Protein

MIA_05881_1

Length
307 amino acids

Browser: contig09:598452-599376+

Protein function

EGGNOG:0PJ2HPGUG_00151Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
SGD closest match:S000005016RNH201Ribonuclease H2 subunit A
CGD closest match:CAL0000175451RNH35Ribonuclease

Protein alignments

%idAln lengthE-value
MCA_03977_162.662%3082.24e-143MCA_03977_1
A0A0J9XBR8_GEOCN58.741%2865.03e-114Ribonuclease OS=Geotrichum candidum GN=BN980_GECA08s03574g PE=3 SV=1
UniRef50_A0A0J9XBR858.741%2861.03e-110Ribonuclease n=4 Tax=Saccharomycetales TaxID=4892 RepID=A0A0J9XBR8_GEOCN
A0A161HNV1_9ASCO55.161%3102.39e-110Ribonuclease OS=Sugiyamaella lignohabitans GN=RNH201 PE=3 SV=1
A0A060TAQ0_BLAAD59.551%2671.16e-105Ribonuclease OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D21494g PE=3 SV=1
A0A1E3PNV6_9ASCO56.204%2742.31e-97Ribonuclease OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49556 PE=3 SV=1
Q6C813_YARLI50.161%3111.62e-95Ribonuclease OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D23661g PE=3 SV=1
Q5AGX6_CANAL47.766%2911.22e-77Ribonuclease OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=RNH35 PE=3 SV=1
A0A1E4TJR8_9ASCO47.148%2632.62e-76Ribonuclease OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_576 PE=3 SV=1
RNH2A_YEAST45.196%2812.83e-65Ribonuclease H2 subunit A OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RNH201 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0525

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 307

Detailed signature matches

  1. Family IPR004649
    Ribonuclease H2, subunit A
    1. TIGR00729
  2. Domain IPR012337
    Ribonuclease H-like domain
    1. SSF53098 (Ribonucle...)
    2. G3DSA:3.30.42...
  3. Domain IPR024567
    Ribonuclease HII/HIII domain
    1. PF01351 (RNase_HII)
  4. Domain IPR023160
    Ribonuclease HII, helix-loop-helix cap domain
    1. G3DSA:1.10.10...
Unintegrated signatures no IPR
Unintegrated signatures
  1. cd07181 (RNase_HII_...)

Residue annotation

  1. active site cd07181
  2. RNA/DNA hybrid bin...
  3. trimer interface c...

Protein sequence

>MIA_05881_1
MVKPNIPQNPFESLTYHEPLVSPEEFAEPCILGVDEAGRGPVIGPMVYACAFCPLSYKDALAKAGYNDSKQLTAATRSNL
LDVVCADPHVSWAVRVMSARDISSGMLRPKASAYNLNSQAHDVTIALIQQTLERGVNVAEIYVDTVGPPASYQDKLSRRF
PGIKVTVAKKADSLYPIVSAASICAKVTRDECLEVHDESGDGSWGSGYPSDPRTVTWLKGSADPLFGYSGQVRFSWSTVK
DLLSSGRDVKWADDYDEEAKKRAKGIDRFFSNDSKEEKEEKRNMKLEELSVSTSWYGKPGGKQDLWM

GO term prediction

Biological Process

GO:0016070 RNA metabolic process

Molecular Function

GO:0003676 nucleic acid binding
GO:0004523 RNA-DNA hybrid ribonuclease activity

Cellular Component

None predicted.