MIA_05931_1

Protein

Length

514 amino acids

Protein function

EGGNOG:	0QDYJ	FG02865.1	resistance protein
SGD closest match:	S000000212	FLR1	Fluconazole resistance protein 1
CGD closest match:	CAL0000173998	MDR1	Multidrug resistance protein 1

Protein alignments

	%id	Aln length	E-value
MCA_04025_1	57.328%	464	0.0	MCA_04025_1
A0A0J9XL11_GEOCN	49.565%	575	0.0	Similar to Saccharomyces cerevisiae YBR008C FLR1 Plasma membrane multidrug transporter of the major facilitator superfamily OS=Geotrichum candidum GN=BN980_GECA27s00021g PE=4 SV=1
UniRef50_A0A0J9X5S8	53.144%	493	4.29e-178	Similar to Saccharomyces cerevisiae YBR008C FLR1 Plasma membrane multidrug transporter of the major facilitator superfamily n=3 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X5S8_GEOCN
A0A1E3PJA3_9ASCO	42.781%	561	1.43e-150	SCR1 protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47140 PE=4 SV=1
A0A060T943_BLAAD	40.489%	573	4.70e-147	ARAD1D12672p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D12672g PE=4 SV=1
MDR1_CANAL	39.714%	559	4.75e-137	Multidrug resistance protein 1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MDR1 PE=1 SV=2
Q6C0D8_YARLI	38.113%	551	8.84e-131	YALI0F25597p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F25597g PE=4 SV=1
A0A167CAG3_9ASCO	41.578%	469	4.19e-119	Flr1p OS=Sugiyamaella lignohabitans GN=FLR1 PE=4 SV=1
FLR1_YEAST	41.372%	481	7.37e-118	Fluconazole resistance protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FLR1 PE=1 SV=1
A0A1E4TIX5_9ASCO	32.068%	474	3.45e-75	Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_14557 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.8849

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
58 - 507
Major facilitator superfamily domain (IPR020846)

1 50 100 150 200 250 300 350 400 450 514

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  80 - 459
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. PS50850 (MFS)
  
  75 - 507
  
  PROSITE profiles
  PS50850 (MFS)
2. SSF103473 (MFS gene...)
  
  58 - 501
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
3. cd06174 (MFS)
  
  76 - 502
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

191 - 201

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

370 - 380

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 73

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

435 - 440

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

503 - 514

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

131 - 141

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

253 - 299

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

67 - 266

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

293 - 511

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

328 - 346

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

464 - 482

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

94 - 112

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

163 - 167

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

228 - 232

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

402 - 412

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

111 - 133

TMHMM
TMhelix (TMhelix)

300 - 322

TMHMM
TMhelix (TMhelix)

167 - 189

TMHMM
TMhelix (TMhelix)

380 - 402

TMHMM
TMhelix (TMhelix)

74 - 96

TMHMM
TMhelix (TMhelix)

412 - 434

TMHMM
TMhelix (TMhelix)

345 - 367

TMHMM
TMhelix (TMhelix)

202 - 224

TMHMM
TMhelix (TMhelix)

441 - 463

TMHMM
TMhelix (TMhelix)

140 - 162

TMHMM
TMhelix (TMhelix)

229 - 251

TMHMM
TMhelix (TMhelix)

478 - 500

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

142 - 162

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

413 - 434

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

233 - 252

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

483 - 502

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

381 - 401

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

300 - 327

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

113 - 130

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

202 - 227

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

441 - 463

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

74 - 93

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

168 - 190

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

347 - 369

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

Residue annotation

putative substrate...

90S

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

93F

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

94V

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

95S

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

97S

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

98T

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

115L

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

118Y

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

119L

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

122F

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

126P

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

127M

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

129L

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

130S

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

178S

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

179A

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

182L

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

183A

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

186G

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

187A

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

190G

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

202I

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

203V

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

206S

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

207A

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

213P

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

320Y

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

323F

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

324N

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

327F

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

328E

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

331P

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

345M

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

349Y

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

353I

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

356G

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

360A

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

420T

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

423A

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

424F

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

427F

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

431F

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

432S

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

435G

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

445V

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

446F

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

449N

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

450A

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

453R

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

454S

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

457A

putative substrate translocation pore
90S, 93F, 94V, 95S, 97S, 98T, 115L, 118Y, 119L, 122F, 126P, 127M, 129L, 130S, 178S, 179A, 182L, 183A, 186G, 187A, 190G, 202I, 203V, 206S, 207A, 213P, 320Y, 323F, 324N, 327F, 328E, 331P, 345M, 349Y, 353I, 356G, 360A, 420T, 423A, 424F, 427F, 431F, 432S, 435G, 445V, 446F, 449N, 450A, 453R, 454S, 457A
CDD
cd06174 (MFS)

Protein sequence

>MIA_05931_1
MTPDILRESVTGFIINKLSGAKFLPFPEEKPDFVVPEMYQVKENDSDEKTILVDWYGPDDPANPKNWSIYKKSWIVFSIS
FLTIVMYMASSIFVSGSTQMMKDLNTTRVKATLPLTTYLLGFGFAPMILSPLSEHAPIGRSIIYVTAVAFFCVIQVPTAL
VHTIEKIIGLRLLAGIASAPSLAIGGATIGDTVSLRHVPYAIVFWSAGAIGGPALGPFIGSLFAALVNWRWNFWFLCIVS
GACLLAYALFLPETSRGTILHRRALRLRKLTGNPLIKSPYEVHEKTTLKKLVIEIFWRPVFLIFCEPIVFCIDFYMAFIY
VIFNSWFEALPISFVEIYHFTTIEMGTVYFAVIVGGYLAAIIYFFIIPRINNSKNPTIEKFLLPAIFGSFFLPIGLFIFS
WSSSPDTHWMGPIMSIGIFTFGAFFIFQSLFSYFGKGFHRYLASVFAGNALLRSTLAAVFPLFTPPMYHNLAIKRFPVAW
GGTIWACVGTILIIIPFFLYKFGVQLRGRSKYAN

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features