Protein

MIA_05845_1

Length
567 amino acids

Browser: contig09:498484-500188+

Protein function

EGGNOG:0PFYMGPA2Guanine nucleotide-binding protein alpha-3 subunit
SGD closest match:S000000822GPA2Guanine nucleotide-binding protein alpha-2 subunit
CGD closest match:CAL0000186613GPA2Guanine nucleotide-binding protein subunit alpha

Protein alignments

%idAln lengthE-value
MCA_04046_166.582%3921.76e-180MCA_04046_1
A0A0J9X8E1_GEOCN66.313%3771.60e-175Similar to Saccharomyces cerevisiae YER020W GPA2 Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients OS=Geotrichum candidum GN=BN980_GECA05s02738g PE=4 SV=1
A0A060T1L1_BLAAD53.924%4973.12e-171ARAD1C25586p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C25586g PE=4 SV=1
A0A167F5H1_9ASCO65.591%3721.76e-169Guanine nucleotide-binding protein subunit alpha OS=Sugiyamaella lignohabitans GN=GPA2 PE=4 SV=1
Q6CHF1_YARLI54.712%3828.58e-145YALI0A09592p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A09592g PE=4 SV=1
A0A1E3PJC6_9ASCO58.730%3781.83e-143G-alpha-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83388 PE=4 SV=1
UniRef50_Q5DPY955.467%3756.04e-142Guanine nucleotide-binding protein alpha-3 subunit n=14 Tax=Fungi TaxID=4751 RepID=Q5DPY9_PARBR
A0A1E4TJF5_9ASCO53.989%3761.62e-137Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_42505 PE=4 SV=1
A0A1D8PJG1_CANAL51.175%3831.11e-126Guanine nucleotide-binding protein subunit alpha OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=GPA2 PE=4 SV=1
GPA2_YEAST68.240%2337.22e-116Guanine nucleotide-binding protein alpha-2 subunit OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GPA2 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0015
Predicted cleavage: 112

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 567

Detailed signature matches

  1. Family IPR001019
    Guanine nucleotide binding protein (G-protein), alpha subunit
    1. cd00066 (G-alpha)
    2. PF00503 (G-alpha)
    3. SM00275 (galpha_1)
    4. PR00318 (GPROTEINA)
  2. Family IPR002975
    Fungal G-protein, alpha subunit
    1. PR01241 (GPROTEINAFNG)
  3. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  4. Domain IPR011025
    G protein alpha subunit, helical insertion
    1. SSF47895 (Transduci...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. mobidb-lite (disord...)

Residue annotation

  1. G1 box cd00066
  2. GTP/Mg2+ binding s...
  3. GoLoco binding sit...
  4. Switch I region cd...
  5. G2 box cd00066
  6. beta - gamma compl...
  7. adenylyl cyclase i...
  8. G3 box cd00066
  9. Switch II region c...
  10. G4 box cd00066
  11. putative receptor ...
  12. G5 box cd00066

Protein sequence

>MIA_05845_1
MGNCVSSDKPSGAPQASAAGKPMSSANRAPGSKEQPSGSHATTPAGFAGAGTTPQQQQQQQQNTSANGAQNNQPLPNGDQ
LSSNTTSSQPQNLNELKPNYSLNGTTASDRPRSTNGSIQGGSSTTNYEASSLPSSNINDSNGQSSRSHHTSIANSSNHYP
SDGSSSFSNGAAAGQPVNATNNNNANSTNNSKRPEVKILLLGAGESGKSTILKQMKIIHQNGYSPEEMIMYKTTVYKNLL
DCAKIIVEVAVQFDIDLSKNPNSQQQQVDASTSTSSDTTAVSTSPATDDAPNDPASTDITTQAPDQQQHPYMSQADLDYI
SNSIISPDPDSTLDPKLALLISKLWAHPAVKDLLATRRADFYIMDSAPYFFRNVSRIGDPEFVPTVADILRARIKTTGIY
DAKFSMGQLNIHMYDVGGQRSERKKWIHCFDNVTLIIFCVALSDYDQVLLEESSQNRMAESLVLFESIVNSRWFTRTTIV
LFLNKIDIFTEKLSVSPLENYFPDYTGGDDIKKAAKYILWRFTQLNRNNLTIYPHITQATDTSNIRLVFAAVKESILENS
LRDSGLL

GO term prediction

Biological Process

GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway

Molecular Function

GO:0001664 G-protein coupled receptor binding
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding

Cellular Component

GO:0005834 heterotrimeric G-protein complex