MCA_02421_1

Protein

Length

1,498 amino acids

RNA-seq: read pairs 2294, FPKM 18.9, percentile rank 40.0% (100% = highest expression)

Protein function

EGGNOG:	0QDPW		Ras guanine-nucleotide exchange protein
SGD closest match:	S000004301	CDC25	Cell division control protein 25
CGD closest match:	CAL0000195920	BUD5	Ras family guanine nucleotide exchange factor

Protein alignments

	%id	Aln length	E-value
MIA_05865_1	43.21%	685	8e-150	MIA_05865_1
A0A0J9XL13_GEOCN	45.80%	583	7e-139	Similar to Saccharomyces cerevisiae YLR310C CDC25 Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor) OS=Geotrichum candidum GN=BN980_GECA27s00142g PE=4 SV=1
UniRef50_A0A0J9XL13	45.80%	583	1e-135	Similar to Saccharomyces cerevisiae YLR310C CDC25 Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor) n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XL13_GEOCN
A0A167FHQ4_9ASCO	40.69%	467	2e-82	Ras family guanine nucleotide exchange factor CDC25 OS=Sugiyamaella lignohabitans GN=CDC25 PE=4 SV=1
A0A060T9D4_BLAAD	35.64%	491	2e-76	ARAD1C43648p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C43648g PE=4 SV=1
Q6C637_YARLI	40.65%	433	4e-69	YALI0E12705p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E12705g PE=4 SV=1
A0A1E3PNY6_9ASCO	56.36%	165	6e-54	Ras GEF OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49394 PE=4 SV=1
A0A1D8PTC8_CANAL	41.04%	173	7e-34	Ras family guanine nucleotide exchange factor OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=BUD5 PE=4 SV=1
A0A1E4TM85_9ASCO	34.96%	226	1e-27	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_1456 PE=4 SV=1
CDC25_YEAST	39.51%	162	4e-25	Cell division control protein 25 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CDC25 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0681

Protein family membership

None predicted.

Domains and repeats

Domain
115 - 193
SH3 domain (IPR001452)
927 - 1,060
Ras-like guanine nucleotide exchange factor, N-terminal (IPR000651)
1,169 - 1,498
Ras guanine-nucleotide exchange factors catalytic domain (IPR001895)
Domain
919 - 1,042
Ras guanine nucleotide exchange factor domain (IPR023578)
1,162 - 1,354
Ras guanine nucleotide exchange factor domain (IPR023578)
1,434 - 1,497
Ras guanine nucleotide exchange factor domain (IPR023578)

1 200 400 600 800 1000 1200 1498

Detailed signature matches

IPR001452

SH3 domain
1. SM00326 (SH3_2)
  
  119 - 187
  
  SMART
  SM00326 (SH3_2)
2. SSF50044 (SH3-domain)
  
  115 - 193
  
  SUPERFAMILY
  SSF50044 (SH3-domain)
3. PS50002 (SH3)
  
  116 - 188
  
  PROSITE profiles
  PS50002 (SH3)
IPR023578

Ras guanine nucleotide exchange factor domain
1. SSF48366 (Ras GEF)
  
  1,434 - 1,497
  
  SUPERFAMILY
  SSF48366 (Ras GEF)
  
  1,162 - 1,354
  
  SUPERFAMILY
  SSF48366 (Ras GEF)
  
  919 - 1,042
  
  SUPERFAMILY
  SSF48366 (Ras GEF)
IPR000651

Ras-like guanine nucleotide exchange factor, N-terminal
1. SM00229 (rasgefn_5)
  
  927 - 1,056
  
  SMART
  SM00229 (rasgefn_5)
2. cd06224 (REM)
  
  936 - 1,052
  
  CDD
  cd06224 (REM)
3. PS50212 (RASGEF_NTER)
  
  928 - 1,060
  
  PROSITE profiles
  PS50212 (RASGEF_NTER)
4. PF00618 (RasGEF_N)
  
  932 - 1,030
  
  Pfam
  PF00618 (RasGEF_N)
IPR001895

Ras guanine-nucleotide exchange factors catalytic domain
1. cd00155 (RasGEF)
  
  1,176 - 1,350
  
  CDD
  cd00155 (RasGEF)
2. PF00617 (RasGEF)
  
  1,183 - 1,360
  
  Pfam
  PF00617 (RasGEF)
3. SM00147 (RasGEF_3)
  
  1,176 - 1,498
  
  SMART
  SM00147 (RasGEF_3)
4. PS50009 (RASGEF_CAT)
  
  1,180 - 1,497
  
  PROSITE profiles
  PS50009 (RASGEF_CAT)
5. G3DSA:1.10.84...
  
  1,169 - 1,498
  
  GENE3D
  G3DSA:1.10.840.10 (G3DSA:1.10.840.10)

no IPR

Unintegrated signatures

Coil

1,100 - 1,120

COILS
Coil (Coil)

573 - 593

COILS
Coil (Coil)
G3DSA:2.30.30.40

18 - 191

GENE3D
G3DSA:2.30.30.40 (G3DSA:2.30.30.40)
mobidb-lite (disord...)

1,113 - 1,157

MobiDB Lite
mobidb-lite (disorder_prediction)

212 - 254

MobiDB Lite
mobidb-lite (disorder_prediction)

1,375 - 1,425

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 103

MobiDB Lite
mobidb-lite (disorder_prediction)

604 - 645

MobiDB Lite
mobidb-lite (disorder_prediction)

359 - 491

MobiDB Lite
mobidb-lite (disorder_prediction)

797 - 863

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

GTPase interaction...

947E

GTPase interaction site
947E, 1,001M, 1,005S, 1,006K, 1,009S, 1,012K, 1,013R, 1,047A, 1,048T, 1,051E
CDD
cd06224 (REM)

1,001M

GTPase interaction site
947E, 1,001M, 1,005S, 1,006K, 1,009S, 1,012K, 1,013R, 1,047A, 1,048T, 1,051E
CDD
cd06224 (REM)

1,005S

GTPase interaction site
947E, 1,001M, 1,005S, 1,006K, 1,009S, 1,012K, 1,013R, 1,047A, 1,048T, 1,051E
CDD
cd06224 (REM)

1,006K

GTPase interaction site
947E, 1,001M, 1,005S, 1,006K, 1,009S, 1,012K, 1,013R, 1,047A, 1,048T, 1,051E
CDD
cd06224 (REM)

1,009S

GTPase interaction site
947E, 1,001M, 1,005S, 1,006K, 1,009S, 1,012K, 1,013R, 1,047A, 1,048T, 1,051E
CDD
cd06224 (REM)

1,012K

GTPase interaction site
947E, 1,001M, 1,005S, 1,006K, 1,009S, 1,012K, 1,013R, 1,047A, 1,048T, 1,051E
CDD
cd06224 (REM)

1,013R

GTPase interaction site
947E, 1,001M, 1,005S, 1,006K, 1,009S, 1,012K, 1,013R, 1,047A, 1,048T, 1,051E
CDD
cd06224 (REM)

1,047A

GTPase interaction site
947E, 1,001M, 1,005S, 1,006K, 1,009S, 1,012K, 1,013R, 1,047A, 1,048T, 1,051E
CDD
cd06224 (REM)

1,048T

GTPase interaction site
947E, 1,001M, 1,005S, 1,006K, 1,009S, 1,012K, 1,013R, 1,047A, 1,048T, 1,051E
CDD
cd06224 (REM)

1,051E

GTPase interaction site
947E, 1,001M, 1,005S, 1,006K, 1,009S, 1,012K, 1,013R, 1,047A, 1,048T, 1,051E
CDD
cd06224 (REM)
Ras interaction si...

1,209F

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,210S

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,211L

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,222I

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,223N

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,225M

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,226T

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,227M

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,229T

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,230N

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,233S

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,234S

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,237G

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,271N

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,274M

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,275T

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,277I

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,278S

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,279A

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,281Q

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,282S

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,283V

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,284N

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,286M

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,287R

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,307K

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,310L

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,315N

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,316Y

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,317S

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,320R

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,333F

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,334L

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,335G

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,338L

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,339T

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,340D

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,342T

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,343F

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,344V

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,346E

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,347G

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,348N

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

1,349P

Ras interaction site
1,209F, 1,210S, 1,211L, 1,222I, 1,223N, 1,225M, 1,226T, 1,227M, 1,229T, 1,230N, 1,233S, 1,234S, 1,237G, 1,271N, 1,274M, 1,275T, 1,277I, 1,278S, 1,279A, 1,281Q, 1,282S, 1,283V, 1,284N, 1,286M, 1,287R, 1,307K, 1,310L, 1,315N, 1,316Y, 1,317S, 1,320R, 1,333F, 1,334L, 1,335G, 1,338L, 1,339T, 1,340D, 1,342T, 1,343F, 1,344V, 1,346E, 1,347G, 1,348N, 1,349P
CDD
cd00155 (RasGEF)

Protein sequence

>MCA_02421_1
MQISNKNKTTFETEMLNSSSSNSARRQGSSSEEPNISSKPSSTNLSTSLSSENNFSHQPHHHHNQNKNSITSNSSETSFS
NPSSNLNRNSDPNYQDQDQQSQPASFDLTTFQESGTGYPFLRALHSFDASTLFTNSPDEDPSSICLSFQESEIVLLHSIH
PSGWGDATILSNASRGWIPTNYFTPYSDPKIVPVLSAVLNFVLAPKSHPLPKPYYNNDSSNGRNFKNGVTSSTSDPADNA
SDSNSTTGGSDEEVKYTFSPPAISAIVAGVRSLLEACGTLTRDTPIVRRSQSIRKFRKILLAELAILVSLAKQYKYTTDD
ANIERLVTGSYKIIFRAVIFLDIWTIDMSNTESNSTIPDLNTSISSQQLSPTSPTSGIPLIENQTENSQNEKEPNEHKDD
LDQNQQEKRPQHTQPSTQQSQKPQQSLRHGTPSIDNLRNSLGNDEFSPQRGQFVRNIDTIPEGQSDDNPLGPESLGRLST
PNTAVPAAPRNNRNANRESVVFHLSPPYALHRLDEVNDALTSYLGNFLHRTNLLDSDPSACTQLLLNTRKSMLACRELLA
TVESISSRYLPRNRELEECKDKLFNQIKELVTAARDVVASTPASDLLIPQPGSDDEVESYNTKNKPENDTSNTKDKIETS
SNYKGSQHATTHLITIARECAKTSGECVVRCRYILERVGDFQLSPTRDYPDFSDGIIAVYNNDQNEDASNDTNNMINAYS
SLSISEETQSPTSDTNSNTETLEKSKYNMDLHSKHASLLPKIPAISPLIPLGDDSSPAGNTVRTELSVSTNTSLIDNNPF
SATTPTTATLLSPVPRNSSHVTQGNNSRPNSYFSSPLNTSAPTTPLSANTTPPAPIDDIPRRGRSFTTNGIDTFHGSLNG
GTSISVVPEEDTLEFDGAVDEAVAARNAAILKAIEEIPLDERILKDAATGRVRAGTLEALVKTLTDENCDQDPCFISAFF
LNFRQFTNPYDLAEALIKRYNQTEGEVVDDDMSESNFESIMTRRSKIYSTIKRWMESHWYQSTDAPALPLIMEFAKTNSM
IPANAKATLTELCAKVTQLPDNVVMIPRLIMVPGGNVVRTAALSYSHTPVVLHTVSKHQAALLLKNAEATEQEIASSEDD
KSNSNGQSSETRSRNNSLNKDPNSSDADEGKSTVSSSSWSNSLRMVKMSPHQVISILDIDALDIAKQLAVLDNRLFCKIK
PSEFLDQNFSLKRRHLGLALNINAMTMFTNQLSSFVGDSILNADVPIKTRQKLLKHWIKVAERSFELHNFNSLMTIISAL
QSVNIMRLRKTWEGLSARHITSFTRLKTLLSMEKNYSNYRTELRNISLPCVPFLGLYLTDLTFVGEGNPTMRALTVDIEH
NNEIILVSGHKYPLPTKQINNHHQQQLHKSSKSEDTTSSTASTLTSNNNHNNNNNSSMFGSNKNNGPTPPSFLAINFDRF
DRITRIIGEVQNFQIPYRVASSTELQSWLKAEMAKSYMIVTKDHNGLWRRSCIVEPKQ

GO term prediction

Biological Process

GO:0007264 small GTPase mediated signal transduction

Molecular Function

GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding

Cellular Component