Protein

MIA_05818_1

Length
1,024 amino acids

Browser: contig09:416826-419901+

Protein function

EGGNOG:0PFMHLIG4dna ligase
SGD closest match:S000005531DNL4DNA ligase 4
CGD closest match:CAL0000187710LIG4DNA ligase 4

Protein alignments

%idAln lengthE-value
MCA_02462_146.439%10530.0MCA_02462_1
A0A0J9XHB9_GEOCN34.363%10041.93e-178DNA ligase OS=Geotrichum candidum GN=BN980_GECA18s00098g PE=3 SV=1
UniRef50_A0A0J9XHB934.363%10043.94e-175DNA ligase n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XHB9_GEOCN
DNLI4_YARLI30.507%10261.53e-140DNA ligase 4 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=LIG4 PE=3 SV=1
A0A1E3PIA4_9ASCO30.366%9552.03e-131DNA ligase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_66750 PE=3 SV=1
A0A1E4TJ77_9ASCO32.178%8087.02e-133DNA ligase (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_15943 PE=3 SV=1
A0A060SZN6_BLAAD31.179%6194.04e-77ARAD1C02090p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C02090g PE=3 SV=1
DNLI4_CANAL26.871%8821.14e-76DNA ligase 4 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=LIG4 PE=2 SV=4
DNLI4_YEAST27.338%8341.47e-72DNA ligase 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DNL4 PE=1 SV=1
A0A167CYF3_9ASCO34.056%4614.08e-74DNA ligase (ATP) DNL4 OS=Sugiyamaella lignohabitans GN=DNL4 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2836
Predicted cleavage: 28

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 700 800 900 1024

Detailed signature matches

  1. Domain IPR012308
    DNA ligase, ATP-dependent, N-terminal
    1. PF04675 (DNA_ligase...)
    2. G3DSA:1.10.32...
  2. Domain IPR012310
    DNA ligase, ATP-dependent, central
    1. PS50160 (DNA_LIGASE_A3)
    2. PF01068 (DNA_ligase...)
  3. Domain IPR012340
    Nucleic acid-binding, OB-fold
    1. SSF50249 (Nucleic a...)
  4. Domain IPR012309
    DNA ligase, ATP-dependent, C-terminal
    1. PF04679 (DNA_ligase...)
  5. Domain IPR001357
    BRCT domain
    1. SSF52113 (BRCT domain)
    2. G3DSA:3.40.50...
    3. PS50172 (BRCT)
    4. PF16589 (BRCT_2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. G3DSA:2.40.50...
  3. G3DSA:3.30.14...
  4. NON_CYTOPLASM... (N...)
  5. SSF56091 (DNA ligas...)
  6. TRANSMEMBRANE (Tran...)
  7. cd07903 (Adenylatio...)
  8. cd07968 (OBF_DNA_li...)

Residue annotation

  1. active site cd07903
  2. DNA binding site c...
  3. DNA binding site c...

Protein sequence

>MIA_05818_1
MNNDYPKKPINRASMPFRLLVSFLDRLQSDKVTPTQRREIIVELAGVWRKKCGSDIFPCFRLLLPDRDIARVFHLKEKRL
ALELIKILRIDPKSNDGVAMLKWKDGASVGVGDFARRCRENIFKRQGKKNYSDLDLDQVNDYLDQLAVCSDKKGDAQRKV
IEKLLELMNAHEMYWLIKIIIKSMKIHLSEKTVLGFWHPSAYKLFNITSDLKRVCWQLCDESVTVSTTEVSPFLCFKPQM
AAYGFKDYTDLLERIGAKAFYIEEKIDGERIQLHMKDGKFKFFSRRGQDRTNNYGHSYNSNGSFTPFLKGFVKDNIKSVI
LDGELVSWNETEGCIEGFGRAKGAMVNLQDLGELFGVKGIRSFTFSEIHNRDADDDEEEFQPSSYNRPKDEVIHRWKTAV
ETAMFRAKRHGFFLVYDLLYLNGISLLAYPLRERIKALNAVINPIPHYLETLEQVEGSTIQDIDKRFLEVMGKGGEGLVI
KNPEATYGLNIRDNSWIKVKPEYIDTIKDTLDLLIIGGYYGNGNRAGQLSSFLCGIRVSNKEEEDEFLDEQSMPKYYSFC
KVGTGFTGQEYKLIRTLFEGKTFPYDPKNPNLPPCLEIGSQTPDVWIHPKDSIVIEVKGSQITYTTSYRANMTLRFPRYA
SFRHDKNWRNAVTLNQIHSIQEDSIANRQKREEEFQNAKLKKKAAAAHTKRAKFSVVTIKTDPIHFTGPLQSNLFQTYFF
YILSSQRNPVYMSQAKIEEMVQMNGGNIIKDYEILKNQLLLDAKSVFIVADLHSVAVTGFTKKQPQIAIVRPLYFTESLN
HKDFLPLEPKHFLVSSEHDLHMARCHVDRYGDAYYNTTTSTSDLTNLLNRLVPSKLELCNNPNKFHNSLSAFQETFEKVF
HSDPIPRSLLFANTVMYFDFEETSLAYFSQDEIIDDADEEYPWMPSKLVCKLDAKADLLKCQRYAQYGGAVITSNILDPK
LTTIVCSPKDPYRARALRGGIIEHFGSKQVYFVNTSWISISWKEQTRLPEEHFPVPKFIDFTSF

GO term prediction

Biological Process

GO:0006281 DNA repair
GO:0006310 DNA recombination

Molecular Function

GO:0003677 DNA binding
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding

Cellular Component

None predicted.