Protein

MIA_05720_1

Length
833 amino acids

Browser: contig09:139102-141654+

Protein function

EGGNOG:0PFUWFG05453.1DNA ligase
SGD closest match:S000002323CDC9DNA ligase 1
CGD closest match:CAL0000199743orf19.6155DNA ligase

Protein alignments

%idAln lengthE-value
MCA_06271_176.923%6240.0MCA_06271_1
A0A0J9XD90_GEOCN70.759%6190.0DNA ligase OS=Geotrichum candidum GN=BN980_GECA10s03387g PE=3 SV=1
A0A060SZQ8_BLAAD66.993%6120.0DNA ligase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C10252g PE=3 SV=1
A0A1E3PQ32_9ASCO61.489%6180.0DNA ligase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_21939 PE=3 SV=1
Q6C3B6_YARLI61.175%6130.0DNA ligase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F01034g PE=3 SV=1
A0A167FCC8_9ASCO69.020%5100.0DNA ligase OS=Sugiyamaella lignohabitans GN=CDC9 PE=3 SV=1
A0A1D8PJ08_CANAL59.486%6220.0DNA ligase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.6155 PE=3 SV=1
A0A1E4T9H7_9ASCO59.330%6270.0DNA ligase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_29619 PE=3 SV=1
UniRef50_A0A1X7QYK057.468%6160.0Similar to Saccharomyces cerevisiae YDL164C CDC9 DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazakis during DNA replication n=1 Tax=Kazachstania saulgeensis TaxID=1789683 RepID=A0A1X7QYK0_9SACH
DNLI1_YEAST55.682%6160.0DNA ligase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CDC9 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9961
Predicted cleavage: 24

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 700 833

Detailed signature matches

  1. Family IPR000977
    DNA ligase, ATP-dependent
    1. TIGR00574
  2. Domain IPR012308
    DNA ligase, ATP-dependent, N-terminal
    1. SSF117018 (ATP-depe...)
    2. PF04675 (DNA_ligase...)
    3. G3DSA:1.10.32...
  3. Domain IPR012310
    DNA ligase, ATP-dependent, central
    1. PS50160 (DNA_LIGASE_A3)
    2. PF01068 (DNA_ligase...)
  4. Domain IPR012340
    Nucleic acid-binding, OB-fold
    1. SSF50249 (Nucleic a...)
  5. Domain IPR012309
    DNA ligase, ATP-dependent, C-terminal
    1. PF04679 (DNA_ligase...)
  6. SITE IPR016059
    DNA ligase, ATP-dependent, conserved site
    1. PS00333 (DNA_LIGASE_A2)
    2. PS00697 (DNA_LIGASE_A1)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:2.40.50...
  2. G3DSA:3.30.14...
  3. G3DSA:3.30.47...
  4. NON_CYTOPLASM... (N...)
  5. SIGNAL_PEPTIDE (Sig...)
  6. SIGNAL_PEPTID... (S...)
  7. SIGNAL_PEPTID... (S...)
  8. SIGNAL_PEPTID... (S...)
  9. SSF56091 (DNA ligas...)
  10. cd07900 (Adenylatio...)
  11. cd07969 (OBF_DNA_li...)
  12. mobidb-lite (disord...)

Residue annotation

  1. active site cd07900
  2. DNA binding site c...
  3. DNA binding site c...

Protein sequence

>MIA_05720_1
MIRFPKRIFSVALRSSLSYTPRICPVTMAPVKTLKTSSASHGPAKKQKSMMDFFKPKKETTTAKKETLKNDPSKEDLSKP
DLSSSLADKKISPKKTRKRVLMDESDEETLPKEEPKSPKSPKPPKSPSASPSKKKLKETLQSSEDAALETPSEGSETPAS
QTSVTRESTPEEVESPKNKKKSKKPTEKKLTPDPPKSIPKLSLLPDKSIPYEMLVQGFEEIEENSSRLKIISLACEVFLN
TLRLKPEELTSVVYLCINRLGPEYEGLELGLGESIIIKALGESTGRSNAQIKAEYRTEGDLGLVALKLRKTQPTMFQPKP
LSIETVFKGLHEIAVTTGKDSQGRKIAIIKRLLTAAKGFQAKFIVRSLEGKLRIGLAEKSVLTGLAQAFVSWEYEKAKAA
STKHVERPDSQTVSKAEELIREVHCQVPNYGTIIDAAIAGGIFNIAETCKLSAGVPLKPMLAKPTKSITEILDRFHGEEF
TCEYKYDGERAQVHQTEDGKLHVYSRNMEDMSQRYPDILSSIAQFANKENTTSYILDCEAVAWDRAESKLLPFQVLSTRK
RKDVEEDKITVRICLFAFDLLYLNGQPLLNKTLEERRELLRQHFTPLEGHFTFAKSINSNNVEDIQTFLDQSVKDSCEGL
MIKVLKGNESGYEPSKRSRNWLKLKKDYLQGVGDSLDLVVLGAFYGKGKRTNRYGAFLLGCYNSDTEQYETICKIGTGFS
DENLEEFYKALSATVIEKPKGYYSYDTASNNQPDVWFQPTMVWEVLTADLSLSPVYKAGIDTLGKGVSLRFPRFMRVRDD
KGVEDVTTSDQVVEFYRRQASVTQNKDSLSDDE

GO term prediction

Biological Process

GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0051103 DNA ligation involved in DNA repair
GO:0071897 DNA biosynthetic process

Molecular Function

GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding

Cellular Component

None predicted.