MIA_05969_1

Protein

Length

969 amino acids

Protein function

EGGNOG:	0PH5D	FG00327.1	replication factor C subunit
SGD closest match:	S000005743	RFC1	Replication factor C subunit 1
CGD closest match:	CAL0000180025	RFC1	Replication factor C subunit 1

Protein alignments

	%id	Aln length
MCA_02363_1	65.503%	745	MCA_02363_1
A0A0J9X700_GEOCN	59.184%	735	Similar to Saccharomyces cerevisiae YOR217W RFC1 Subunit of heteropentameric Replication factor C (RF-C) OS=Geotrichum candidum GN=BN980_GECA04s01946g PE=4 SV=1
A0A060T2G1_BLAAD	55.941%	749	ARAD1C24992p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C24992g PE=4 SV=1
A0A170QZK8_9ASCO	53.824%	693	Replication factor C subunit 1 OS=Sugiyamaella lignohabitans GN=RFC1 PE=4 SV=1
UniRef50_A0A170QZK8	53.824%	693	Replication factor C subunit 1 n=1 Tax=Sugiyamaella lignohabitans TaxID=796027 RepID=A0A170QZK8_9ASCO
A0A1E3PH46_9ASCO	55.015%	658	DNA replication factor C, large subunit OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_26640 PE=4 SV=1
Q6CEB7_YARLI	54.082%	686	YALI0B16918p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B16918g PE=4 SV=1
RFC1_YEAST	52.135%	679	Replication factor C subunit 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RFC1 PE=1 SV=1
A0A1E4TEA6_9ASCO	46.821%	692	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_43772 PE=4 SV=1
A0A1D8PHI0_CANAL	47.536%	690	Replication factor C subunit 1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=RFC1 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0188

Protein family membership

Replication factor C subunit 1 (IPR012178)

Domains and repeats

Domain
175 - 330
BRCT domain (IPR001357)
383 - 622
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
AAA+ ATPase domain (IPR003593)
708 - 862
DNA replication factor RFC1, C-terminal (IPR013725)
Domain
436 - 521
ATPase, AAA-type, core (IPR003959)
637 - 780
DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal (IPR008921)

1 100 200 300 400 500 600 700 800 900 969

Detailed signature matches

IPR012178

Replication factor C subunit 1
1. PIRSF036578 (RFC1)
  
  1 - 958
  
  PIRSF
  PIRSF036578 (RFC1)
IPR001357

BRCT domain
1. cd00027 (BRCT)
  
  257 - 328
  
  CDD
  cd00027 (BRCT)
2. SSF52113 (BRCT domain)
  
  251 - 328
  
  SUPERFAMILY
  SSF52113 (BRCT domain)
3. SM00292 (BRCT_7)
  
  252 - 330
  
  SMART
  SM00292 (BRCT_7)
4. G3DSA:3.40.50...
  
  175 - 330
  
  GENE3D
  G3DSA:3.40.50.10190 (G3DSA:3.40.50.10190)
5. PF00533 (BRCT)
  
  252 - 327
  
  Pfam
  PF00533 (BRCT)
6. PS50172 (BRCT)
  
  250 - 328
  
  PROSITE profiles
  PS50172 (BRCT)
IPR027417

P-loop containing nucleoside triphosphate hydrolase
1. SSF52540 (P-loop co...)
  
  383 - 622
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
IPR003593

AAA+ ATPase domain
1. SM00382 (AAA_5)
  
  432 - 567
  
  SMART
  SM00382 (AAA_5)
IPR003959

ATPase, AAA-type, core
1. PF00004 (AAA)
  
  436 - 521
  
  Pfam
  PF00004 (AAA)
IPR008921

DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal
1. SSF48019 (post-AAA+...)
  
  637 - 780
  
  SUPERFAMILY
  SSF48019 (post-AAA+ oligomerization domain-like)
IPR013725

DNA replication factor RFC1, C-terminal
1. PF08519 (RFC1)
  
  708 - 862
  
  Pfam
  PF08519 (RFC1)

no IPR

Unintegrated signatures

Coil

344 - 375

COILS
Coil (Coil)
G3DSA:1.10.8.60

566 - 637

GENE3D
G3DSA:1.10.8.60 (G3DSA:1.10.8.60)
G3DSA:1.20.27...

639 - 753

GENE3D
G3DSA:1.20.272.10 (G3DSA:1.20.272.10)
G3DSA:3.40.50...

382 - 563

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
cd00009 (AAA)

430 - 564

CDD
cd00009 (AAA)
mobidb-lite (disord...)

889 - 969

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 205

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

Dimer interface cd...

272E

Dimer interface
272E, 276S, 279T, 282K, 284T
CDD
cd00027 (BRCT)

276S

Dimer interface
272E, 276S, 279T, 282K, 284T
CDD
cd00027 (BRCT)

279T

Dimer interface
272E, 276S, 279T, 282K, 284T
CDD
cd00027 (BRCT)

282K

Dimer interface
272E, 276S, 279T, 282K, 284T
CDD
cd00027 (BRCT)

284T

Dimer interface
272E, 276S, 279T, 282K, 284T
CDD
cd00027 (BRCT)
BRCT sequence moti...

322G

BRCT sequence motif
322G, 326L
CDD
cd00027 (BRCT)

326L

BRCT sequence motif
322G, 326L
CDD
cd00027 (BRCT)
Walker A motif cd0...

440G

Walker A motif
440G, 441P, 442P, 443G, 444I, 445G, 446K, 447T
CDD
cd00009 (AAA)

441P

Walker A motif
440G, 441P, 442P, 443G, 444I, 445G, 446K, 447T
CDD
cd00009 (AAA)

442P

Walker A motif
440G, 441P, 442P, 443G, 444I, 445G, 446K, 447T
CDD
cd00009 (AAA)

443G

Walker A motif
440G, 441P, 442P, 443G, 444I, 445G, 446K, 447T
CDD
cd00009 (AAA)

444I

Walker A motif
440G, 441P, 442P, 443G, 444I, 445G, 446K, 447T
CDD
cd00009 (AAA)

445G

Walker A motif
440G, 441P, 442P, 443G, 444I, 445G, 446K, 447T
CDD
cd00009 (AAA)

446K

Walker A motif
440G, 441P, 442P, 443G, 444I, 445G, 446K, 447T
CDD
cd00009 (AAA)

447T

Walker A motif
440G, 441P, 442P, 443G, 444I, 445G, 446K, 447T
CDD
cd00009 (AAA)
ATP binding site c...

441P

ATP binding site
441P, 442P, 443G, 444I, 445G, 446K, 447T, 448T, 512D, 544N
CDD
cd00009 (AAA)

442P

ATP binding site
441P, 442P, 443G, 444I, 445G, 446K, 447T, 448T, 512D, 544N
CDD
cd00009 (AAA)

443G

ATP binding site
441P, 442P, 443G, 444I, 445G, 446K, 447T, 448T, 512D, 544N
CDD
cd00009 (AAA)

444I

ATP binding site
441P, 442P, 443G, 444I, 445G, 446K, 447T, 448T, 512D, 544N
CDD
cd00009 (AAA)

445G

ATP binding site
441P, 442P, 443G, 444I, 445G, 446K, 447T, 448T, 512D, 544N
CDD
cd00009 (AAA)

446K

ATP binding site
441P, 442P, 443G, 444I, 445G, 446K, 447T, 448T, 512D, 544N
CDD
cd00009 (AAA)

447T

ATP binding site
441P, 442P, 443G, 444I, 445G, 446K, 447T, 448T, 512D, 544N
CDD
cd00009 (AAA)

448T

ATP binding site
441P, 442P, 443G, 444I, 445G, 446K, 447T, 448T, 512D, 544N
CDD
cd00009 (AAA)

512D

ATP binding site
441P, 442P, 443G, 444I, 445G, 446K, 447T, 448T, 512D, 544N
CDD
cd00009 (AAA)

544N

ATP binding site
441P, 442P, 443G, 444I, 445G, 446K, 447T, 448T, 512D, 544N
CDD
cd00009 (AAA)
Walker B motif cd0...

508V

Walker B motif
508V, 509L, 510I, 511M, 512D, 513E
CDD
cd00009 (AAA)

509L

Walker B motif
508V, 509L, 510I, 511M, 512D, 513E
CDD
cd00009 (AAA)

510I

Walker B motif
508V, 509L, 510I, 511M, 512D, 513E
CDD
cd00009 (AAA)

511M

Walker B motif
508V, 509L, 510I, 511M, 512D, 513E
CDD
cd00009 (AAA)

512D

Walker B motif
508V, 509L, 510I, 511M, 512D, 513E
CDD
cd00009 (AAA)

513E

Walker B motif
508V, 509L, 510I, 511M, 512D, 513E
CDD
cd00009 (AAA)
arginine finger cd...

556R

arginine finger
556R
CDD
cd00009 (AAA)

Protein sequence

>MIA_05969_1
MSDLRKYFAVKPKKETKTAVAPKKTSKRRIIESDDEDDTEPVDEVKAKKPEPKKQKQEESVEVSDYFSQHSARKTRSATA
QAKPQPEKPAPKKTASTKPIEVSDDDFDDSIDIDEVFKDSRPTPKPAPKPVAKPAPKPASRPTSKRNTAENEDYEIEEVV
PAKVQLAKRASRASSVRAPTASSSAKATVKKTTHAKDQPPPAGKTAEEVLAKIPNATLPEVDEEKKFSFHDFKARGDQPV
LESDIQIPEARPACLTGLKILFTGVLPHLTREQCVSIVTKYKGTVVSSISSRTSVVVLGVDAGPSKIKKIKTIGTKVIDE
DGFLQLLRDMPAAGGSGELAQKMMLKQKQEEQKINDAAESLKKEMAERYKTASNDETGGVNNELWTTKYAPTKMSEIIGN
PGAVRKLQAWLANWKKNYKSGFKKPGPDGSGVYRAVIIHGPPGIGKTTAAHLVAKTMGFDVLENNASDTRSKGQLSEQVT
SILTNTSIVGYFGTKADPHAHKKKKNLVLIMDEVDGMSAGDRGGVGQMAALCRITHVPIILICNERTLPKMRPFDRVTFD
IPFRRPDANAARVRLMSIAKQENLKMEGGVIEQLVASTHADIRQIINIMSTYARTRSSLNVDESVDLSKASEKHTILKPF
DILARFFSPGTFSANSRMTLNDKIELYFHDHDFTPLMVQENYLNTIPVSAGNDRIKHLEAVVNASESISDGDLVDARIHS
SEQLWSLMPLHAVMSSVRPSSFVCGQGRSRYNFTSYLGNNSKRGKYDRLLQEIHAHMRLKISGDQEEVREDYMPLLTMLL
LKPLMKKGIEGVEQVIEVMDDYYLTKEDWDVIMELGVGDHRAEEYVKKLPTAVKSGFTRKYNGMNHPVPFMKSASSVKVG
VGAGPAVVPDLEETLGEEVAVDDGEGEDEKKKEEEEEGDLTKDKYIKVGKPKKAAAKKAGAGTKKRAATTSSASGSTKTS
RGTKRASTK

GO term prediction

Biological Process

GO:0006260 DNA replication
GO:0006281 DNA repair

Molecular Function

GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0005524 ATP binding

Cellular Component

GO:0005663 DNA replication factor C complex

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Entry type

Status

Per-residue features