Protein
MIA_05563_1
Length
410 amino acids
Browser: contig08:820278-821511-
Protein function
EGGNOG: | 0PFTF | URA9 | Dihydroorotate dehydrogenase |
---|---|---|---|
SGD closest match: | S000001699 | URA1 | Dihydroorotate dehydrogenase (fumarate) |
CGD closest match: | CAL0000178448 | URA9 | Dihydroorotate dehydrogenase (quinone), mitochondrial |
Protein alignments
%id | Aln length | E-value | ||
---|---|---|---|---|
MCA_02045_1 | 76.039% | 409 | 0.0 | MCA_02045_1 |
M1X873_GEOCN | 72.616% | 409 | 0.0 | Dihydroorotate dehydrogenase (quinone), mitochondrial OS=Geotrichum candidum GN=URA1 PE=3 SV=1 |
UniRef50_M1X873 | 72.616% | 409 | 0.0 | Dihydroorotate dehydrogenase (quinone), mitochondrial n=3 Tax=Saccharomycetales TaxID=4892 RepID=M1X873_GEOCN |
A0A167FW03_9ASCO | 59.391% | 394 | 2.80e-163 | Uncharacterized protein OS=Sugiyamaella lignohabitans GN=AWJ20_3415 PE=4 SV=1 |
A0A060SYX1_BLAAD | 56.743% | 393 | 1.16e-149 | Dihydroorotate dehydrogenase (quinone), mitochondrial OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C00682g PE=3 SV=1 |
Q6C8K4_YARLI | 54.242% | 389 | 1.73e-138 | Dihydroorotate dehydrogenase (quinone), mitochondrial OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D18920g PE=3 SV=1 |
PYRD_CANAL | 51.870% | 401 | 3.71e-134 | Dihydroorotate dehydrogenase (quinone), mitochondrial OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=URA9 PE=1 SV=1 |
A0A1E4THX2_9ASCO | 53.351% | 388 | 1.15e-130 | Dihydroorotate dehydrogenase (quinone), mitochondrial OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_57589 PE=3 SV=1 |
A0A1E3PSP9_9ASCO | 52.750% | 400 | 8.31e-126 | Dihydroorotate dehydrogenase (quinone), mitochondrial OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81411 PE=3 SV=1 |
PYRD_YEAST | 22.785% | 316 | 3.54e-08 | Dihydroorotate dehydrogenase (fumarate) OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=URA1 PE=1 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.7959
Predicted cleavage: 33
Protein family membership
- Dihydroorotate dehydrogenase, class 2 (IPR005719)
Domains and repeats
-
Domain
-
Domain
1
50
100
150
200
250
300
350
410
Detailed signature matches
-
-
PF01180 (DHO_dh)
-
no IPR
Unintegrated signatures
-
NON_CYTOPLASM... (N...)
-
SIGNAL_PEPTIDE (Sig...)
-
SIGNAL_PEPTID... (S...)
-
SIGNAL_PEPTID... (S...)
-
SIGNAL_PEPTID... (S...)
-
SSF51395 (FMN-linke...)
-
Residue annotation
-
quinone interactio...
-
active site cd04738
-
catalytic residues...
-
FMN binding site c...
-
substrate binding ...
Protein sequence
>MIA_05563_1 MFKYTRKAVTLTTVLGVGGLGLYFATGRDARTSAQKYVLGPAVRAVLDGEQAHKFAIEVFKHPSLAPRIPADWDQTHDPK ETLKVTLFQHSANKKVKPLTLQSPVGIAAGFDKNGEAIDTLYNLGFSWVEIGSITPLPQPGNPKPRVFRLEKDNAVINRY GFNSDGHIAVVARLKMRESELPPSATNFAGIPNHVLGVNLGKNKTGDEVQDYIKGVDTFGPHADVLIVNVSSPNTPGLRD LQSEEKLTNLLQTLVSRRDALPLESLPPIVVKIAPDLTSPEIESIAAAVKASKVDGVIVSNTTVQRPASLRSSPALASQV GGLSGTPVKPYSIQALKTLRKELGKDITIIGCGGIADGTDALDFARAGADFVQLYTSLVYKGPGVAAEVKEGIIEGLNGK KWTDVVGTDL
GO term prediction
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0055114 oxidation-reduction process
Molecular Function
GO:0003824 catalytic activity
GO:0004152 dihydroorotate dehydrogenase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane