Protein

MCA_00240_1

Length
574 amino acids

Gene name: DLD1A

Description: D-lactate dehydrogenase [cytochrome] 1, mitochondrial

Browser: contigA:739944-741669-

RNA-seq: read pairs 18583, FPKM 399.3, percentile rank 93.5% (100% = highest expression)

Protein function

Annotation:DLD1AD-lactate dehydrogenase [cytochrome] 1, mitochondrial
KEGG:K00102LDHD D-lactate dehydrogenase (cytochrome) [EC:1.1.2.4]
EGGNOG:0PGHWDLD1d-lactate dehydrogenase
SGD closest match:S000002333DLD1D-lactate dehydrogenase [cytochrome] 1, mitochondrial
CGD closest match:CAL0000191678orf19.6043Uncharacterized protein

Protein alignments

%idAln lengthE-value
MIA_05746_172.92%5170.0MIA_05746_1
A0A0J9XAT2_GEOCN69.57%5160.0Similar to Saccharomyces cerevisiae YDL174C DLD1 D-lactate dehydrogenase, oxidizes D-lactate to pyruvate,transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate OS=Geotrichum candidum GN=BN980_GECA06s02133g PE=4 SV=1
A0A060T5Z6_BLAAD59.60%5520.0ARAD1B11814p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B11814g PE=4 SV=1
UniRef50_A0A060T5Z659.60%5520.0ARAD1B11814p n=17 Tax=saccharomyceta TaxID=716545 RepID=A0A060T5Z6_BLAAD
A0A1E3PM09_9ASCO63.73%4770.0FAD-binding domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_50389 PE=4 SV=1
A0A1E4TLA1_9ASCO53.75%4803e-176Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_20771 PE=4 SV=1
A0A167CKJ9_9ASCO50.73%4778e-164Dld1p OS=Sugiyamaella lignohabitans GN=DLD1 PE=4 SV=1
DLD1_YEAST49.80%5021e-160D-lactate dehydrogenase [cytochrome] 1, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DLD1 PE=1 SV=2
Q5ABC8_CANAL45.25%5262e-146Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.6043 PE=4 SV=1
Q6C773_YARLI45.30%4792e-143YALI0E03212p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E03212g PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9939
Predicted cleavage: 35

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 100 200 300 400 500 574

Detailed signature matches

  1. Domain IPR016167
    FAD-binding, type 2, subdomain 1
    1. G3DSA:3.30.43.10
  2. Domain IPR016166
    FAD-binding, type 2
    1. PS51387 (FAD_PCMH)
    2. SSF56176 (FAD-bindi...)
  3. Domain IPR006094
    FAD linked oxidase, N-terminal
    1. PF01565 (FAD_binding_4)
  4. Domain IPR016169
    CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2
    1. G3DSA:3.30.46...
  5. Domain IPR016164
    FAD-linked oxidase-like, C-terminal
    1. SSF55103 (FAD-linke...)
  6. Domain IPR004113
    FAD-linked oxidase, C-terminal
    1. PF02913 (FAD-oxidase_C)
  7. Domain IPR016171
    Vanillyl-alcohol oxidase, C-terminal subdomain 2
    1. G3DSA:1.10.45.10
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. NON_CYTOPLASM... (N...)
  3. SIGNAL_PEPTIDE (Sig...)
  4. SIGNAL_PEPTID... (S...)
  5. SIGNAL_PEPTID... (S...)
  6. SIGNAL_PEPTID... (S...)
  7. TRANSMEMBRANE (Tran...)
  8. mobidb-lite (disord...)

Protein sequence

>MCA_00240_1
MIRSRINLLARPRLSVSSAATLRSRTVNRFTARFNSTKQTTPPNASSSAPKSSASPLVSFVVGVTLTGLIMAYGPQLSTK
SSDEIIPITELSQLTPPKYATPDQLTKAFAEITAIVGEENVSNKPDVFDTHSDTFWNTHHAKPDERPQLVVYPSSTEEVS
EIMKICTKYKVPIVPFAGGTSLEGHFTPIYGGISLDFTNMSKILQLHKEDLDIVVQPGLGWEELDDYLEDYELAFGPDPG
PGAQISGMIGTGCSGTNAYRYGTMRDNVLNLTVVLSDGSVIKTRQRPRKSSAGYNLTQLFIGSEGTLGIVTEATLKLVPR
PQNEGIAMVTFNSIKDAAAAAAEVVQAGLQVGAIEILDDVMMKAVNDAGQTRRKWIEKPTIAFKFSGSVTTVKDMISQVK
AISKSHNNQSFDFATSKEQREELWAARKAALWSTIEVAPKGHHAWTTDVAVPMSNLPQIINETKKDIVDSGLFGTIVGHV
GDGNFHTILMYDPNTERDVAEGVVHRMVNRALELDGTCTGEHGVGVGKKLYLAKELGPGAVGLMRRLKLTLDPLCILNPD
KVVTVNPLSPELGD

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
GO:0050660 flavin adenine dinucleotide binding

Cellular Component

None predicted.