Protein

MIA_06073_1

Length
191 amino acids


Browser: contig10:150944-151581+

Protein function

EGGNOG:0PHSVPUP3The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity)
SGD closest match:S000000896PUP3Proteasome subunit beta type-3
CGD closest match:CAL0000180706PUP3Proteasome core particle subunit beta 3

Protein alignments

%idAln lengthE-value
MCA_00865_189.005%1911.81e-119MCA_00865_1
A0A0J9X3P5_GEOCN86.458%1923.76e-116Similar to Saccharomyces cerevisiae YER094C PUP3 Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism OS=Geotrichum candidum GN=BN980_GECA01s11351g PE=4 SV=1
A0A167CM50_9ASCO82.199%1911.89e-112Proteasome core particle subunit beta 3 OS=Sugiyamaella lignohabitans GN=PUP3 PE=4 SV=1
A0A1E3PNM7_9ASCO79.058%1918.24e-108N-terminal nucleophile aminohydrolase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49473 PE=4 SV=1
A0A060T0R0_BLAAD76.963%1911.34e-105ARAD1C10318p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C10318g PE=4 SV=1
PSB3_YEAST76.963%1912.94e-104Proteasome subunit beta type-3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PUP3 PE=1 SV=1
UniRef50_P2545176.963%1917.03e-101Proteasome subunit beta type-3 n=326 Tax=Eukaryota TaxID=2759 RepID=PSB3_YEAST
A0A1D8PRB6_CANAL78.125%1921.27e-102Proteasome core particle subunit beta 3 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PUP3 PE=4 SV=1
Q6C0R7_YARLI77.604%1922.40e-100YALI0F22341p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F22341g PE=4 SV=1
A0A1E4TGV7_9ASCO73.298%1911.59e-100Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_24172 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1035

Protein family membership

Domains and repeats

  1. Domain
1 20 40 60 80 100 120 140 160 180 191

Detailed signature matches

    1. PF00227 (Proteasome)
    1. PS51476 (PROTEASOME...)
    1. cd03759 (proteasome...)
    1. SSF56235 (N-termina...)

Residue annotation

  1. active site cd03759
  2. beta subunit inter...

Protein sequence

>MIA_06073_1
MVGKDCFAIACDLRLGMQSIGVSNNFEKIFNYDNTFLGLTGLATDVISLSEVFRLKTNMYKMREDHPIEPETFANLVSST
LYQKRFGPYFIGPVVAGINSKTGKPFICSFDLIGCIDFSKDFAVSGTASDQLFGMCESLWEPDLEPEELFEVISQALLNA
VDRDALSGWGAVVYVVTKDKVVKRLLKTRQD

GO term prediction

Biological Process

GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051603 proteolysis involved in cellular protein catabolic process

Molecular Function

GO:0004298 threonine-type endopeptidase activity

Cellular Component

GO:0005839 proteasome core complex
GO:0019774 proteasome core complex, beta-subunit complex