Protein

MCA_03977_1

Length
304 amino acids

Gene name: RNH201

Description: Ribonuclease H2, subunit A

Browser: contigC:1680531-1681446+

RNA-seq: read pairs 479, FPKM 19.4, percentile rank 40.6% (100% = highest expression)

Protein function

Annotation:RNH201Ribonuclease H2, subunit A
KEGG:K10743RNASEH2A ribonuclease H2 subunit A [EC:3.1.26.4]
EGGNOG:0PJ2HPGUG_00151Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
SGD closest match:S000005016RNH201Ribonuclease H2 subunit A
CGD closest match:CAL0000175451RNH35Ribonuclease

Protein alignments

%idAln lengthE-value
MIA_05881_162.66%3081e-141MIA_05881_1
A0A0J9XBR8_GEOCN51.68%2982e-104Ribonuclease OS=Geotrichum candidum GN=BN980_GECA08s03574g PE=3 SV=1
UniRef50_A0A0J9XBR851.68%2983e-101Ribonuclease n=4 Tax=Saccharomycetales TaxID=4892 RepID=A0A0J9XBR8_GEOCN
A0A161HNV1_9ASCO53.72%2964e-102Ribonuclease OS=Sugiyamaella lignohabitans GN=RNH201 PE=3 SV=1
A0A060TAQ0_BLAAD50.50%3012e-94Ribonuclease OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D21494g PE=3 SV=1
A0A1E3PNV6_9ASCO53.31%2723e-92Ribonuclease OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49556 PE=3 SV=1
Q6C813_YARLI53.00%2832e-88Ribonuclease OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D23661g PE=3 SV=1
Q5AGX6_CANAL49.81%2615e-72Ribonuclease OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=RNH35 PE=3 SV=1
A0A1E4TJR8_9ASCO44.36%2571e-70Ribonuclease OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_576 PE=3 SV=1
RNH2A_YEAST47.27%2561e-58Ribonuclease H2 subunit A OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RNH201 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1207

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 304

Detailed signature matches

  1. Family IPR004649
    Ribonuclease H2, subunit A
    1. TIGR00729
  2. Domain IPR012337
    Ribonuclease H-like domain
    1. SSF53098 (Ribonucle...)
    2. G3DSA:3.30.42...
  3. Domain IPR024567
    Ribonuclease HII/HIII domain
    1. PF01351 (RNase_HII)
Unintegrated signatures no IPR
Unintegrated signatures
  1. cd07181 (RNase_HII_...)

Residue annotation

  1. active site cd07181
  2. RNA/DNA hybrid bin...
  3. trimer interface c...

Protein sequence

>MCA_03977_1
MQSDNIPKNPFSSLTYHSQLSKKFTVTEPCILGVDEAGRGPAIGPMVYACAYCPISYRDDLAKAGYNDSKVLNAATRENL
LEKIEADELIGWSVRVMSAQEISSAMLRPKVSVYNLNHQAHDTTMMLIDEIVTKKKVNVKEVYVDTVGPPDTYQAKLSRR
FPGIKFTVAKKADSLFPIVSAASICAKVTRDTCLKVHDESNGTWGSGYPSDPNTTSWLNSTLDPFWGFSSQVRFSWGTIR
QLLLNHVDIKWADDLEEDSRKKATNVSKYFKGNTEIDEITTDHELPKLTTAWYGAPGGKKELWF

GO term prediction

Biological Process

GO:0016070 RNA metabolic process

Molecular Function

GO:0003676 nucleic acid binding
GO:0004523 RNA-DNA hybrid ribonuclease activity

Cellular Component

None predicted.