Protein
MIA_05610_1
Length
428 amino acids
Browser: contig08:924031-925364-
Protein function
| EGGNOG: | 0QD6T | SIL1 | Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2 |
|---|---|---|---|
| SGD closest match: | S000005391 | SIL1 | Nucleotide exchange factor SIL1 |
| CGD closest match: | CAL0000176393 | SIL1 | Nucleotide exchange factor SIL1 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| A0A0J9X5I4_GEOCN | 38.149% | 443 | 3.18e-80 | Similar to Saccharomyces cerevisiae YOL031C SIL1 Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER OS=Geotrichum candidum GN=BN980_GECA03s02419g PE=4 SV=1 |
| UniRef50_A0A0J9X5I4 | 38.149% | 443 | 6.50e-77 | Similar to Saccharomyces cerevisiae YOL031C SIL1 Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X5I4_GEOCN |
| SIL1_YARLI | 27.842% | 431 | 4.24e-37 | Nucleotide exchange factor SIL1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=SIL1 PE=1 SV=2 |
| MCA_02017_1 | 27.365% | 296 | 6.71e-30 | MCA_02017_1 |
| A0A167FXF4_9ASCO | 26.009% | 446 | 6.06e-30 | Sil1p OS=Sugiyamaella lignohabitans GN=SIL1 PE=4 SV=1 |
| SIL1_CANAL | 27.594% | 424 | 1.77e-28 | Nucleotide exchange factor SIL1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SIL1 PE=3 SV=1 |
| SIL1_YEAST | 49.296% | 71 | 5.05e-17 | Nucleotide exchange factor SIL1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SIL1 PE=1 SV=1 |
| A0A1E3PMT0_9ASCO | 68.182% | 44 | 8.53e-15 | Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_41374 PE=4 SV=1 |
| A0A060TAM4_BLAAD | 25.887% | 282 | 1.84e-13 | ARAD1D25058p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D25058g PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0677
Protein family membership
- Nucleotide exchange factor Sil1, fungi (IPR031884)
Domains and repeats
-
Domain
1
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428
Detailed signature matches
Protein sequence
>MIA_05610_1 MISTAIASSSPIEPINVRGDSICFLKEGKETCYPKVFEPSTKWQEILPGQEIPAGLHVRMNVETGLREAKLLDSKDGSEV NAVEVKLPDTEAIVKELNNIEVEELPEDPEVDLLAEIPEVEEEDSEADKELRDKIRLSSSSGQEGQLYESIENIKKYQKI EPRILSQSLEVLADLGHELEFGERIVSSNTKELLEILQKKEIPPHIREIAARALGASMRNNPGALAKAAGQGIVKSLLEV VDSSDNDKLSGRLIYAVGSVVSTGEGSEVMSQNDAEYLEGNGGEVFRRAFDEGTGDLKRKISTFVFDRALKLEWPDREFS EWSNIFQKALLKKELKGEDKLRVFEALTQIQEYMVDHSSSGEKRVVKRGVAEMLPVRDDFLEWLAKEADAYRERRGLDDT EEQFKEVLLQSRHSVFGNPLAGRKNEEL
GO term prediction
Biological Process
None predicted.
Molecular Function
GO:0000774 adenyl-nucleotide exchange factor activity
GO:0005488 binding
Cellular Component
GO:0005783 endoplasmic reticulum