Protein

MIA_05709_1

Length
500 amino acids

Browser: contig09:117206-118709-

Protein function

EGGNOG:0PGMGFG08736.1bleomycin hydrolase
SGD closest match:S000005183LAP3Cysteine proteinase 1, mitochondrial
CGD closest match:CAL0000187653LAP3Bleomycin hydrolase

Protein alignments

%idAln lengthE-value
MCA_06275_172.800%5000.0MCA_06275_1
A0A0J9XIB3_GEOCN58.221%5170.0Similar to Saccharomyces cerevisiae YNL239W LAP3 Cysteine aminopeptidase with homocysteine-thiolactonase activity OS=Geotrichum candidum GN=BN980_GECA20s00296g PE=4 SV=1
A0A167FWM4_9ASCO53.892%5010.0Lap3p OS=Sugiyamaella lignohabitans GN=LAP3 PE=4 SV=1
A0A060TEG4_BLAAD51.587%5040.0ARAD1D14938p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D14938g PE=4 SV=1
UniRef50_K0KE5648.967%4841.72e-162Bleomycin hydrolase n=28 Tax=Saccharomycetales TaxID=4892 RepID=K0KE56_WICCF
Q5A6L5_CANAL48.643%4793.52e-156Bleomycin hydrolase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=LAP3 PE=4 SV=1
Q6C2Q6_YARLI50.676%4449.32e-155YALI0F05940p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F05940g PE=4 SV=1
A0A1E4TGU8_9ASCO45.666%4731.42e-141Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_115187 PE=4 SV=1
BLH1_YEAST38.936%4701.10e-109Cysteine proteinase 1, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LAP3 PE=1 SV=3

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0127

Protein family membership

Domains and repeats

None predicted.

Detailed signature matches

  1. Family IPR004134
    Peptidase C1B, bleomycin hydrolase
    1. PF03051 (Peptidase_...)
    2. PIRSF005700 (PepC)
    3. cd00585 (Peptidase_C1B)
  2. SITE IPR000169
    Cysteine peptidase, cysteine active site
    1. PS00139 (THIOL_PROT...)
  3. SITE IPR025660
    Cysteine peptidase, histidine active site
    1. PS00639 (THIOL_PROT...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.90.70.10
  2. SSF54001 (Cysteine ...)
  3. mobidb-lite (disord...)

Residue annotation

  1. trimer interface c...
  2. active site cd00585
  3. G bulge cd00585

Protein sequence

>MIA_05709_1
MGNTESVQAPRQSRQYKAPSEKLAIAPAPSSADNLTEELSRLILSSKTRISGTANPISTDSLGEWESEVLADPKNRLAQA
AITKGAIANIIKNPKVFQDDSVHVFSELIANEGAPITNQHSSGRCWLFASTSLLRIGIQTRLKIDEFQLSQSFLFFYDKL
EKCNYFLQNLIETADYDLDSRLVAALLLDDVSDGGQWDFLINIVQKYGLVPRTVFPESFSSDNSYKIDYIISNKIREFGL
NLRKAKLEQNADITTLSVLKEKYMQEIFNILTITFGSPPKPTDTFTWEYTDTYGKYHSITTTPLGFYQDIVKFDVSSYFS
LIHDPRNPYDELYTVDRNNNMQGGKPLEFVNVPIDVLKQAAITAIQNDEAVFFGSDVGQFSDSLSGIMDTEAWDFQLAYN
TKFNLDKADRVRLGLSQMTHAMLLTGVDIVDGKPVKWKVMNSWGTDVGDKGYFTMSDKWFDEYVYQVVTTPKYIGKKYTD
IWKAKDFKVLPRWDPYGSLA

GO term prediction

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0004197 cysteine-type endopeptidase activity

Cellular Component

None predicted.