Protein

MCA_02363_1

Length
1,035 amino acids

Gene name: RFC1

Description: Replication factor C subunit 1

Browser: contigB:1060942-1064328-

RNA-seq: read pairs 1449, FPKM 17.3, percentile rank 37.4% (100% = highest expression)

Protein function

Annotation:RFC1Replication factor C subunit 1
KEGG:K10754RFC1 replication factor C subunit 1
EGGNOG:0PH5DFG00327.1replication factor C subunit
SGD closest match:S000005743RFC1Replication factor C subunit 1
CGD closest match:CAL0000180025RFC1Replication factor C subunit 1

Protein alignments

%idAln lengthE-value
MIA_05969_166.29%7030.0MIA_05969_1
A0A0J9X700_GEOCN60.29%7680.0Similar to Saccharomyces cerevisiae YOR217W RFC1 Subunit of heteropentameric Replication factor C (RF-C) OS=Geotrichum candidum GN=BN980_GECA04s01946g PE=4 SV=1
A0A060T2G1_BLAAD58.53%7500.0ARAD1C24992p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C24992g PE=4 SV=1
A0A170QZK8_9ASCO55.77%7190.0Replication factor C subunit 1 OS=Sugiyamaella lignohabitans GN=RFC1 PE=4 SV=1
UniRef50_A0A170QZK855.77%7190.0Replication factor C subunit 1 n=1 Tax=Sugiyamaella lignohabitans TaxID=796027 RepID=A0A170QZK8_9ASCO
A0A1E3PH46_9ASCO55.79%6740.0DNA replication factor C, large subunit OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_26640 PE=4 SV=1
Q6CEB7_YARLI55.95%6810.0YALI0B16918p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B16918g PE=4 SV=1
RFC1_YEAST49.49%6810.0Replication factor C subunit 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RFC1 PE=1 SV=1
A0A1E4TEA6_9ASCO49.93%6670.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_43772 PE=4 SV=1
A0A1D8PHI0_CANAL49.08%4912e-147Replication factor C subunit 1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=RFC1 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.8745
Predicted cleavage: 45

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 700 800 900 1035

Detailed signature matches

  1. Family IPR012178
    Replication factor C subunit 1
    1. PIRSF036578 (RFC1)
  2. Domain IPR001357
    BRCT domain
    1. SSF52113 (BRCT domain)
    2. cd00027 (BRCT)
    3. SM00292 (BRCT_7)
    4. G3DSA:3.40.50...
    5. PF00533 (BRCT)
    6. PS50172 (BRCT)
  3. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  4. Domain IPR003593
    AAA+ ATPase domain
    1. SM00382 (AAA_5)
  5. Domain IPR003959
    ATPase, AAA-type, core
    1. PF00004 (AAA)
  6. Domain IPR008921
    DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal
    1. SSF48019 (post-AAA+...)
  7. Domain IPR013725
    DNA replication factor RFC1, C-terminal
    1. PF08519 (RFC1)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:1.10.8.60
  3. G3DSA:1.20.27...
  4. G3DSA:3.40.50...
  5. cd00009 (AAA)
  6. mobidb-lite (disord...)

Residue annotation

  1. Dimer interface cd...
  2. BRCT sequence moti...
  3. Walker A motif cd0...
  4. ATP binding site c...
  5. Walker B motif cd0...

Protein sequence

>MCA_02363_1
MADIRNFFGAKPAGKKSEPTKKTTKPVSKKVSKKRVIGSDDEEEEEDVKPTPSKHQAKKIKSEPSEEPTEVSSYFSSFNS
DEKDEKDNKPSKSTKAEPSKPVKKEPAADKKPATRASRSASRSRKAKKIQDDDEEEYKEEDNEEPEESDDEIVKPGKKSI
KKEEDEDDGFDDDIEEIVKPAKSRRKVINEEEEDDGFDDDEIEVVSTRSKRKAPTKTTKSVPVKKLVTKDLAEPTKPKSQ
PKPAAPKSKPDTKKSASAAPAGGSTAQDILRSIPDAILPDVDPSKPINFHALMASRLPDDQPGLSDDIEIPVAQENCLAG
LKIIFTGTMPHLSRERASGIVKQYGGEVVKSLSGRTSLVVIGADAGPAKIKKIKSLGTKTIDEDGFLQLLRDMPASGGSG
EVAQKAMLKKQEEEKKIEQAAREMQQNNKKDKQKTSSSKGKVVKEEQEQEQVDDELWTTKYAPKKLSDIIGNAGAVKKLS
SWLANWQKNYKTGFKKPGPDGSGIYRAVIIHGPPGIGKTTAAHLVAELQGYDVIENNASDTRSKNLLAENVTGTLSNTSI
SGFFGTDHDPVIHKQKKNIVMIMDEVDGMSGGDRGGVGQMAALCRTTNIPIILVCNERTLPKMRPFDRVTYDIPFRRPDA
NAARVRIMSIARSEGLNLEPGVVDQLVASTHADIRQILNMLSTFATTHKNLSNEKTVDMSKQWEKEVVLKPFDIVGRFFS
GATFSPNSKMTMNDKIELYFNDHDFTPLMIQENYLNTLPARTGDNRVAHLDAVVKAAESISDGDLVDSKIHGSQQQWSLM
PLHAVVSSIRPAFYVAGQGRTRFNFTSYLGNNSKKGKYDRLLQEIHAHARLRISGDRQEVRQDYMPLLTTKLLKPLVEEG
ADGVSEIIKVMDEYYLTKEDWDVIMELGVGSNKPEDVLKSVPTAVKSGFTRKYNTTSHPVPFMKSASSLSAKATASVSQE
IPDLPEALGEEIEPSPEDTEENGVDEDEDVGKDKYIKVGKPKTKRAAKRGPASTGDIKETKTPRKRATTSRSKTK

GO term prediction

Biological Process

GO:0006260 DNA replication
GO:0006281 DNA repair

Molecular Function

GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0005524 ATP binding

Cellular Component

GO:0005663 DNA replication factor C complex