Protein

MCA_06271_1

Length
786 amino acids

Gene name: CDC9

Description: DNA ligase 1

Browser: contigD:3734638-3736999+

RNA-seq: read pairs 915, FPKM 14.4, percentile rank 33.1% (100% = highest expression)

Protein function

Annotation:CDC9DNA ligase 1
KEGG:K10747LIG1 DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
EGGNOG:0PFUWFG05453.1DNA ligase
SGD closest match:S000002323CDC9DNA ligase 1
CGD closest match:CAL0000199743orf19.6155DNA ligase

Protein alignments

%idAln lengthE-value
MIA_05720_174.73%6410.0MIA_05720_1
A0A0J9XD90_GEOCN72.13%6100.0DNA ligase OS=Geotrichum candidum GN=BN980_GECA10s03387g PE=3 SV=1
A0A060SZQ8_BLAAD62.50%6480.0DNA ligase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C10252g PE=3 SV=1
Q6C3B6_YARLI61.64%6100.0DNA ligase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F01034g PE=3 SV=1
A0A1E3PQ32_9ASCO62.64%6130.0DNA ligase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_21939 PE=3 SV=1
A0A167FCC8_9ASCO69.31%5050.0DNA ligase OS=Sugiyamaella lignohabitans GN=CDC9 PE=3 SV=1
A0A1D8PJ08_CANAL58.91%6620.0DNA ligase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.6155 PE=3 SV=1
UniRef50_Q6CR2059.61%6190.0DNA ligase n=12 Tax=Saccharomycetales TaxID=4892 RepID=Q6CR20_KLULA
DNLI1_YEAST57.93%6180.0DNA ligase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CDC9 PE=1 SV=2
A0A1E4T9H7_9ASCO58.36%6220.0DNA ligase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_29619 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.5203

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 700 786

Detailed signature matches

  1. Family IPR000977
    DNA ligase, ATP-dependent
    1. TIGR00574
  2. Family IPR022865
    DNA ligase, ATP-dependent, bacterial/archaeal
    1. MF_00407 (DNA_ligase)
  3. Domain IPR012308
    DNA ligase, ATP-dependent, N-terminal
    1. SSF117018 (ATP-depe...)
    2. PF04675 (DNA_ligase...)
    3. G3DSA:1.10.32...
  4. Domain IPR012310
    DNA ligase, ATP-dependent, central
    1. PS50160 (DNA_LIGASE_A3)
    2. PF01068 (DNA_ligase...)
  5. Domain IPR012340
    Nucleic acid-binding, OB-fold
    1. SSF50249 (Nucleic a...)
  6. Domain IPR012309
    DNA ligase, ATP-dependent, C-terminal
    1. PF04679 (DNA_ligase...)
  7. SITE IPR016059
    DNA ligase, ATP-dependent, conserved site
    1. PS00333 (DNA_LIGASE_A2)
    2. PS00697 (DNA_LIGASE_A1)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:2.40.50...
  2. G3DSA:3.30.14...
  3. G3DSA:3.30.47...
  4. SSF56091 (DNA ligas...)
  5. cd07900 (Adenylatio...)
  6. cd07969 (OBF_DNA_li...)
  7. mobidb-lite (disord...)

Residue annotation

  1. DNA binding site c...
  2. active site cd07900
  3. DNA binding site c...

Protein sequence

>MCA_06271_1
MPAPNSVSQKSINSFFSQSKGSMKSKKPQQTLDSLFNKQKTTDTKKTEEDKDVEATQKPKERRSRIIEDDEDEITSTETT
VATPPGKESDHTMDVDSPSNVSTKRKSTSKSPPNSPPKKQIKLENSKPIETDVKMEDEEKPVSILEIEKEAAPASSIKIL
SHDNSLDYALLVDTFEKIEATPQRLKIVAFISELFLEVLRVKPEELAKVVYLCINRLGPEYEPGLELGLGETLIIKALAE
ATGRTNAQIKNDYKEVGDLGLVALKSRNNQPTMFKPKPLSVKSVFEGLKDIASMSGKDSQTRKIRVIKRLLTSSKGVQAK
FLVRSLEGKLRIGLAEKSVLTGLAQAFVAWEHEKSGSKAKVSPEVVTKAEETIREVYCQVPNYGVIIDAAIASGIESVSE
TCKLSAGIPLKPMLAKPTKSITEILDRFSGEEFTCEYKYDGERAQVHLTEDGQLRVYSRNMEDMSQRYPDIISSIAQFSK
KDTTKSYIIDCEAVAWDREQGKLLPFQVLSTRKRKDVEEDKIKVRICLFAFDLLYLNGESLLKKPLKERRELLREHFIPA
EGHFAFAQSLNSNNVDDIQTFLDQSVKDSCEGLMIKVLKGTESGYEPSKRSRNWLKLKKDYLSGVGDSLDLVVLGAYYGK
GKRTSNYGAFLLGSYNSESETYETICKIGTGFSDEMLDTIYKSLSPTVIEKPKGYYSYSSASQAQPDVWFEPTMVWEVLT
ADLSLSPIYQAGIDILGKGVSLRFPRFIRIRDDKGVEDATTSEQVVELYRRQASISNGGGANSDED

GO term prediction

Biological Process

GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0051103 DNA ligation involved in DNA repair
GO:0071897 DNA biosynthetic process

Molecular Function

GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding

Cellular Component

None predicted.