Protein

MIA_06020_1

Length
765 amino acids

Browser: contig10:16311-18609-

Protein function

EGGNOG:0PGJMSIS2Component of the phosphopantothenoylcysteine decarboxylase (PPCDC) involved in the coenzyme A synthesis. Acts as an inhibitory subunit of protein phosphatase PPZ1, which is involved in many cellular processes such as G1-S transition or salt tolerance
SGD closest match:S000001780SIS2Phosphopantothenoylcysteine decarboxylase subunit SIS2
CGD closest match:CAL0000188367orf19.7378Phosphopantothenoylcysteine decarboxylase complex subunit

Protein alignments

%idAln lengthE-value
MCA_05211_191.549%2135.85e-139MCA_05211_1
A0A0J9XCS5_GEOCN84.951%2063.97e-126Similar to Saccharomyces cerevisiae YKR072C SIS2 Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase OS=Geotrichum candidum GN=BN980_GECA09s03640g PE=4 SV=1
UniRef50_A0A0J9XCS584.951%2068.13e-123Similar to Saccharomyces cerevisiae YKR072C SIS2 Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase n=2 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XCS5_GEOCN
A0A1E3PJQ1_9ASCO81.095%2011.21e-116Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_46315 PE=4 SV=1
Q6CCV1_YARLI78.500%2003.33e-115YALI0C06281p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C06281g PE=4 SV=1
A0A167BY42_9ASCO78.109%2014.46e-105Phosphopantothenoylcysteine decarboxylase complex subunit SIS2 OS=Sugiyamaella lignohabitans GN=SIS2 PE=4 SV=1
A0A060TD17_BLAAD73.134%2019.91e-106ARAD1D44132p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D44132g PE=4 SV=1
A0A1D8PKD2_CANAL66.019%2068.28e-96Phosphopantothenoylcysteine decarboxylase complex subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.7378 PE=4 SV=1
SIS2_YEAST53.975%2396.17e-86Phosphopantothenoylcysteine decarboxylase subunit SIS2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SIS2 PE=1 SV=1
A0A1E4TCV6_9ASCO50.667%2251.15e-71Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_4202 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0062

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 765

Detailed signature matches

  1. Domain IPR003382
    Flavoprotein
    1. SSF52507 (Homo-olig...)
    2. PF02441 (Flavoprotein)
    3. G3DSA:3.40.50...
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. mobidb-lite (disord...)

Protein sequence

>MIA_06020_1
MPESPVSGPVPASILSTGHTSTLQPSNSPSTTSPSQKPPSSSPTPSLSTHPLPPPSILSFSEKSQNGEPVSAPSAHPTAS
SSIDSSSPSPVPLTNPTTTVTAPSPPTTATSSLNRHNSTHVSNHPPFAAQPAPVSTPISEEDAQKEASKLTEKISKVKGK
VLVPPTAIPAIKPSPSLLAKSPPIIPFNPSHSTLPTPEPVETRPVVPLVSSSINVSGVSTAAPAVPKSALAGAVASSSTQ
STQFSSTTLPHTSNNDNDNTSNNSINTPPQIIPSDTELSPAVSPSTVHLKQPSIHAHFLLEEVMGHIPRSRSGSGSGSVS
SVAGGILQPTQQQPTSSSSSPSIKQPSQIDHPKSPDLPITPPVVAVPSAATNTVPPSPHNHSTPVAFSEPISPRSDAHPI
TSTLPVPASPEPHLAAAALAASTPTPGAATTTTDVSGSSGSTSKQTVPAGTTDLPTDPRLPQDDGKLHILLAATGSISTG
KLRLIISKLNDIYGSSRASVQIILTKAAENFVSRGEIPSYVRIWRDQDEWATWTTRSDPVVHIELRRWADILVIAPLSAN
TLGKIALGLCDNLLTNVVRAWNTQYPILIAPAMVPYAYNNPATKRHLQVIKDEMPWIEVLKPVEKVVGSYGDIGMGGMMD
WNEIVNRIVLKLGGYPEDDDDDEDNDNDDDDDDDDDDDDDDDDDGAQGSTRSGSVTSSNVNVSTTSISTNTGTTRKSSNT
SSNQDQTKRKEFENSSFDDDDIDVVLNKLTLADRENLSALKRHPR

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003824 catalytic activity

Cellular Component

None predicted.