Protein

MCA_05276_1

Length
754 amino acids

Gene name: ERG7

Description: Lanosterol synthase

Browser: contigD:845473-847738+

RNA-seq: read pairs 3469, FPKM 56.8, percentile rank 68.1% (100% = highest expression)

Protein function

Annotation:ERG7Lanosterol synthase
KEGG:K01852LSS lanosterol synthase [EC:5.4.99.7]
EGGNOG:0PHHRERG7Lanosterol synthase
SGD closest match:S000001114ERG7Lanosterol synthase
CGD closest match:CAL0000184383ERG7Lanosterol synthase

Protein alignments

%idAln lengthE-value
MIA_05869_178.73%7430.0MIA_05869_1
A0A0J9X5D5_GEOCN73.42%7450.0Terpene cyclase/mutase family member OS=Geotrichum candidum GN=BN980_GECA03s01572g PE=3 SV=1
A0A060T1G0_BLAAD68.66%7370.0Terpene cyclase/mutase family member OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C24420g PE=3 SV=1
A0A167FSM5_9ASCO67.04%7190.0Terpene cyclase/mutase family member OS=Sugiyamaella lignohabitans GN=ERG7 PE=3 SV=1
A0A1E3PLS3_9ASCO56.96%7620.0Terpene cyclase/mutase family member OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45763 PE=3 SV=1
UniRef50_A0A1X7QZL756.08%7400.0Similar to Saccharomyces cerevisiae YHR072W ERG7 Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis n=1 Tax=Kazachstania saulgeensis TaxID=1789683 RepID=A0A1X7QZL7_9SACH
ERG7_YEAST55.90%7370.0Lanosterol synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ERG7 PE=1 SV=6
ERG7_CANAL55.75%7390.0Lanosterol synthase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ERG7 PE=3 SV=2
Q6C2X2_YARLI54.02%7330.0Terpene cyclase/mutase family member OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F04378g PE=3 SV=1
A0A1E4TDD4_9ASCO46.94%7350.0Terpene cyclase/mutase family member OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_143341 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0479

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 700 754

Detailed signature matches

  1. Family IPR018333
    Squalene cyclase
    1. TIGR01787
    2. cd02892 (SQCY_1)
  2. Domain IPR032697
    Squalene cyclase, N-terminal
    1. PF13249 (SQHop_cycl...)
  3. Domain IPR008930
    Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
    1. SSF48239 (Terpenoid...)
  4. Domain IPR032696
    Squalene cyclase, C-terminal
    1. PF13243 (SQHop_cycl...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.50.10.20
  2. SFLDG01016 (Prenylt...)

Residue annotation

  1. Active site cavity...
  2. SFLDG01016
  3. catalytic acid cd0...

Protein sequence

>MCA_05276_1
MASTFQSDEPVNAQNFTFPSDTYNLPKTDHTRWRLKVDELGRQVWKYNRSDDHLTSDPPSNYTKYQLELPSSNPPKLSST
LYEAEDGKKSYFEDPLKSASAAFSFLSYIQEPDSGTFPCQYSGPMFMLIGYVVAKYYTHTPFSEEEKIEIIRYLANRAHP
VDGGWGLHTYDKSTVYGTTINYVILRILGIDKDHPLAAKARKKLHSLGDARGNPHWGKAYLALLNLYEWEGVNPAPPDLW
LLPYDYTPIHPGRWWVHTRAIYLPLGYLSALRKKMELTPLLKELREEIYKVPYDTIDFSKYRNYVNGVDLYYPHSKLLDV
ANKALIYYEKLRPKWLLKKACDYAFELVLKDLQNTDHLAIAPVSNALNAIVVYEELGADSEVFQRFLYRWPDFLYMTPDG
LMMNGTNGVQVWDVAFIVQYAILTNLQDVPGFRDTIIKAYRFLTRSQFVEECVEGSFRDKRVGGFPFSTQTQGFTVSDCT
AEAVKAIIMVQNLPGYEFLKEEFPEERLCKAIDVLLTLQNKGSFHYGSFASYEKIKASPKLELLNPAEVFGNIMVEYPYV
ECTDSSVLGLHYFAKYYSYKRDEVKQAIDDAIKSIIRYQNSDGSWYGSWGVCHTYAGMFAIEALETVGYNYENSDVVKKG
CDFIVARQEEDGGWAESIRSSELFTYVRHTSSQVVQTSWAVIMLILAGYPDQEVIKRGVRFIMSKQKQDGSFGYNHVEGV
FNHSCGIEYPNYKFAFTMKAVGLYAKYYGTEKLF

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0016866 intramolecular transferase activity

Cellular Component

None predicted.