Protein

MCA_04006_1

Length
492 amino acids

Gene name: SHM1

Description: Serine hydroxymethyltransferase, mitochondrial

Browser: contigC:1760039-1761646+

RNA-seq: read pairs 5259, FPKM 131.8, percentile rank 83.1% (100% = highest expression)

Protein function

Annotation:SHM1Serine hydroxymethyltransferase, mitochondrial
KEGG:K00600glyA glycine hydroxymethyltransferase [EC:2.1.2.1]
EGGNOG:0PFHXSHM1Interconversion of serine and glycine (By similarity)
SGD closest match:S000000467SHM1Serine hydroxymethyltransferase, mitochondrial
CGD closest match:CAL0000174200SHM1Serine hydroxymethyltransferase

Protein alignments

%idAln lengthE-value
MIA_05849_184.65%4950.0MIA_05849_1
A0A0J9X3J8_GEOCN79.23%4910.0Serine hydroxymethyltransferase OS=Geotrichum candidum GN=BN980_GECA02s04520g PE=3 SV=1
A0A060TF56_BLAAD77.78%4860.0ARAD1D20350p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D20350g PE=3 SV=1
A0A1E3PGH8_9ASCO76.95%4860.0Serine hydroxymethyltransferase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_53013 PE=3 SV=1
A0A1D8PRB3_CANAL70.73%4920.0Serine hydroxymethyltransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SHM1 PE=3 SV=1
A0A167CB82_9ASCO80.86%4180.0Serine hydroxymethyltransferase OS=Sugiyamaella lignohabitans GN=SHM1 PE=3 SV=1
UniRef50_A0A167CB8280.86%4180.0Serine hydroxymethyltransferase n=8 Tax=Eukaryota TaxID=2759 RepID=A0A167CB82_9ASCO
Q6C859_YARLI68.25%4850.0Serine hydroxymethyltransferase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D22484g PE=3 SV=1
GLYM_YEAST66.10%4690.0Serine hydroxymethyltransferase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SHM1 PE=1 SV=2
A0A1E4TFX7_9ASCO62.74%4670.0Serine hydroxymethyltransferase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_109062 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9733
Predicted cleavage: 24

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 450 492

Detailed signature matches

  1. Family IPR001085
    Serine hydroxymethyltransferase
    1. MF_00051 (SHMT)
    2. PIRSF000412 (SHMT)
    3. cd00378 (SHMT)
  2. Domain IPR015424
    Pyridoxal phosphate-dependent transferase
    1. SSF53383 (PLP-depen...)
  3. Domain IPR015421
    Pyridoxal phosphate-dependent transferase, major region, subdomain 1
    1. G3DSA:3.40.64...
  4. Domain IPR015422
    Pyridoxal phosphate-dependent transferase, subdomain 2
    1. G3DSA:3.90.11...
  5. SITE IPR019798
    Serine hydroxymethyltransferase, pyridoxal phosphate binding site
    1. PS00096 (SHMT)
Unintegrated signatures no IPR
Unintegrated signatures
  1. PF00464 (SHMT)

Residue annotation

  1. dimer interface cd...
  2. glycine-pyridoxal ...
  3. active site cd00378
  4. folate binding sit...

Protein sequence

>MCA_04006_1
MLSIRRSLSKFSPSTLAQQARCYSISKGQLSLISNSVQQADPELHAILERERQRQKESITLIPSENFTSKAVMDMLGSEM
QNKYSEGYPGARYYGGNQFIDQAESLCQKRALEAFNLNPEEWGVNVQPLSGAPANLYTYSAIMNVGDRLMGLDLPHGGHL
SHGYQTPTKKISFISKYFQTMPYRLDESTGLIDFEQLAISAKLFRPKVIVAGASAYSRAIDYAKFREIADSVDAYLMADM
AHIAGLVAAGVTPSPFPYSDIVTTTSHKSLRGPRGAMIFFRKGVRKTDKKGKQILYDLESKINFSVFPGHQGGPHNHTIS
ALAVALGQAATPEFKEYQQDVINNAQTFAKALQERGYKLVSDGTDTHLILIDLKPKKIDGARVETVLELINIAANKNTVP
GDKSALVPGGLRVGTPAMTTRGFGPEDFVKVAEYIDRAVQITIDIKAKVAEKGEKTKIADFRGHAEGNPEIEALKAEVTE
WAKTFPVPGEQA

GO term prediction

Biological Process

GO:0006545 glycine biosynthetic process
GO:0035999 tetrahydrofolate interconversion

Molecular Function

GO:0003824 catalytic activity
GO:0004372 glycine hydroxymethyltransferase activity
GO:0030170 pyridoxal phosphate binding

Cellular Component

None predicted.