Protein

MIA_05746_1

Length
578 amino acids

Browser: contig09:207054-208791-

Protein function

EGGNOG:0PGHWDLD1d-lactate dehydrogenase
SGD closest match:S000002333DLD1D-lactate dehydrogenase [cytochrome] 1, mitochondrial
CGD closest match:CAL0000191678orf19.6043Uncharacterized protein

Protein alignments

%idAln lengthE-value
MCA_00240_172.921%5170.0MCA_00240_1
A0A0J9XAT2_GEOCN66.411%5210.0Similar to Saccharomyces cerevisiae YDL174C DLD1 D-lactate dehydrogenase, oxidizes D-lactate to pyruvate,transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate OS=Geotrichum candidum GN=BN980_GECA06s02133g PE=4 SV=1
A0A060T5Z6_BLAAD60.456%5260.0ARAD1B11814p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B11814g PE=4 SV=1
UniRef50_A0A060T5Z660.456%5260.0ARAD1B11814p n=17 Tax=saccharomyceta TaxID=716545 RepID=A0A060T5Z6_BLAAD
A0A1E3PM09_9ASCO61.004%5180.0FAD-binding domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_50389 PE=4 SV=1
DLD1_YEAST52.305%4991.61e-180D-lactate dehydrogenase [cytochrome] 1, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DLD1 PE=1 SV=2
A0A1E4TLA1_9ASCO52.301%4780.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_20771 PE=4 SV=1
A0A167CKJ9_9ASCO47.826%5068.31e-169Dld1p OS=Sugiyamaella lignohabitans GN=DLD1 PE=4 SV=1
Q5ABC8_CANAL48.419%5066.53e-162Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.6043 PE=4 SV=1
Q6C773_YARLI47.034%4722.42e-149YALI0E03212p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E03212g PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9981
Predicted cleavage: 52

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 100 200 300 400 500 578

Detailed signature matches

  1. Domain IPR016167
    FAD-binding, type 2, subdomain 1
    1. G3DSA:3.30.43.10
  2. Domain IPR016166
    FAD-binding, type 2
    1. SSF56176 (FAD-bindi...)
    2. PS51387 (FAD_PCMH)
  3. Domain IPR006094
    FAD linked oxidase, N-terminal
    1. PF01565 (FAD_binding_4)
  4. Domain IPR016169
    CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2
    1. G3DSA:3.30.46...
  5. Domain IPR016164
    FAD-linked oxidase-like, C-terminal
    1. SSF55103 (FAD-linke...)
  6. Domain IPR004113
    FAD-linked oxidase, C-terminal
    1. PF02913 (FAD-oxidase_C)
  7. Domain IPR016171
    Vanillyl-alcohol oxidase, C-terminal subdomain 2
    1. G3DSA:1.10.45.10
Unintegrated signatures no IPR
Unintegrated signatures
  1. NON_CYTOPLASM... (N...)
  2. SIGNAL_PEPTIDE (Sig...)
  3. SIGNAL_PEPTID... (S...)
  4. SIGNAL_PEPTID... (S...)
  5. SIGNAL_PEPTID... (S...)

Protein sequence

>MIA_05746_1
MLRQSIGRAQTAIIRNAAAKRPTTALQMRQTMKRFSSSSSSAGASAHKSRTGSAAMLFAAGAISGVAALTLTSSFTESAQ
AFSGASTVETSTTKLEELATPKYALHKECEKAYAEITKLIGAENVTRKKDDLDAHSDTFWNTHHAKPNQRPGIVVFPEST
EQVSQILKITHKYRVPIVPFAGGTSLEGHFTPIYGGVSIDFTRMSSVVALHKKDLDIVVQPGLGWEELDDYLADNDLFFG
PDPGPGAQISGMVGTGCSGTNAYRYGTMRENVIGLVVVLADGTIVKTRQRPRKSSAGYNLTQLFIGSEGTLGIVTEATLK
LHPRPENEGIAMVTFDSVKNAAEAAAEVVQGGHQVAAIEILDEVMMKAVNDAGSTERKWLERPTIAFKFNGTKALVADQV
KTVREISAKHGNKTFDFATTPEQRQELWAARKAALWSTIEVAPKGHNAWTTDVAVPISKLGQIVNETKADIVASGLFGTI
VGHIGDGNFHTILMYDPVTERKTAEGVVHRMVERALSYEGTCTGEHGIGVGKKLYLTKELGPEAVDLMRRLKESLDPLSL
LNPDKVVTINPTTTERGD

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
GO:0050660 flavin adenine dinucleotide binding

Cellular Component

None predicted.