MCA_04025_1

Protein

Length

610 amino acids

Gene name: MDR1A

Description: Multidrug resistance protein 1

Browser: contigC:1799067-1800900+

RNA-seq: read pairs 21, FPKM 0.4, percentile rank 6.5% (100% = highest expression)

Protein function

Annotation:		MDR1A	Multidrug resistance protein 1
KEGG:	K08158	MDR1	MFS transporter, DHA1 family, multidrug resistance protein
EGGNOG:	0QDYJ	FG02865.1	resistance protein
SGD closest match:	S000000212	FLR1	Fluconazole resistance protein 1
CGD closest match:	CAL0000173998	MDR1	Multidrug resistance protein 1

Protein alignments

	%id	Aln length	E-value
MIA_05930_1	60.62%	612	0.0	MIA_05930_1
A0A0J9XL11_GEOCN	51.47%	614	0.0	Similar to Saccharomyces cerevisiae YBR008C FLR1 Plasma membrane multidrug transporter of the major facilitator superfamily OS=Geotrichum candidum GN=BN980_GECA27s00021g PE=4 SV=1
UniRef50_A0A0J9X5S8	50.65%	612	0.0	Similar to Saccharomyces cerevisiae YBR008C FLR1 Plasma membrane multidrug transporter of the major facilitator superfamily n=3 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X5S8_GEOCN
A0A1E3PJA3_9ASCO	43.97%	614	4e-162	SCR1 protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47140 PE=4 SV=1
A0A060T943_BLAAD	42.56%	618	3e-152	ARAD1D12672p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D12672g PE=4 SV=1
Q6C0D8_YARLI	39.57%	609	1e-140	YALI0F25597p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F25597g PE=4 SV=1
MDR1_CANAL	46.71%	471	3e-133	Multidrug resistance protein 1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MDR1 PE=1 SV=2
A0A167CAG3_9ASCO	41.60%	524	5e-117	Flr1p OS=Sugiyamaella lignohabitans GN=FLR1 PE=4 SV=1
FLR1_YEAST	39.02%	469	2e-99	Fluconazole resistance protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FLR1 PE=1 SV=1
A0A1E4TIX5_9ASCO	34.39%	471	2e-72	Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_14557 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.6883

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
156 - 603
Major facilitator superfamily domain (IPR020846)

1 100 200 300 400 500 610

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  177 - 557
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. PS50850 (MFS)
  
  173 - 600
  
  PROSITE profiles
  PS50850 (MFS)
2. SSF103473 (MFS gene...)
  
  156 - 603
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
3. cd06174 (MFS)
  
  174 - 594
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

531 - 536

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

289 - 294

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

228 - 238

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

601 - 610

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 170

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

350 - 396

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

463 - 482

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

164 - 365

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

397 - 604

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

260 - 264

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

191 - 209

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

560 - 578

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

424 - 442

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

500 - 504

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

317 - 327

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

509 - 531

TMHMM
TMhelix (TMhelix)

477 - 499

TMHMM
TMhelix (TMhelix)

397 - 419

TMHMM
TMhelix (TMhelix)

575 - 597

TMHMM
TMhelix (TMhelix)

172 - 194

TMHMM
TMhelix (TMhelix)

538 - 560

TMHMM
TMhelix (TMhelix)

442 - 464

TMHMM
TMhelix (TMhelix)

265 - 287

TMHMM
TMhelix (TMhelix)

209 - 231

TMHMM
TMhelix (TMhelix)

240 - 259

TMHMM
TMhelix (TMhelix)

326 - 348

TMHMM
TMhelix (TMhelix)

294 - 316

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

295 - 316

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

171 - 190

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

537 - 559

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

210 - 227

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

505 - 530

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

397 - 423

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

483 - 499

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

328 - 349

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

579 - 600

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

239 - 259

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

443 - 462

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

265 - 288

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
mobidb-lite (disord...)

51 - 85

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative substrate...

188S

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

191Y

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

192T

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

193P

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

195A

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

196A

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

213L

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

216F

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

217V

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

220Y

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

224P

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

225M

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

227L

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

228S

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

276A

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

277S

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

280L

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

281S

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

284G

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

285A

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

288G

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

300L

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

301A

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

303S

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

304I

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

310P

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

416Y

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

419I

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

420N

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

423F

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

424E

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

427P

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

441G

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

445Y

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

449I

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

452G

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

456G

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

516S

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

519G

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

520I

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

523F

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

527F

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

528A

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

531G

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

542Y

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

543A

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

546C

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

549R

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

550S

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

553A

putative substrate translocation pore
188S, 191Y, 192T, 193P, 195A, 196A, 213L, 216F, 217V, 220Y, 224P, 225M, 227L, 228S, 276A, 277S, 280L, 281S, 284G, 285A, 288G, 300L, 301A, 303S, 304I, 310P, 416Y, 419I, 420N, 423F, 424E, 427P, 441G, 445Y, 449I, 452G, 456G, 516S, 519G, 520I, 523F, 527F, 528A, 531G, 542Y, 543A, 546C, 549R, 550S, 553A
CDD
cd06174 (MFS)

Protein sequence

>MCA_04025_1
MASDLIRESAVGFFINKFSKGKILPYTEEKPDFVVPQRYLEDPPLLSRQRSLASSIHSNHQTHQYTTEVESPESKPESFK
GFDSDGTRVESLYHEKSDQSDDEENGLCEKPVAYTTENCENIVELKPYKSQDPLASPDDSRSTDHGQYIVVDWYGPDDKD
NPKNWPAWKKLWTVFAIAFLTVSIYMGSSIYTPGAAQIMSDLNTTRTKAVLPLTMFVIGYGVGPMVLSPLSEHPPLGRTF
LYIINLALFCILQVPIALAKNVETIIGLRFLAGVFASPALSTGGATVGDVLSEHMFVGLLAWSIGAFCGPTFGPLIGGVF
SQLVSWRWTFWFLCCISGFALAILSVFLPETNHATILHRRAARLRKLTGNMAIRSSFEVQEKQTTTELIKDTLWRPIVII
FEPIVTCLNIYSAFIYIVINSWFESLPIVFNEFYKFNLIEGGLVYLAAIVGGLIGGCFYYYTYNRINKSNNPNIEKYLIP
AKIGAFFLPVALFIFSWGTSTETHWMAPVSSLTIFSIGGIFIFQSIFAYLGKGFPRFLASVYAGNCLVRSVSASVFPLFT
HSMYARLAREKFPVALAGTIWACISVLMIAIPFLISHYGVRLRGRSKYAN

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features