MIA_05865_1

Protein

Length

1,773 amino acids

Protein function

EGGNOG:	0QDPW		Ras guanine-nucleotide exchange protein
SGD closest match:	S000004301	CDC25	Cell division control protein 25
CGD closest match:	CAL0000195920	BUD5	Ras family guanine nucleotide exchange factor

Protein alignments

	%id	Aln length	E-value
MCA_02421_1	43.212%	685	8.25e-149	MCA_02421_1
A0A0J9X939_GEOCN	50.296%	507	7.87e-140	Similar to Saccharomyces cerevisiae YLR310C CDC25 Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor) OS=Geotrichum candidum GN=BN980_GECA05s05092g PE=4 SV=1
UniRef50_A0A0J9X939	50.296%	507	1.61e-136	Similar to Saccharomyces cerevisiae YLR310C CDC25 Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor) n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X939_GEOCN
A0A060T9D4_BLAAD	47.259%	529	9.16e-127	ARAD1C43648p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C43648g PE=4 SV=1
A0A167FHQ4_9ASCO	45.545%	505	7.68e-121	Ras family guanine nucleotide exchange factor CDC25 OS=Sugiyamaella lignohabitans GN=CDC25 PE=4 SV=1
Q6C637_YARLI	35.484%	558	7.21e-90	YALI0E12705p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E12705g PE=4 SV=1
A0A1E3PNY6_9ASCO	47.260%	292	7.38e-72	Ras GEF OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49394 PE=4 SV=1
A0A1D8PTC8_CANAL	31.034%	319	2.07e-41	Ras family guanine nucleotide exchange factor OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=BUD5 PE=4 SV=1
A0A1E4TAP2_9ASCO	29.934%	304	8.53e-31	Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_13579 PE=4 SV=1
CDC25_YEAST	35.429%	175	5.12e-25	Cell division control protein 25 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CDC25 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0128

Protein family membership

None predicted.

Domains and repeats

Domain
470 - 550
SH3 domain (IPR001452)
1,227 - 1,377
Ras guanine nucleotide exchange factor domain (IPR023578)
1,475 - 1,667
Ras guanine nucleotide exchange factor domain (IPR023578)
1,705 - 1,772
Ras guanine nucleotide exchange factor domain (IPR023578)
Domain
1,225 - 1,361
Ras-like guanine nucleotide exchange factor, N-terminal (IPR000651)
1,489 - 1,773
Ras guanine-nucleotide exchange factors catalytic domain (IPR001895)

1 200 400 600 800 1000 1200 1400 1600 1773

Detailed signature matches

IPR001452

SH3 domain
1. SM00326 (SH3_2)
  
  476 - 544
  
  SMART
  SM00326 (SH3_2)
2. SSF50044 (SH3-domain)
  
  470 - 550
  
  SUPERFAMILY
  SSF50044 (SH3-domain)
3. PS50002 (SH3)
  
  473 - 545
  
  PROSITE profiles
  PS50002 (SH3)
IPR000651

Ras-like guanine nucleotide exchange factor, N-terminal
1. SM00229 (rasgefn_5)
  
  1,225 - 1,361
  
  SMART
  SM00229 (rasgefn_5)
2. cd06224 (REM)
  
  1,234 - 1,333
  
  CDD
  cd06224 (REM)
3. PS50212 (RASGEF_NTER)
  
  1,226 - 1,361
  
  PROSITE profiles
  PS50212 (RASGEF_NTER)
4. PF00618 (RasGEF_N)
  
  1,230 - 1,324
  
  Pfam
  PF00618 (RasGEF_N)
IPR023578

Ras guanine nucleotide exchange factor domain
1. SSF48366 (Ras GEF)
  
  1,227 - 1,377
  
  SUPERFAMILY
  SSF48366 (Ras GEF)
  
  1,705 - 1,772
  
  SUPERFAMILY
  SSF48366 (Ras GEF)
  
  1,475 - 1,667
  
  SUPERFAMILY
  SSF48366 (Ras GEF)
IPR001895

Ras guanine-nucleotide exchange factors catalytic domain
1. cd00155 (RasGEF)
  
  1,489 - 1,745
  
  CDD
  cd00155 (RasGEF)
2. PF00617 (RasGEF)
  
  1,496 - 1,662
  
  Pfam
  PF00617 (RasGEF)
3. SM00147 (RasGEF_3)
  
  1,489 - 1,773
  
  SMART
  SM00147 (RasGEF_3)
4. PS50009 (RASGEF_CAT)
  
  1,493 - 1,772
  
  PROSITE profiles
  PS50009 (RASGEF_CAT)
5. G3DSA:1.10.84...
  
  1,489 - 1,773
  
  GENE3D
  G3DSA:1.10.840.10 (G3DSA:1.10.840.10)

no IPR

Unintegrated signatures

Coil

1,772 - 1,773

COILS
Coil (Coil)

857 - 877

COILS
Coil (Coil)
G3DSA:1.20.87...

1,182 - 1,399

GENE3D
G3DSA:1.20.870.10 (G3DSA:1.20.870.10)
G3DSA:2.30.30.40

442 - 548

GENE3D
G3DSA:2.30.30.40 (G3DSA:2.30.30.40)
mobidb-lite (disord...)

68 - 88

MobiDB Lite
mobidb-lite (disorder_prediction)

1,447 - 1,476

MobiDB Lite
mobidb-lite (disorder_prediction)

565 - 585

MobiDB Lite
mobidb-lite (disorder_prediction)

1,022 - 1,196

MobiDB Lite
mobidb-lite (disorder_prediction)

167 - 291

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 24

MobiDB Lite
mobidb-lite (disorder_prediction)

683 - 759

MobiDB Lite
mobidb-lite (disorder_prediction)

333 - 465

MobiDB Lite
mobidb-lite (disorder_prediction)

884 - 915

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

GTPase interaction...

1,245D

GTPase interaction site
1,245D, 1,296T, 1,300Q, 1,302K, 1,305N, 1,308K, 1,309R
CDD
cd06224 (REM)

1,296T

GTPase interaction site
1,245D, 1,296T, 1,300Q, 1,302K, 1,305N, 1,308K, 1,309R
CDD
cd06224 (REM)

1,300Q

GTPase interaction site
1,245D, 1,296T, 1,300Q, 1,302K, 1,305N, 1,308K, 1,309R
CDD
cd06224 (REM)

1,302K

GTPase interaction site
1,245D, 1,296T, 1,300Q, 1,302K, 1,305N, 1,308K, 1,309R
CDD
cd06224 (REM)

1,305N

GTPase interaction site
1,245D, 1,296T, 1,300Q, 1,302K, 1,305N, 1,308K, 1,309R
CDD
cd06224 (REM)

1,308K

GTPase interaction site
1,245D, 1,296T, 1,300Q, 1,302K, 1,305N, 1,308K, 1,309R
CDD
cd06224 (REM)

1,309R

GTPase interaction site
1,245D, 1,296T, 1,300Q, 1,302K, 1,305N, 1,308K, 1,309R
CDD
cd06224 (REM)
Ras interaction si...

1,522F

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,523S

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,524L

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,535V

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,536S

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,538M

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,539T

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,540L

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,542T

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,543N

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,546S

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,547F

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,550G

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,584N

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,587M

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,588T

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,590V

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,591S

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,592A

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,594Q

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,595S

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,596V

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,597N

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,599V

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,600R

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,620K

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,623L

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,628N

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,629Y

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,630S

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,633R

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,646Y

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,647L

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,648G

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,651L

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,652T

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,653D

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,655T

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,656F

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,657V

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,659E

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,660G

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,661N

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,662H

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,717R

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

1,721I

Ras interaction site
1,522F, 1,523S, 1,524L, 1,535V, 1,536S, 1,538M, 1,539T, 1,540L, 1,542T, 1,543N, 1,546S, 1,547F, 1,550G, 1,584N, 1,587M, 1,588T, 1,590V, 1,591S, 1,592A, 1,594Q, 1,595S, 1,596V, 1,597N, 1,599V, 1,600R, 1,620K, 1,623L, 1,628N, 1,629Y, 1,630S, 1,633R, 1,646Y, 1,647L, 1,648G, 1,651L, 1,652T, 1,653D, 1,655T, 1,656F, 1,657V, 1,659E, 1,660G, 1,661N, 1,662H, 1,717R, 1,721I
CDD
cd00155 (RasGEF)

Protein sequence

>MIA_05865_1
MDSSSATVKAAAAAPGPATLHASSSSTYIPGFSCFSPPVLSSSSTTDFDFSSTAPSVIRTRRASLIPVLSSPSPGPSPSP
TSLSPVSPVSPMAHLAVSPPYHYSFHQYHPNSSTGSAGFTGTSPYPSSNLSAIKVARRCASTTSLVKSPSSSASASSLAT
LIAPNSANHQPFLHPSPTAPTTRSASNTALVGPSEEPSVIVSTATAKVDSQSKQPVSSSSSSTSTSTPSSSSSSSTSSSI
PQSRPHHLLMSHSSTSSLAGRHSTLDPAVVGTAPNATSTTSTLGGHSDSRLTRHHSFLRSRISSSLKRTNISSVTLATNL
GTSATNSTSSLALLSSTKQTPMQATSFATRGENKRQLRAPTTATATPLKTSPKASPRTSPKPPTDRHSSSSSSTRSSDRS
SGSSSTYTSSSSTGKNMPVSSTSSSSASAPSQKSSHVQPASSSTTATTTSSSSAASNPDQNAFDLSSFQESTSGYPFLRA
LHSFDASTLFSGQSDDDPSSICLSFQESEIVLLHSIHPSGWGDATILSNAARGWIPTNYFTPYSDPKIVPVLSAVLNFVL
APKSHPLPRPSSKQSQNQSLDSPQEPRYTFPPAAISAIVAGVRSLLEACGTLTRDTPIVRRSQSIRKFRKILLAELAILV
SLAKQYKYTTDDANIERLVTGSYKIIFRAVIFLDIWTLDRGSSTSTTSSEQNSENVTPTSTNATKTETSKDERPTGAASA
TESHSPGSIKEVDIPTDSHAVPRSADPREPSAAPSPVPVIIPPRRSLVPNRESVIFHDVPPSALQRLEEVHDALTSYLGN
FLNQRLNLDMLSGASLTLDANSSACTQILVNTRKSMLACRELLAAVESISSHSLPRNKDLEKRKDRLFSQIRQLVSVARD
VVASTPATAEAQEDEEDEDEPTPTSSEVPDEISPRRKARAAKLAYAVESRRLVETAAICARTSDECVAMCRLIIDRIGDF
QLSPTREYPDFSDGLVAETPTELEHKTEATSMPTTAIAASAKTSEPVNSTLDSTAKSFSSLSLAHRHTPSTTSTITDAVP
APQTSTSTAVSSASVPSTSAMSSKATLFPSTTDSKMSPMLPDIPTILPLLSDQFDDPPMHSPDSGAFPYPQQSTQDHHNS
NNNVNANANANANTNANTNTSNNTNSLSHAPITPVAGPSTSFSANTTAPLPTDPGSSSPVSRQSNHLQQSPQTSIIPAAI
INESDARVRAAIAALPADERVLREVGTARIRGASLPALVKVLTDDTTPEDPDAHLLSTFFLTFRQFTTPLDLVNTLITRF
QNPPKNSNDPDEDLHTQIRQAKVYNILKRWMESYWKQSTDAPALPRILTFANTSLFNSVGGYYSPYALSKSVLTDLAAKI
PHLPDGEPLVPRPIAVPGADEARRSALTYSTTPLIPVHLSRHQIALLAKAVDAQESIASPSSVKEVTSDDGRVGSVTANA
WNRMVRASSSETGSDSVTSATATASGASGTSSLSHSEPYGATAHTIVLFLDIDAAELAKQITLLDSGLLCLIRPEELLDQ
NFSLKRRSLGLAPNVSAMTLLTNQLSFFVGDTILNPDISSKTRQRVLKHWIKTAEKCHELSSFNALMTIVSALQSVNVVR
LRKTWAGIAPRHANALATLKSLLSMDKNYSAYRAALRAAPIPRVPYLGLYLTDLTFVGEGNHPLRSLTVDLTTHEVVPAV
AARRAPQAMGTQSQGTGPVQPAPPPSFAVINFDRYDRITRIIGDLQCQQVPYRVAPCSELQAWLRMEMARSYAVVSKDHN
GLWRRSMIIEPKQ

GO term prediction

Biological Process

GO:0007264 small GTPase mediated signal transduction

Molecular Function

GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding

Cellular Component