Protein

MIA_05869_1

Length
748 amino acids

Browser: contig09:570928-573278-

Protein function

EGGNOG:0PHHRERG7Lanosterol synthase
SGD closest match:S000001114ERG7Lanosterol synthase
CGD closest match:CAL0000184383ERG7Lanosterol synthase

Protein alignments

%idAln lengthE-value
A0A0J9X5D5_GEOCN78.854%7330.0Terpene cyclase/mutase family member OS=Geotrichum candidum GN=BN980_GECA03s01572g PE=3 SV=1
MCA_05276_178.735%7430.0MCA_05276_1
A0A060T1G0_BLAAD70.954%7230.0Terpene cyclase/mutase family member OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C24420g PE=3 SV=1
A0A167FSM5_9ASCO67.376%7050.0Terpene cyclase/mutase family member OS=Sugiyamaella lignohabitans GN=ERG7 PE=3 SV=1
A0A1E3PLS3_9ASCO56.881%7630.0Terpene cyclase/mutase family member OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45763 PE=3 SV=1
UniRef50_A0A1X7QZL758.783%7230.0Similar to Saccharomyces cerevisiae YHR072W ERG7 Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis n=1 Tax=Kazachstania saulgeensis TaxID=1789683 RepID=A0A1X7QZL7_9SACH
ERG7_YEAST56.712%7300.0Lanosterol synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ERG7 PE=1 SV=6
ERG7_CANAL56.534%7270.0Lanosterol synthase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ERG7 PE=3 SV=2
Q6C2X2_YARLI54.621%7250.0Terpene cyclase/mutase family member OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F04378g PE=3 SV=1
A0A1E4TDD4_9ASCO48.189%7180.0Terpene cyclase/mutase family member OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_143341 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0526

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 748

Detailed signature matches

  1. Family IPR018333
    Squalene cyclase
    1. TIGR01787
    2. cd02892 (SQCY_1)
  2. Domain IPR032697
    Squalene cyclase, N-terminal
    1. PF13249 (SQHop_cycl...)
  3. Domain IPR008930
    Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
    1. SSF48239 (Terpenoid...)
  4. Domain IPR032696
    Squalene cyclase, C-terminal
    1. PF13243 (SQHop_cycl...)
  5. SITE IPR002365
    Terpene synthase, conserved site
    1. PS01074 (TERPENE_SY...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.50.10.20
  2. SFLDG01016 (Prenylt...)

Residue annotation

  1. Active site cavity...
  2. SFLDG01016
  3. catalytic acid cd0...

Protein sequence

>MIA_05869_1
MTTTAPSEPKPPSETVETANGFKFPSDFYGLPKTDHSRWRLKVDALGRQTWVYNRDENHLERDPPSNYTKYQLELNSFNP
PTFPKAKTPLEAAKNVFSFLSHIQEEDSGTFPCQYSGPMFMLIGYVVAKYYTGVPFSEEERTEIIRYLINRAHPVDGGWG
LHTYDKSTVFGTSINYIILRILGLDRDHPAIVKARTKLHSLGDARGNPHWGKMYLALLNLYDWEGVNPAPPELWMLPYSA
PIHPGRWWVHTRAIYLPMGYLSAKRKRMQLNPLLTEIREEIYKVPYDTIDFSKLRNYVNGVDLYYPHSKVLDVANECLVF
YERYLRPNWLLDKSCDYAFELVMKDLENTDHLAIAPVSNALNAIVVFEEKGIDSPEFKRFIYRWPDFLYMTPDGLMMNGT
NGVQVWDVAFVIQYAILIGLGELPEFRDTIIRSYRFLTRSQFVEECVPGSFRDKRVGGFPFSTQTQGFTVSDCTAEAVKA
IIMVQNLPGFEFLKDEFPEERLHKAIDILLGLQNRGSFHFGSFASYEKIKATTKMELLNPAEVFGNIMVEFPYVECTDSS
VLGIYYFRKYYNYRAKEIDQAISDALNYIVQSQDIDGSWYGSWGVCYTYAGMFAIEALETAGYSYENHEAVRKGCDFIVK
RQEPDGGWAENIRSNELFSYVRHTSSQPVQTSWALIMLILARYPDKEVIKRGIKFLMSKQNLDGSFRYNHVEGVFNHSCA
IEYPTYKFSFTMKAMGLYAKYYGDEELF

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0016866 intramolecular transferase activity

Cellular Component

None predicted.