PIKKc_ATM)

2,734A

activation loop (A-loop)
2,730D, 2,731L, 2,732G, 2,733I, 2,734A, 2,735F, 2,736D, 2,737A, 2,738G, 2,739K, 2,740L, 2,741L, 2,742A, 2,743I, 2,744P, 2,745E, 2,746I, 2,747V, 2,748P, 2,749F, 2,750R, 2,751L, 2,752T
CDD
cd05171 (PIKKc_ATM)

2,735F

activation loop (A-loop)
2,730D, 2,731L, 2,732G, 2,733I, 2,734A, 2,735F, 2,736D, 2,737A, 2,738G, 2,739K, 2,740L, 2,741L, 2,742A, 2,743I, 2,744P, 2,745E, 2,746I, 2,747V, 2,748P, 2,749F, 2,750R, 2,751L, 2,752T
CDD
cd05171 (PIKKc_ATM)

2,736D

activation loop (A-loop)
2,730D, 2,731L, 2,732G, 2,733I, 2,734A, 2,735F, 2,736D, 2,737A, 2,738G, 2,739K, 2,740L, 2,741L, 2,742A, 2,743I, 2,744P, 2,745E, 2,746I, 2,747V, 2,748P, 2,749F, 2,750R, 2,751L, 2,752T
CDD
cd05171 (PIKKc_ATM)

2,737A

activation loop (A-loop)
2,730D, 2,731L, 2,732G, 2,733I, 2,734A, 2,735F, 2,736D, 2,737A, 2,738G, 2,739K, 2,740L, 2,741L, 2,742A, 2,743I, 2,744P, 2,745E, 2,746I, 2,747V, 2,748P, 2,749F, 2,750R, 2,751L, 2,752T
CDD
cd05171 (PIKKc_ATM)

2,738G

activation loop (A-loop)
2,730D, 2,731L, 2,732G, 2,733I, 2,734A, 2,735F, 2,736D, 2,737A, 2,738G, 2,739K, 2,740L, 2,741L, 2,742A, 2,743I, 2,744P, 2,745E, 2,746I, 2,747V, 2,748P, 2,749F, 2,750R, 2,751L, 2,752T
CDD
cd05171 (PIKKc_ATM)

2,739K

activation loop (A-loop)
2,730D, 2,731L, 2,732G, 2,733I, 2,734A, 2,735F, 2,736D, 2,737A, 2,738G, 2,739K, 2,740L, 2,741L, 2,742A, 2,743I, 2,744P, 2,745E, 2,746I, 2,747V, 2,748P, 2,749F, 2,750R, 2,751L, 2,752T
CDD
cd05171 (PIKKc_ATM)

2,740L

activation loop (A-loop)
2,730D, 2,731L, 2,732G, 2,733I, 2,734A, 2,735F, 2,736D, 2,737A, 2,738G, 2,739K, 2,740L, 2,741L, 2,742A, 2,743I, 2,744P, 2,745E, 2,746I, 2,747V, 2,748P, 2,749F, 2,750R, 2,751L, 2,752T
CDD
cd05171 (PIKKc_ATM)

2,741L

activation loop (A-loop)
2,730D, 2,731L, 2,732G, 2,733I, 2,734A, 2,735F, 2,736D, 2,737A, 2,738G, 2,739K, 2,740L, 2,741L, 2,742A, 2,743I, 2,744P, 2,745E, 2,746I, 2,747V, 2,748P, 2,749F, 2,750R, 2,751L, 2,752T
CDD
cd05171 (PIKKc_ATM)

2,742A

activation loop (A-loop)
2,730D, 2,731L, 2,732G, 2,733I, 2,734A, 2,735F, 2,736D, 2,737A, 2,738G, 2,739K, 2,740L, 2,741L, 2,742A, 2,743I, 2,744P, 2,745E, 2,746I, 2,747V, 2,748P, 2,749F, 2,750R, 2,751L, 2,752T
CDD
cd05171 (PIKKc_ATM)

2,743I

activation loop (A-loop)
2,730D, 2,731L, 2,732G, 2,733I, 2,734A, 2,735F, 2,736D, 2,737A, 2,738G, 2,739K, 2,740L, 2,741L, 2,742A, 2,743I, 2,744P, 2,745E, 2,746I, 2,747V, 2,748P, 2,749F, 2,750R, 2,751L, 2,752T
CDD
cd05171 (PIKKc_ATM)

2,744P

activation loop (A-loop)
2,730D, 2,731L, 2,732G, 2,733I, 2,734A, 2,735F, 2,736D, 2,737A, 2,738G, 2,739K, 2,740L, 2,741L, 2,742A, 2,743I, 2,744P, 2,745E, 2,746I, 2,747V, 2,748P, 2,749F, 2,750R, 2,751L, 2,752T
CDD
cd05171 (PIKKc_ATM)

2,745E

activation loop (A-loop)
2,730D, 2,731L, 2,732G, 2,733I, 2,734A, 2,735F, 2,736D, 2,737A, 2,738G, 2,739K, 2,740L, 2,741L, 2,742A, 2,743I, 2,744P, 2,745E, 2,746I, 2,747V, 2,748P, 2,749F, 2,750R, 2,751L, 2,752T
CDD
cd05171 (PIKKc_ATM)

2,746I

activation loop (A-loop)
2,730D, 2,731L, 2,732G, 2,733I, 2,734A, 2,735F, 2,736D, 2,737A, 2,738G, 2,739K, 2,740L, 2,741L, 2,742A, 2,743I, 2,744P, 2,745E, 2,746I, 2,747V, 2,748P, 2,749F, 2,750R, 2,751L, 2,752T
CDD
cd05171 (PIKKc_ATM)

2,747V

activation loop (A-loop)
2,730D, 2,731L, 2,732G, 2,733I, 2,734A, 2,735F, 2,736D, 2,737A, 2,738G, 2,739K, 2,740L, 2,741L, 2,742A, 2,743I, 2,744P, 2,745E, 2,746I, 2,747V, 2,748P, 2,749F, 2,750R, 2,751L, 2,752T
CDD
cd05171 (PIKKc_ATM)

2,748P

activation loop (A-loop)
2,730D, 2,731L, 2,732G, 2,733I, 2,734A, 2,735F, 2,736D, 2,737A, 2,738G, 2,739K, 2,740L, 2,741L, 2,742A, 2,743I, 2,744P, 2,745E, 2,746I, 2,747V, 2,748P, 2,749F, 2,750R, 2,751L, 2,752T
CDD
cd05171 (PIKKc_ATM)

2,749F

activation loop (A-loop)
2,730D, 2,731L, 2,732G, 2,733I, 2,734A, 2,735F, 2,736D, 2,737A, 2,738G, 2,739K, 2,740L, 2,741L, 2,742A, 2,743I, 2,744P, 2,745E, 2,746I, 2,747V, 2,748P, 2,749F, 2,750R, 2,751L, 2,752T
CDD
cd05171 (PIKKc_ATM)

2,750R

activation loop (A-loop)
2,730D, 2,731L, 2,732G, 2,733I, 2,734A, 2,735F, 2,736D, 2,737A, 2,738G, 2,739K, 2,740L, 2,741L, 2,742A, 2,743I, 2,744P, 2,745E, 2,746I, 2,747V, 2,748P, 2,749F, 2,750R, 2,751L, 2,752T
CDD
cd05171 (PIKKc_ATM)

2,751L

activation loop (A-loop)
2,730D, 2,731L, 2,732G, 2,733I, 2,734A, 2,735F, 2,736D, 2,737A, 2,738G, 2,739K, 2,740L, 2,741L, 2,742A, 2,743I, 2,744P, 2,745E, 2,746I, 2,747V, 2,748P, 2,749F, 2,750R, 2,751L, 2,752T
CDD
cd05171 (PIKKc_ATM)

2,752T

activation loop (A-loop)
2,730D, 2,731L, 2,732G, 2,733I, 2,734A, 2,735F, 2,736D, 2,737A, 2,738G, 2,739K, 2,740L, 2,741L, 2,742A, 2,743I, 2,744P, 2,745E, 2,746I, 2,747V, 2,748P, 2,749F, 2,750R, 2,751L, 2,752T
CDD
cd05171 (PIKKc_ATM)

Protein sequence

>MIA_06100_1
MAELIDINRTCQLLGSSKSIDRGSGLKEVQLLLEPGSKSRAFLPKNTTAILQGLSSLLVAECSLKAGVPSKRILDASACL
KEIVKSTAPSQTPDKFISIIETITKTFPKTVVDDESYKQFAGNYGKILHEIFRHRKHLESFSQKHAHSGPKLLDFISETI
ESALVVPEDDDDEYVHRRHSQSTGIFKTFPHFLTDFLECMIYVLELPIVFKEKYLQNAWVSINRYFYYSNERFNQMLALK
ASIMLFYHTLSIQSELCSVIAVRVYKYLPTMWETKTFALKELILVFLRVSLPLMLETALSFDSASERDQSLFYQSVTSLH
QFMKEEHPLNICEIEIIGENPNKKSETSEWFKTDTFRLKSTASVFSWVSSAAYYSVCYFYAIINKSKFCFNRKRPRLAAS
PYTPSSAFSSFSSNQIEQYEENGEDTDKTLDRHIIKILSSPLSSIDQCIHHVQFFLFYCNDTDIKETSCDSIFQSLCEWV
YEDNLELSSWSLLGINLLLQRFPNHDFSSSLLDNLWGIVFQRLHTQEFGPVGCQFIKNVLSGKRYSPTQHKLHVEKVIST
FNTTGPKLSSPTINLVYNVLIKMPTFSQVKSDARESLIFWAISQVINTSPGHIERFYHVNPLSAASIFLALCGIKLETPT
ELDKDPCYYGNIPAFQALFRNHLASEEYIYESWKKEDQEEPTSSNSVPFSHFNEFELPFEEVTKILKHTKATAAVLQSKL
KTREIWKRFLATPLSLKHIIDCYASFFLIVSRIYDRYKDASGICDECISLVITLFSELQILLESENLQQDHFSNILLGVD
NLFQIFPYLSQERSHINAYSSILTKLLKIFVKAIEKRKSKNNVDENDIDKHVENRNKFIDFELLGFKNFPVLSQMHRWHI
NETNLEIHVFHIFTILKIKVKCIRPPGEPSGVTLDEINASMIANQDPLIIFHNLSILNLPIHNLSSDNDHDLKQFLTVLD
FAYSRLICKGSLFNAESTLILFFQVLERYISLWIVLELKKSPVYDIIDALFKLTKNVNGVQVQFAMLSFLASVIRHDHLF
MLPKDGVNVISKFAEVFHSTRIAQFYGTSFLGDIFSAIPFYNHYEIYQQAIRPNFPKGRHDNLVFCIYTILQSSLHSSNI
LSLSLYDILSFGVFQSENVANSAFASVAIQKIAAKYKFSKPQNLFVKFSNAILFHWCFEYEKEKMTNGNYLTNENIDESP
RIFKFPFYMLGIKTLLDFLFLCIDDSIIWTLKLYDDCKDRIESTVIAAGLNIDKILVQKFSSLFVGSLLSSDEILPKTSP
FEVFNLWLPEYEVSNLVSSQALDIFLKAIQNIDVYGYDESQGIAPNYFFKTMLPVYGSVVPTPIAPLDAFYLCPEQFNFI
IQNITNDSDIKSLIGEARIYSFLSRTLIDKIRKSINPVERLLNFRRLVFFICYADVSFSSYLLKMTLGSIILFSNYFWDL
PEMEKEVDVTIRYFLKRFNGVLTIDESCLYIPLLFKIVENIFILKTKNKLSYSEVINRVSWLQQELIRLDKHAVLLDIIL
DWLLDKEIKDTMQFEYQFLLDPENTASAKKAFLQIISCQAEMQPSVTYVLLKDVDIKPVVNLLLDFISSGKASDQFIYWV
ARLIGDQCKKDGVKSMNAFFTEDPTDFAAISLDDSFKFIFDTVQDRIHFDNLEIISKAEYCLRHLIFYQDVERICSNYST
LLDEALDQKYFVIFSYLPHVNSIPLPNYSLEKLQFFLEDPNQWLVSLQVILIEKMTQVVHGFLSLAPLITSDPKFCESIF
PYLVSIYLSTIPGRELSDDLNQAFSEALTDQSTHVKIIDSITNAYLFLRKMQNYGQNGGTLHLSIDFTLMLQALIRAGLY
EKAYMVLELQWSADKFENTYNYNYLIANQIYESINSLDMFYARQNSYNFWDTLKRFFHEKDYGKLLQFQSAAMSAGYDQS
NSPLIPETLQKYGLEGVSKLLSNNTVFENDAEVYSYAWKLDQWDLPEVVAPKSRGEIMYNIMKKLHDDYQNCFKTLDEAR
KSTISLIYDRNQTKEVLQTLQIIEECNEIYCARTPNSIERASKNLLTLNLGLDSTHDSSFEEVEDLLLARNLSWKFKDVF
TRHCYQTLGGFMADGLYNSDNGFEPCALAFSISQYCEVAREKKALQKAINGSSELDYLYERFKNMKNSDNAQKIMLISQM
EKAKVMWQVGEKSYAINLLRGLEAFNLLPFLEQEWKLMIRSKLIEWFNDSGFDLSSKVTDIYLRPAIGDIQKLALDSRIK
AGILHTLAEFCNKQYQDKEKWDRLDLLEKQIDVKDNQVRSLKRQKLENSESITLNRYQKIIVNDKQESEEIKNYIQYYLE
SCGSLYLLASITDGRNGEDVAKFMSIWFGDIENEGLNKVLTQQANFLAPILFVPWVNQLTSRLDSNTSEPYQMNVRMIVQ
SLCEYHPYHIVYPLRSLSVDFGKTRMSPAMSPEEVSRVEAGQELWNVMISNAAVGTLFSNVDKFISNAIHVATVKPGKSN
QCSLNSLSKSRFWWKRELEKLKIPSPTLHITPRADCNYSREPFLPLITSADDTVILASGLSRPKIIKLYLSDGHISKILL
KGGNDDMRQDSIMEQVFEQINALFKKYEETRKRNLSIRTYKVIPLGKSAGIIEFVENTVASTDFLSNAHRRYWPNDISER
DARNAIAEAVSGTRENRIRVYREVVARIHPVMHMFFLERFFSCDKWFSSKTNYIRSTAANSILGHVLGIGDRHMGNILLD
TLTGDVVHIDLGIAFDAGKLLAIPEIVPFRLTPDWVDGMGVCGINGPFIRSCNFTLSVLRDEISSFDTILNVLRHDPLHS
WTFRPGKFKGGKNQAHEIEFNEFLGNGASIEGGEFDRVLGAVRKKLSKELTVETEVWNLIHQASDPNNLALMFRGTFLLK

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0016301 kinase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

MIA_06100_1

Protein function

Protein alignments

Mitochondrial localization by mitoprotII

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

Protein sequence

GO term prediction

Biological Process

Molecular Function

Cellular Component