Protein

MIA_05577_1

Length
1,178 amino acids

Browser: contig08:856213-859819-

Protein function

EGGNOG:0PH74SET1Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1 2 3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation
SGD closest match:S000001161SET1Histone-lysine N-methyltransferase, H3 lysine-4 specific
CGD closest match:CAL0000198993SET1Histone-lysine N-methyltransferase, H3 lysine-4 specific

Protein alignments

%idAln lengthE-value
MCA_02031_170.294%3401.02e-158MCA_02031_1
SET1_YARLI60.182%3292.17e-121Histone-lysine N-methyltransferase, H3 lysine-4 specific OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=SET1 PE=3 SV=1
UniRef50_C4Y70158.239%3521.27e-122Histone-lysine N-methyltransferase n=1 Tax=Clavispora lusitaniae (strain ATCC 42720) TaxID=306902 RepID=C4Y701_CLAL4
SET1_CANAL57.878%3116.31e-108Histone-lysine N-methyltransferase, H3 lysine-4 specific OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SET1 PE=3 SV=1
A0A1E3PS70_9ASCO61.071%2802.89e-110SET-domain-containing protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81181 PE=4 SV=1
SET1_YEAST53.293%3342.27e-99Histone-lysine N-methyltransferase, H3 lysine-4 specific OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SET1 PE=1 SV=1
A0A060T0W6_BLAAD56.604%3184.22e-98Histone-lysine N-methyltransferase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C16016g PE=3 SV=1
A0A1E4TD55_9ASCO47.207%3586.33e-88Histone-lysine N-methyltransferase, H3 lysine-4 specific OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_46103 PE=3 SV=1
A0A161HKP6_9ASCO53.558%2677.76e-76Histone-lysine N-methyltransferase OS=Sugiyamaella lignohabitans GN=SET1 PE=3 SV=1
A0A0J9XK07_GEOCN34.328%1341.53e-21Similar to Saccharomyces cerevisiae YJL168C SET2 Histone methyltransferase with a role in transcriptional elongation OS=Geotrichum candidum GN=BN980_GECA20s01858g PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1054

Protein family membership

Domains and repeats

  1. Domain
1 200 400 600 800 1000 1178

Detailed signature matches

  1. Family IPR017111
    Histone H3-K4 methyltransferase Set1, fungal
    1. PS51572 (SAM_MT43_1)
    2. PIRSF037104 (H3K4_H...)
  2. Domain IPR024657
    COMPASS complex Set1 subunit, N-SET domain
    1. SM01291 (N_SET_2)
    2. PF11764 (N-SET)
  3. Domain IPR001214
    SET domain
    1. PF00856 (SET)
    2. PS50280 (SET)
    3. SM00317 (set_7)
  4. Domain IPR003616
    Post-SET domain
    1. PS50868 (POST_SET)
    2. SM00508 (PostSET_3)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:2.170.2...
  3. G3DSA:3.30.70...
  4. SSF82199 (SET domain)
  5. mobidb-lite (disord...)

Protein sequence

>MIA_05577_1
MPASHDEKSDLATFFPDRKKGSHYNSSSSSARRPSSSKFRPRSSSSSSSSSLLSSSKHPKSSYSSDQLPSPFTSSYRIHD
EKLPPAGSSDNDKRPLSIVDSKTWRDTPKPFNKDDLFFHKKIKQKPEETHSHYLPSPQSSSTSNSDSRQLTKEPETHDYR
SSKSTKRTNYQVIYDPDLSRTKSGGSKPKLRYNGEGQPDPTDPRFYKGIRYTRSKTGKKEYLKYCTVPVFIKDENTIAPP
AETKLLMSGLSTLTKKSTIMYKLLEYGPISDLEMVHDQTSGEFLGVCYFKFDGEPRISNKIAQKILADHQHLFIDAKNPH
LQFDEKGVIKERIISEIIKTKNEYFSAPKEPQAKPDVFRNPTTAAHSREAKSSSLSTQESKPSVVRRKMYLKSGKLPVFF
EVSEPCIFISNHFISTRVKIMPIVNWFSKQTDAIFVCPRYFIIAFRDRGVAKRCFKERNNTQFGLNVVSMKLFLYGITDV
EADEAYEAEEKASKLGYEQLKKRELEKASGKPILQTNPREMKQLGYDINKRSTQQALSDPIVNPYKNKIPITSTSSATAE
ISVEEKSPSSNRFNPLPSSVLSLPRFKKTSTISAPSKLQLTTARSREKVSARPMNHGLNDDSSDEEDDDSESATQTPVYP
QAASDTSLSTTSEKIESSPKLPLQKPENPSENPNEEEPLTASKSNKSKRRNLKEFLHYTSSEGESDGELAESRLHKKLKL
GTDNTIKTPLRSKSKLTNPPVESQITPEASPTNHDSEESKKEQARRIFKREDESLNKILVPLISPEEESEDEQNKQPKLE
ELKEEAEDEAKDIKPKLQAPEASDAPEYHDPEWDSMFEEHPISQEITNPKLSWDPSEGQMEPVCVDDFSTLLDLDGFQTF
VKDDEDLDLLKQVLKGVESEDLGPVDFWCWNQKEMKSVNYGRESVGKPLLVEGGIEETLRWSSQTGASRSDGFKRIADKD
KAAYLPHRRKIHEPIDTIREEPDTSTASSAAPAGGFNSRHNRASNRRLANDISLQKQMLSTETDILNFNQLKKRKKPVKF
ARSAIHNWGLYAIEPIAANDMIIEYVGEVVRQKVAELREKKYLRSGIGSSYLFRIDEQTVIDATKLGGIARFINHSCTPS
CTAKIIKVEGKKRIVIYALRDIQANEELTYDYKFEREVNDEERIPCLCGSSGCKGYLN

GO term prediction

Biological Process

GO:0034968 histone lysine methylation

Molecular Function

GO:0005515 protein binding
GO:0018024 histone-lysine N-methyltransferase activity

Cellular Component

GO:0048188 Set1C/COMPASS complex