Protein

MCA_02031_1

Length
1,051 amino acids

Gene name: SET1

Description: Histone-lysine N-methyltransferase, H3 lysine-4 specific

Browser: contigB:60671-63827+

RNA-seq: read pairs 1607, FPKM 18.9, percentile rank 40.0% (100% = highest expression)

Protein function

Annotation:SET1Histone-lysine N-methyltransferase, H3 lysine-4 specific
KEGG:K11422SETD1 histone-lysine N-methyltransferase SETD1 [EC:2.1.1.43]
EGGNOG:0PH74SET1Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1 2 3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation
SGD closest match:S000001161SET1Histone-lysine N-methyltransferase, H3 lysine-4 specific
CGD closest match:CAL0000198993SET1Histone-lysine N-methyltransferase, H3 lysine-4 specific

Protein alignments

%idAln lengthE-value
MIA_05577_170.00%3402e-146MIA_05577_1
SET1_YARLI61.90%3365e-117Histone-lysine N-methyltransferase, H3 lysine-4 specific OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=SET1 PE=3 SV=1
UniRef50_A0A1E4U0A460.29%3401e-113Histone-lysine N-methyltransferase (Fragment) n=1 Tax=Pachysolen tannophilus NRRL Y-2460 TaxID=669874 RepID=A0A1E4U0A4_PACTA
SET1_CANAL57.49%3342e-104Histone-lysine N-methyltransferase, H3 lysine-4 specific OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SET1 PE=3 SV=1
A0A060T0W6_BLAAD55.12%3032e-94Histone-lysine N-methyltransferase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C16016g PE=3 SV=1
SET1_YEAST53.55%3383e-91Histone-lysine N-methyltransferase, H3 lysine-4 specific OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SET1 PE=1 SV=1
A0A1E3PS70_9ASCO62.41%2743e-97SET-domain-containing protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81181 PE=4 SV=1
A0A1E4TD55_9ASCO77.98%1688e-82Histone-lysine N-methyltransferase, H3 lysine-4 specific OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_46103 PE=3 SV=1
A0A0J9XK07_GEOCN34.81%1351e-22Similar to Saccharomyces cerevisiae YJL168C SET2 Histone methyltransferase with a role in transcriptional elongation OS=Geotrichum candidum GN=BN980_GECA20s01858g PE=4 SV=1
A0A161HKP6_9ASCO33.70%1818e-23Histone-lysine N-methyltransferase OS=Sugiyamaella lignohabitans GN=SET1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2253

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 800 900 1000 1051

Detailed signature matches

  1. Family IPR017111
    Histone H3-K4 methyltransferase Set1, fungal
    1. PS51572 (SAM_MT43_1)
    2. PIRSF037104 (H3K4_H...)
  2. Domain IPR024657
    COMPASS complex Set1 subunit, N-SET domain
    1. SM01291 (N_SET_2)
    2. PF11764 (N-SET)
  3. Domain IPR001214
    SET domain
    1. PF00856 (SET)
    2. PS50280 (SET)
    3. SM00317 (set_7)
  4. Domain IPR003616
    Post-SET domain
    1. PS50868 (POST_SET)
    2. SM00508 (PostSET_3)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:2.170.2...
  3. G3DSA:3.30.70...
  4. SSF82199 (SET domain)
  5. mobidb-lite (disord...)

Protein sequence

>MCA_02031_1
MKKYNESSSMETFFPKRRTSNIVPISTLPEKPDNAYYTSRDDTPSNFRTKENFTTSRRTGKLMENKTELNEYSGKTRKSE
KSLHNTKITDPSLSSSSSNTGLSGSNPKNYKLIYDPELSKSKSRGSKPLYRFGGEGSSDPKDPRYVKSICYPRTSRGKKA
FILSCPSLQYSNDENSVAPETHIILTGLSTLTQKSSIMSQLSTFGTVEDFQMKFDPSSQEFLGICHFRFKEDKPNSNKLA
LQFVSQIDKLIIDSIRPSAILDYSKEKIDSIVNKALESKKPIFKTYPDECTYNIPFRNGTLPPNFKIPGFCIFISSTYID
TNLQFLALRKWLYPYEAKNYYVNKDGFYLSFPNEYSMQRVYKKLNKTYFLNRKIYMDMFYDGIVESMIKEIKHKEALAKK
TANPKQIESHAQKLTMQKAFDSVSDSDEGKIDIKANDEQMKLQTEEAVNHIINDLRSFMYRDIRERVQAPAIVEFLHPNR
FEKHKPKEKREAFDDERRLSKKDTDETVDQSSSLPVLPHFKKRVSYKHLDNSKAFSSNKFLKKSDKPSKKSNEANNKRKE
PSESSTLTKSGKVENSTISNDKNPLFEIEKLNKSSLQESEPDSQHQDSSKLKRKYNKDELYYSSTDGEVSDLNDESTDLK
STKKPKLHKDNTSSYPESFDENTVMIQKPDCIKTDYSQPTEIILVSPEQDSHDESDSTYEFGKLATILSLKPSSHPLSIT
ASSSSIRWQPTEGQFLSVCDDSELNNSLDINGIQSLVKDKEDYAFLQKALSFVYPEDIGNADYWAWNNKEMASYDDHTIN
EDEVLLDNNDLEYQIRWTNKTGSSRSEGYSKIADADKSAYLPHRKKIHVPIDTIQESSDISLTSTNRASNSRHNRASNRR
LANDINLQKQMLSNETDILNFNQLMKRKKPVKFARSAIHNWGLYAIEPIAANEMIIEYVGEVVRQKVAEIREKKYLRSGI
GSSYLFRIDEQTVIDATMLGGIARFINHCCTPSCTAKIIKVEGKKRIVIYALRDIAANEELTYDYKFEREANDEERIPCL
CGSTGCKGFLN

GO term prediction

Biological Process

GO:0034968 histone lysine methylation

Molecular Function

GO:0005515 protein binding
GO:0018024 histone-lysine N-methyltransferase activity

Cellular Component

GO:0048188 Set1C/COMPASS complex