MCA_06151_1

Protein

Length

2,824 amino acids

Gene name: TEL1

Description: Serine/threonine protein kinase Tel1; in S. cerevisiae primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage

Browser: contigD:3374202-3382889+

RNA-seq: read pairs 985, FPKM 4.3, percentile rank 16.3% (100% = highest expression)

Protein function

Annotation:		TEL1	Serine/threonine protein kinase Tel1; in S. cerevisiae primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage
KEGG:	K04728	ATM	ataxia telangiectasia mutated family protein [EC:2.7.11.1]
EGGNOG:	0PFW9	TEL1	Serine threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence ST -Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity)
SGD closest match:	S000000184	TEL1	Serine/threonine-protein kinase TEL1
CGD closest match:	CAL0000195481	TEL1	Serine/threonine-protein kinase TEL1

Protein alignments

	%id	Aln length	E-value
MIA_06100_1	28.69%	2903	0.0	MIA_06100_1
A0A0J9XD48_GEOCN	30.26%	1950	0.0	Similar to Saccharomyces cerevisiae YBL088C TEL1 Protein kinase primarily involved in telomere length regulation OS=Geotrichum candidum GN=BN980_GECA10s02419g PE=3 SV=1
UniRef50_A0A0J9XD48	30.26%	1950	0.0	Similar to Saccharomyces cerevisiae YBL088C TEL1 Protein kinase primarily involved in telomere length regulation n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XD48_GEOCN
A0A060TA48_BLAAD	33.68%	1164	1e-165	ARAD1D16368p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D16368g PE=3 SV=1
A0A167E140_9ASCO	32.44%	1159	5e-152	DNA-binding protein kinase TEL1 OS=Sugiyamaella lignohabitans GN=TEL1 PE=3 SV=1
ATM_CANAL	27.26%	1559	5e-123	Serine/threonine-protein kinase TEL1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TEL1 PE=3 SV=2
ATM_YARLI	38.99%	572	3e-110	Serine/threonine-protein kinase TEL1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=TEL1 PE=3 SV=1
ATM_YEAST	29.08%	1104	3e-105	Serine/threonine-protein kinase TEL1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TEL1 PE=1 SV=3
A0A1E4TMF2_9ASCO	39.51%	329	7e-70	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_23198 PE=3 SV=1
A0A1E3PPX1_9ASCO	46.52%	230	3e-60	Uncharacterized protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_9314 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1159

Protein family membership

None predicted.

Domains and repeats

Domain
7 - 146
Telomere-length maintenance and DNA damage repair (IPR021668)
1,720 - 2,349
PIK-related kinase (IPR014009)
2,792 - 2,824
FATC domain (IPR003152)
Domain
2,425 - 2,824
Protein kinase-like domain (IPR011009)
Phosphatidylinositol 3-/4-kinase, catalytic domain (IPR000403)

1 500 1000 1500 2000 2500 2824

Detailed signature matches

IPR021668

Telomere-length maintenance and DNA damage repair
1. PF11640 (TAN)
  
  7 - 146
  
  Pfam
  PF11640 (TAN)
IPR014009

PIK-related kinase
1. PS51189 (FAT)
  
  1,720 - 2,349
  
  PROSITE profiles
  PS51189 (FAT)
IPR011009

Protein kinase-like domain
1. SSF56112 (Protein k...)
  
  2,590 - 2,747
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
  
  2,425 - 2,557
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR000403

Phosphatidylinositol 3-/4-kinase, catalytic domain
1. PS50290 (PI3_4_KINA...)
  
  2,479 - 2,824
  
  PROSITE profiles
  PS50290 (PI3_4_KINASE_3)
2. SM00146 (pi3k_hr1_6)
  
  2,481 - 2,785
  
  SMART
  SM00146 (pi3k_hr1_6)
3. PF00454 (PI3_PI4_ki...)
  
  2,486 - 2,725
  
  Pfam
  PF00454 (PI3_PI4_kinase)
4. G3DSA:1.10.10...
  
  2,571 - 2,761
  
  GENE3D
  G3DSA:1.10.1070.11 (G3DSA:1.10.1070.11)
IPR003152

FATC domain
1. SM01343 (FATC_2)
  
  2,792 - 2,824
  
  SMART
  SM01343 (FATC_2)
2. PF02260 (FATC)
  
  2,794 - 2,823
  
  Pfam
  PF02260 (FATC)
3. PS51190 (FATC)
  
  2,792 - 2,824
  
  PROSITE profiles
  PS51190 (FATC)
IPR018936

Phosphatidylinositol 3/4-kinase, conserved site
1. PS00916 (PI3_4_KINA...)
  
  2,619 - 2,639
  
  PROSITE patterns
  PS00916 (PI3_4_KINASE_2)
2. PS00915 (PI3_4_KINA...)
  
  2,483 - 2,498
  
  PROSITE patterns
  PS00915 (PI3_4_KINASE_1)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

727 - 1,001

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
Coil

1,963 - 1,983

COILS
Coil (Coil)

2,190 - 2,210

COILS
Coil (Coil)
G3DSA:3.30.10...

2,374 - 2,539

GENE3D
G3DSA:3.30.1010.10 (G3DSA:3.30.1010.10)
NON_CYTOPLASM... (N...)

1 - 707

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1,025 - 2,824

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TRANSMEMBRANE (Tran...)

708 - 726

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,002 - 1,024

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
cd05171 (PIKKc_ATM)

2,454 - 2,726

CDD
cd05171 (PIKKc_ATM)

Residue annotation

ATP binding site c...

2,460A

ATP binding site
2,460A, 2,462G, 2,463L, 2,464S, 2,466P, 2,482L, 2,484K, 2,488D, 2,523Y, 2,535I, 2,536E, 2,537F, 2,538V, 2,543S, 2,639N, 2,641L, 2,652I, 2,653D
CDD
cd05171 (PIKKc_ATM)

2,462G

ATP binding site
2,460A, 2,462G, 2,463L, 2,464S, 2,466P, 2,482L, 2,484K, 2,488D, 2,523Y, 2,535I, 2,536E, 2,537F, 2,538V, 2,543S, 2,639N, 2,641L, 2,652I, 2,653D
CDD
cd05171 (PIKKc_ATM)

2,463L

ATP binding site
2,460A, 2,462G, 2,463L, 2,464S, 2,466P, 2,482L, 2,484K, 2,488D, 2,523Y, 2,535I, 2,536E, 2,537F, 2,538V, 2,543S, 2,639N, 2,641L, 2,652I, 2,653D
CDD
cd05171 (PIKKc_ATM)

2,464S

ATP binding site
2,460A, 2,462G, 2,463L, 2,464S, 2,466P, 2,482L, 2,484K, 2,488D, 2,523Y, 2,535I, 2,536E, 2,537F, 2,538V, 2,543S, 2,639N, 2,641L, 2,652I, 2,653D
CDD
cd05171 (PIKKc_ATM)

2,466P

ATP binding site
2,460A, 2,462G, 2,463L, 2,464S, 2,466P, 2,482L, 2,484K, 2,488D, 2,523Y, 2,535I, 2,536E, 2,537F, 2,538V, 2,543S, 2,639N, 2,641L, 2,652I, 2,653D
CDD
cd05171 (PIKKc_ATM)

2,482L

ATP binding site
2,460A, 2,462G, 2,463L, 2,464S, 2,466P, 2,482L, 2,484K, 2,488D, 2,523Y, 2,535I, 2,536E, 2,537F, 2,538V, 2,543S, 2,639N, 2,641L, 2,652I, 2,653D
CDD
cd05171 (PIKKc_ATM)

2,484K

ATP binding site
2,460A, 2,462G, 2,463L, 2,464S, 2,466P, 2,482L, 2,484K, 2,488D, 2,523Y, 2,535I, 2,536E, 2,537F, 2,538V, 2,543S, 2,639N, 2,641L, 2,652I, 2,653D
CDD
cd05171 (PIKKc_ATM)

2,488D

ATP binding site
2,460A, 2,462G, 2,463L, 2,464S, 2,466P, 2,482L, 2,484K, 2,488D, 2,523Y, 2,535I, 2,536E, 2,537F, 2,538V, 2,543S, 2,639N, 2,641L, 2,652I, 2,653D
CDD
cd05171 (PIKKc_ATM)

2,523Y

ATP binding site
2,460A, 2,462G, 2,463L, 2,464S, 2,466P, 2,482L, 2,484K, 2,488D, 2,523Y, 2,535I, 2,536E, 2,537F, 2,538V, 2,543S, 2,639N, 2,641L, 2,652I, 2,653D
CDD
cd05171 (PIKKc_ATM)

2,535I

ATP binding site
2,460A, 2,462G, 2,463L, 2,464S, 2,466P, 2,482L, 2,484K, 2,488D, 2,523Y, 2,535I, 2,536E, 2,537F, 2,538V, 2,543S, 2,639N, 2,641L, 2,652I, 2,653D
CDD
cd05171 (PIKKc_ATM)

2,536E

ATP binding site
2,460A, 2,462G, 2,463L, 2,464S, 2,466P, 2,482L, 2,484K, 2,488D, 2,523Y, 2,535I, 2,536E, 2,537F, 2,538V, 2,543S, 2,639N, 2,641L, 2,652I, 2,653D
CDD
cd05171 (PIKKc_ATM)

2,537F

ATP binding site
2,460A, 2,462G, 2,463L, 2,464S, 2,466P, 2,482L, 2,484K, 2,488D, 2,523Y, 2,535I, 2,536E, 2,537F, 2,538V, 2,543S, 2,639N, 2,641L, 2,652I, 2,653D
CDD
cd05171 (PIKKc_ATM)

2,538V

ATP binding site
2,460A, 2,462G, 2,463L, 2,464S, 2,466P, 2,482L, 2,484K, 2,488D, 2,523Y, 2,535I, 2,536E, 2,537F, 2,538V, 2,543S, 2,639N, 2,641L, 2,652I, 2,653D
CDD
cd05171 (PIKKc_ATM)

2,543S

ATP binding site
2,460A, 2,462G, 2,463L, 2,464S, 2,466P, 2,482L, 2,484K, 2,488D, 2,523Y, 2,535I, 2,536E, 2,537F, 2,538V, 2,543S, 2,639N, 2,641L, 2,652I, 2,653D
CDD
cd05171 (PIKKc_ATM)

2,639N

ATP binding site
2,460A, 2,462G, 2,463L, 2,464S, 2,466P, 2,482L, 2,484K, 2,488D, 2,523Y, 2,535I, 2,536E, 2,537F, 2,538V, 2,543S, 2,639N, 2,641L, 2,652I, 2,653D
CDD
cd05171 (PIKKc_ATM)

2,641L

ATP binding site
2,460A, 2,462G, 2,463L, 2,464S, 2,466P, 2,482L, 2,484K, 2,488D, 2,523Y, 2,535I, 2,536E, 2,537F, 2,538V, 2,543S, 2,639N, 2,641L, 2,652I, 2,653D
CDD
cd05171 (PIKKc_ATM)

2,652I

ATP binding site
2,460A, 2,462G, 2,463L, 2,464S, 2,466P, 2,482L, 2,484K, 2,488D, 2,523Y, 2,535I, 2,536E, 2,537F, 2,538V, 2,543S, 2,639N, 2,641L, 2,652I, 2,653D
CDD
cd05171 (PIKKc_ATM)

2,653D

ATP binding site
2,460A, 2,462G, 2,463L, 2,464S, 2,466P, 2,482L, 2,484K, 2,488D, 2,523Y, 2,535I, 2,536E, 2,537F, 2,538V, 2,543S, 2,639N, 2,641L, 2,652I, 2,653D
CDD
cd05171 (PIKKc_ATM)
catalytic loop cd0...

2,631G

catalytic loop
2,631G, 2,632I, 2,633G, 2,634D, 2,635R, 2,636H, 2,637C, 2,638S, 2,639N
CDD
cd05171 (PIKKc_ATM)

2,632I

catalytic loop
2,631G, 2,632I, 2,633G, 2,634D, 2,635R, 2,636H, 2,637C, 2,638S, 2,639N
CDD
cd05171 (PIKKc_ATM)

2,633G

catalytic loop
2,631G, 2,632I, 2,633G, 2,634D, 2,635R, 2,636H, 2,637C, 2,638S, 2,639N
CDD
cd05171 (PIKKc_ATM)

2,634D

catalytic loop
2,631G, 2,632I, 2,633G, 2,634D, 2,635R, 2,636H, 2,637C, 2,638S, 2,639N
CDD
cd05171 (PIKKc_ATM)

2,635R

catalytic loop
2,631G, 2,632I, 2,633G, 2,634D, 2,635R, 2,636H, 2,637C, 2,638S, 2,639N
CDD
cd05171 (PIKKc_ATM)

2,636H

catalytic loop
2,631G, 2,632I, 2,633G, 2,634D, 2,635R, 2,636H, 2,637C, 2,638S, 2,639N
CDD
cd05171 (PIKKc_ATM)

2,637C

catalytic loop
2,631G, 2,632I, 2,633G, 2,634D, 2,635R, 2,636H, 2,637C, 2,638S, 2,639N
CDD
cd05171 (PIKKc_ATM)

2,638S

catalytic loop
2,631G, 2,632I, 2,633G, 2,634D, 2,635R, 2,636H, 2,637C, 2,638S, 2,639N
CDD
cd05171 (PIKKc_ATM)

2,639N

catalytic loop
2,631G, 2,632I, 2,633G, 2,634D, 2,635R, 2,636H, 2,637C, 2,638S, 2,639N
CDD
cd05171 (PIKKc_ATM)
activation loop (A...

2,653D

activation loop (A-loop)
2,653D, 2,654L, 2,655G, 2,656I, 2,657A, 2,658F, 2,659D, 2,660Q, 2,661G, 2,662K, 2,663L, 2,664L, 2,665P, 2,666I, 2,667P, 2,668E, 2,669I, 2,670I, 2,671P, 2,672F, 2,673R, 2,674L, 2,675S
CDD
cd05171 (PIKKc_ATM)

2,654L

activation loop (A-loop)
2,653D, 2,654L, 2,655G, 2,656I, 2,657A, 2,658F, 2,659D, 2,660Q, 2,661G, 2,662K, 2,663L, 2,664L, 2,665P, 2,666I, 2,667P, 2,668E, 2,669I, 2,670I, 2,671P, 2,672F, 2,673R, 2,674L, 2,675S
CDD
cd05171 (PIKKc_ATM)

2,655G

activation loop (A-loop)
2,653D, 2,654L, 2,655G, 2,656I, 2,657A, 2,658F, 2,659D, 2,660Q, 2,661G, 2,662K, 2,663L, 2,664L, 2,665P, 2,666I, 2,667P, 2,668E, 2,669I, 2,670I, 2,671P, 2,672F, 2,673R, 2,674L, 2,675S
CDD
cd05171 (PIKKc_ATM)

2,656I

activation loop (A-loop)
2,653D, 2,654L, 2,655G, 2,656I, 2,657A, 2,658F, 2,659D, 2,660Q, 2,661G, 2,662K, 2,663L, 2,664L, 2,665P, 2,666I, 2,667P, 2,668E, 2,669I, 2,670I, 2,671P, 2,672F, 2,673R, 2,674L, 2,675S
CDD
cd05171 (PIKKc_ATM)

2,657A

activation loop (A-loop)
2,653D, 2,654L, 2,655G, 2,656I, 2,657A, 2,658F, 2,659D, 2,660Q, 2,661G, 2,662K, 2,663L, 2,664L, 2,665P, 2,666I, 2,667P, 2,668E, 2,669I, 2,670I, 2,671P, 2,672F, 2,673R, 2,674L, 2,675S
CDD
cd05171 (PIKKc_ATM)

2,658F

activation loop (A-loop)
2,653D, 2,654L, 2,655G, 2,656I, 2,657A, 2,658F, 2,659D, 2,660Q, 2,661G, 2,662K, 2,663L, 2,664L, 2,665P, 2,666I, 2,667P, 2,668E, 2,669I, 2,670I, 2,671P, 2,672F, 2,673R, 2,674L, 2,675S
CDD
cd05171 (PIKKc_ATM)

2,659D

activation loop (A-loop)
2,653D, 2,654L, 2,655G, 2,656I, 2,657A, 2,658F, 2,659D, 2,660Q, 2,661G, 2,662K, 2,663L, 2,664L, 2,665P, 2,666I, 2,667P, 2,668E, 2,669I, 2,670I, 2,671P, 2,672F, 2,673R, 2,674L, 2,675S
CDD
cd05171 (PIKKc_ATM)

2,660Q

activation loop (A-loop)
2,653D, 2,654L, 2,655G, 2,656I, 2,657A, 2,658F, 2,659D, 2,660Q, 2,661G, 2,662K, 2,663L, 2,664L, 2,665P, 2,666I, 2,667P, 2,668E, 2,669I, 2,670I, 2,671P, 2,672F, 2,673R, 2,674L, 2,675S
CDD
cd05171 (PIKKc_ATM)

2,661G

activation loop (A-loop)
2,653D, 2,654L, 2,655G, 2,656I, 2,657A, 2,658F, 2,659D, 2,660Q, 2,661G, 2,662K, 2,663L, 2,664L, 2,665P, 2,666I, 2,667P, 2,668E, 2,669I, 2,670I, 2,671P, 2,672F, 2,673R, 2,674L, 2,675S
CDD
cd05171 (PIKKc_ATM)

2,662K

activation loop (A-loop)
2,653D, 2,654L, 2,655G, 2,656I, 2,657A, 2,658F, 2,659D, 2,660Q, 2,661G, 2,662K, 2,663L, 2,664L, 2,665P, 2,666I, 2,667P, 2,668E, 2,669I, 2,670I, 2,671P, 2,672F, 2,673R, 2,674L, 2,675S
CDD
cd05171 (PIKKc_ATM)

2,663L

activation loop (A-loop)
2,653D, 2,654L, 2,655G, 2,656I, 2,657A, 2,658F, 2,659D, 2,660Q, 2,661G, 2,662K, 2,663L, 2,664L, 2,665P, 2,666I, 2,667P, 2,668E, 2,669I, 2,670I, 2,671P, 2,672F, 2,673R, 2,674L, 2,675S
CDD
cd05171 (PIKKc_ATM)

2,664L

activation loop (A-loop)
2,653D, 2,654L, 2,655G, 2,656I, 2,657A, 2,658F, 2,659D, 2,660Q, 2,661G, 2,662K, 2,663L, 2,664L, 2,665P, 2,666I, 2,667P, 2,668E, 2,669I, 2,670I, 2,671P, 2,672F, 2,673R, 2,674L, 2,675S
CDD
cd05171 (PIKKc_ATM)

2,665P

activation loop (A-loop)
2,653D, 2,654L, 2,655G, 2,656I, 2,657A, 2,658F, 2,659D, 2,660Q, 2,661G, 2,662K, 2,663L, 2,664L, 2,665P, 2,666I, 2,667P, 2,668E, 2,669I, 2,670I, 2,671P, 2,672F, 2,673R, 2,674L, 2,675S
CDD
cd05171 (PIKKc_ATM)

2,666I

activation loop (A-loop)
2,653D, 2,654L, 2,655G, 2,656I, 2,657A, 2,658F, 2,659D, 2,660Q, 2,661G, 2,662K, 2,663L, 2,664L, 2,665P, 2,666I, 2,667P, 2,668E, 2,669I, 2,670I, 2,671P, 2,672F, 2,673R, 2,674L, 2,675S
CDD
cd05171 (PIKKc_ATM)

2,667P

activation loop (A-loop)
2,653D, 2,654L, 2,655G, 2,656I, 2,657A, 2,658F, 2,659D, 2,660Q, 2,661G, 2,662K, 2,663L, 2,664L, 2,665P, 2,666I, 2,667P, 2,668E, 2,669I, 2,670I, 2,671P, 2,672F, 2,673R, 2,674L, 2,675S
CDD
cd05171 (PIKKc_ATM)

2,668E

activation loop (A-loop)
2,653D, 2,654L, 2,655G, 2,656I, 2,657A, 2,658F, 2,659D, 2,660Q, 2,661G, 2,662K, 2,663L, 2,664L, 2,665P, 2,666I, 2,667P, 2,668E, 2,669I, 2,670I, 2,671P, 2,672F, 2,673R, 2,674L, 2,675S
CDD
cd05171 (PIKKc_ATM)

2,669I

activation loop (A-loop)
2,653D, 2,654L, 2,655G, 2,656I, 2,657A, 2,658F, 2,659D, 2,660Q, 2,661G, 2,662K, 2,663L, 2,664L, 2,665P, 2,666I, 2,667P, 2,668E, 2,669I, 2,670I, 2,671P, 2,672F, 2,673R, 2,674L, 2,675S
CDD
cd05171 (PIKKc_ATM)

2,670I

activation loop (A-loop)
2,653D, 2,654L, 2,655G, 2,656I, 2,657A, 2,658F, 2,659D, 2,660Q, 2,661G, 2,662K, 2,663L, 2,664L, 2,665P, 2,666I, 2,667P, 2,668E, 2,669I, 2,670I, 2,671P, 2,672F, 2,673R, 2,674L, 2,675S
CDD
cd05171 (PIKKc_ATM)

2,671P

activation loop (A-loop)
2,653D, 2,654L, 2,655G, 2,656I, 2,657A, 2,658F, 2,659D, 2,660Q, 2,661G, 2,662K, 2,663L, 2,664L, 2,665P, 2,666I, 2,667P, 2,668E, 2,669I, 2,670I, 2,671P, 2,672F, 2,673R, 2,674L, 2,675S
CDD
cd05171 (PIKKc_ATM)

2,672F

activation loop (A-loop)
2,653D, 2,654L, 2,655G, 2,656I, 2,657A, 2,658F, 2,659D, 2,660Q, 2,661G, 2,662K, 2,663L, 2,664L, 2,665P, 2,666I, 2,667P, 2,668E, 2,669I, 2,670I, 2,671P, 2,672F, 2,673R, 2,674L, 2,675S
CDD
cd05171 (PIKKc_ATM)

2,673R

activation loop (A-loop)
2,653D, 2,654L, 2,655G, 2,656I, 2,657A, 2,658F, 2,659D, 2,660Q, 2,661G, 2,662K, 2,663L, 2,664L, 2,665P, 2,666I, 2,667P, 2,668E, 2,669I, 2,670I, 2,671P, 2,672F, 2,673R, 2,674L, 2,675S
CDD
cd05171 (PIKKc_ATM)

2,674L

activation loop (A-loop)
2,653D, 2,654L, 2,655G, 2,656I, 2,657A, 2,658F, 2,659D, 2,660Q, 2,661G, 2,662K, 2,663L, 2,664L, 2,665P, 2,666I, 2,667P, 2,668E, 2,669I, 2,670I, 2,671P, 2,672F, 2,673R, 2,674L, 2,675S
CDD
cd05171 (PIKKc_ATM)

2,675S

activation loop (A-loop)
2,653D, 2,654L, 2,655G, 2,656I, 2,657A, 2,658F, 2,659D, 2,660Q, 2,661G, 2,662K, 2,663L, 2,664L, 2,665P, 2,666I, 2,667P, 2,668E, 2,669I, 2,670I, 2,671P, 2,672F, 2,673R, 2,674L, 2,675S
CDD
cd05171 (PIKKc_ATM)

Protein sequence

>MCA_06151_1
MAVRPLNSIKNDICAPQTSKIKSGLKDLKEFLNFSPDVLSELSTEKEPLLLGILGTSIRNERSVYVASLLRGKSVSASEE
RLRLSADSIKIIVDKTAANLTSLQIIDLIELIIDSSLQDIADEPICEPVISSYSKILERIVASPINRFKIPISHIYQTIE
YLSTIIQEIVNKSGIVDSITEDVLTSQSLSRSYSRIPTYTNELFTSLSTLLRYTIQIPFVTLSETWKCIQLYVTYYKKES
ESHASIMACINSIIYHTLNQSDTESNFYEMVITITYSILPNLWKTKSSKLKGEITVFVLITFYKFYELLDSLDDADSHSQ
QLIYDSLTHLNNFTKSDKPLDISEIIITDDLDDVPIWLKSSCFYLKPNVSIKRWMNMLTNTSISYLHIHLTGQGFYRSLK
KNTTIEAKPQNDLFKEYIGNPANYSFSNSKIHTLQLFILFSSEHDFLEYDPKPLLSLFISLISENDLNTSGWALLGINRL
LMMFPNHDFFVSEVEFIYKFYLQRVHSKTIGPVTCNFIKILLDQKRYHISSFRTIYEEVISLYDSNALQVSLPSLELIQC
LLENLPKVGMDKEKVRERLTGWFLYHLTSMESLKLYKYSDIRSDTFVATFLSVLGIRSQISNASNIQYFGVFLQYYNLFL
PHIKASHTLKANRFSFLVKKIDRPPLNLSLPSAEIAKFVTQLNLKLSMLPNEILNQNLSFMLSSHPSVIQFLLQNISFIF
VVLFQIHQKYKISSIQECLKTFSTIVYDIIKLFENIDFQSIHIPFMMSGITAITCLKNFYNFEGEFKTIHLSILNQLRNL
VEKKNSSISSVDSSMNPFSFNISDSILSSIENIDIYDYSINKYDSNLNNYRIYQTLKIMTLIGNNDYINSFYPTVQDLMS
DLATVEQFILVGDTISQFFPQQRNISSKDVYNEFLNFVYYSLSQHPLFQQIIASETITLLFIELLKNNTSHWVSNTTDKL
SRKVLTACFNVCKTDLGSTTSRFALCSIFSELLFFSKNKSSIVSNISLLIKGLPLLQFHCSFLLEKIFKSIPINQHYEIY
RIAFSDLMQPAERNINISLINLYFLEAIARNSKSLLSSVIYDMIQYGDSNFISDQVKESIERVSSNVNGHRNSSELLSTI
FDSLICKWMNFNDLFDFPFELFGISEAQFFESYFDTLLVYALRLNYDNSSLQLMSKVASKNLHEHLKQIFPVAYAFGFAT
ILDSQYSNTRDILNMYENWFSKSDIRALINENWIAILVNLFALVDMSEIRNEFLNKQINFVKPFRFEDLYSINTSPDKIS
LPFNLAIDFDFFSEVIEETKRMITVESDVIFKLSEPQILSYCVWKFLKDANTPVNPSEKILKLRQVSFFLSYLNSDLDNY
TCVGLIRSLISLLESKTGLHIEVLQLLEVITTKHTSNLTLDQPLIFNVFLEILLCFFKLKNDIKQMDLDTEYTVSWLNSL
INFLHGDQQQIVRYLLDALYDRLFDFNDHIFYSIFLDSKTDESSKKLLILIISYQFSYNNSTFTELFDGINIQSVLPHLI
PSADIQVSDEYKIWLARLLARHHFLKGPLEMLDSLASQKFNIDGSDLAYSIERIFEISVSCLFSLDISLIEVTDNILRIF
HSKLDKSLRPIFDKIVADNHLENSINFFPPQIENSYMGTSPNIQKLKKELATSFETPSSWISCFELILLNRLSGKYAVFK
ALSRLIQSHETFSFKVFPYLFHLFLENNMLRPLDSELKSIILECLQNEKTDIKIIQILCDTFLYSRKVTLNNILVAENFL
NIDYIEMSKALVRVGLAEHAYMLFELDWSSNQLNGQAPQENLEVLKNEIYEKISDPDMYYAKSLSVTLESTLNRFAYEKN
YNRLLQFESAMLGKGGNPSDLKIPLPTSLQKCGLDGISNIVSERLPIMKDLDLYSDSWKLGNWDIPESSAPNNKDEIIYN
LLKAYHDHYEPLSQVIDQQYIASFSIFLNSKNILDSLQVFHIIKESEDLLEDEKQEYDLIEGKKSFSAWMEYSSFDDIED
ILLARNIIRRFKFADNNKDSNAILALSDSLLNYCRLSRNKGFLQKAVNSLVELSKIEECFKQQKQHSSQLENPENSSLLL
LSTAINFEQSTIMWEFGEKDTAIEILQDWYAKHNNNIGADWKLIIAAQLVEWFKDFGFDYPENITTQYLEPVSITYPNSK
LSLDKKAKLLHSLADFCILQFNNKLRNERLERLKKLRKDKLMEIEALQELHKQRKLEGPRRNMLIKASKVLDTDELEIKE
LLTSKNEHLLLGATLYLQAAKCSDETGDNISKFMAVWFQNINETKLNNGISDIISEVPAILLVPWINQLSSRLGETSQSY
SINLETMIEMACSSHPFHSLYTLKSLMTKPSNGKFTTESDRSRYYAGEKMWAKLKRYKFLVETLDSVSNFCDVCLNVSRV
PVPKTATKCSLDKVTTPRHWWKKIKHLSIPVPTRSIPLRADCNYSSIPRMTLADDTVSIASGLSHPKIIRLQSSDGKWDT
MLIKGGNDDMRQDAIMEQVFSQVNIFFQKRDFTKERRLFVRTYTVIPLGKNGGIIEFVPNTISFMDYLSSAHKKYRPNDM
DLKKARQRLAAAKSLPSDKKLAEYNYIASKLKPVLHMFFFDYFYSVDLWFESKMRYIRSTAAISILGYVLGIGDRHCSNI
LLDYRNGDVVHIDLGIAFDQGKLLPIPEIIPFRLSRDVVDGMGVCGLKGPFTRSCQFTLSVLRDEAKSIDTILNVLRHDP
LYSWTLSPVKAKKFRSKMSSGNGEENPVNDSTIEIHADNENSNNSDALGSLNSEDGGEAERVLENVRNKLSKELSVEASV
KILILEAKDPANLSQLFVGWSPFY

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0016301 kinase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

MCA_06151_1

Protein function

Protein alignments

Mitochondrial localization by mitoprotII

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

Protein sequence

GO term prediction

Biological Process

Molecular Function

Cellular Component