MIA_06080_1

Protein

Length

1,151 amino acids

Protein function

EGGNOG:	0PGTD	RAD2	DNA excision repair protein
SGD closest match:	S000003490	RAD2	DNA repair protein RAD2
CGD closest match:	CAL0000187217	RAD2	SsDNA endodeoxyribonuclease

Protein alignments

	%id	Aln length	E-value
MCA_00874_1	57.812%	384	1.42e-123	MCA_00874_1
A0A0J9XJW3_GEOCN	59.355%	310	2.25e-114	Similar to Saccharomyces cerevisiae YGR258C RAD2 Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA OS=Geotrichum candidum GN=BN980_GECA20s00714g PE=4 SV=1
UniRef50_A0A0J9XJW3	59.355%	310	4.60e-111	Similar to Saccharomyces cerevisiae YGR258C RAD2 Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XJW3_GEOCN
A0A167DVL9_9ASCO	64.479%	259	1.61e-104	SsDNA endodeoxyribonuclease RAD2 OS=Sugiyamaella lignohabitans GN=RAD2 PE=4 SV=1
A0A060T6D4_BLAAD	51.118%	313	5.92e-91	ARAD1B15004p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B15004g PE=4 SV=1
A0A1D8PLU8_CANAL	50.903%	277	6.49e-80	SsDNA endodeoxyribonuclease OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=RAD2 PE=4 SV=1
RAD2_YEAST	53.878%	245	1.11e-76	DNA repair protein RAD2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RAD2 PE=1 SV=2
Q6C8E7_YARLI	47.925%	265	1.50e-65	YALI0D20240p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D20240g PE=4 SV=1
A0A1E4TFR7_9ASCO	61.783%	157	3.68e-59	Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_19392 PE=4 SV=1
A0A1E3PHQ3_9ASCO	66.429%	140	4.16e-56	PIN domain-like protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_12063 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.4336

Protein family membership

XPG/Rad2 endonuclease (IPR006084)
- XPG/Rad2 endonuclease, eukaryotes (IPR001044)

Domains and repeats

Domain
1 - 98
XPG N-terminal (IPR006085)
884 - 931
5'-3' exonuclease, C-terminal domain (IPR020045)
965 - 1,033
5'-3' exonuclease, C-terminal domain (IPR020045)
Domain
3 - 899
PIN domain-like (IPR029060)
Domain
814 - 899
XPG-I domain (IPR006086)

1 200 400 600 800 1000 1151

Detailed signature matches

IPR006084

XPG/Rad2 endonuclease
1. PR00853 (XPGRADSUPER)
  
  72 - 91
  
  PRINTS
  PR00853 (XPGRADSUPER)
  
  813 - 830
  
  PRINTS
  PR00853 (XPGRADSUPER)
  
  24 - 38
  
  PRINTS
  PR00853 (XPGRADSUPER)
  
  834 - 854
  
  PRINTS
  PR00853 (XPGRADSUPER)
  
  889 - 904
  
  PRINTS
  PR00853 (XPGRADSUPER)
IPR001044

XPG/Rad2 endonuclease, eukaryotes
1. PR00066 (XRODRMPGMNTG)
  
  2 - 19
  
  PRINTS
  PR00066 (XRODRMPGMNTG)
  
  54 - 77
  
  PRINTS
  PR00066 (XRODRMPGMNTG)
IPR006085

XPG N-terminal
1. SM00485 (xpgn3)
  
  1 - 98
  
  SMART
  SM00485 (xpgn3)
2. PF00752 (XPG_N)
  
  1 - 96
  
  Pfam
  PF00752 (XPG_N)
IPR029060

PIN domain-like
1. G3DSA:3.40.50...
  
  4 - 885
  
  GENE3D
  G3DSA:3.40.50.1010 (G3DSA:3.40.50.1010)
2. SSF88723 (PIN domai...)
  
  785 - 899
  
  SUPERFAMILY
  SSF88723 (PIN domain-like)
  
  3 - 102
  
  SUPERFAMILY
  SSF88723 (PIN domain-like)
IPR006086

XPG-I domain
1. SM00484 (xpgineu)
  
  814 - 884
  
  SMART
  SM00484 (xpgineu)
2. PF00867 (XPG_I)
  
  815 - 899
  
  Pfam
  PF00867 (XPG_I)
IPR020045

5'-3' exonuclease, C-terminal domain
1. SSF47807 (5' to 3' ...)
  
  965 - 1,033
  
  SUPERFAMILY
  SSF47807 (5' to 3' exonuclease, C-terminal subdomain)
  
  884 - 931
  
  SUPERFAMILY
  SSF47807 (5' to 3' exonuclease, C-terminal subdomain)
IPR019974

XPG conserved site
1. PS00842 (XPG_2)
  
  817 - 831
  
  PROSITE patterns
  PS00842 (XPG_2)
2. PS00841 (XPG_1)
  
  70 - 84
  
  PROSITE patterns
  PS00841 (XPG_1)
IPR008918

Helix-hairpin-helix motif, class 2
1. SM00279 (HhH_4)
  
  886 - 919
  
  SMART
  SM00279 (HhH_4)

no IPR

Unintegrated signatures

Coil

710 - 730

COILS
Coil (Coil)

356 - 376

COILS
Coil (Coil)
G3DSA:1.10.15...

886 - 973

GENE3D
G3DSA:1.10.150.20 (G3DSA:1.10.150.20)
cd09868 (PIN_XPG)

1 - 130

CDD
cd09868 (PIN_XPG)

785 - 1,028

CDD
cd09868 (PIN_XPG)
cd09904 (H3TH_XPG)

888 - 988

CDD
cd09904 (H3TH_XPG)
mobidb-lite (disord...)

748 - 770

MobiDB Lite
mobidb-lite (disorder_prediction)

1,055 - 1,151

MobiDB Lite
mobidb-lite (disorder_prediction)

366 - 594

MobiDB Lite
mobidb-lite (disorder_prediction)

639 - 713

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

metal binding site...

30D

metal binding site 1
30D, 77D
CDD
cd09868 (PIN_XPG)

77D

metal binding site 1
30D, 77D
CDD
cd09868 (PIN_XPG)
active site cd09868

30D

active site
30D, 77D
CDD
cd09868 (PIN_XPG)

77D

active site
30D, 77D
CDD
cd09868 (PIN_XPG)
putative 5' ssDNA ...

82I

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

83L

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

84K

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

85R

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

86N

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

87T

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

88I

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

89L

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

90N

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

91R

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

92K

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

93E

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

94R

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

95R

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

96K

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

97V

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

98R

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

99K

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

100E

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

101T

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

102A

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

103S

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

104S

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

105I

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

106A

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

107A

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

108K

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

109I

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

110L

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

111T

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

112L

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

113Q

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

114L

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

119A

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

120E

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

121Q

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

122V

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

123K

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

124K

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

125K

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

126K

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

127N

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

128A

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

129A

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)

130E

putative 5' ssDNA interaction site
82I, 83L, 84K, 85R, 86N, 87T, 88I, 89L, 90N, 91R, 92K, 93E, 94R, 95R, 96K, 97V, 98R, 99K, 100E, 101T, 102A, 103S, 104S, 105I, 106A, 107A, 108K, 109I, 110L, 111T, 112L, 113Q, 114L, 119A, 120E, 121Q, 122V, 123K, 124K, 125K, 126K, 127N, 128A, 129A, 130E
CDD
cd09868 (PIN_XPG)
putative 5' ssDNA ...

789Q

putative 5' ssDNA interaction site
789Q, 790Q, 791A, 792H, 793K, 794G, 795M, 796R, 797D, 798A, 799D, 800E, 801V, 802T, 803P
CDD
cd09868 (PIN_XPG)

790Q

putative 5' ssDNA interaction site
789Q, 790Q, 791A, 792H, 793K, 794G, 795M, 796R, 797D, 798A, 799D, 800E, 801V, 802T, 803P
CDD
cd09868 (PIN_XPG)

791A

putative 5' ssDNA interaction site
789Q, 790Q, 791A, 792H, 793K, 794G, 795M, 796R, 797D, 798A, 799D, 800E, 801V, 802T, 803P
CDD
cd09868 (PIN_XPG)

792H

putative 5' ssDNA interaction site
789Q, 790Q, 791A, 792H, 793K, 794G, 795M, 796R, 797D, 798A, 799D, 800E, 801V, 802T, 803P
CDD
cd09868 (PIN_XPG)

793K

putative 5' ssDNA interaction site
789Q, 790Q, 791A, 792H, 793K, 794G, 795M, 796R, 797D, 798A, 799D, 800E, 801V, 802T, 803P
CDD
cd09868 (PIN_XPG)

794G

putative 5' ssDNA interaction site
789Q, 790Q, 791A, 792H, 793K, 794G, 795M, 796R, 797D, 798A, 799D, 800E, 801V, 802T, 803P
CDD
cd09868 (PIN_XPG)

795M

putative 5' ssDNA interaction site
789Q, 790Q, 791A, 792H, 793K, 794G, 795M, 796R, 797D, 798A, 799D, 800E, 801V, 802T, 803P
CDD
cd09868 (PIN_XPG)

796R

putative 5' ssDNA interaction site
789Q, 790Q, 791A, 792H, 793K, 794G, 795M, 796R, 797D, 798A, 799D, 800E, 801V, 802T, 803P
CDD
cd09868 (PIN_XPG)

797D

putative 5' ssDNA interaction site
789Q, 790Q, 791A, 792H, 793K, 794G, 795M, 796R, 797D, 798A, 799D, 800E, 801V, 802T, 803P
CDD
cd09868 (PIN_XPG)

798A

putative 5' ssDNA interaction site
789Q, 790Q, 791A, 792H, 793K, 794G, 795M, 796R, 797D, 798A, 799D, 800E, 801V, 802T, 803P
CDD
cd09868 (PIN_XPG)

799D

putative 5' ssDNA interaction site
789Q, 790Q, 791A, 792H, 793K, 794G, 795M, 796R, 797D, 798A, 799D, 800E, 801V, 802T, 803P
CDD
cd09868 (PIN_XPG)

800E

putative 5' ssDNA interaction site
789Q, 790Q, 791A, 792H, 793K, 794G, 795M, 796R, 797D, 798A, 799D, 800E, 801V, 802T, 803P
CDD
cd09868 (PIN_XPG)

801V

putative 5' ssDNA interaction site
789Q, 790Q, 791A, 792H, 793K, 794G, 795M, 796R, 797D, 798A, 799D, 800E, 801V, 802T, 803P
CDD
cd09868 (PIN_XPG)

802T

putative 5' ssDNA interaction site
789Q, 790Q, 791A, 792H, 793K, 794G, 795M, 796R, 797D, 798A, 799D, 800E, 801V, 802T, 803P
CDD
cd09868 (PIN_XPG)

803P

putative 5' ssDNA interaction site
789Q, 790Q, 791A, 792H, 793K, 794G, 795M, 796R, 797D, 798A, 799D, 800E, 801V, 802T, 803P
CDD
cd09868 (PIN_XPG)
metal binding site...

826E

metal binding site 1
826E, 828E
CDD
cd09868 (PIN_XPG)

828E

metal binding site 1
826E, 828E
CDD
cd09868 (PIN_XPG)
active site cd09868

826E

active site
826E, 828E, 847D, 849D
CDD
cd09868 (PIN_XPG)

828E

active site
826E, 828E, 847D, 849D
CDD
cd09868 (PIN_XPG)

847D

active site
826E, 828E, 847D, 849D
CDD
cd09868 (PIN_XPG)

849D

active site
826E, 828E, 847D, 849D
CDD
cd09868 (PIN_XPG)
metal binding site...

847D

metal binding site 2
847D, 849D
CDD
cd09868 (PIN_XPG)

849D

metal binding site 2
847D, 849D
CDD
cd09868 (PIN_XPG)
putative DNA bindi...

896L

putative DNA binding site
896L, 897G, 898S, 899D, 900Y, 901T, 903G, 904V, 905T, 906G, 907V, 908G, 910V, 911T, 912A, 913M
CDD
cd09904 (H3TH_XPG)

897G

putative DNA binding site
896L, 897G, 898S, 899D, 900Y, 901T, 903G, 904V, 905T, 906G, 907V, 908G, 910V, 911T, 912A, 913M
CDD
cd09904 (H3TH_XPG)

898S

putative DNA binding site
896L, 897G, 898S, 899D, 900Y, 901T, 903G, 904V, 905T, 906G, 907V, 908G, 910V, 911T, 912A, 913M
CDD
cd09904 (H3TH_XPG)

899D

putative DNA binding site
896L, 897G, 898S, 899D, 900Y, 901T, 903G, 904V, 905T, 906G, 907V, 908G, 910V, 911T, 912A, 913M
CDD
cd09904 (H3TH_XPG)

900Y

putative DNA binding site
896L, 897G, 898S, 899D, 900Y, 901T, 903G, 904V, 905T, 906G, 907V, 908G, 910V, 911T, 912A, 913M
CDD
cd09904 (H3TH_XPG)

901T

putative DNA binding site
896L, 897G, 898S, 899D, 900Y, 901T, 903G, 904V, 905T, 906G, 907V, 908G, 910V, 911T, 912A, 913M
CDD
cd09904 (H3TH_XPG)

903G

putative DNA binding site
896L, 897G, 898S, 899D, 900Y, 901T, 903G, 904V, 905T, 906G, 907V, 908G, 910V, 911T, 912A, 913M
CDD
cd09904 (H3TH_XPG)

904V

putative DNA binding site
896L, 897G, 898S, 899D, 900Y, 901T, 903G, 904V, 905T, 906G, 907V, 908G, 910V, 911T, 912A, 913M
CDD
cd09904 (H3TH_XPG)

905T

putative DNA binding site
896L, 897G, 898S, 899D, 900Y, 901T, 903G, 904V, 905T, 906G, 907V, 908G, 910V, 911T, 912A, 913M
CDD
cd09904 (H3TH_XPG)

906G

putative DNA binding site
896L, 897G, 898S, 899D, 900Y, 901T, 903G, 904V, 905T, 906G, 907V, 908G, 910V, 911T, 912A, 913M
CDD
cd09904 (H3TH_XPG)

907V

putative DNA binding site
896L, 897G, 898S, 899D, 900Y, 901T, 903G, 904V, 905T, 906G, 907V, 908G, 910V, 911T, 912A, 913M
CDD
cd09904 (H3TH_XPG)

908G

putative DNA binding site
896L, 897G, 898S, 899D, 900Y, 901T, 903G, 904V, 905T, 906G, 907V, 908G, 910V, 911T, 912A, 913M
CDD
cd09904 (H3TH_XPG)

910V

putative DNA binding site
896L, 897G, 898S, 899D, 900Y, 901T, 903G, 904V, 905T, 906G, 907V, 908G, 910V, 911T, 912A, 913M
CDD
cd09904 (H3TH_XPG)

911T

putative DNA binding site
896L, 897G, 898S, 899D, 900Y, 901T, 903G, 904V, 905T, 906G, 907V, 908G, 910V, 911T, 912A, 913M
CDD
cd09904 (H3TH_XPG)

912A

putative DNA binding site
896L, 897G, 898S, 899D, 900Y, 901T, 903G, 904V, 905T, 906G, 907V, 908G, 910V, 911T, 912A, 913M
CDD
cd09904 (H3TH_XPG)

913M

putative DNA binding site
896L, 897G, 898S, 899D, 900Y, 901T, 903G, 904V, 905T, 906G, 907V, 908G, 910V, 911T, 912A, 913M
CDD
cd09904 (H3TH_XPG)
putative metal bin...

899D

putative metal binding site
899D
CDD
cd09904 (H3TH_XPG)

Protein sequence

>MIA_06080_1
MGVRGLWEIVAPAARPVNLENISGYRLAIDASIWIYHFLKAMRDSQGKVLRYAHVVGFFRRICKLIFFGIKPVFVFDGGA
PILKRNTILNRKERRKVRKETASSIAAKILTLQLHKHAAEQVKKKKNAAERVVSYLQLSDDDDSSDHEDSREIAYLDEVS
VDKDKRTNVFKVKPADISQNTTHDPYFLPEIDEEAINNNVHNDPRLLSHEDVEEYANHVQTKLQSGEYDQEEIDYESPAF
KALPLATQYQIISRARLRSRLRMGLTVDQLETQFPDRLAFSKFQINRVKQRNYLTQKLMNMANADGPDVAQTGVKTHVGR
IASNRGREYVLQKSENGWTLALENEDIKSNIIKIDVDDTEIHDDELKRKAAKEEEESDDDEDVEWEDVDVSKSPASAMTV
SEANPDYMSQLPESLSGFETALQREKLYESLREKAQQGNDPKSAAPKTKPKSEKAFILEDESGDEEQPTQSEPPKPERPE
AALEKPRTQEKPETNTGLGQKLSFSKSLFARAAKSSASDATLNTSASAKAPETESEKKKEDTYVPPWFSSDTIAGLTKTK
TSSSQEKASIIPSSPENDNDEDEDEDNDELVSYSTVLKRRQRQLYQEESPEINEVVGFDEESSEADEFDDSVQIINPEEF
NKPKDTFVSTTAPSATTPVTVGEANGRDSHVGKQSLGEAVKPAEELAGSNKVSPTKRPTDEEIFKPTNYSKEHEEELARM
EEEYGEQEDEELMEQLEKEIEETHRFTESFKTQPAPQAAMAGFPTTNTTDPIELQSIESYDDEISALRQQAHKGMRDADE
VTPEMVEECQELLRRFGIPFITAPMEAEAQCATLMTMGLVDGIVTDDSDCFLFGGTKVFKNMFSQGDKYVECYDAEDIKR
EFGLDQHKLIELAYLLGSDYTDGVTGVGPVTAMEILANFDTADGLIRFRDWWKDVQLKGADKGKSVVEGARPETEFERKF
KRNAAKIFLSEDFPLKEVEQAYLHPEVDTDSTPFKWGVPDLDALRTFLLRRVGWPEAKTDELLVPVIKAMNKKLTEASTR
QTLLKDFFLDIGGGSSNIRSNGTTKSGAAAPGRSSRMTKAITAMSGRMRRREEADLESSSDEEKEQGAKGSDRSTEKVPS
GNRTKKPKKNNTSKPVSPSKKNPSVSLSKKK

GO term prediction

Biological Process

GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair

Molecular Function

GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0016788 hydrolase activity, acting on ester bonds

Cellular Component

GO:0005634 nucleus

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Entry type

Status

Per-residue features