Protein

MIA_05849_1

Length
495 amino acids

Browser: contig09:512772-514402+

Protein function

EGGNOG:0PFHXSHM1Interconversion of serine and glycine (By similarity)
SGD closest match:S000000467SHM1Serine hydroxymethyltransferase, mitochondrial
CGD closest match:CAL0000174200SHM1Serine hydroxymethyltransferase

Protein alignments

%idAln lengthE-value
MCA_04006_184.646%4950.0MCA_04006_1
A0A0J9X3J8_GEOCN82.591%4940.0Serine hydroxymethyltransferase OS=Geotrichum candidum GN=BN980_GECA02s04520g PE=3 SV=1
A0A060TF56_BLAAD79.588%4850.0ARAD1D20350p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D20350g PE=3 SV=1
A0A1E3PGH8_9ASCO76.971%4820.0Serine hydroxymethyltransferase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_53013 PE=3 SV=1
A0A167CB82_9ASCO81.579%4180.0Serine hydroxymethyltransferase OS=Sugiyamaella lignohabitans GN=SHM1 PE=3 SV=1
UniRef50_A0A167CB8281.579%4180.0Serine hydroxymethyltransferase n=8 Tax=Eukaryota TaxID=2759 RepID=A0A167CB82_9ASCO
A0A1D8PRB3_CANAL69.758%4960.0Serine hydroxymethyltransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SHM1 PE=3 SV=1
Q6C859_YARLI71.652%4480.0Serine hydroxymethyltransferase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D22484g PE=3 SV=1
GLYM_YEAST63.374%4860.0Serine hydroxymethyltransferase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SHM1 PE=1 SV=2
A0A1E4TFX7_9ASCO63.248%4680.0Serine hydroxymethyltransferase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_109062 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9678
Predicted cleavage: 27

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 450 495

Detailed signature matches

  1. Family IPR001085
    Serine hydroxymethyltransferase
    1. MF_00051 (SHMT)
    2. PIRSF000412 (SHMT)
    3. cd00378 (SHMT)
  2. Domain IPR015424
    Pyridoxal phosphate-dependent transferase
    1. SSF53383 (PLP-depen...)
  3. Domain IPR015421
    Pyridoxal phosphate-dependent transferase, major region, subdomain 1
    1. G3DSA:3.40.64...
  4. Domain IPR015422
    Pyridoxal phosphate-dependent transferase, subdomain 2
    1. G3DSA:3.90.11...
  5. SITE IPR019798
    Serine hydroxymethyltransferase, pyridoxal phosphate binding site
    1. PS00096 (SHMT)
Unintegrated signatures no IPR
Unintegrated signatures
  1. PF00464 (SHMT)

Residue annotation

  1. dimer interface cd...
  2. glycine-pyridoxal ...
  3. active site cd00378
  4. folate binding sit...

Protein sequence

>MIA_05849_1
MLSLRQSLAKSIRAPVLSRTTQIRSYSLTKDQLHLISSPVQEVDSELFAIVERERKRQKESITLIPSENFTSRAVMDVLG
SEMQNKYSEGYPGARYYGGNQFIDQAESLCQQRALKAFNLDPELWGVNVQPLSGAPANLYTYSALLEVGDRLMGLDLPHG
GHLSHGYQTPTKKISYISKYFQTMPYRLNEETGIIDFETLETTSKLFRPKIIVAGASAYSRAIDYSRFRKIADNVDAYLM
ADMAHIAGLVAAGVTPSPFEYADIVTTTSHKSLRGPRGAMIFFRKGVRKTDKKGREILYDLESKINFSVFPGHQGGPHNH
TITALAVALGQAATPEFKQYQQAVVDNAQAFAKALQARGYKLVSGGTDTHLILIDLKPQKIDGARVETVLELINIAANKN
TVPGDKSALVPGGLRVGTPAMTTRGFTPADFEKVAEYIDKAVKITSQIKAEVAAKGEKTKIADFRGHAESHPELEQLKAE
VTEWAKTFPVPGEQA

GO term prediction

Biological Process

GO:0006545 glycine biosynthetic process
GO:0035999 tetrahydrofolate interconversion

Molecular Function

GO:0003824 catalytic activity
GO:0004372 glycine hydroxymethyltransferase activity
GO:0030170 pyridoxal phosphate binding

Cellular Component

None predicted.